ES2512491T3 - Derivados de la piridina pirazolo como inhibidores de la NADPH oxidasa - Google Patents

Derivados de la piridina pirazolo como inhibidores de la NADPH oxidasa Download PDF

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ES2512491T3
ES2512491T3 ES12187254.3T ES12187254T ES2512491T3 ES 2512491 T3 ES2512491 T3 ES 2512491T3 ES 12187254 T ES12187254 T ES 12187254T ES 2512491 T3 ES2512491 T3 ES 2512491T3
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optionally substituted
alkyl
aryl
heteroaryl
alkenyl
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Patrick Page
Mike Orchard
Laetitia Fioraso-Cartier
Bianca Mottironi
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Calliditas Therapeutics Suisse SA
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Genkyotex SA
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Abstract

Un derivado de la piridina pirazolo de acuerdo con la Fórmula (I):**Fórmula** donde G1 es H; G2 es opcionalmente sustituido fenilo; G3 se selecciona de H, opcionalmente sustituido C1- C6 alquilo, opcionalmente sustituido C2-C6 alquenilo, opcionalmente sustituido C2-C6 alquinil, opcionalmente sustituido arilo, opcionalmente sustituido C1-C6 alquil arilo, opcionalmente sustituido alquil arilo, opcionalmente sustituido heteroarilo, opcionalmente sustituido C1-C6 alquil heteroarilo, opcionalmente sustituido heteroaril alquilo, opcionalmente sustituido C2-C6 alquenil arilo, opcionalmente sustituido aril alquenilo, opcionalmente sustituido C2-C6 alquenilo heteroaril, opcionalmente sustituido heteroaril alquenilo, opcionalmente sustituido C3-C8-cicloalquilo, opcionalmente sustituido heterocicloalquilo, opcionalmente sustituido C1-C6 alquil C3-C8-cicloalquilo, opcionalmente sustituido alquil C3-C8-cicloalquilo, opcionalmente sustituido C1-C6 alquil heterocicloalquilo y opcionalmente sustituido heterocicloalquil alquilo; G4 se selecciona de H, opcionalmente sustituido C1-C6 alquilo, opcionalmente sustituido C2-C6 alquenilo, opcionalmente sustituido alquinil C2-C6, arilo, opcionalmente sustituido C1-C6 alquil arilo, opcionalmente sustituido aril alquilo, opcionalmente sustituido heteroarilo, opcionalmente sustituido C1-C6 alquil heteroarilo, opcionalmente sustituido heteroaril alquilo, opcionalmente sustituido C2-C6 alquenil arilo, opcionalmente sustituido aril alquenilo, opcionalmente sustituido C2-C6 alquenil heteroarilo, opcionalmente sustituido heteroaril alquenilo, opcionalmente sustituido C3-C8-cicloalquilo, opcionalmente sustituido heterocicloalquilo, opcionalmente sustituido C1-C6 alquil C3-C8-cicloalquil, opcionalmente sustituido C3-C8-cicloalquil alquilo, opcionalmente sustituido C1-C6 alquil heterocicloalquil y opcionalmente sustituido heterocicloalquil alquilo; G5 es H; los tautómeros, los isómeros geométricos, las formas ópticamente activas tales como los enantiómeros, diastereomeros y sus formas racémicas, así como las sales aceptables farmacéuticamente de los mismos, para su uso como un medicamento, en donde el término "sustituido" se refiere a grupos sustituidos con de 1 a 5 sustituyentes seleccionados del grupo que consiste de "alquilo", "alquenilo", "alquinilo", "C3-C8-cicloalquilo", "heterocicloalquilo", "alquil arilo", "alquil heteroarilo", "alquil cicloalquilo", "alquil heterocicloalquilo", "amino", "aminosulfonil", "amonio", " acil amina", "amino carbonilo," "arilo", "heteroarilo", "sulfinilo", "sulfonilo", "alcoxi", "alcoxi carbonilo", "carbamato", "sulfanilo", "halógeno", "trihalometil", ciano, hidroxi, mercapto y nitro.

Description

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Claims (1)

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ES12187254.3T 2007-03-22 2008-03-20 Derivados de la piridina pirazolo como inhibidores de la NADPH oxidasa Active ES2512491T3 (es)

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Application Number Priority Date Filing Date Title
US89628407P 2007-03-22 2007-03-22
US896284P 2007-03-22
EP07109555 2007-06-04
EP07109555A EP2002835A1 (en) 2007-06-04 2007-06-04 Pyrazolo pyridine derivatives as NADPH oxidase inhibitors

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ES12187254.3T Active ES2512491T3 (es) 2007-03-22 2008-03-20 Derivados de la piridina pirazolo como inhibidores de la NADPH oxidasa
ES08718102T Active ES2398994T3 (es) 2007-03-22 2008-03-20 Derivados de pirazolo piridina como inhibidores de la NAPDH oxidasa

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ES08718102T Active ES2398994T3 (es) 2007-03-22 2008-03-20 Derivados de pirazolo piridina como inhibidores de la NAPDH oxidasa

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EP (3) EP2002835A1 (es)
JP (2) JP5715340B2 (es)
CN (2) CN105061422B (es)
AU (1) AU2008228186C1 (es)
BR (1) BRPI0808824B8 (es)
CA (1) CA2676954C (es)
CY (2) CY1113556T1 (es)
DK (2) DK2545918T3 (es)
ES (2) ES2512491T3 (es)
HK (2) HK1141734A1 (es)
HR (2) HRP20130143T1 (es)
IL (1) IL201009A (es)
PL (2) PL2139477T3 (es)
PT (2) PT2139477E (es)
RS (2) RS52640B (es)
SI (2) SI2545918T1 (es)
WO (1) WO2008113856A1 (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2002835A1 (en) * 2007-06-04 2008-12-17 GenKyo Tex Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2000176A1 (en) 2007-06-04 2008-12-10 GenKyo Tex Tetrahydroindole derivatives as NADPH Oxidase inhibitors
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EP2165707A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
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