NO308741B1 - Isoksazolderivater, mellomprodukter, farmasøytiske preparater og anvendelse av derivatene - Google Patents
Isoksazolderivater, mellomprodukter, farmasøytiske preparater og anvendelse av derivateneInfo
- Publication number
- NO308741B1 NO308741B1 NO970892A NO970892A NO308741B1 NO 308741 B1 NO308741 B1 NO 308741B1 NO 970892 A NO970892 A NO 970892A NO 970892 A NO970892 A NO 970892A NO 308741 B1 NO308741 B1 NO 308741B1
- Authority
- NO
- Norway
- Prior art keywords
- group
- derivatives
- ring
- integer
- alkylthio
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20536394 | 1994-08-30 | ||
JP15057195 | 1995-06-16 | ||
PCT/JP1995/001714 WO1996006837A1 (fr) | 1994-08-30 | 1995-08-29 | Isoxazoles |
Publications (3)
Publication Number | Publication Date |
---|---|
NO970892D0 NO970892D0 (no) | 1997-02-27 |
NO970892L NO970892L (no) | 1997-04-29 |
NO308741B1 true NO308741B1 (no) | 2000-10-23 |
Family
ID=26480122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO970892A NO308741B1 (no) | 1994-08-30 | 1997-02-27 | Isoksazolderivater, mellomprodukter, farmasøytiske preparater og anvendelse av derivatene |
Country Status (20)
Country | Link |
---|---|
US (2) | US5965591A (xx) |
EP (1) | EP0779281B1 (xx) |
KR (1) | KR970705549A (xx) |
CN (1) | CN1098843C (xx) |
AT (1) | ATE253057T1 (xx) |
AU (1) | AU688102B2 (xx) |
CA (1) | CA2198457A1 (xx) |
CZ (1) | CZ290961B6 (xx) |
DE (1) | DE69532039T2 (xx) |
DK (1) | DK0779281T3 (xx) |
ES (1) | ES2208690T3 (xx) |
FI (1) | FI970864A (xx) |
HK (1) | HK1018878A1 (xx) |
HU (1) | HU221138B1 (xx) |
MX (1) | MX9701630A (xx) |
NO (1) | NO308741B1 (xx) |
NZ (1) | NZ291508A (xx) |
PT (1) | PT779281E (xx) |
RU (1) | RU2140414C1 (xx) |
WO (1) | WO1996006837A1 (xx) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0779281T3 (da) * | 1994-08-30 | 2004-03-08 | Sankyo Co | Isoxazoler |
CA2247439A1 (en) * | 1996-02-27 | 1997-09-04 | Sankyo Company, Limited | Isoxazole derivatives |
US6339099B1 (en) * | 1997-06-20 | 2002-01-15 | Dupont Pharmaceuticals Company | Guanidine mimics as factor Xa inhibitors |
AU1616600A (en) * | 1998-11-12 | 2000-05-29 | Eli Lilly And Company | Aminobenzisoxazole compounds and libraries thereof |
US6497928B1 (en) | 1999-05-14 | 2002-12-24 | Canon Kabushiki Kaisha | Liquid crystal device, mesomorphic functional material and liquid crystal apparatus |
US6638981B2 (en) | 2001-08-17 | 2003-10-28 | Epicept Corporation | Topical compositions and methods for treating pain |
AU2004312511A1 (en) * | 2003-12-29 | 2005-07-21 | Sepracor Inc. | Benzo(d)isoxazol-3-ol DAAO inhibitors |
WO2005066135A2 (en) * | 2003-12-29 | 2005-07-21 | Sepracor Inc. | Pyrrole and pyrazole daao inhibitors |
JP2007529468A (ja) * | 2004-03-16 | 2007-10-25 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ベンズイソオキサゾール |
MX2008000250A (es) | 2005-07-06 | 2008-03-19 | Sepracor Inc | Combinaciones de eszopiclona y trans-4-(3,4-diclorofenil)-1,2,3,4- tetrahidro-n-metil-1-naftalenamina o trans 4-(3,4-diclorofenil)-1, 2,3,4-tetrahidro-1-naftalenamina y metodos de tratamiento de menopausia y trastornos del estado de animo, ansiedad y |
WO2007081542A2 (en) * | 2006-01-06 | 2007-07-19 | Sepracor Inc. | Tetralone-based monoamine reuptake inhibitors |
RU2430913C2 (ru) | 2006-01-06 | 2011-10-10 | Сепракор Инк. | Циклоалкиламины в качестве ингибиторов повторного поглощения моноамина |
ES2555315T3 (es) | 2006-03-31 | 2015-12-30 | Sunovion Pharmaceuticals Inc. | Preparación de amidas y aminas quirales |
US7579370B2 (en) * | 2006-06-30 | 2009-08-25 | Sepracor Inc. | Fused heterocycles |
US7884124B2 (en) * | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
