HK1018878A1 - Isoxazoles - Google Patents
IsoxazolesInfo
- Publication number
- HK1018878A1 HK1018878A1 HK98113089A HK98113089A HK1018878A1 HK 1018878 A1 HK1018878 A1 HK 1018878A1 HK 98113089 A HK98113089 A HK 98113089A HK 98113089 A HK98113089 A HK 98113089A HK 1018878 A1 HK1018878 A1 HK 1018878A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- group
- ring
- integer
- alkylthio
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20536394 | 1994-08-30 | ||
JP15057195 | 1995-06-16 | ||
PCT/JP1995/001714 WO1996006837A1 (fr) | 1994-08-30 | 1995-08-29 | Isoxazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1018878A1 true HK1018878A1 (en) | 2000-01-07 |
Family
ID=26480122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK98113089A HK1018878A1 (en) | 1994-08-30 | 1998-12-10 | Isoxazoles |
Country Status (20)
Country | Link |
---|---|
US (2) | US5965591A (xx) |
EP (1) | EP0779281B1 (xx) |
KR (1) | KR970705549A (xx) |
CN (1) | CN1098843C (xx) |
AT (1) | ATE253057T1 (xx) |
AU (1) | AU688102B2 (xx) |
CA (1) | CA2198457A1 (xx) |
CZ (1) | CZ290961B6 (xx) |
DE (1) | DE69532039T2 (xx) |
DK (1) | DK0779281T3 (xx) |
ES (1) | ES2208690T3 (xx) |
FI (1) | FI970864A (xx) |
HK (1) | HK1018878A1 (xx) |
HU (1) | HU221138B1 (xx) |
MX (1) | MX9701630A (xx) |
NO (1) | NO308741B1 (xx) |
NZ (1) | NZ291508A (xx) |
PT (1) | PT779281E (xx) |
RU (1) | RU2140414C1 (xx) |
WO (1) | WO1996006837A1 (xx) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ291508A (en) * | 1994-08-30 | 1999-07-29 | Sankyo Co | Isoxazoles; preparation and medicaments |
AU711927B2 (en) * | 1996-02-27 | 1999-10-21 | Sankyo Company Limited | Isoxazole derivatives |
US6339099B1 (en) * | 1997-06-20 | 2002-01-15 | Dupont Pharmaceuticals Company | Guanidine mimics as factor Xa inhibitors |
EP1135023A4 (en) * | 1998-11-12 | 2003-03-05 | Lilly Co Eli | AMINOBENZISOXAZOLE COMPOUNDS AND LIBRARIES THEREOF |
US6497928B1 (en) | 1999-05-14 | 2002-12-24 | Canon Kabushiki Kaisha | Liquid crystal device, mesomorphic functional material and liquid crystal apparatus |
US8933236B2 (en) | 2012-05-22 | 2015-01-13 | Xenon Pharmaceuticals Inc. | N-substituted benzamides and methods of use thereof |
US6638981B2 (en) * | 2001-08-17 | 2003-10-28 | Epicept Corporation | Topical compositions and methods for treating pain |
US7166725B2 (en) * | 2003-12-29 | 2007-01-23 | Sepracor Inc. | Benzo[d]isoxazol-3-ol DAAO inhibitors |
NZ548212A (en) * | 2003-12-29 | 2010-07-30 | Sepracor Inc | Pyrrole and pyrazole DAAO inhibitors |
WO2005089753A2 (en) * | 2004-03-16 | 2005-09-29 | Janssen Pharmaceutica N.V. | Daao inhibiting bξnzisoxazoles and their use for the treatment of mental disorders |
CA2957667A1 (en) | 2005-07-06 | 2007-01-11 | Sepracor Inc. | Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders |
CA2636275C (en) * | 2006-01-06 | 2013-02-12 | Sepracor Inc. | Tetralone-based monoamine reuptake inhibitors |
ES2594156T3 (es) * | 2006-01-06 | 2016-12-16 | Sunovion Pharmaceuticals Inc. | Cicloalquilaminas como inhibidores de la recaptación de monoaminas |
EP2816024B8 (en) | 2006-03-31 | 2018-04-04 | Sunovion Pharmaceuticals Inc. | Chiral amines |
US7579370B2 (en) * | 2006-06-30 | 2009-08-25 | Sepracor Inc. | Fused heterocycles |
US7884124B2 (en) * | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
US20080082066A1 (en) * | 2006-10-02 | 2008-04-03 | Weyerhaeuser Co. | Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks |
EP2079694B1 (en) | 2006-12-28 | 2017-03-01 | Rigel Pharmaceuticals, Inc. | N-substituted-heterocycloalkyloxybenzamide compounds and methods of use |
