AR116080A1 - Derivados de 1-imidazotiadiazol-2h-pirrol-5-ona - Google Patents
Derivados de 1-imidazotiadiazol-2h-pirrol-5-onaInfo
- Publication number
- AR116080A1 AR116080A1 ARP190101197A ARP190101197A AR116080A1 AR 116080 A1 AR116080 A1 AR 116080A1 AR P190101197 A ARP190101197 A AR P190101197A AR P190101197 A ARP190101197 A AR P190101197A AR 116080 A1 AR116080 A1 AR 116080A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- alkyl
- imidazotiadiazol
- pirrol
- ona
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Derivados de 1-imidazo[2,1-b][1,3,4]tiadiazol-2H-pirrol-5-ona, composición farmacéutica que los comprende, y el su uso de los mismos para el tratamiento de la epilepsia, la epileptogénesis y las convulsiones, en particular, las convulsiones refractarias. Reivindicación 1: Un compuesto de acuerdo con la fórmula (1), o una sal aceptable para uso farmacéutico del mismo, caracterizado porque R¹ es un alquilo C₁₋₄ o un cicloalquilo C₃₋₅, cualquiera de dichos grupos está sustituido de manera opcional por uno o más sustituyentes halógeno; R² es un alquilo C₁₋₄ sustituido por un sustituyente hidroxi o alcoxi; R³ es un halógeno; o alquilo C₁₋₄ o cicloalquilo C₃₋₄, cualquiera de dichos grupos está sustituido de manera opcional por uno o más átomos de halógeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18171130 | 2018-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR116080A1 true AR116080A1 (es) | 2021-03-31 |
Family
ID=62142955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP190101197A AR116080A1 (es) | 2018-05-08 | 2019-05-07 | Derivados de 1-imidazotiadiazol-2h-pirrol-5-ona |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11286266B2 (es) |
| EP (1) | EP3790885B1 (es) |
| JP (1) | JP7340542B2 (es) |
| CN (1) | CN112088160B (es) |
| AR (1) | AR116080A1 (es) |
| CA (1) | CA3097818A1 (es) |
| ES (1) | ES2947618T3 (es) |
| MX (1) | MX2020011170A (es) |
| TW (1) | TW201946926A (es) |
| UY (1) | UY38217A (es) |
| WO (1) | WO2019215062A1 (es) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0004297D0 (en) | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| EP1912966A2 (en) * | 2005-06-01 | 2008-04-23 | Ucb, S.A. | 2-oxo-1-pyrrolidine derivatives and their therapeutic use on the central nervous system |
| CN100580670C (zh) | 2005-06-03 | 2010-01-13 | 国际商业机器公司 | 用于由用户触发的内容恢复的方法和计算机系统 |
| EP2152262A2 (en) | 2007-04-27 | 2010-02-17 | UCB Pharma, S.A. | New heterocyclic derivatives useful for the treatment of cns disorders |
| CN102574869A (zh) | 2009-10-23 | 2012-07-11 | Ucb医药有限公司 | 2-氧代-1-吡咯烷基咪唑并噻二唑衍生物 |
| WO2012143116A1 (en) * | 2011-04-18 | 2012-10-26 | Ucb Pharma, S.A. | 4-oxo-1-imidazolidinyl imidazothiadiazole derivatives |
| RS54487B1 (en) * | 2011-04-18 | 2016-06-30 | Ucb Biopharma Sprl | 2-OXO-1-IMIDAZOLIDINIL DERIVATIVES IMIDAZOTIADIAZOL |
| CA3083166A1 (en) * | 2017-12-12 | 2019-06-20 | UCB Biopharma SRL | 2-oxo-1-pyrrolidinyl imidazothiadiazole derivatives |
-
2019
- 2019-05-06 JP JP2020560493A patent/JP7340542B2/ja active Active
- 2019-05-06 ES ES19722856T patent/ES2947618T3/es active Active
- 2019-05-06 US US17/052,978 patent/US11286266B2/en active Active
- 2019-05-06 MX MX2020011170A patent/MX2020011170A/es unknown
- 2019-05-06 WO PCT/EP2019/061498 patent/WO2019215062A1/en unknown
