LT4065575T - Pakeisti tricikliniai junginiai - Google Patents
Pakeisti tricikliniai junginiaiInfo
- Publication number
- LT4065575T LT4065575T LTEPPCT/IB2020/061248T LTIB2020061248T LT4065575T LT 4065575 T LT4065575 T LT 4065575T LT IB2020061248 T LTIB2020061248 T LT IB2020061248T LT 4065575 T LT4065575 T LT 4065575T
- Authority
- LT
- Lithuania
- Prior art keywords
- tricyclic compounds
- substituted tricyclic
- substituted
- compounds
- tricyclic
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201921049157 | 2019-11-29 | ||
| IN202021035414 | 2020-08-17 | ||
| PCT/IB2020/061248 WO2021105960A1 (en) | 2019-11-29 | 2020-11-28 | Substituted tricyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT4065575T true LT4065575T (lt) | 2024-05-27 |
Family
ID=73856201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEPPCT/IB2020/061248T LT4065575T (lt) | 2019-11-29 | 2020-11-28 | Pakeisti tricikliniai junginiai |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20230013778A1 (lt) |
| EP (1) | EP4065575B1 (lt) |
| JP (1) | JP2023504113A (lt) |
| KR (1) | KR20220110241A (lt) |
| CN (1) | CN114746411B (lt) |
| AU (1) | AU2020393205A1 (lt) |
| BR (1) | BR112022010383A2 (lt) |
| CA (1) | CA3154914A1 (lt) |
| CL (1) | CL2022001392A1 (lt) |
| CO (1) | CO2022008997A2 (lt) |
| CR (1) | CR20220312A (lt) |
| DK (1) | DK4065575T3 (lt) |
| EC (1) | ECSP22050936A (lt) |
| FI (1) | FI4065575T3 (lt) |
| HR (1) | HRP20240547T1 (lt) |
| IL (1) | IL292721A (lt) |
| LT (1) | LT4065575T (lt) |
| MX (1) | MX2022006475A (lt) |
| PE (1) | PE20221336A1 (lt) |
| PL (1) | PL4065575T3 (lt) |
| PT (1) | PT4065575T (lt) |
| RS (1) | RS65526B1 (lt) |
| SI (1) | SI4065575T1 (lt) |
| WO (1) | WO2021105960A1 (lt) |
| ZA (1) | ZA202206253B (lt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115697994B (zh) * | 2020-06-10 | 2024-08-13 | 江苏恒瑞医药股份有限公司 | 稠合喹唑啉类衍生物、其制备方法及其在医药上的应用 |
| TW202227460A (zh) | 2020-09-15 | 2022-07-16 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2022187236A1 (en) * | 2021-03-02 | 2022-09-09 | Viva Star Biosciences (Suzhou) Co., Ltd. | Novel substituted tricyclic aza-heterocycles as sos1 inhibitors |
| MX2023011633A (es) | 2021-03-31 | 2023-12-15 | Sevenless Therapeutics Ltd | Inhibidores de sos1 e inhibidores de ras para su uso en el tratamiento del dolor. |
| WO2022222875A1 (zh) * | 2021-04-19 | 2022-10-27 | 昆药集团股份有限公司 | 一种苯并嘧啶三环衍生物及其制备方法和应用 |
| CN115490699B (zh) * | 2021-06-19 | 2024-08-09 | 成都海博为药业有限公司 | 一种稠环化合物及其药物组合物和用途 |
| WO2023287730A1 (en) * | 2021-07-13 | 2023-01-19 | Recurium Ip Holdings, Llc | Tricyclic compounds |
| CN115677699A (zh) * | 2021-07-23 | 2023-02-03 | 武汉誉祥医药科技有限公司 | 三并环化合物及其药物组合物和应用 |
| WO2023030216A1 (zh) * | 2021-08-30 | 2023-03-09 | 浙江海正药业股份有限公司 | 喹唑啉类衍生物、或其制备方法和用途 |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
| CA3240780A1 (en) | 2021-12-17 | 2023-06-22 | Zhenyu Wang | Heterocyclic compound having anti-tumor activity and use thereof |
| WO2023114954A1 (en) | 2021-12-17 | 2023-06-22 | Genzyme Corporation | Pyrazolopyrazine compounds as shp2 inhibitors |
| CN116425796A (zh) * | 2022-01-12 | 2023-07-14 | 如东凌达生物医药科技有限公司 | 一类嘧啶并杂环类化合物、制备方法和用途 |
| WO2023135260A1 (en) | 2022-01-14 | 2023-07-20 | Jazz Pharmaceuticals Ireland Limited | Novel amine-substituted phthalazines and derivatives as sos1 inhibitors |
| AU2023209542A1 (en) * | 2022-01-21 | 2024-08-08 | Foshan Ionova Biotherapeutics Co., Inc. | Fused heterocyclic compounds as modulators of ras signalling |
| EP4227307A1 (en) | 2022-02-11 | 2023-08-16 | Genzyme Corporation | Pyrazolopyrazine compounds as shp2 inhibitors |
| GB202203976D0 (en) | 2022-03-22 | 2022-05-04 | Jazz Pharmaceuticals Ireland Ltd | Tricyclic phthalazines and derivatives as sos1 inhibitors |
| WO2023240263A1 (en) | 2022-06-10 | 2023-12-14 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| AU2003256323A1 (en) | 2002-06-26 | 2004-01-19 | Chiron Corporation | Sos1 inhibitors |
