ATE253057T1 - Isoxazole - Google Patents

Isoxazole

Info

Publication number
ATE253057T1
ATE253057T1 AT95929249T AT95929249T ATE253057T1 AT E253057 T1 ATE253057 T1 AT E253057T1 AT 95929249 T AT95929249 T AT 95929249T AT 95929249 T AT95929249 T AT 95929249T AT E253057 T1 ATE253057 T1 AT E253057T1
Authority
AT
Austria
Prior art keywords
group
ring
integer
alkylthio
amino
Prior art date
Application number
AT95929249T
Other languages
English (en)
Inventor
Koichi Kojima
Yuichi Aizawa
Isao Kaneko
Junichi Sakai
Masao Kozuka
Kazuo Koyama
Naozumi Samata
Kenji Yoshimi
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Application granted granted Critical
Publication of ATE253057T1 publication Critical patent/ATE253057T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
AT95929249T 1994-08-30 1995-08-29 Isoxazole ATE253057T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP20536394 1994-08-30
JP15057195 1995-06-16
PCT/JP1995/001714 WO1996006837A1 (fr) 1994-08-30 1995-08-29 Isoxazoles

Publications (1)

Publication Number Publication Date
ATE253057T1 true ATE253057T1 (de) 2003-11-15

Family

ID=26480122

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95929249T ATE253057T1 (de) 1994-08-30 1995-08-29 Isoxazole

Country Status (20)

Country Link
US (2) US5965591A (de)
EP (1) EP0779281B1 (de)
KR (1) KR970705549A (de)
CN (1) CN1098843C (de)
AT (1) ATE253057T1 (de)
AU (1) AU688102B2 (de)
CA (1) CA2198457A1 (de)
CZ (1) CZ290961B6 (de)
DE (1) DE69532039T2 (de)
DK (1) DK0779281T3 (de)
ES (1) ES2208690T3 (de)
FI (1) FI970864A (de)
HK (1) HK1018878A1 (de)
HU (1) HU221138B1 (de)
MX (1) MX9701630A (de)
NO (1) NO308741B1 (de)
NZ (1) NZ291508A (de)
PT (1) PT779281E (de)
RU (1) RU2140414C1 (de)
WO (1) WO1996006837A1 (de)

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DK0779281T3 (da) * 1994-08-30 2004-03-08 Sankyo Co Isoxazoler
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US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
WO2000027199A1 (en) * 1998-11-12 2000-05-18 Eli Lilly And Company Aminobenzisoxazole compounds and libraries thereof
US6497928B1 (en) 1999-05-14 2002-12-24 Canon Kabushiki Kaisha Liquid crystal device, mesomorphic functional material and liquid crystal apparatus
US6638981B2 (en) 2001-08-17 2003-10-28 Epicept Corporation Topical compositions and methods for treating pain
RU2361862C2 (ru) * 2003-12-29 2009-07-20 Сепракор Инк. Пиррольные и пиразольные ингибиторы daao
KR20060128978A (ko) * 2003-12-29 2006-12-14 세프라코 아이엔시. 벤조［디］이속사졸­３­올 디에이에이오 억제제
EP1746991A2 (de) * 2004-03-16 2007-01-31 Janssen Pharmaceutica N.V. Daao-hemmende benzisoxazole zur behandlung von geisteskrankheiten
AU2006264317B2 (en) 2005-07-06 2012-02-23 Sunovion Pharmaceuticals Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
US8053603B2 (en) * 2006-01-06 2011-11-08 Sunovion Pharmaceuticals Inc. Tetralone-based monoamine reuptake inhibitors
NZ569630A (en) 2006-01-06 2011-09-30 Sepracor Inc Cycloalkylamines as monoamine reuptake inhibitors
DK2816024T3 (en) 2006-03-31 2017-10-30 Sunovion Pharmaceuticals Inc CHIRALE AMINER
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
EP2079694B1 (de) 2006-12-28 2017-03-01 Rigel Pharmaceuticals, Inc. N-substituierte heterocycloalkyloxybenzamidverbindungen und verfahren zu ihrer verwendung
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
ZA200904686B (en) * 2007-01-18 2010-09-29 Sepracor Inc Inhibitiors of D-amino acid oxidase
CN103936605B (zh) 2007-05-31 2017-09-01 赛诺维信制药公司 苯基取代的环烷胺作为一元胺再摄取抑制剂
EP2254420A4 (de) 2008-02-20 2012-02-15 Targia Pharmaceuticals Zns-pharmazeutika und verfahren für ihre verwendung
US20100120740A1 (en) * 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US20110034434A1 (en) * 2009-08-07 2011-02-10 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
JP2013519685A (ja) 2010-02-11 2013-05-30 ヴァンダービルト ユニバーシティー ｍＧｌｕＲ４アロステリック増強剤としてのベンズイソオキサゾール類およびアザベンズイソオキサゾール類、組成物、および神経機能不全を治療する方法
WO2013064983A1 (en) 2011-10-31 2013-05-10 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
CA2855019A1 (en) 2011-10-31 2013-05-10 Xenon Pharmaceuticals Inc. Biaryl ether sulfonamides and their use as therapeutic agents
IN2014MN02574A (de) 2012-05-22 2015-07-24 Genentech Inc
WO2014008458A2 (en) 2012-07-06 2014-01-09 Genentech, Inc. N-substituted benzamides and methods of use thereof
BR112015022488A2 (pt) 2013-03-14 2017-07-18 Genentech Inc triazolopiridinas substituídas e métodos de uso das mesmas
WO2014144545A2 (en) * 2013-03-15 2014-09-18 Genentech, Inc. Substituted benzoxazoles and methods of use thereof
CN105492430B (zh) * 2013-03-15 2017-10-10 基因泰克公司 取代的苯并噁唑及其使用方法
EA201691085A1 (ru) 2013-11-27 2017-02-28 Дженентек, Инк. Замещенные бензамиды и способы их применения
WO2016007534A1 (en) 2014-07-07 2016-01-14 Genentech, Inc. Therapeutic compounds and methods of use thereof
NZ737536A (en) 2015-05-22 2019-04-26 Genentech Inc Substituted benzamides and methods of use thereof
EP3341353A1 (de) 2015-08-27 2018-07-04 Genentech, Inc. Therapeutische verbindungen und verfahren zur verwendung davon
WO2017091592A1 (en) 2015-11-25 2017-06-01 Genentech, Inc. Substituted benzamides useful as sodium channel blockers
EP3854782A1 (de) 2016-03-30 2021-07-28 Genentech, Inc. Substituierte benzamide und verfahren zur verwendung davon
CN105801510A (zh) * 2016-04-08 2016-07-27 李勇 一种治疗抑郁症的药物组合物
CR20190236A (es) 2016-10-17 2019-09-09 Genentech Inc Compuestos terapéuticos y métodos para utilizarlos
EP3601273B1 (de) 2017-03-24 2021-12-01 Genentech, Inc. 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamid-derivate als natriumkanalinhibitoren
EP3759098A1 (de) 2018-02-26 2021-01-06 Genentech, Inc. Pyridinsulfonamidverbindungen und deren verwendung gegen schmerz und verwandte störungen
JP2021519788A (ja) 2018-03-30 2021-08-12 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ナトリウムチャネル阻害剤としての縮合環ヒドロピリド化合物
CN114349690B (zh) * 2022-02-15 2023-04-25 甘肃皓天医药科技有限责任公司 一种多拉韦林中间体合成方法

