NO308741B1 - Isoksazolderivater, mellomprodukter, farmasøytiske preparater og anvendelse av derivatene - Google Patents

Isoksazolderivater, mellomprodukter, farmasøytiske preparater og anvendelse av derivatene

Info

Publication number
NO308741B1
NO308741B1 NO970892A NO970892A NO308741B1 NO 308741 B1 NO308741 B1 NO 308741B1 NO 970892 A NO970892 A NO 970892A NO 970892 A NO970892 A NO 970892A NO 308741 B1 NO308741 B1 NO 308741B1
Authority
NO
Norway
Prior art keywords
group
derivatives
ring
integer
alkylthio
Prior art date
Application number
NO970892A
Other languages
English (en)
Other versions
NO970892D0 (no
NO970892L (no
Inventor
Koichi Kojima
Junichi Sakai
Yuichi Aizawa
Naozumi Samata
Masao Kozuka
Kenji Yoshimi
Isao Kaneko
Kazuro Koyama
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of NO970892D0 publication Critical patent/NO970892D0/no
Publication of NO970892L publication Critical patent/NO970892L/no
Publication of NO308741B1 publication Critical patent/NO308741B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
NO970892A 1994-08-30 1997-02-27 Isoksazolderivater, mellomprodukter, farmasøytiske preparater og anvendelse av derivatene NO308741B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP20536394 1994-08-30
JP15057195 1995-06-16
PCT/JP1995/001714 WO1996006837A1 (fr) 1994-08-30 1995-08-29 Isoxazoles

Publications (3)

Publication Number Publication Date
NO970892D0 NO970892D0 (no) 1997-02-27
NO970892L NO970892L (no) 1997-04-29
NO308741B1 true NO308741B1 (no) 2000-10-23

Family

ID=26480122

Family Applications (1)

Application Number Title Priority Date Filing Date
NO970892A NO308741B1 (no) 1994-08-30 1997-02-27 Isoksazolderivater, mellomprodukter, farmasøytiske preparater og anvendelse av derivatene

Country Status (20)

Country Link
US (2) US5965591A (no)
EP (1) EP0779281B1 (no)
KR (1) KR970705549A (no)
CN (1) CN1098843C (no)
AT (1) ATE253057T1 (no)
AU (1) AU688102B2 (no)
CA (1) CA2198457A1 (no)
CZ (1) CZ290961B6 (no)
DE (1) DE69532039T2 (no)
DK (1) DK0779281T3 (no)
ES (1) ES2208690T3 (no)
FI (1) FI970864A (no)
HK (1) HK1018878A1 (no)
HU (1) HU221138B1 (no)
MX (1) MX9701630A (no)
NO (1) NO308741B1 (no)
NZ (1) NZ291508A (no)
PT (1) PT779281E (no)
RU (1) RU2140414C1 (no)
WO (1) WO1996006837A1 (no)

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AU711927B2 (en) * 1996-02-27 1999-10-21 Sankyo Company Limited Isoxazole derivatives
US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
EP1135023A4 (en) * 1998-11-12 2003-03-05 Lilly Co Eli AMINOBENZISOXAZOLE COMPOUNDS AND LIBRARIES THEREOF
US6497928B1 (en) 1999-05-14 2002-12-24 Canon Kabushiki Kaisha Liquid crystal device, mesomorphic functional material and liquid crystal apparatus
US8933236B2 (en) 2012-05-22 2015-01-13 Xenon Pharmaceuticals Inc. N-substituted benzamides and methods of use thereof
US6638981B2 (en) * 2001-08-17 2003-10-28 Epicept Corporation Topical compositions and methods for treating pain
US7166725B2 (en) * 2003-12-29 2007-01-23 Sepracor Inc. Benzo[d]isoxazol-3-ol DAAO inhibitors
NZ548212A (en) * 2003-12-29 2010-07-30 Sepracor Inc Pyrrole and pyrazole DAAO inhibitors
WO2005089753A2 (en) * 2004-03-16 2005-09-29 Janssen Pharmaceutica N.V. Daao inhibiting bξnzisoxazoles and their use for the treatment of mental disorders
CA2957667A1 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
CA2636275C (en) * 2006-01-06 2013-02-12 Sepracor Inc. Tetralone-based monoamine reuptake inhibitors
ES2594156T3 (es) * 2006-01-06 2016-12-16 Sunovion Pharmaceuticals Inc. Cicloalquilaminas como inhibidores de la recaptación de monoaminas
EP2816024B8 (en) 2006-03-31 2018-04-04 Sunovion Pharmaceuticals Inc. Chiral amines
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
EP2079694B1 (en) 2006-12-28 2017-03-01 Rigel Pharmaceuticals, Inc. N-substituted-heterocycloalkyloxybenzamide compounds and methods of use
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
WO2008089453A2 (en) * 2007-01-18 2008-07-24 Sepracor Inc. Inhibitors of d-amino acid oxidase
BRPI0811639A2 (pt) 2007-05-31 2014-09-30 Sepracor Inc Cicloaquilaminas fenil substituídas como inibidores da recaptação de monoamina
EP2254420A4 (en) 2008-02-20 2012-02-15 Targia Pharmaceuticals CNS PHARMACEUTICALS AND METHOD FOR THEIR USE
US20100120740A1 (en) * 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US20110034434A1 (en) * 2009-08-07 2011-02-10 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
KR20120120416A (ko) 2010-02-11 2012-11-01 벤더르빌트 유니버시티 Ｍｇｌｕｒ4 알로스테릭 강화제로서 벤즈이속사졸 및 아자벤즈이속사졸, 조성물, 및 신경 기능이상을 치료하는 방법
MX2014005304A (es) 2011-10-31 2015-03-20 Xenon Pharmaceuticals Inc Biaril eter sulfonamidas y su uso como agentes terapeuticos.
RU2014121984A (ru) 2011-10-31 2015-12-10 Ксенон Фармасьютикалз Инк. Бензолсульфонамидные соединения и их применение в качестве терапевтических средств
US10071957B2 (en) 2012-07-06 2018-09-11 Genentech, Inc. N-substituted benzamides and methods of use thereof
CA2898679A1 (en) 2013-03-14 2014-09-25 Xenon Pharmaceuticals Inc. Substituted triazolopyridines and methods of use thereof
EP2970156B1 (en) * 2013-03-15 2018-07-25 Genentech, Inc. Substituted benzoxazoles and methods of use thereof
CN105492430B (zh) * 2013-03-15 2017-10-10 基因泰克公司 取代的苯并噁唑及其使用方法
EP3074377B1 (en) 2013-11-27 2018-10-17 Genentech, Inc. Substituted benzamides and methods of use thereof
JP2017525677A (ja) 2014-07-07 2017-09-07 ジェネンテック， インコーポレイテッド 治療用化合物及びその使用方法
NZ737536A (en) 2015-05-22 2019-04-26 Genentech Inc Substituted benzamides and methods of use thereof
MA42683A (fr) 2015-08-27 2018-07-04 Genentech Inc Composés thérapeutiques et leurs méthodes utilisation
CN108495851A (zh) 2015-11-25 2018-09-04 基因泰克公司 取代的苯甲酰胺及其使用方法
CN109071426A (zh) 2016-03-30 2018-12-21 基因泰克公司 取代的苯甲酰胺及其使用方法
CN105801510A (zh) * 2016-04-08 2016-07-27 李勇 一种治疗抑郁症的药物组合物
MA46546A (fr) 2016-10-17 2021-05-05 Genentech Inc Composés thérapeutiques et leurs procédés d'utilisation
EP3601273B1 (en) 2017-03-24 2021-12-01 Genentech, Inc. 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors
US11028075B2 (en) 2018-02-26 2021-06-08 Genentech, Inc. Therapeutic compounds and methods of use thereof
JP2021519788A (ja) 2018-03-30 2021-08-12 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ナトリウムチャネル阻害剤としての縮合環ヒドロピリド化合物
CN114349690B (zh) * 2022-02-15 2023-04-25 甘肃皓天医药科技有限责任公司 一种多拉韦林中间体合成方法

