MX2009008506A - Derivados del pirazol como inhibidores de 11-b-hsd1. - Google Patents
Derivados del pirazol como inhibidores de 11-b-hsd1.Info
- Publication number
- MX2009008506A MX2009008506A MX2009008506A MX2009008506A MX2009008506A MX 2009008506 A MX2009008506 A MX 2009008506A MX 2009008506 A MX2009008506 A MX 2009008506A MX 2009008506 A MX2009008506 A MX 2009008506A MX 2009008506 A MX2009008506 A MX 2009008506A
- Authority
- MX
- Mexico
- Prior art keywords
- beta
- pyrazole derivatives
- hsd1 inhibitors
- hsd1
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de fórmula (I): y una sal farmacéuticamente aceptable de lo mismo en donde definen los grupos variables dentro; su uso en la inhibición de 11ßHSD1, los procesos para producirlos y las composiciones farmacéuticas que las comprenden también descritas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88933607P | 2007-02-12 | 2007-02-12 | |
US98573507P | 2007-11-06 | 2007-11-06 | |
PCT/GB2008/000454 WO2008099145A1 (en) | 2007-02-12 | 2008-02-11 | Pyrazole derivatives as 11-beta-hsd1 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009008506A true MX2009008506A (es) | 2009-10-12 |
Family
ID=39438215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009008506A MX2009008506A (es) | 2007-02-12 | 2008-02-11 | Derivados del pirazol como inhibidores de 11-b-hsd1. |
Country Status (23)
Country | Link |
---|---|
US (2) | US7816391B2 (es) |
EP (2) | EP2292228A1 (es) |
JP (1) | JP2010518063A (es) |
KR (1) | KR20090108726A (es) |
CN (1) | CN102503891A (es) |
AR (1) | AR065300A1 (es) |
AU (1) | AU2008215976B2 (es) |
BR (1) | BRPI0808450A2 (es) |
CA (1) | CA2676154A1 (es) |
CL (1) | CL2008000422A1 (es) |
CO (1) | CO6220949A2 (es) |
EC (1) | ECSP099571A (es) |
IL (1) | IL200047A0 (es) |
MX (1) | MX2009008506A (es) |
NZ (1) | NZ578568A (es) |
PE (2) | PE20090649A1 (es) |
RU (2) | RU2462456C2 (es) |
SA (1) | SA08290055B1 (es) |
SG (1) | SG177892A1 (es) |
TW (1) | TW200836719A (es) |
UY (1) | UY30912A1 (es) |
WO (1) | WO2008099145A1 (es) |
ZA (1) | ZA201000838B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2006316087B2 (en) | 2005-11-21 | 2011-03-10 | Shionogi & Co., Ltd. | Heterocyclic compound having inhibitory activity on 11-beta-hydroxysteroid dehydrogenase type I |
TW200827346A (en) | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
TW200836719A (en) | 2007-02-12 | 2008-09-16 | Astrazeneca Ab | Chemical compounds |
BRPI0811191A2 (pt) | 2007-05-18 | 2014-10-29 | Shionogi & Co | Derivado heterocíclico contendo nitrogênio tendo atividade inibitória para 11beta-hidroxiesteroide deidrogenase tipo 1 |
ES2423181T3 (es) | 2007-07-17 | 2013-09-18 | F. Hoffmann-La Roche Ag | Inhibidores de la 11ß-hidroxiesteroide-deshidrogenasa |
KR20100126306A (ko) * | 2008-02-04 | 2010-12-01 | 아스트라제네카 아베 | 4-[4-(2-(아다만틸카르바모일)-5-tert-부틸-피라졸-1-일]벤조산의 신규한 결정형 |
CA2719936A1 (en) * | 2008-04-22 | 2009-10-29 | Astrazeneca Ab | Substituted pyrimidin-5-carboxamides 281 |
EP2391607A1 (en) * | 2009-01-30 | 2011-12-07 | AstraZeneca AB | Novel process for preparing carboxy-containing pyrazoleamido compounds 597 |
EP2243479A3 (en) | 2009-04-20 | 2011-01-19 | Abbott Laboratories | Novel amide and amidine derivates and uses thereof |
US8871208B2 (en) * | 2009-12-04 | 2014-10-28 | Abbvie Inc. | 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
