CL2016001287A1 - Benzamidas sustituidas y procedimiento para su uso - Google Patents

Benzamidas sustituidas y procedimiento para su uso

Info

Publication number
CL2016001287A1
CL2016001287A1 CL2016001287A CL2016001287A CL2016001287A1 CL 2016001287 A1 CL2016001287 A1 CL 2016001287A1 CL 2016001287 A CL2016001287 A CL 2016001287A CL 2016001287 A CL2016001287 A CL 2016001287A CL 2016001287 A1 CL2016001287 A1 CL 2016001287A1
Authority
CL
Chile
Prior art keywords
procedure
substituted benzamides
compounds
compositions
subindice
Prior art date
Application number
CL2016001287A
Other languages
English (en)
Inventor
Sultan Chowdhury
Qi Jia
Jun Li
Brian Safina
Jean Christophe Andrez
Paul Robert Bichler
Chien-An Chen
Shannon Marie Decker
Christoph Martin Dehnhardt
Tilo Focken
Michael Edward Grimwood
Ivan William Hemeon
Zhiguo Liu
Daniel F Ortwine
Daniel Sutherlin
Tao Sheng
Shaoyi Sun
Andrew D White
Michael Scott Wilson
Alla Yureva Zenova
Jiuxiang Zhu
Original Assignee
Xenon Pharmaceuticals Inc
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc, Genentech Inc filed Critical Xenon Pharmaceuticals Inc
Publication of CL2016001287A1 publication Critical patent/CL2016001287A1/es

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

<p>La invención provee compuestos con Ia fármula general I: (dibujo) y sales farmacéuticamente aceptables de estos. en los que las variables RA,  el subindice n. el anillo A, X2, L, el subindice m, X 1 , R 1 , R.  R31  R4, R5  y RN  tienen el significado que se describió en Ia presente y composiciones que contienen tales compuestos y los métodos para utilizar dichos compuestos y composiciones. </p>
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