CU20220023A7 - Derivados de 2-azaspiro[3,4]octano como agonistas de m4 - Google Patents
Derivados de 2-azaspiro[3,4]octano como agonistas de m4Info
- Publication number
- CU20220023A7 CU20220023A7 CU2022000023A CU20220023A CU20220023A7 CU 20220023 A7 CU20220023 A7 CU 20220023A7 CU 2022000023 A CU2022000023 A CU 2022000023A CU 20220023 A CU20220023 A CU 20220023A CU 20220023 A7 CU20220023 A7 CU 20220023A7
- Authority
- CU
- Cuba
- Prior art keywords
- agonists
- azaspiro
- octane derivatives
- formula
- octane
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
<p>En la presente se proporcionan compuestos de acuerdo con la Fórmula (I)</p> <p> </p> <p>ESPACIO PARA FÓRMULA</p> <p> </p> <p>o una sal farmacéuticamente aceptable de los mismos, en donde R1, R2, R3, R5, y R7 se definen en la presente. También se proporcionan en la presente composiciones farmacéuticas que comprenden un compuesto de Fórmula (I) así como el uso de dichos compuestos como agonistas del receptor M4.</p>
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962912980P | 2019-10-09 | 2019-10-09 | |
PCT/IB2020/059430 WO2021070090A1 (en) | 2019-10-09 | 2020-10-07 | 2-azaspiro[3.4]octane derivatives as m4 agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
CU20220023A7 true CU20220023A7 (es) | 2022-11-07 |
Family
ID=72944205
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU2022000023A CU20220023A7 (es) | 2019-10-09 | 2020-10-07 | Derivados de 2-azaspiro[3,4]octano como agonistas de m4 |
Country Status (21)
Country | Link |
---|---|
US (2) | US11548865B2 (es) |
EP (1) | EP4041389A1 (es) |
JP (1) | JP7349570B2 (es) |
KR (1) | KR20220079921A (es) |
CN (1) | CN114555592A (es) |
AR (1) | AR120170A1 (es) |
AU (1) | AU2020361735B2 (es) |
CA (1) | CA3156320A1 (es) |
CL (1) | CL2022000893A1 (es) |
CO (1) | CO2022004341A2 (es) |
CR (1) | CR20220141A (es) |
CU (1) | CU20220023A7 (es) |
EC (1) | ECSP22027287A (es) |
IL (1) | IL291316A (es) |
JO (1) | JOP20220082A1 (es) |
MX (1) | MX2022004213A (es) |
PE (1) | PE20221453A1 (es) |
TW (1) | TW202128649A (es) |
UY (1) | UY38906A (es) |
WO (1) | WO2021070090A1 (es) |
ZA (1) | ZA202202912B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20221453A1 (es) * | 2019-10-09 | 2022-09-21 | Novartis Ag | Derivados de 2-azaspiro[3,4]octano como agonistas de m4 |
WO2024059249A1 (en) * | 2022-09-16 | 2024-03-21 | Cerevel Therapeutics, Llc | M4 activators/modulators and uses thereof |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060276520A1 (en) | 2002-11-13 | 2006-12-07 | Rigel Pharmaceuticals, Inc. | Rhodanine derivatives and pharmaceutical compositions containing them |
US7479496B2 (en) | 2004-02-19 | 2009-01-20 | Bristol-Myers Squibb Company | Substituted spiro azabicyclics as modulators of chemokine receptor activity |
WO2006006490A1 (ja) | 2004-07-08 | 2006-01-19 | Ono Pharmaceutical Co., Ltd. | スピロ化合物 |
US7880007B2 (en) * | 2004-11-29 | 2011-02-01 | Vertex Pharmaceuticals Incorporated | Bicyclic substituted phenyl piperidine modulators of muscarinic receptors |
JP5420408B2 (ja) | 2006-08-25 | 2014-02-19 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1型のインヒビター |
AU2009309988A1 (en) | 2008-10-29 | 2010-05-06 | Grunenthal Gmbh | Substituted spiroamines |
CN102361876B (zh) | 2009-01-26 | 2015-02-04 | 以色列生物研究所 | 二环杂环螺环化合物 |
EP2675812B1 (en) | 2011-02-18 | 2017-08-30 | Vertex Pharmaceuticals Incorporated | Chroman - spirocyclic piperidine amides as modulators of ion channels |
JP6062432B2 (ja) | 2011-07-27 | 2017-01-18 | ナンジン アルゲン ファルマ カンパニー リミテッドNanjing Allgen Pharma Co. Ltd. | プロテインキナーゼ阻害薬用スピロ環状分子 |
WO2014039489A1 (en) | 2012-09-07 | 2014-03-13 | Zoetis Llc | Spirocyclic derivatives as antiparasitic agents |
DK2897948T3 (en) * | 2012-09-18 | 2016-12-05 | Heptares Therapeutics Ltd | BICYCLIC AZA RELATIONS AS MUSCARIN M1 RECEPTOR AGONISTS |
