AR107310A1 - Inhibidores de tetrahidrocarbazol de receptores sirt1 - Google Patents

Inhibidores de tetrahidrocarbazol de receptores sirt1

Info

Publication number
AR107310A1
AR107310A1 ARP170100034A ARP170100034A AR107310A1 AR 107310 A1 AR107310 A1 AR 107310A1 AR P170100034 A ARP170100034 A AR P170100034A AR P170100034 A ARP170100034 A AR P170100034A AR 107310 A1 AR107310 A1 AR 107310A1
Authority
AR
Argentina
Prior art keywords
sirt1
inhibitors
deuterium
tetrahydrocarbazol
receptors
Prior art date
Application number
ARP170100034A
Other languages
English (en)
Inventor
Ralph Laufer
Chengzhi Zhang
Original Assignee
Auspex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Auspex Pharmaceuticals Inc filed Critical Auspex Pharmaceuticals Inc
Publication of AR107310A1 publication Critical patent/AR107310A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings

Abstract

Se describen compuestos tetrahidrocarbazol sustituido con deuterio como inhibidores de sirtuina 1 (SIRT1). También se describen composiciones farmacéuticas que comprenden los compuestos tetrahidrocarbazol sustituido con deuterio y métodos de uso de los mismos. Reivindicación 1: Un compuesto que tiene la estructura de la fórmula (1) o una sal, profármaco, o solvato del mismo, en donde R¹ - R⁷ son, independientemente, hidrógeno o deuterio; por lo menos uno de R¹ - R⁷ es deuterio; y por lo menos uno de R¹ - R⁷ tiene un enriquecimiento de deuterio no menor del 10%.
ARP170100034A 2016-01-06 2017-01-06 Inhibidores de tetrahidrocarbazol de receptores sirt1 AR107310A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662275444P 2016-01-06 2016-01-06

Publications (1)

Publication Number Publication Date
AR107310A1 true AR107310A1 (es) 2018-04-18

Family

ID=57868399

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170100034A AR107310A1 (es) 2016-01-06 2017-01-06 Inhibidores de tetrahidrocarbazol de receptores sirt1

Country Status (5)

Country Link
US (2) US9884819B2 (es)
EP (1) EP3400212A1 (es)
AR (1) AR107310A1 (es)
TW (1) TW201726617A (es)
WO (1) WO2017120409A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114173780A (zh) * 2018-12-18 2022-03-11 小利兰·斯坦福大学托管委员会 用于降低含有延伸的核苷酸重复序列的基因的有害活性的化合物
WO2022192645A1 (en) * 2021-03-12 2022-09-15 The General Hospital Corporation Compounds for brain imaging

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1734950A4 (en) 2004-01-29 2010-06-16 Elixir Pharmaceuticals Inc TREATMENT OF A VIRUS DISEASE
WO2007047604A2 (en) 2005-10-18 2007-04-26 Elixir Pharmaceuticals, Inc. Sirt1 inhibition
KR102317399B1 (ko) 2012-01-26 2021-10-26 반다 파마슈티칼즈, 인코퍼레이티드. 일주기 리듬 장애의 치료

Also Published As

Publication number Publication date
EP3400212A1 (en) 2018-11-14
US9884819B2 (en) 2018-02-06
US20180127366A1 (en) 2018-05-10
US20170190664A1 (en) 2017-07-06
TW201726617A (zh) 2017-08-01
WO2017120409A1 (en) 2017-07-13

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