Family Cites Families (15)

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GB1265824A (de) * 1968-03-28 1972-03-08
US3812187A (en) * 1970-02-05 1974-05-21 Merck & Co Inc Hydrazides
SU539522A3 (ru) * 1970-02-05 1976-12-15 Мерк Энд Ко. Инк. (Фирма) Способ получени гидразин- -фенилпропионовой кислоты
JPS476302Y1 (de) * 1970-06-08 1972-03-04
US5321037A (en) * 1986-12-26 1994-06-14 Sankyo Company, Limited Isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants
IE62276B1 (en) * 1988-03-30 1995-01-25 Sankyo Co "New isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants"
US5116839A (en) * 1989-06-26 1992-05-26 Sankyo Company, Limited Use of isoxazolin-3-one derivatives as antidepressants
US5352688A (en) * 1991-02-14 1994-10-04 The Mount Sinai School Of Medicine Of The City University Of New York Methods for the treatment of bradyphrenia in parkinson's disease
US5750542A (en) * 1993-09-28 1998-05-12 Pfizer Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors
JPH0588630A (ja) * 1991-09-30 1993-04-09 Toshiba Lighting & Technol Corp 表示装置
KR100263428B1 (ko) * 1992-10-28 2000-11-01 나카노 가쓰히코 신규한1,2-벤조이속사졸유도체또는그의염,및이를포함하는뇌보호제
US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
DK0779281T3 (da) * 1994-08-30 2004-03-08 Sankyo Co Isoxazoler
CA2190708A1 (en) * 1995-12-08 1997-06-09 Johannes Aebi Aminoalkyl substituted benzo-heterocyclic compounds
JP5229734B2 (ja) * 2008-11-26 2013-07-03 住化エンビロサイエンス株式会社 木材保存組成物

Also Published As

Publication number Publication date
AU3266095A (en) 1996-03-22
NO308741B1 (no) 2000-10-23
DE69532039D1 (de) 2003-12-04
EP0779281A4 (de) 2000-07-26
NO970892D0 (no) 1997-02-27
HU221138B1 (en) 2002-08-28
KR970705549A (ko) 1997-10-09
AU688102B2 (en) 1998-03-05
HK1018878A1 (en) 2000-01-07
CN1162957A (zh) 1997-10-22
HUT77225A (hu) 1998-03-02
NO970892L (no) 1997-04-29
CN1098843C (zh) 2003-01-15
NZ291508A (en) 1999-07-29
US5965591A (en) 1999-10-12
US6096771A (en) 2000-08-01
CZ290961B6 (cs) 2002-11-13
FI970864A (fi) 1997-04-24
WO1996006837A1 (fr) 1996-03-07
PT779281E (pt) 2004-02-27
DE69532039T2 (de) 2004-07-08
CZ59897A3 (en) 1997-07-16
ES2208690T3 (es) 2004-06-16
MX9701630A (es) 1997-06-28
RU2140414C1 (ru) 1999-10-27
DK0779281T3 (da) 2004-03-08
CA2198457A1 (en) 1996-03-07
EP0779281A1 (de) 1997-06-18
EP0779281B1 (de) 2003-10-29
FI970864A0 (fi) 1997-02-28

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