AU2000235960A1 - Lxr modulators - Google Patents

Lxr modulators

Info

Publication number
AU2000235960A1
AU2000235960A1 AU2000235960A AU3596000A AU2000235960A1 AU 2000235960 A1 AU2000235960 A1 AU 2000235960A1 AU 2000235960 A AU2000235960 A AU 2000235960A AU 3596000 A AU3596000 A AU 3596000A AU 2000235960 A1 AU2000235960 A1 AU 2000235960A1
Authority
AU
Australia
Prior art keywords
lxr modulators
lxr
modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2000235960A
Inventor
Leping Li
Julio Cesar Medina
Bei Shan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tularik Inc
Original Assignee
Tularik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tularik Inc filed Critical Tularik Inc
Publication of AU2000235960A1 publication Critical patent/AU2000235960A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2000235960A 2000-02-14 2000-02-14 Lxr modulators Abandoned AU2000235960A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/003806 WO2001060818A1 (en) 2000-02-14 2000-02-14 Lxr modulators

Publications (1)

Publication Number Publication Date
AU2000235960A1 true AU2000235960A1 (en) 2001-08-27

Family

ID=21741063

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2000235960A Abandoned AU2000235960A1 (en) 2000-02-14 2000-02-14 Lxr modulators

Country Status (2)

Country Link
AU (1) AU2000235960A1 (en)
WO (1) WO2001060818A1 (en)

Families Citing this family (27)

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US6673543B2 (en) * 2000-04-05 2004-01-06 Tularik, Inc. Solid phase synthesis of LXR ligands
EP1318976B1 (en) * 2000-09-18 2004-11-24 Glaxo Group Limited Substituted aminopropoxyaryl derivatives useful as agonists for lxr
US6924311B2 (en) 2001-10-17 2005-08-02 X-Ceptor Therapeutics, Inc. Methods for affecting various diseases utilizing LXR compounds
GB2381866A (en) * 2001-11-12 2003-05-14 Karobio Ab Assays for liver X receptor (LXR) modulators
BR0215258A (en) * 2001-12-21 2004-12-07 Pharmacia Corp Aromatic Thioether Liver x-receptor Modulators
AU2002351412B2 (en) 2001-12-21 2010-05-20 Exelixis Patent Company Llc Modulators of LXR
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
ATE521599T1 (en) 2001-12-21 2011-09-15 X Ceptor Therapeutics Inc HETEROCYCLIC MODULATORS OF NUCLEAR RECEPTORS
AU2003208952B2 (en) 2002-01-30 2008-04-24 Amgen Inc. Heterocyclic arylsulfonamidobenzylic compounds
WO2004043939A1 (en) * 2002-03-27 2004-05-27 Smithkline Beecham Corporation Amide compounds and methods of using the same
WO2003082205A2 (en) * 2002-03-27 2003-10-09 Smithkline Beecham Corporation Compounds and methods
AU2003223340A1 (en) * 2002-03-27 2003-10-13 Smithkline Beecham Corporation Certain pharmaceutically useful substituted aminoalkyl heterocycles
MXPA04011691A (en) 2002-05-24 2005-09-12 Pharmacia Corp Anilino liver x-receptor modulators.
CA2486651A1 (en) 2002-05-24 2003-12-04 Pharmacia Corporation Sulfone liver x-receptor modulators
AU2003280317A1 (en) * 2002-11-14 2004-06-03 Novo Nordisk A/S Use of nuclear hormone receptors to identify meiosis regulating compounds
DE60335911D1 (en) 2002-12-20 2011-03-10 Daiichi Sankyo Co Ltd ISOCHINOLINE DERIVATIVES AND THEIR USE AS MEDICAMENTS
WO2004076418A1 (en) * 2003-02-28 2004-09-10 Galderma Research & Development, S.N.C. Ligands that modulate lxr-type receptors
US20040238114A1 (en) 2003-06-02 2004-12-02 Dow Global Technologies Inc. Air bag system and method of forming the same
NZ555325A (en) 2004-10-27 2009-07-31 Daiichi Sankyo Co Ltd Benzene compound having 2 or more substituents
WO2007002559A1 (en) 2005-06-27 2007-01-04 Exelixis, Inc. Pyrazole based lxr modulators
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7727978B2 (en) 2006-08-24 2010-06-01 Bristol-Myers Squibb Company Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors
EP2142533B1 (en) 2007-03-30 2011-11-16 F. Hoffmann-La Roche AG Imidazolidinone derivatives
US8119658B2 (en) 2007-10-01 2012-02-21 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
WO2012033353A2 (en) 2010-09-07 2012-03-15 서울대학교 산학협력단 Sesterterpene compounds and use thereof
TW201242953A (en) 2011-03-25 2012-11-01 Bristol Myers Squibb Co Imidazole prodrug LXR modulators
MX2014015205A (en) 2012-06-14 2015-08-14 Ambrx Inc Anti-psma antibodies conjugated to nuclear receptor ligand polypeptides.

