MX2016006936A - Benzamidas sustituidas y metodos para usarlas. - Google Patents

Benzamidas sustituidas y metodos para usarlas.

Info

Publication number
MX2016006936A
MX2016006936A MX2016006936A MX2016006936A MX2016006936A MX 2016006936 A MX2016006936 A MX 2016006936A MX 2016006936 A MX2016006936 A MX 2016006936A MX 2016006936 A MX2016006936 A MX 2016006936A MX 2016006936 A MX2016006936 A MX 2016006936A
Authority
MX
Mexico
Prior art keywords
methods
substituted benzamides
compounds
subscript
compositions
Prior art date
Application number
MX2016006936A
Other languages
English (en)
Inventor
Tao Sheng
Shaoyi Sun
Sultan Chowdhury
Brian Safina
Qi Jia
Sutherlin Daniel
Chien-An Chen
Daniel F Ortwine
Michael Scott Wilson
Alla Yurevna Zenova
Jean-Christophe Andrez
Christoph Martin Dehnhardt
Thilo Focken
Michael Edward Grimwood
Ivan William Hemeon
Paul Robert Bichler
Shannon Marie Decker
Li Jun
Liu Zhiguo
D White Andrew
Zhu Jiuxiang
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2016006936A publication Critical patent/MX2016006936A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

La invención provee compuestos con la fórmula general I: (ver Fórmula) y sales farmacéuticamente aceptables de estos, en los que las variables RA, el subíndice n, el anillo A, X2, L, el subíndice m, X1, R1, R2, R3, R4, R5 y RN tienen el significado que se describió en la presente y composiciones que contienen tales compuestos y los métodos para utilizar dichos compuestos y composiciones.
MX2016006936A 2013-11-27 2014-11-26 Benzamidas sustituidas y metodos para usarlas. MX2016006936A (es)

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