CL2022001392A1 - Compuestos tricíclicos sustituidos - Google Patents

Compuestos tricíclicos sustituidos

Info

Publication number
CL2022001392A1
CL2022001392A1 CL2022001392A CL2022001392A CL2022001392A1 CL 2022001392 A1 CL2022001392 A1 CL 2022001392A1 CL 2022001392 A CL2022001392 A CL 2022001392A CL 2022001392 A CL2022001392 A CL 2022001392A CL 2022001392 A1 CL2022001392 A1 CL 2022001392A1
Authority
CL
Chile
Prior art keywords
compound
formula
rasopathies
infectious
disorders
Prior art date
Application number
CL2022001392A
Other languages
English (en)
Inventor
Sethi Sachin
Sreedharan Nair Prathap
Ramprasad Shukla Manojkumar
Dattatraya Sindkhedkar Milind
P Palle Venkata
Kumar Kamboj Rajender
Phukan Samiron
Rangrao Patil Pradeep
Raghunath Khedkar Nilesh
Dube Dagadu
Sitaram Tambe Vikas
Maruti Balgude Sudhakar
Ganesh
Kakade
Balu Pradip
Wagh
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of CL2022001392A1 publication Critical patent/CL2022001392A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Se divulgan compuestos de fórmula general (I), su forma tautomérica, su estereoisómero, su sal farmacéuticamente aceptable, su polimorfo o solvato del mismo, en donde, el anillo A, de R1 a R5, X, Y, m, y n son como se definen en el presente documento, para su uso como inhibidores de SOS1 en el tratamiento de enfermedades o trastornos proliferativos infecciosos y rasopatías. También se divulgan métodos para sintetizar el compuesto de fórmula I, composiciones farmacéuticas que contienen el compuesto de fórmula I, un método para el tratamiento de enfermedades o trastornos proliferativos, infecciosos o rasopatías, por ejemplo, un cáncer, administrando dicho compuesto y combinaciones del compuesto de fórmula I con otros principios activos.
CL2022001392A 2019-11-29 2022-05-27 Compuestos tricíclicos sustituidos CL2022001392A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201921049157 2019-11-29
IN202021035414 2020-08-17

Publications (1)

Publication Number Publication Date
CL2022001392A1 true CL2022001392A1 (es) 2023-03-17

Family

ID=73856201

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2022001392A CL2022001392A1 (es) 2019-11-29 2022-05-27 Compuestos tricíclicos sustituidos

Country Status (27)