GB201004301D0 (en) * | 2010-03-15 | 2010-04-28 | Syngenta Participations Ag | Process |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
JP5605104B2 (ja) * | 2010-09-10 | 2014-10-15 | セントラル硝子株式会社 | ピラゾール化合物の製造方法 |
CN103635461B (zh) | 2011-06-22 | 2016-01-20 | 中央硝子株式会社 | 吡唑化合物的制造方法 |
JP5915004B2 (ja) * | 2011-06-22 | 2016-05-11 | セントラル硝子株式会社 | ピラゾール化合物の製造方法 |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
JP2015129094A (ja) * | 2012-04-16 | 2015-07-16 | 大日本住友製薬株式会社 | アリールアミノピラゾール誘導体 |
CN111148734B (zh) * | 2017-08-28 | 2023-01-06 | 中国医学科学院药物研究所 | 吡咯-2-甲酰胺类化合物及其制备方法和用途 |
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PL1928840T3 (pl) | 2005-04-05 | 2012-01-31 | Hoffmann La Roche | 1H-pirazolo-4-karboksyamidy, ich wytwarzanie i ich zastosowanie jako inhibitory dehydrogenazy 11-beta-hydroksysteroidowej |
MX2007012213A (es) | 2005-04-06 | 2007-12-10 | Hoffmann La Roche | Derivados de piridin-3-carboxamida como agonistas inversos de canabinoides. |
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JP2008542247A (ja) | 2005-05-24 | 2008-11-27 | アストラゼネカ アクチボラグ | グルコキナーゼモジュレーターとしての2−フェニル置換イミダゾール[4,5b]ピリジン/ピラジンおよびプリン誘導体 |
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EA200702498A1 (ru) | 2005-06-16 | 2008-06-30 | Пфайзер Инк. | N-(пиридин-2-ил)сульфонамидные производные |
NZ575514A (en) | 2005-07-09 | 2009-11-27 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
JP2009504621A (ja) | 2005-08-09 | 2009-02-05 | アストラゼネカ アクチボラグ | 糖尿病の処置のためのヘテロアリールカルバモイルベンゼン誘導体 |
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AU2006316087B2 (en) * | 2005-11-21 | 2011-03-10 | Shionogi & Co., Ltd. | Heterocyclic compound having inhibitory activity on 11-beta-hydroxysteroid dehydrogenase type I |
WO2007089683A1 (en) | 2006-01-31 | 2007-08-09 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
KR20110007258A (ko) | 2006-03-22 | 2011-01-21 | 에프. 호프만-라 로슈 아게 | 11-베타-hsd-1로서의 피라졸 |
BRPI0710669A2 (pt) | 2006-04-07 | 2011-08-16 | High Point Pharmaceuticals Llc | compostos ativos de dehidrogenase de 11b-hidroxiesteróide tipo 1 |
JP2009534440A (ja) | 2006-04-27 | 2009-09-24 | ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | カリウムチャンネルモジュレーターとしてのcbxカンナビノイド受容体モジュレーターの使用 |
WO2008012532A2 (en) | 2006-07-27 | 2008-01-31 | Astrazeneca Ab | : pyridine-3-carboxamide compounds and their use for inhibiting 11-beta-hydroxysteroid dehydrogenase |
TW200827346A (en) * | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
TW200836719A (en) | 2007-02-12 | 2008-09-16 | Astrazeneca Ab | Chemical compounds |
BRPI0811191A2 (pt) | 2007-05-18 | 2014-10-29 | Shionogi & Co | Derivado heterocíclico contendo nitrogênio tendo atividade inibitória para 11beta-hidroxiesteroide deidrogenase tipo 1 |
ES2423181T3 (es) | 2007-07-17 | 2013-09-18 | F. Hoffmann-La Roche Ag | Inhibidores de la 11ß-hidroxiesteroide-deshidrogenasa |
US20110060022A1 (en) * | 2007-11-06 | 2011-03-10 | Astrazeneca Ab | 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]Benzoic Acid - 465 |
KR20100126306A (ko) | 2008-02-04 | 2010-12-01 | 아스트라제네카 아베 | 4-[4-(2-(아다만틸카르바모일)-5-tert-부틸-피라졸-1-일]벤조산의 신규한 결정형 |
CA2719936A1 (en) | 2008-04-22 | 2009-10-29 | Astrazeneca Ab | Substituted pyrimidin-5-carboxamides 281 |
EP2391607A1 (en) | 2009-01-30 | 2011-12-07 | AstraZeneca AB | Novel process for preparing carboxy-containing pyrazoleamido compounds 597 |