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US3812187A (en) * 1970-02-05 1974-05-21 Merck & Co Inc Hydrazides
SU539522A3 (ru) * 1970-02-05 1976-12-15 Мерк Энд Ко. Инк. (Фирма) Способ получени гидразин- -фенилпропионовой кислоты
JPS476302Y1 (no) * 1970-06-08 1972-03-04
US5321037A (en) * 1986-12-26 1994-06-14 Sankyo Company, Limited Isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants
IE62276B1 (en) * 1988-03-30 1995-01-25 Sankyo Co "New isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants"
US5116839A (en) * 1989-06-26 1992-05-26 Sankyo Company, Limited Use of isoxazolin-3-one derivatives as antidepressants
US5352688A (en) * 1991-02-14 1994-10-04 The Mount Sinai School Of Medicine Of The City University Of New York Methods for the treatment of bradyphrenia in parkinson's disease
US5750542A (en) * 1993-09-28 1998-05-12 Pfizer Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors
JPH0588630A (ja) * 1991-09-30 1993-04-09 Toshiba Lighting & Technol Corp 表示装置
CA2146755A1 (en) * 1992-10-28 1994-05-11 Kenji Takeda Novel 1,2-benzoisoxazole derivative or its salt and brain-protecting agent comprising the same
US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
NZ291508A (en) * 1994-08-30 1999-07-29 Sankyo Co Isoxazoles; preparation and medicaments
CA2190708A1 (en) * 1995-12-08 1997-06-09 Johannes Aebi Aminoalkyl substituted benzo-heterocyclic compounds
JP5229734B2 (ja) * 2008-11-26 2013-07-03 住化エンビロサイエンス株式会社 木材保存組成物

Also Published As

Publication number Publication date
NZ291508A (en) 1999-07-29
FI970864A (fi) 1997-04-24
FI970864A0 (fi) 1997-02-28
US6096771A (en) 2000-08-01
US5965591A (en) 1999-10-12
HU221138B1 (en) 2002-08-28
NO970892D0 (no) 1997-02-27
HK1018878A1 (en) 2000-01-07
EP0779281B1 (en) 2003-10-29
AU3266095A (en) 1996-03-22
CZ290961B6 (cs) 2002-11-13
DK0779281T3 (da) 2004-03-08
EP0779281A4 (en) 2000-07-26
CN1098843C (zh) 2003-01-15
ATE253057T1 (de) 2003-11-15
CN1162957A (zh) 1997-10-22
DE69532039T2 (de) 2004-07-08
HUT77225A (hu) 1998-03-02
ES2208690T3 (es) 2004-06-16
KR970705549A (ko) 1997-10-09
WO1996006837A1 (fr) 1996-03-07
CZ59897A3 (en) 1997-07-16
MX9701630A (es) 1997-06-28
NO970892L (no) 1997-04-29
DE69532039D1 (de) 2003-12-04
RU2140414C1 (ru) 1999-10-27
AU688102B2 (en) 1998-03-05
PT779281E (pt) 2004-02-27
CA2198457A1 (en) 1996-03-07
EP0779281A1 (en) 1997-06-18

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