Country Link
US (1) US20230013778A1 (es)
EP (1) EP4065575B1 (es)
JP (1) JP2023504113A (es)
KR (1) KR20220110241A (es)
CN (1) CN114746411B (es)
AU (1) AU2020393205A1 (es)
BR (1) BR112022010383A2 (es)
CA (1) CA3154914A1 (es)
CL (1) CL2022001392A1 (es)
CO (1) CO2022008997A2 (es)
CR (1) CR20220312A (es)
DK (1) DK4065575T3 (es)
EC (1) ECSP22050936A (es)
ES (1) ES2982576T3 (es)
FI (1) FI4065575T3 (es)
HR (1) HRP20240547T1 (es)
HU (1) HUE066732T2 (es)
IL (1) IL292721A (es)
LT (1) LT4065575T (es)
MX (1) MX2022006475A (es)
PE (1) PE20221336A1 (es)
PL (1) PL4065575T3 (es)
PT (1) PT4065575T (es)
RS (1) RS65526B1 (es)
SI (1) SI4065575T1 (es)
WO (1) WO2021105960A1 (es)
ZA (1) ZA202206253B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202214654A (zh) * 2020-06-10 2022-04-16 大陸商江蘇恆瑞醫藥股份有限公司 稠合喹唑啉類衍生物、其製備方法及其在醫藥上的應用
CA3194067A1 (en) 2020-09-15 2022-03-24 Revolution Medicines, Inc. Ras inhibitors
CN117561258A (zh) * 2021-03-02 2024-02-13 唯久生物技术(苏州)有限公司 作为sos1抑制剂的新型取代的三环氮杂杂环
MX2023011633A (es) 2021-03-31 2023-12-15 Sevenless Therapeutics Ltd Inhibidores de sos1 e inhibidores de ras para su uso en el tratamiento del dolor.
WO2022222875A1 (zh) * 2021-04-19 2022-10-27 昆药集团股份有限公司 一种苯并嘧啶三环衍生物及其制备方法和应用
CN115490699B (zh) * 2021-06-19 2024-08-09 成都海博为药业有限公司 一种稠环化合物及其药物组合物和用途
WO2023287730A1 (en) * 2021-07-13 2023-01-19 Recurium Ip Holdings, Llc Tricyclic compounds
CN115677699A (zh) * 2021-07-23 2023-02-03 武汉誉祥医药科技有限公司 三并环化合物及其药物组合物和应用
WO2023030216A1 (zh) * 2021-08-30 2023-03-09 浙江海正药业股份有限公司 喹唑啉类衍生物、或其制备方法和用途
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
CN116265462A (zh) 2021-12-17 2023-06-20 石药集团中奇制药技术（石家庄）有限公司 一种具有抗肿瘤活性的杂环化合物及其用途
TW202340214A (zh) 2021-12-17 2023-10-16 美商健臻公司 做為shp2抑制劑之吡唑并吡𠯤化合物
CN116425796A (zh) * 2022-01-12 2023-07-14 如东凌达生物医药科技有限公司 一类嘧啶并杂环类化合物、制备方法和用途
WO2023135260A1 (en) 2022-01-14 2023-07-20 Jazz Pharmaceuticals Ireland Limited Novel amine-substituted phthalazines and derivatives as sos1 inhibitors
WO2023138691A1 (en) * 2022-01-21 2023-07-27 Shenzhen Ionova Life Science Co., Ltd. Fused heterocyclic compounds as modulators of ras signalling
EP4227307A1 (en) 2022-02-11 2023-08-16 Genzyme Corporation Pyrazolopyrazine compounds as shp2 inhibitors
GB202203976D0 (en) 2022-03-22 2022-05-04 Jazz Pharmaceuticals Ireland Ltd Tricyclic phthalazines and derivatives as sos1 inhibitors
WO2023240263A1 (en) 2022-06-10 2023-12-14 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2024211663A1 (en) 2023-04-07 2024-10-10 Revolution Medicines, Inc. Condensed macrocyclic compounds as ras inhibitors
WO2024211712A1 (en) 2023-04-07 2024-10-10 Revolution Medicines, Inc. Condensed macrocyclic compounds as ras inhibitors

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
WO2004003152A2 (en) 2002-06-26 2004-01-08 Chiron Corporation Sos1 inhibitors
US20070065622A1 (en) 2005-09-22 2007-03-22 Scientific Technologies Incorporated Safety Mat Active Joining Trim
MA33926B1 (fr) 2009-12-17 2013-01-02 Merck Sharp & Dohme Aminopyrimidines en tant qu'inhibiteurs de la syk
CA2906740A1 (en) * 2013-03-15 2014-09-18 Dana-Farber Cancer Institute, Inc. Stabilized sos1 peptides
WO2016077793A1 (en) 2014-11-14 2016-05-19 Children's Hospital Medical Center Sos1 inhibitors for cancer treatment
CN109071560B (zh) 2016-02-12 2022-01-14 瓦洛健康公司 用作泛素特异性蛋白酶抑制剂的噻吩并吡啶甲酰胺
US10898487B2 (en) * 2016-12-22 2021-01-26 Boehringer Ingelheim International Gmbh Benzylamino substituted quinazolines and derivatives as SOS1 inhibitors
CA3056970A1 (en) * 2017-03-21 2018-09-27 Bayer Pharma Aktiengesellschaft 2-methyl-quinazolines
SG11202005881YA (en) * 2017-12-21 2020-07-29 Boehringer Ingelheim Int Novel benzylamino substituted pyridopyrimidinones and derivatives as sos1 inhibitors
EP3781565A1 (en) 2018-04-18 2021-02-24 Bayer Pharma Aktiengesellschaft 2-methyl-aza-quinazolines
US20230148450A9 (en) 2019-03-01 2023-05-11 Revolution Medicines, Inc. Bicyclic heteroaryl compounds and uses thereof
JP2022522778A (ja) 2019-03-01 2022-04-20 レボリューション メディシンズ インコーポレイテッド 二環式ヘテロシクリル化合物及びその使用