JP6479029B2 (ja) * | 2014-02-06 | 2019-03-06 | ヘプタレス セラピューティクス リミテッドHeptares Therapeutics Limited | ムスカリンm1受容体アゴニストとしての二環式アザ化合物 |
CN107108597B (zh) | 2014-10-31 | 2020-04-17 | 英立维尔英国有限公司 | 多巴胺d3受体拮抗剂化合物 |
GB201504675D0 (en) * | 2015-03-19 | 2015-05-06 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
GB201513743D0 (en) | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonists |
GB201513740D0 (en) * | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonist |
GB201513742D0 (en) | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonists |
GB201519352D0 (en) | 2015-11-02 | 2015-12-16 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
BR122024002146A2 (pt) | 2016-06-10 | 2024-03-05 | Vitae Pharmaceuticals, Inc. | Compostos inibidores da interação de menina-llm e forma cristalina destes |
GB201617454D0 (en) | 2016-10-14 | 2016-11-30 | Heptares Therapeutics Limited | Pharmaceutical compounds |
CN108456208B (zh) | 2017-02-22 | 2021-04-16 | 广州市恒诺康医药科技有限公司 | 氮杂螺环类化合物及其制备方法和应用 |
CN110691779B (zh) | 2017-03-24 | 2023-10-10 | 库拉肿瘤学公司 | 治疗血液系统恶性肿瘤和尤因肉瘤的方法 |
GB201709652D0 (en) | 2017-06-16 | 2017-08-02 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
EP4219464A1 (en) | 2018-03-23 | 2023-08-02 | Pfizer Inc. | Piperazine azaspiro derivaves |
GB201810245D0 (en) | 2018-06-22 | 2018-08-08 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
PE20221453A1 (es) * | 2019-10-09 | 2022-09-21 | Novartis Ag | Derivados de 2-azaspiro[3,4]octano como agonistas de m4 |
WO2021070091A1 (en) * | 2019-10-09 | 2021-04-15 | Novartis Ag | 5-oxa-2-azaspiro[3.4]octane derivatives as m4 agonists |
-
2020
- 2020-10-07 PE PE2022000553A patent/PE20221453A1/es unknown
- 2020-10-07 MX MX2022004213A patent/MX2022004213A/es unknown
- 2020-10-07 US US17/065,360 patent/US11548865B2/en active Active
- 2020-10-07 CR CR20220141A patent/CR20220141A/es unknown
- 2020-10-07 TW TW109134714A patent/TW202128649A/zh unknown
- 2020-10-07 JP JP2022521118A patent/JP7349570B2/ja active Active
- 2020-10-07 EP EP20793460.5A patent/EP4041389A1/en active Pending
- 2020-10-07 AU AU2020361735A patent/AU2020361735B2/en active Active
- 2020-10-07 CU CU2022000023A patent/CU20220023A7/es unknown
- 2020-10-07 JO JOP/2022/0082A patent/JOP20220082A1/ar unknown
- 2020-10-07 CA CA3156320A patent/CA3156320A1/en active Pending
- 2020-10-07 UY UY0001038906A patent/UY38906A/es unknown
- 2020-10-07 KR KR1020227015315A patent/KR20220079921A/ko unknown
- 2020-10-07 WO PCT/IB2020/059430 patent/WO2021070090A1/en active Application Filing
- 2020-10-07 AR ARP200102775A patent/AR120170A1/es unknown
- 2020-10-07 CN CN202080071012.7A patent/CN114555592A/zh active Pending
-
2022
- 2022-03-10 ZA ZA2022/02912A patent/ZA202202912B/en unknown
- 2022-03-13 IL IL291316A patent/IL291316A/en unknown
- 2022-04-05 CO CONC2022/0004341A patent/CO2022004341A2/es unknown
- 2022-04-06 EC ECSENADI202227287A patent/ECSP22027287A/es unknown
- 2022-04-07 CL CL2022000893A patent/CL2022000893A1/es unknown
- 2022-12-06 US US18/062,356 patent/US20230212139A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20220079921A (ko) | 2022-06-14 |
AR120170A1 (es) | 2022-02-02 |
AU2020361735B2 (en) | 2024-04-18 |
CO2022004341A2 (es) | 2022-04-29 |
US20210107889A1 (en) | 2021-04-15 |
UY38906A (es) | 2021-05-31 |
IL291316A (en) | 2022-05-01 |
JP2022552244A (ja) | 2022-12-15 |
MX2022004213A (es) | 2022-05-03 |
AU2020361735A1 (en) | 2022-04-21 |
EP4041389A1 (en) | 2022-08-17 |
JP7349570B2 (ja) | 2023-09-22 |
ZA202202912B (en) | 2023-04-26 |
CA3156320A1 (en) | 2021-04-15 |
JOP20220082A1 (ar) | 2023-01-30 |
CL2022000893A1 (es) | 2023-01-20 |
PE20221453A1 (es) | 2022-09-21 |
TW202128649A (zh) | 2021-08-01 |
US20230212139A1 (en) | 2023-07-06 |
WO2021070090A1 (en) | 2021-04-15 |
US11548865B2 (en) | 2023-01-10 |
CR20220141A (es) | 2022-05-03 |
ECSP22027287A (es) | 2022-12-30 |
CN114555592A (zh) | 2022-05-27 |
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