US7902252B2 (en) * | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
WO2008089453A2 (en) * | 2007-01-18 | 2008-07-24 | Sepracor Inc. | Inhibitors of d-amino acid oxidase |
BRPI0811639A2 (pt) | 2007-05-31 | 2014-09-30 | Sepracor Inc | Cicloaquilaminas fenil substituídas como inibidores da recaptação de monoamina |
EP2254420A4 (en) | 2008-02-20 | 2012-02-15 | Targia Pharmaceuticals | CNS PHARMACEUTICALS AND METHOD FOR THEIR USE |
US20100120740A1 (en) * | 2008-08-07 | 2010-05-13 | Sepracor Inc. | Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase |
US20110034434A1 (en) * | 2009-08-07 | 2011-02-10 | Sepracor Inc. | Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase |
KR20120120416A (ko) | 2010-02-11 | 2012-11-01 | 벤더르빌트 유니버시티 | Mglur4 알로스테릭 강화제로서 벤즈이속사졸 및 아자벤즈이속사졸, 조성물, 및 신경 기능이상을 치료하는 방법 |
MX2014005304A (es) | 2011-10-31 | 2015-03-20 | Xenon Pharmaceuticals Inc | Biaril eter sulfonamidas y su uso como agentes terapeuticos. |
RU2014121984A (ru) | 2011-10-31 | 2015-12-10 | Ксенон Фармасьютикалз Инк. | Бензолсульфонамидные соединения и их применение в качестве терапевтических средств |
US10071957B2 (en) | 2012-07-06 | 2018-09-11 | Genentech, Inc. | N-substituted benzamides and methods of use thereof |
CA2898679A1 (en) | 2013-03-14 | 2014-09-25 | Xenon Pharmaceuticals Inc. | Substituted triazolopyridines and methods of use thereof |
EP2970156B1 (en) * | 2013-03-15 | 2018-07-25 | Genentech, Inc. | Substituted benzoxazoles and methods of use thereof |
CN105492430B (zh) * | 2013-03-15 | 2017-10-10 | 基因泰克公司 | 取代的苯并噁唑及其使用方法 |
EP3074377B1 (en) | 2013-11-27 | 2018-10-17 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
JP2017525677A (ja) | 2014-07-07 | 2017-09-07 | ジェネンテック, インコーポレイテッド | 治療用化合物及びその使用方法 |
NZ737536A (en) | 2015-05-22 | 2019-04-26 | Genentech Inc | Substituted benzamides and methods of use thereof |
MA42683A (fr) | 2015-08-27 | 2018-07-04 | Genentech Inc | Composés thérapeutiques et leurs méthodes utilisation |
CN108495851A (zh) | 2015-11-25 | 2018-09-04 | 基因泰克公司 | 取代的苯甲酰胺及其使用方法 |
CN109071426A (zh) | 2016-03-30 | 2018-12-21 | 基因泰克公司 | 取代的苯甲酰胺及其使用方法 |
CN105801510A (zh) * | 2016-04-08 | 2016-07-27 | 李勇 | 一种治疗抑郁症的药物组合物 |
MA46546A (fr) | 2016-10-17 | 2021-05-05 | Genentech Inc | Composés thérapeutiques et leurs procédés d'utilisation |
EP3601273B1 (en) | 2017-03-24 | 2021-12-01 | Genentech, Inc. | 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors |
US11028075B2 (en) | 2018-02-26 | 2021-06-08 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
JP2021519788A (ja) | 2018-03-30 | 2021-08-12 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ナトリウムチャネル阻害剤としての縮合環ヒドロピリド化合物 |
CN114349690B (zh) * | 2022-02-15 | 2023-04-25 | 甘肃皓天医药科技有限责任公司 | 一种多拉韦林中间体合成方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1265824A (xx) * | 1968-03-28 | 1972-03-08 | ||
US3812187A (en) * | 1970-02-05 | 1974-05-21 | Merck & Co Inc | Hydrazides |
SU539522A3 (ru) * | 1970-02-05 | 1976-12-15 | Мерк Энд Ко. Инк. (Фирма) | Способ получени гидразин- -фенилпропионовой кислоты |
JPS476302Y1 (xx) * | 1970-06-08 | 1972-03-04 | ||
US5321037A (en) * | 1986-12-26 | 1994-06-14 | Sankyo Company, Limited | Isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants |
IE62276B1 (en) * | 1988-03-30 | 1995-01-25 | Sankyo Co | "New isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants" |
US5116839A (en) * | 1989-06-26 | 1992-05-26 | Sankyo Company, Limited | Use of isoxazolin-3-one derivatives as antidepressants |