Also Published As

Publication number Publication date
JP2023504113A (ja) 2023-02-01
ECSP22050936A (es) 2022-07-29
ES2982576T3 (es) 2024-10-16
US20230013778A1 (en) 2023-01-19
EP4065575A1 (en) 2022-10-05
KR20220110241A (ko) 2022-08-05
AU2020393205A1 (en) 2022-06-30
PE20221336A1 (es) 2022-09-13
FI4065575T3 (fi) 2024-05-02
HRP20240547T1 (hr) 2024-07-05
BR112022010383A2 (pt) 2022-08-23
RS65526B1 (sr) 2024-06-28
SI4065575T1 (sl) 2024-06-28
CO2022008997A2 (es) 2022-07-19
CN114746411B (zh) 2024-06-25
MX2022006475A (es) 2022-09-07
EP4065575B1 (en) 2024-01-31
PT4065575T (pt) 2024-05-03
CN114746411A (zh) 2022-07-12
PL4065575T3 (pl) 2024-06-24
CA3154914A1 (en) 2021-06-03
CR20220312A (es) 2022-08-05
HUE066732T2 (hu) 2024-09-28
WO2021105960A1 (en) 2021-06-03
IL292721A (en) 2022-07-01
ZA202206253B (en) 2023-01-25
LT4065575T (lt) 2024-05-27
DK4065575T3 (da) 2024-04-15

Similar Documents

Publication Publication Date Title
CL2022001392A1 (es) Compuestos tricíclicos sustituidos
CO2022010460A2 (es) Compuestos tricíclicos sustituidos
MX2023000410A (es) Analogos de rapamicina como inhibidores de mtor.
PE20181093A1 (es) Compuestos heterociclicos y usos de los mismos
CO2021015698A2 (es) Moduladores de thr-β y métodos de uso de estos
PE20221910A1 (es) Derivados de pirazolilo utiles como agentes anticancerigenos
CO2017000399A2 (es) Inhibidores de cinasa de interacción con proteína cinasa activada por mitógeno (mnk) y métodos relacionados con los mismos
MX2021012756A (es) Derivado de un anillo inhibidor de btk, metodo de preparacion de este y aplicacion farmaceutica para este.
PE20191817A1 (es) Tienopiridinas y benzotiofenos utiles como inhibidores de cinasa 4 asociada al receptor de interleucina 1 (irak4)
BR112017010354B8 (pt) Compostos de triazolopirimidina, seu uso, e composição farmacêutica
PE20181778A1 (es) Derivados de indolina sustituidos como inhibidores de la replicacion viral del dengue
DOP2024000039A (es) Derivados de quinolina como inhibidores de la integrina alfa4beta7
UY36207A (es) Inhibidores de la syk
CL2019002297A1 (es) Inhibidores de mnk sustituidos con piperidina y métodos relacionados con los mismos.
ECSP18003372A (es) Compuestos tricíclicos y su uso como inhibidores de la fosfodiesterasa
CL2020002139A1 (es) Compuestos de sulfonimidoilpurinona 7-sustituidos y sus derivados para el tratamiento y prevención del cáncer de hígado.
AR126854A1 (es) Compuestos macrocíclicos para el tratamiento de cáncer
UY39181A (es) COMPUESTOS Y COMPOSICIONES PARA INHIBIR LA ACTIVIDAD DE HIF2a Y SUS MÉTODOS DE USO
ECSP22027784A (es) Derivados de 2–azaespiro[3.4]octano como agonistas de m4
AR109328A1 (es) Derivado de triazolopirazinona útil como un inhibidor de pde1 humana
UY39625A (es) Derivados tricíclicos útiles como inhibidores de parp7
CL2022000893A1 (es) Derivados de 2-azaspiro[3,4]octano como agonistas de m4
BR112020026507A8 (pt) Composto de isotiazolo[5,4-d]pirimidinas como inibidor de irak4
AR105923A1 (es) Compuestos terapéuticos para el dolor y síntesis de estos
UY35743A (es) Procedimiento de síntesis para la preparación de analogos c1-ceto macrociclicos de halicondrina b e intermediarios útiles en el mismo