AU2001288623A1 - Fxr modulators - Google Patents
Fxr modulatorsInfo
- Publication number
- AU2001288623A1 AU2001288623A1 AU2001288623A AU8862301A AU2001288623A1 AU 2001288623 A1 AU2001288623 A1 AU 2001288623A1 AU 2001288623 A AU2001288623 A AU 2001288623A AU 8862301 A AU8862301 A AU 8862301A AU 2001288623 A1 AU2001288623 A1 AU 2001288623A1
- Authority
- AU
- Australia
- Prior art keywords
- fxr modulators
- fxr
- modulators
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/75—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23058500P | 2000-09-05 | 2000-09-05 | |
US60/230,585 | 2000-09-05 | ||
US25809200P | 2000-12-22 | 2000-12-22 | |
US60/258,092 | 2000-12-22 | ||
PCT/US2001/027239 WO2002020463A2 (en) | 2000-09-05 | 2001-08-31 | Fxr modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001288623A1 true AU2001288623A1 (en) | 2002-03-22 |
Family
ID=26924371
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001288623A Abandoned AU2001288623A1 (en) | 2000-09-05 | 2001-08-31 | Fxr modulators |
Country Status (3)
Country | Link |
---|---|
US (2) | US6777446B2 (en) |
AU (1) | AU2001288623A1 (en) |
WO (1) | WO2002020463A2 (en) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020119958A1 (en) * | 2001-02-13 | 2002-08-29 | Shinichiro Tojo | Therapeutic agent for hyperlipidemia |
EP1392714B1 (en) | 2001-03-12 | 2005-08-31 | Intercept Pharmaceuticals, Inc. | Steroids as agonists for fxr |
WO2003059874A2 (en) | 2001-12-21 | 2003-07-24 | Pharmacia Corporation | Aromatic thioether liver x-receptor modulators |
EP1465882B1 (en) | 2001-12-21 | 2011-08-24 | X-Ceptor Therapeutics, Inc. | Hetrocyclic modulators of nuclear receptors |
US6987121B2 (en) | 2002-04-25 | 2006-01-17 | Smithkline Beecham Corporation | Compositions and methods for hepatoprotection and treatment of cholestasis |
MXPA04011690A (en) * | 2002-05-24 | 2005-03-31 | Pharmacia Corp | Sulfone liver x-receptor modulators. |
MXPA04011691A (en) * | 2002-05-24 | 2005-09-12 | Pharmacia Corp | Anilino liver x-receptor modulators. |
US6894061B2 (en) | 2002-12-04 | 2005-05-17 | Wyeth | Substituted dihydrophenanthridinesulfonamides |
US7816385B2 (en) * | 2002-12-20 | 2010-10-19 | High Point Pharmaceuticals, Llc | Dimeric dicarboxylic acid derivatives, their preparation and use |
ES2303960T3 (en) * | 2003-12-23 | 2008-09-01 | H. Lundbeck A/S | DERIVATIVES OF 2- (1H-INDOLILSULFANIL) -BENCILAMINE AS SSRI. |
US10987362B2 (en) | 2004-03-12 | 2021-04-27 | Intercept Pharmaceuticals, Inc. | Treatment of fibrosis using FXR ligands |
EP2712617B2 (en) * | 2004-03-12 | 2020-11-18 | Intercept Pharmaceuticals, Inc. | Treatment of fibrosis using Fxr ligands |
US7276606B2 (en) | 2004-04-30 | 2007-10-02 | 4Sc Ag | Phenantridine analogues and uses thereof |
EP1652841A1 (en) * | 2004-04-30 | 2006-05-03 | Switch Biotech Aktiengesellschaft | Novel phenantridine analogues and their use as inhibitors of hyperproliferation of T cells and/or keratinocytes |
AR052308A1 (en) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | DERIVATIVES OF 2- (1H-INDOLILSULFANIL) -ARILAMINE AND A PHARMACEUTICAL COMPOSITION CONTAINING THE COMPOUND |
US20060252670A1 (en) * | 2004-10-14 | 2006-11-09 | Intercept Pharmaceuticals Inc. | Method of reducing drug-induced adverse side effects in a patient |
WO2006041150A1 (en) * | 2004-10-15 | 2006-04-20 | Mitsubishi Pharma Corporation | Preventive and/or therapeutic agent for diabetes |
ITMI20050912A1 (en) * | 2005-05-19 | 2006-11-20 | Erregierre Spa | PROCESS OF PREPARATION OF ACIDS 3-A-YA (B) -DIDROSSI-6-A (B) -ALCHIL-5B-COLANICI |
US7618956B2 (en) * | 2005-05-31 | 2009-11-17 | The Gillette Company | Reduction of hair growth |
US7629473B2 (en) * | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
AR054393A1 (en) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | DERIVATIVES OF BENZO (B) FURANO AND BENZO (B) THIOPHEN, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DISEASES MEDIATED BY THE INHIBITION OF THE REINFORCEMENT OF AMINA BOSS NEUTRANTS. |
TW200817319A (en) | 2006-08-10 | 2008-04-16 | Astellas Pharma Inc | Sulfonamide compound or salt thereof |
EP1886685A1 (en) * | 2006-08-11 | 2008-02-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods, uses and compositions for modulating replication of hcv through the farnesoid x receptor (fxr) activation or inhibition |
JP5345534B2 (en) | 2006-08-24 | 2013-11-20 | ユニバーシティ オブ テネシー リサーチ ファウンデーション | Substituted acylanilides and methods for their use |
TW200827346A (en) | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