UY32954A (es) * | 2009-10-20 | 2011-05-31 | Astrazeneca Ab | PIRIMIDINAS SUSTITUIDAS CON ADAMANTILIMINOCARBONILO COMO INHIBIDORES DE 11-ß-HSD1 826?. |
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2008
- 2008-02-05 TW TW097104688A patent/TW200836719A/zh unknown
- 2008-02-08 CL CL2008000422A patent/CL2008000422A1/es unknown
- 2008-02-09 SA SA8290055A patent/SA08290055B1/ar unknown
- 2008-02-11 MX MX2009008506A patent/MX2009008506A/es not_active Application Discontinuation
- 2008-02-11 JP JP2009548741A patent/JP2010518063A/ja active Pending
- 2008-02-11 WO PCT/GB2008/000454 patent/WO2008099145A1/en active Application Filing
- 2008-02-11 PE PE2008000295A patent/PE20090649A1/es not_active Application Discontinuation
- 2008-02-11 EP EP10183055A patent/EP2292228A1/en not_active Withdrawn
- 2008-02-11 SG SG2011091865A patent/SG177892A1/en unknown
- 2008-02-11 CA CA002676154A patent/CA2676154A1/en not_active Abandoned
- 2008-02-11 BR BRPI0808450-5A patent/BRPI0808450A2/pt not_active IP Right Cessation
- 2008-02-11 RU RU2009133259/04A patent/RU2462456C2/ru not_active IP Right Cessation
- 2008-02-11 AR ARP080100584A patent/AR065300A1/es not_active Application Discontinuation
- 2008-02-11 NZ NZ578568A patent/NZ578568A/en not_active IP Right Cessation
- 2008-02-11 PE PE2012000020A patent/PE20120355A1/es not_active Application Discontinuation
- 2008-02-11 AU AU2008215976A patent/AU2008215976B2/en not_active Ceased
- 2008-02-11 EP EP08702088A patent/EP2124937A1/en not_active Withdrawn
- 2008-02-11 CN CN2011102665044A patent/CN102503891A/zh active Pending
- 2008-02-11 KR KR1020097018195A patent/KR20090108726A/ko not_active Application Discontinuation
- 2008-02-12 UY UY30912A patent/UY30912A1/es not_active Application Discontinuation
- 2008-10-28 US US12/259,562 patent/US7816391B2/en not_active Expired - Fee Related
-
2009
- 2009-07-23 IL IL200047A patent/IL200047A0/en unknown
- 2009-08-11 EC EC2009009571A patent/ECSP099571A/es unknown
- 2009-08-12 CO CO09084454A patent/CO6220949A2/es not_active Application Discontinuation
-
2010
- 2010-02-04 ZA ZA2010/00838A patent/ZA201000838B/en unknown
- 2010-09-09 US US12/878,416 patent/US8344016B2/en active Active
-
2012
- 2012-06-20 RU RU2012125372/04A patent/RU2012125372A/ru not_active Application Discontinuation
Also Published As
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PE20120355A1 (es) | 2012-05-17 |
ZA201000838B (en) | 2010-10-27 |
JP2010518063A (ja) | 2010-05-27 |
IL200047A0 (en) | 2010-04-15 |
RU2012125372A (ru) | 2013-12-27 |
AU2008215976B2 (en) | 2011-11-24 |
WO2008099145A1 (en) | 2008-08-21 |
UY30912A1 (es) | 2008-09-30 |
CN102503891A (zh) | 2012-06-20 |
EP2292228A1 (en) | 2011-03-09 |
SG177892A1 (en) | 2012-02-28 |
CO6220949A2 (es) | 2010-11-19 |
AR065300A1 (es) | 2009-05-27 |
RU2462456C2 (ru) | 2012-09-27 |
EP2124937A1 (en) | 2009-12-02 |
US8344016B2 (en) | 2013-01-01 |
PE20090649A1 (es) | 2009-06-26 |
NZ578568A (en) | 2012-01-12 |
US7816391B2 (en) | 2010-10-19 |
BRPI0808450A2 (pt) | 2014-08-12 |
CL2008000422A1 (es) | 2009-01-02 |
US20110224273A1 (en) | 2011-09-15 |
TW200836719A (en) | 2008-09-16 |
RU2009133259A (ru) | 2011-03-20 |
AU2008215976A1 (en) | 2008-08-21 |
CA2676154A1 (en) | 2008-08-21 |
SA08290055B1 (ar) | 2012-09-26 |
ECSP099571A (es) | 2009-09-29 |
US20090221663A1 (en) | 2009-09-03 |
KR20090108726A (ko) | 2009-10-16 |
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