| US20070065622A1 (en) | 2005-09-22 | 2007-03-22 | Scientific Technologies Incorporated | Safety Mat Active Joining Trim |
| JP5242857B2 (ja) | 2009-12-17 | 2013-07-24 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｓｙｋ阻害剤としてのアミノピリミジン類 |
| EP2970392B1 (en) | 2013-03-15 | 2019-07-10 | Dana-Farber Cancer Institute, Inc. | Stabilized sos1 peptides |
| WO2016077793A1 (en) | 2014-11-14 | 2016-05-19 | Children's Hospital Medical Center | Sos1 inhibitors for cancer treatment |
| EP3414252B1 (en) | 2016-02-12 | 2022-07-06 | Valo Health, Inc. | Thienopyridine carboxamides as ubiquitin-specific protease inhibitors |
| US10898487B2 (en) * | 2016-12-22 | 2021-01-26 | Boehringer Ingelheim International Gmbh | Benzylamino substituted quinazolines and derivatives as SOS1 inhibitors |
| CA3056970A1 (en) * | 2017-03-21 | 2018-09-27 | Bayer Pharma Aktiengesellschaft | 2-methyl-quinazolines |
| TWI810230B (zh) | 2017-12-21 | 2023-08-01 | 德商百靈佳殷格翰國際股份有限公司 | 作為sos1抑制劑之新穎芐胺基取代吡啶并嘧啶酮及衍生物 |
| EP3781565A1 (en) | 2018-04-18 | 2021-02-24 | Bayer Pharma Aktiengesellschaft | 2-methyl-aza-quinazolines |
| AU2020232616A1 (en) | 2019-03-01 | 2021-09-09 | Revolution Medicines, Inc. | Bicyclic heterocyclyl compounds and uses thereof |
| WO2020180768A1 (en) | 2019-03-01 | 2020-09-10 | Revolution Medicines, Inc. | Bicyclic heteroaryl compounds and uses thereof |
-
2020
- 2020-11-28 WO PCT/IB2020/061248 patent/WO2021105960A1/en active Application Filing
- 2020-11-28 CA CA3154914A patent/CA3154914A1/en active Pending
- 2020-11-28 FI FIEP20828308.5T patent/FI4065575T3/fi active
- 2020-11-28 LT LTEPPCT/IB2020/061248T patent/LT4065575T/lt unknown
- 2020-11-28 JP JP2022531526A patent/JP2023504113A/ja active Pending
- 2020-11-28 AU AU2020393205A patent/AU2020393205A1/en active Pending
- 2020-11-28 RS RS20240468A patent/RS65526B1/sr unknown
- 2020-11-28 SI SI202030421T patent/SI4065575T1/sl unknown
- 2020-11-28 KR KR1020227022095A patent/KR20220110241A/ko unknown
- 2020-11-28 DK DK20828308.5T patent/DK4065575T3/da active
- 2020-11-28 CN CN202080083011.4A patent/CN114746411B/zh active Active
- 2020-11-28 US US17/775,679 patent/US20230013778A1/en active Pending
- 2020-11-28 HR HRP20240547TT patent/HRP20240547T1/hr unknown
- 2020-11-28 PE PE2022000814A patent/PE20221336A1/es unknown
- 2020-11-28 PL PL20828308.5T patent/PL4065575T3/pl unknown
- 2020-11-28 BR BR112022010383A patent/BR112022010383A2/pt unknown
- 2020-11-28 PT PT208283085T patent/PT4065575T/pt unknown
- 2020-11-28 CR CR20220312A patent/CR20220312A/es unknown
- 2020-11-28 EP EP20828308.5A patent/EP4065575B1/en active Active
- 2020-11-28 MX MX2022006475A patent/MX2022006475A/es unknown
-
2022
- 2022-05-03 IL IL292721A patent/IL292721A/en unknown
- 2022-05-27 CL CL2022001392A patent/CL2022001392A1/es unknown
- 2022-06-06 ZA ZA2022/06253A patent/ZA202206253B/en unknown
- 2022-06-28 EC ECSENADI202250936A patent/ECSP22050936A/es unknown
- 2022-06-28 CO CONC2022/0008997A patent/CO2022008997A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL292721A (en) | 2022-07-01 |
| JP2023504113A (ja) | 2023-02-01 |
| MX2022006475A (es) | 2022-09-07 |
| ZA202206253B (en) | 2023-01-25 |
| US20230013778A1 (en) | 2023-01-19 |
| PE20221336A1 (es) | 2022-09-13 |
| CA3154914A1 (en) | 2021-06-03 |
| PL4065575T3 (pl) | 2024-06-24 |
| HRP20240547T1 (hr) | 2024-07-05 |
| SI4065575T1 (sl) | 2024-06-28 |
| FI4065575T3 (fi) | 2024-05-02 |
| PT4065575T (pt) | 2024-05-03 |
| EP4065575A1 (en) | 2022-10-05 |
| KR20220110241A (ko) | 2022-08-05 |
| RS65526B1 (sr) | 2024-06-28 |
| CN114746411B (zh) | 2024-06-25 |
| WO2021105960A1 (en) | 2021-06-03 |
| EP4065575B1 (en) | 2024-01-31 |
| CN114746411A (zh) | 2022-07-12 |
| AU2020393205A1 (en) | 2022-06-30 |
| ECSP22050936A (es) | 2022-07-29 |
| CR20220312A (es) | 2022-08-05 |
| DK4065575T3 (da) | 2024-04-15 |
| CL2022001392A1 (es) | 2023-03-17 |
| BR112022010383A2 (pt) | 2022-08-23 |
| CO2022008997A2 (es) | 2022-07-19 |
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