JP5292310B2 (en) * | 2007-01-19 | 2013-09-18 | インターセプト ファーマシューティカルズ, インコーポレイテッド | 23-substituted bile acids as TGR5 modulators and methods of use thereof |
TW200836719A (en) | 2007-02-12 | 2008-09-16 | Astrazeneca Ab | Chemical compounds |
WO2010014836A2 (en) | 2008-07-30 | 2010-02-04 | Intercept Pharmaceuticals, Inc. | Tgr5 modulators and methods of use thereof |
NZ591366A (en) | 2008-09-11 | 2012-05-25 | Pfizer | Heteroaryls amide derivatives and their use as glucokinase activators |
MX2011005295A (en) | 2008-11-19 | 2011-06-24 | Intercept Pharmaceuticals Inc | Tgr5 modulators and method of use thereof. |
CA2748587A1 (en) | 2009-01-20 | 2010-07-29 | Pfizer Inc. | Substituted pyrazinone amides |
EP2406253B1 (en) | 2009-03-11 | 2013-07-03 | Pfizer Inc. | Benzofuranyl derivatives used as glucokinase inhibitors |
AU2010289397B2 (en) * | 2009-09-03 | 2016-05-26 | Bioenergenix | Heterocyclic compounds for the inhibition of PASK |
FR2962649A1 (en) | 2010-07-19 | 2012-01-20 | Conservatoire Nat Arts Et Metiers | TREATMENT OF A PATHOLOGY ASSOCIATED WITH EXCESSIVE TNF EFFECT BY A BENZENE SULFONAMIDE COMPOUND |
CA2818336C (en) * | 2010-11-16 | 2018-04-24 | Texas Heart Institute | Agonists that enhance binding of integrin-expressing cells to integrin receptors |
US9982008B2 (en) | 2012-06-19 | 2018-05-29 | Intercept Pharmaceuticals, Inc. | Preparation and uses of obeticholic acid |
SG11201408501UA (en) | 2012-06-19 | 2015-01-29 | Intercept Pharmaceuticals Inc | Preparation, uses and solid forms of obeticholic acid |
US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
CN108143728A (en) | 2012-07-13 | 2018-06-12 | Gtx公司 | Purposes of the selective androgen receptor modulators in breast cancer is treated |
JP6462868B2 (en) * | 2014-07-07 | 2019-01-30 | 昆鋒 陳 | Arylamine-substituted quinoxalines as anticancer drugs |
JP7306791B2 (en) | 2015-02-06 | 2023-07-11 | インターセプト ファーマシューティカルズ, インコーポレイテッド | Pharmaceutical composition for combination therapy |
CR20170456A (en) | 2015-04-07 | 2018-06-13 | Intercept Pharmaceuticals Inc | PHARMACEUTICAL COMPOSITIONS FOR COMBINED THERAPIES |
EA034514B1 (en) | 2015-12-15 | 2020-02-14 | Астразенека Аб | Isoindole compounds |
WO2017137931A1 (en) * | 2016-02-10 | 2017-08-17 | Dr. Reddy’S Laboratories Limited | Amine salt of obeticholic acid |
CN110730780A (en) | 2017-06-14 | 2020-01-24 | 阿斯利康(瑞典)有限公司 | 2, 3-dihydroisoindole-1-carboxamides useful as ROR-gamma modulators |
EP3781572A1 (en) | 2018-04-20 | 2021-02-24 | Virginia Tech Intellectual Properties, Inc. | Oxadiazolopyrazines and oxadiazolopyridines useful as mitochondrial uncouplers |
WO2020243590A1 (en) | 2019-05-30 | 2020-12-03 | Intercept Pharmaceuticals, Inc. | Pharmaceutical compositions comprising a fxr agonist and a fibrate for use in the treatment of cholestatic liver disease |
GB201909659D0 (en) | 2019-07-04 | 2019-08-21 | Aberystwyth Univ | Anti-infective compounds |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL123536C (en) * | 1963-07-09 | |||
US3985804A (en) * | 1973-08-18 | 1976-10-12 | Kumiai Chemical Industry Co., Ltd. | Agricultural substituted 2-methylbenzanilide germicide |
GB1516853A (en) * | 1974-06-12 | 1978-07-05 | Kumiai Chemical Industry Co | Benzanilide derivatives and their bactericidal uses |
US4279887A (en) * | 1978-11-29 | 1981-07-21 | Medi-Physics, Inc. | Amides useful as brain imaging agents |
US5470982A (en) * | 1988-01-20 | 1995-11-28 | Bayer Aktiengesellschaft | Disubstituted pyridines |
US5783593A (en) | 1993-11-04 | 1998-07-21 | Abbott Laboratories | Inhibitors of squalene synthetase and protein farnesyltransferase |
US6214880B1 (en) | 1998-09-23 | 2001-04-10 | Tularik Inc. | Arylsulfonanilide ureas |
DE69940958D1 (en) * | 1998-12-23 | 2009-07-16 | Glaxo Group Ltd | DETERMINATION METHOD FOR LIGANDS OF NUCLEAR RECEPTORS |
US6906057B1 (en) * | 1999-06-11 | 2005-06-14 | Allergan, Inc. | Methods for modulating FXR receptor activity |
-
2001
- 2001-08-31 WO PCT/US2001/027239 patent/WO2002020463A2/en active Application Filing
- 2001-08-31 AU AU2001288623A patent/AU2001288623A1/en not_active Abandoned
- 2001-08-31 US US09/945,293 patent/US6777446B2/en not_active Expired - Fee Related
-
2004
- 2004-03-04 US US10/794,228 patent/US7511043B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20040176426A1 (en) | 2004-09-09 |
US6777446B2 (en) | 2004-08-17 |
US20020120137A1 (en) | 2002-08-29 |
US7511043B2 (en) | 2009-03-31 |
WO2002020463A3 (en) | 2003-08-21 |
WO2002020463A2 (en) | 2002-03-14 |
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