US20080082066A1 (en) * | 2006-10-02 | 2008-04-03 | Weyerhaeuser Co. | Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks |
WO2008083124A1 (en) | 2006-12-28 | 2008-07-10 | Rigel Pharmaceuticals, Inc. | N-substituted-heterocycloalkyloxybenzamide compounds and methods of use |
EP2074092A2 (en) * | 2007-01-18 | 2009-07-01 | Sepracor Inc. | Inhibitors of d-amino acid oxidase |
US7902252B2 (en) * | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
CA2688493C (en) | 2007-05-31 | 2016-04-19 | Sepracor Inc. | Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors |
CA2716080C (en) | 2008-02-20 | 2016-12-13 | Targia Pharmaceuticals | Cns pharmaceutical compositions and methods of use |
US20100120740A1 (en) * | 2008-08-07 | 2010-05-13 | Sepracor Inc. | Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase |
WO2011017634A2 (en) * | 2009-08-07 | 2011-02-10 | Sepracore Inc. | Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase |
AU2011215645A1 (en) | 2010-02-11 | 2012-09-20 | Vanderbilt University | Benzisoxazoles and azabenzisoxazoles as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
CN104024251B (zh) | 2011-10-31 | 2017-08-11 | 克赛农制药股份有限公司 | 苯磺酰胺化合物及其作为治疗剂的用途 |
US9481677B2 (en) | 2011-10-31 | 2016-11-01 | Xenon Pharmaceuticals Inc. | Biaryl ether sulfonamides and their use as therapeutic agents |
TW201400446A (zh) | 2012-05-22 | 2014-01-01 | Genentech Inc | N-取代之苯甲醯胺及其使用方法 |
KR101663436B1 (ko) | 2012-07-06 | 2016-10-06 | 제넨테크, 인크. | N-치환된 벤즈아미드 및 이의 사용 방법 |
BR112015022488A2 (pt) | 2013-03-14 | 2017-07-18 | Genentech Inc | triazolopiridinas substituídas e métodos de uso das mesmas |
BR112015023397A2 (pt) | 2013-03-15 | 2017-07-18 | Genentech Inc | benzoxazois substituídos e métodos de uso dos mesmos |
CN105492430B (zh) * | 2013-03-15 | 2017-10-10 | 基因泰克公司 | 取代的苯并噁唑及其使用方法 |
CR20160296A (es) | 2013-11-27 | 2016-09-20 | Genentech Inc | Benzamidas sustituidas y métodos para usarlas |
WO2016007534A1 (en) | 2014-07-07 | 2016-01-14 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
EP3297989A1 (en) | 2015-05-22 | 2018-03-28 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
WO2017035271A1 (en) | 2015-08-27 | 2017-03-02 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
CN108495851A (zh) | 2015-11-25 | 2018-09-04 | 基因泰克公司 | 取代的苯甲酰胺及其使用方法 |
WO2017172802A1 (en) | 2016-03-30 | 2017-10-05 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
CN105801510A (zh) * | 2016-04-08 | 2016-07-27 | 李勇 | 一种治疗抑郁症的药物组合物 |
AU2017347549A1 (en) | 2016-10-17 | 2019-05-02 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
JP2020511511A (ja) | 2017-03-24 | 2020-04-16 | ジェネンテック, インコーポレイテッド | ナトリウムチャネル阻害剤としての4−ピペリジン−n−(ピリミジン−4−イル)クロマン−7−スルホンアミド誘導体 |
WO2019165290A1 (en) | 2018-02-26 | 2019-08-29 | Genentech, Inc. | Pyridine-sulfonamide compounds and their use against pain and related conditions |
EP3774801A1 (en) | 2018-03-30 | 2021-02-17 | F. Hoffmann-La Roche AG | Fused ring hydro-pyrido compounds as sodium channel inhibitors |
CN114349690B (zh) * | 2022-02-15 | 2023-04-25 | 甘肃皓天医药科技有限责任公司 | 一种多拉韦林中间体合成方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1265824A (xx) * | 1968-03-28 | 1972-03-08 | ||
US3812187A (en) * | 1970-02-05 | 1974-05-21 | Merck & Co Inc | Hydrazides |
SU539522A3 (ru) * | 1970-02-05 | 1976-12-15 | Мерк Энд Ко. Инк. (Фирма) | Способ получени гидразин- -фенилпропионовой кислоты |
JPS476302Y1 (xx) * | 1970-06-08 | 1972-03-04 | ||
US5321037A (en) * | 1986-12-26 | 1994-06-14 | Sankyo Company, Limited | Isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants |
IE62276B1 (en) * | 1988-03-30 | 1995-01-25 | Sankyo Co | "New isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants" |