US5352688A (en) * | 1991-02-14 | 1994-10-04 | The Mount Sinai School Of Medicine Of The City University Of New York | Methods for the treatment of bradyphrenia in parkinson's disease |
US5750542A (en) * | 1993-09-28 | 1998-05-12 | Pfizer | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors |
JPH0588630A (ja) * | 1991-09-30 | 1993-04-09 | Toshiba Lighting & Technol Corp | 表示装置 |
CA2146755A1 (en) * | 1992-10-28 | 1994-05-11 | Kenji Takeda | Novel 1,2-benzoisoxazole derivative or its salt and brain-protecting agent comprising the same |
US5494908A (en) * | 1992-11-23 | 1996-02-27 | Hoechst-Roussel Pharmaceutical Incorporated | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds |
NZ291508A (en) * | 1994-08-30 | 1999-07-29 | Sankyo Co | Isoxazoles; preparation and medicaments |
CA2190708A1 (en) * | 1995-12-08 | 1997-06-09 | Johannes Aebi | Aminoalkyl substituted benzo-heterocyclic compounds |
JP5229734B2 (ja) * | 2008-11-26 | 2013-07-03 | 住化エンビロサイエンス株式会社 | 木材保存組成物 |
-
1995
- 1995-08-29 NZ NZ291508A patent/NZ291508A/xx unknown
- 1995-08-29 PT PT95929249T patent/PT779281E/pt unknown
- 1995-08-29 EP EP95929249A patent/EP0779281B1/en not_active Expired - Lifetime
- 1995-08-29 CZ CZ1997598A patent/CZ290961B6/cs not_active IP Right Cessation
- 1995-08-29 MX MX9701630A patent/MX9701630A/es unknown
- 1995-08-29 KR KR1019970701279A patent/KR970705549A/ko active IP Right Grant
- 1995-08-29 DE DE69532039T patent/DE69532039T2/de not_active Expired - Fee Related
- 1995-08-29 AU AU32660/95A patent/AU688102B2/en not_active Ceased
- 1995-08-29 WO PCT/JP1995/001714 patent/WO1996006837A1/ja active IP Right Grant
- 1995-08-29 DK DK95929249T patent/DK0779281T3/da active
- 1995-08-29 CN CN95195758A patent/CN1098843C/zh not_active Expired - Fee Related
- 1995-08-29 ES ES95929249T patent/ES2208690T3/es not_active Expired - Lifetime
- 1995-08-29 HU HU9701740A patent/HU221138B1/hu not_active IP Right Cessation
- 1995-08-29 CA CA002198457A patent/CA2198457A1/en not_active Abandoned
- 1995-08-29 RU RU97103132/04A patent/RU2140414C1/ru not_active IP Right Cessation
- 1995-08-29 AT AT95929249T patent/ATE253057T1/de not_active IP Right Cessation
-
1997
- 1997-02-26 US US08/806,854 patent/US5965591A/en not_active Expired - Fee Related
- 1997-02-27 NO NO970892A patent/NO308741B1/no unknown
- 1997-02-28 FI FI970864A patent/FI970864A/fi not_active IP Right Cessation
-
1998
- 1998-12-10 HK HK98113089A patent/HK1018878A1/xx not_active IP Right Cessation
-
1999
- 1999-02-03 US US09/243,885 patent/US6096771A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NZ291508A (en) | 1999-07-29 |
FI970864A (fi) | 1997-04-24 |
FI970864A0 (fi) | 1997-02-28 |
NO308741B1 (no) | 2000-10-23 |
US6096771A (en) | 2000-08-01 |
US5965591A (en) | 1999-10-12 |
HU221138B1 (en) | 2002-08-28 |
NO970892D0 (no) | 1997-02-27 |
EP0779281B1 (en) | 2003-10-29 |
AU3266095A (en) | 1996-03-22 |
CZ290961B6 (cs) | 2002-11-13 |
DK0779281T3 (da) | 2004-03-08 |
EP0779281A4 (en) | 2000-07-26 |
CN1098843C (zh) | 2003-01-15 |
ATE253057T1 (de) | 2003-11-15 |
CN1162957A (zh) | 1997-10-22 |
DE69532039T2 (de) | 2004-07-08 |
HUT77225A (hu) | 1998-03-02 |
ES2208690T3 (es) | 2004-06-16 |
KR970705549A (ko) | 1997-10-09 |
WO1996006837A1 (fr) | 1996-03-07 |
CZ59897A3 (en) | 1997-07-16 |
MX9701630A (es) | 1997-06-28 |
NO970892L (no) | 1997-04-29 |
DE69532039D1 (de) | 2003-12-04 |
RU2140414C1 (ru) | 1999-10-27 |
AU688102B2 (en) | 1998-03-05 |
PT779281E (pt) | 2004-02-27 |
CA2198457A1 (en) | 1996-03-07 |
EP0779281A1 (en) | 1997-06-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20070829 |