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FI61478C (en) * 1974-04-09 1982-08-10 Ciba Geigy Ag VAEXTFUNGICIDA N- (1'-METOXY- OCH ETOXICARBONYL-ETHYL) -N-ACYL-ANILIN DERIVATIVES
US4204002A (en) * 1974-04-09 1980-05-20 Ciba-Geigy Corporation Methods of using N-(substituted)-N-alkoxy carbonyl anilino compounds
GB1547564A (en) * 1975-06-05 1979-06-20 Lilly Industries Ltd Acylated amino-heteroaryl compounds
GB1548398A (en) * 1975-06-05 1979-07-11 Lilly Industries Ltd Acylamino pyrroles furans and thiophenes
DE2854598A1 (en) * 1978-12-18 1980-07-03 Basf Ag N-SUBSTITUTED CARBONIC ACID ANILIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS FUNGICIDES
DE2854600A1 (en) * 1978-12-18 1980-06-26 Basf Ag SUBSTITUTED CYANAMID
DE2920435A1 (en) * 1979-05-19 1980-12-04 Basf Ag 2-AMINOPROPANAL ACETALS, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FUNGICIDES AND METHOD FOR THE PRODUCTION OF SUBSTITUTED ANILINES
DE2931640A1 (en) * 1979-08-03 1981-02-19 Bayer Ag CYCLOALKAN (ALKEN) CARBONIC ACID ANILIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS FUNGICIDES
JPS6323822A (en) * 1986-07-16 1988-02-01 Tokuyama Soda Co Ltd Schiff base compound
GB9305672D0 (en) * 1993-03-19 1993-05-05 Wyeth John & Brother Ltd Amide derivatives
JPH0756392A (en) * 1993-08-18 1995-03-03 Mitsui Toatsu Chem Inc Electrophotographic toner containing n-phenyl-glycine derivative
JPH07188215A (en) * 1993-12-28 1995-07-25 Meiji Seika Kaisha Ltd Azole derivative and its salt
DE4437999A1 (en) * 1994-10-25 1996-05-02 Thomae Gmbh Dr K New N,N-di:substd. aryl-cycloalkyl-amine derivs.
DE4438020A1 (en) * 1994-10-25 1996-05-02 Thomae Gmbh Dr K New N-aryl:cyclohexyl-N-acyl-amine cpds.
IT1282705B1 (en) * 1996-02-28 1998-03-31 Recordati Chem Pharm USE OF 5-HT | A SEROTONINERGIC RECEPTOR ANTAGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE
WO1999006382A1 (en) * 1997-08-01 1999-02-11 Recordati S.A., Chemical And Pharmaceutical Company 1,4-disubstituted piperazines
DE19804251A1 (en) * 1998-02-04 1999-08-05 Hoechst Marion Roussel De Gmbh Biphenylsulfonylcyanamides, process for their preparation and their use as a medicament
BR9908619A (en) * 1998-03-05 2001-10-02 Agouron Pharma Compound and its production process, pharmaceutical composition, and method to regulate the secretion of gonadotropins in mammals
EP1125922A1 (en) * 1998-11-02 2001-08-22 Welfide Corporation Pyrrolidine compounds and medicinal utilization thereof
US6316503B1 (en) * 1999-03-15 2001-11-13 Tularik Inc. LXR modulators

Also Published As

Publication number Publication date
WO2001060818A1 (en) 2001-08-23

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