US5116839A (en) * | 1989-06-26 | 1992-05-26 | Sankyo Company, Limited | Use of isoxazolin-3-one derivatives as antidepressants |
US5352688A (en) * | 1991-02-14 | 1994-10-04 | The Mount Sinai School Of Medicine Of The City University Of New York | Methods for the treatment of bradyphrenia in parkinson's disease |
US5750542A (en) * | 1993-09-28 | 1998-05-12 | Pfizer | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors |
JPH0588630A (ja) * | 1991-09-30 | 1993-04-09 | Toshiba Lighting & Technol Corp | 表示装置 |
JP3457669B2 (ja) * | 1992-10-28 | 2003-10-20 | 富山化学工業株式会社 | 新規な1,2−ベンゾイソオキサゾール誘導体またはその塩,それらからなる脳保護剤 |
US5494908A (en) * | 1992-11-23 | 1996-02-27 | Hoechst-Roussel Pharmaceutical Incorporated | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds |
DK0779281T3 (da) * | 1994-08-30 | 2004-03-08 | Sankyo Co | Isoxazoler |
CA2190708A1 (en) * | 1995-12-08 | 1997-06-09 | Johannes Aebi | Aminoalkyl substituted benzo-heterocyclic compounds |
JP5229734B2 (ja) * | 2008-11-26 | 2013-07-03 | 住化エンビロサイエンス株式会社 | 木材保存組成物 |
-
1995
- 1995-08-29 DK DK95929249T patent/DK0779281T3/da active
- 1995-08-29 CN CN95195758A patent/CN1098843C/zh not_active Expired - Fee Related
- 1995-08-29 MX MX9701630A patent/MX9701630A/es unknown
- 1995-08-29 WO PCT/JP1995/001714 patent/WO1996006837A1/ja active IP Right Grant
- 1995-08-29 ES ES95929249T patent/ES2208690T3/es not_active Expired - Lifetime
- 1995-08-29 NZ NZ291508A patent/NZ291508A/xx unknown
- 1995-08-29 DE DE69532039T patent/DE69532039T2/de not_active Expired - Fee Related
- 1995-08-29 PT PT95929249T patent/PT779281E/pt unknown
- 1995-08-29 EP EP95929249A patent/EP0779281B1/en not_active Expired - Lifetime
- 1995-08-29 AT AT95929249T patent/ATE253057T1/de not_active IP Right Cessation
- 1995-08-29 CA CA002198457A patent/CA2198457A1/en not_active Abandoned
- 1995-08-29 HU HU9701740A patent/HU221138B1/hu not_active IP Right Cessation
- 1995-08-29 KR KR1019970701279A patent/KR970705549A/ko active IP Right Grant
- 1995-08-29 AU AU32660/95A patent/AU688102B2/en not_active Ceased
- 1995-08-29 RU RU97103132/04A patent/RU2140414C1/ru not_active IP Right Cessation
- 1995-08-29 CZ CZ1997598A patent/CZ290961B6/cs not_active IP Right Cessation
-
1997
- 1997-02-26 US US08/806,854 patent/US5965591A/en not_active Expired - Fee Related
- 1997-02-27 NO NO970892A patent/NO308741B1/no unknown
- 1997-02-28 FI FI970864A patent/FI970864A/fi not_active IP Right Cessation
-
1998
- 1998-12-10 HK HK98113089A patent/HK1018878A1/xx not_active IP Right Cessation
-
1999
- 1999-02-03 US US09/243,885 patent/US6096771A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
HU221138B1 (en) | 2002-08-28 |
EP0779281A1 (en) | 1997-06-18 |
EP0779281A4 (en) | 2000-07-26 |
DE69532039T2 (de) | 2004-07-08 |
CA2198457A1 (en) | 1996-03-07 |
CZ290961B6 (cs) | 2002-11-13 |
WO1996006837A1 (fr) | 1996-03-07 |
KR970705549A (ko) | 1997-10-09 |
NO970892L (no) | 1997-04-29 |
US6096771A (en) | 2000-08-01 |
ES2208690T3 (es) | 2004-06-16 |
PT779281E (pt) | 2004-02-27 |
US5965591A (en) | 1999-10-12 |
HK1018878A1 (en) | 2000-01-07 |
FI970864A (fi) | 1997-04-24 |
HUT77225A (hu) | 1998-03-02 |
RU2140414C1 (ru) | 1999-10-27 |
EP0779281B1 (en) | 2003-10-29 |
CN1162957A (zh) | 1997-10-22 |
NO970892D0 (no) | 1997-02-27 |
MX9701630A (es) | 1997-06-28 |
DK0779281T3 (da) | 2004-03-08 |
NZ291508A (en) | 1999-07-29 |
DE69532039D1 (de) | 2003-12-04 |
ATE253057T1 (de) | 2003-11-15 |
FI970864A0 (fi) | 1997-02-28 |
AU3266095A (en) | 1996-03-22 |
CN1098843C (zh) | 2003-01-15 |
CZ59897A3 (en) | 1997-07-16 |
AU688102B2 (en) | 1998-03-05 |
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