- 2019-05-06 CA CA3097818A patent/CA3097818A1/en active Pending
- 2019-05-06 EP EP19722856.2A patent/EP3790885B1/en active Active
- 2019-05-06 CN CN201980030973.0A patent/CN112088160B/zh active Active
- 2019-05-07 TW TW108115749A patent/TW201946926A/zh unknown
- 2019-05-07 UY UY0001038217A patent/UY38217A/es not_active Application Discontinuation
- 2019-05-07 AR ARP190101197A patent/AR116080A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021522290A (ja) | 2021-08-30 |
| TW201946926A (zh) | 2019-12-16 |
| UY38217A (es) | 2019-11-29 |
| US20210107922A1 (en) | 2021-04-15 |
| CN112088160B (zh) | 2023-07-04 |
| CA3097818A1 (en) | 2019-11-14 |
| JP7340542B2 (ja) | 2023-09-07 |
| CN112088160A (zh) | 2020-12-15 |
| MX2020011170A (es) | 2020-11-12 |
| EP3790885B1 (en) | 2023-04-19 |
| EP3790885A1 (en) | 2021-03-17 |
| US11286266B2 (en) | 2022-03-29 |
| ES2947618T3 (es) | 2023-08-14 |
| WO2019215062A1 (en) | 2019-11-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR114164A1 (es) | Piridopirimidinonas sustituidas con bencilamino y derivados como inhibidores de sos1 | |
| CL2018002410A1 (es) | Inhibidores de mcl-1 y métodos de uso de los mismos | |
| AR110400A1 (es) | Compuestos de amino-triazolopiridina y su uso en el tratamiento del cáncer | |
| AR104176A1 (es) | Inhibidores de ido (indolamina-2,3-dioxigenasa) | |
| BR112021021718A2 (pt) | Moduladores de thr-ss e métodos de uso dos mesmos | |
| AR111314A1 (es) | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue | |
| AR091786A1 (es) | Inhibidores de la produccion de leucotrienos | |
| AR106314A1 (es) | COMPUESTOS DE ESPIRO[3H-INDOL-3,2-PIRROLIDIN]-2(1H)-ONA Y DERIVADOS COMO INHIBIDORES DE MDM2 - p53 | |
| AR102981A1 (es) | Inhibidores de la necrosis celular y métodos de preparación de los mismos | |
| AR088175A1 (es) | 3-pirimidin-4-il-oxazolidin-2-onas utiles para tratar cancer y composiciones farmaceuticas que las contienen | |
| AR100049A1 (es) | Derivados de dihidrotiazina y dihidrooxazina con actividad inhibidora de bace1 | |
| AR090955A1 (es) | Aminas biciclicas c-17 de triterpenoides con actividad inhibidora de la maduracion del vih | |
| CO2021005532A2 (es) | Derivados de quinolina como inhibidores de la integrina alfa4beta7 | |
| AR103232A1 (es) | ANTAGONISTAS DE TGFbR | |
| AR122351A1 (es) | Derivados de metilquinazolinona como inhibidores de braf | |
| AR101964A1 (es) | Compuestos de imidazopiridazina como moduladores de pi3k | |
| AR112086A1 (es) | Compuestos heteroaromáticos como inhibidores de vanina | |
| CO2022008719A2 (es) | Compuestos para modular la actividad de fxr y usos de los mismos | |
| CO2021014210A2 (es) | Compuestos de pirrol | |
| CL2022000893A1 (es) | Derivados de 2-azaspiro[3,4]octano como agonistas de m4 | |
| ECSP22027784A (es) | Derivados de 2azaespiro[3.4]octano como agonistas de m4 | |
| AR116877A1 (es) | 3-amino-piridazinas como inhibidores de atx | |
| AR116036A1 (es) | DERIVADOS DE NAFTIRIDINA COMO INHIBIDORES DE INTEGRINA avb6 | |
| AR114418A1 (es) | Compuesto cíclico de metilactama y su utilización farmacéutica | |
| AR118141A1 (es) | Compuestos para el tratamiento, alivio o prevención de trastornos asociados con los agregados de tau |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |