AR037770A1 - Compuesto inhibidor de la integrasa del vih, composicion farmaceutica que lo comprende y uso del mismo para prepararla - Google Patents

Compuesto inhibidor de la integrasa del vih, composicion farmaceutica que lo comprende y uso del mismo para prepararla

Info

Publication number
AR037770A1
AR037770A1 ARP020104777A ARP020104777A AR037770A1 AR 037770 A1 AR037770 A1 AR 037770A1 AR P020104777 A ARP020104777 A AR P020104777A AR P020104777 A ARP020104777 A AR P020104777A AR 037770 A1 AR037770 A1 AR 037770A1
Authority
AR
Argentina
Prior art keywords
alkyl
aryl
heteroaryl
independently selected
co2r5
Prior art date
Application number
ARP020104777A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR037770A1 publication Critical patent/AR037770A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C207/00—Compounds containing nitroso groups bound to a carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C207/00—Compounds containing nitroso groups bound to a carbon skeleton
    • C07C207/04—Compounds containing nitroso groups bound to a carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/63—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C255/64—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Una composición farmacéutica útil para el tratamiento de infecciones por VIH, que comprende una cantidad terapéutica del compuesto de la fórmula (1) y un portador farmacéuticamente aceptable, la cual puede comprender además una cantidad terapéuticamente efectiva de uno o más de otros agentes para el tratamiento del VIH. Uso de un compuesto de la fórmula (1) o una sal o solvato farmacéuticamente aceptable del mismo, para preparar una composición farmacéutica para inhibir la integrasa de VIH o para aplicar en el tratamiento de una infección por VIH. Reivindicación 1: Un compuesto de la fórmula (1), en donde: R1 es arilo, alquilo C1-6-arilo, alquilo C1-6-S(O)n-arilo, alquilo C1-5-O-arilo; o y en donde R1 está sin sustituir o sustituido independientemente con 1-3 R3; cada R3 se selecciona independientemente de H, halo, CN, alquilo C1-6, cicloalquilo C3-6, -OR4, alquilo C1-10-O-R4, -CO2R5, alquilo C1-10-CO2R5, N(R6)(R7), alquilo C1-10-N(R6)(R7), CON(R6)(R7), alquilo C1-10-CON(R6)(R7), -S(O)nR8, alquilo C1-10-S-(O)nR8, -S(O)n(R9)(R10), alquilo C1-10-S(O)nN(R9)(R10), arilo, -O-arilo, heteroarilo, -O-heteroarilo, alquilo C1-6-arilo, alquilo C1-6-heteroarilo, radical-C(O)-heterocíclico, radical alquilo C1-10-C(O)-heterocíclico, o haloalquilo C1-6; R2 es H, alquilo C1-10, cicloalquilo C3-6, haloalquilo C1-10, arilo, heteroarilo, alquilo C1-6-arilo, alquilo C1-5-O-arilo, alquilo C1-6-heteroarilo, alquilo C1-5-O-heteroarilo, alquilo C1-10-OR4, alquilo C1-10-CO2R5, alquilo C1-10-N(R6)(R7), alquilo C1-10-CON(R6)(R7), alquilo C1-10-S(O)nR8, alquilo C1-10-S(O)nN(R9)(R10), o radical alquilo C1-10-C(O)-heterocíclico; cada R4 se selecciona independientemente de H, alquilo C1-6, cicloalquilo C3-6, alquilo C1-9-CO2R5, alquilo C1-9-N(R6)(R7), alquilo C1-9-CON(R6)(R7), alquilo C1-9-S(O)nR8, o alquilo C1-9-S(O)nN(R9)(R10); cada R5 se selecciona independientemente de H, alquilo C1-6, cicloalquilo C3-6, o alquilo C1-6-arilo; cada R6 se selecciona independientemente de H, alquilo C1-6, arilo, heteroarilo, alquilo C1-6-arilo, alquilo C1-6-heteroarilo, -C(O)-alquiloC1-6, -C(O)-arilo, -C(O)-alquilo C1-6-arilo, -C(O)-heteroarilo, -C(O)-alquilo C1-6-heteroarilo, -C(NH)NH2, -S(O)n-R8, o alquilo C1-6-CO2R5; cada R7 se selecciona independientemente de H, alquilo C1-6, arilo o heteroarilo; cada R8 se selecciona independientemente de alquilo C1-6, arilo o heteroarilo; cada R9 se selecciona independientemente de H, alquilo C1-6, alquilo C1-6-arilo, alquilo C1-6-heteroarilo, -C(O)-alquilo C1-6, -C(O)-arilo, -C(O)-alquilo C1-6-arilo, -C(O)-alquilo C1-6-heteroarilo, arilo, o heteroarilo; cada R10 se selecciona independientemente de H, alquilo C1-6, alquilo C1-6-arilo, alquilo C1-6-heteroarilo, arilo o heteroarilo; R11 es H, arilo, heteroarilo, alquilo C1-6-heteroarilo, cicloalquilo C3-6, alquilo C1-6, alquilo C1-6-arilo, alquilo C1-6-CO2R5, o alquilo C1-6-N(R6)(R7); R12 es H, alquilo C1-6, arilo o heteroarilo; R13 es H, alquilo C1-6, arilo, o heteroarilo; B1 se selecciona del grupo de fórmulas (2) y n es 0, 1 ó 2; o una sal o solvato farmacéuticamente aceptable del mismo.
ARP020104777A 2001-12-12 2002-12-10 Compuesto inhibidor de la integrasa del vih, composicion farmaceutica que lo comprende y uso del mismo para prepararla AR037770A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33967401P 2001-12-12 2001-12-12

Publications (1)

Publication Number Publication Date
AR037770A1 true AR037770A1 (es) 2004-12-01

Family

ID=23330105

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020104777A AR037770A1 (es) 2001-12-12 2002-12-10 Compuesto inhibidor de la integrasa del vih, composicion farmaceutica que lo comprende y uso del mismo para prepararla

Country Status (24)

Country Link
US (1) US6777440B2 (es)
EP (1) EP1467695A2 (es)
JP (1) JP2005515206A (es)
KR (1) KR20040065251A (es)
CN (1) CN1617849A (es)
AR (1) AR037770A1 (es)
AU (1) AU2002366604A1 (es)
BR (1) BR0214842A (es)
CA (1) CA2469592C (es)
CO (1) CO5590909A2 (es)
HR (1) HRP20040534A2 (es)
HU (1) HUP0402675A2 (es)
IL (1) IL162325A0 (es)
IS (1) IS7305A (es)
MX (1) MXPA04005623A (es)
NO (1) NO20042916L (es)
NZ (1) NZ533413A (es)
PE (1) PE20030763A1 (es)
PL (1) PL370664A1 (es)
RU (1) RU2284315C2 (es)
TW (1) TWI252757B (es)
UY (1) UY27577A1 (es)
WO (1) WO2003049690A2 (es)
ZA (1) ZA200404628B (es)

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US7094909B2 (en) 2001-06-11 2006-08-22 Agouron Pharmaceuticals, Inc. HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
US7169932B2 (en) 2001-06-11 2007-01-30 Pfizer Inc. HIV protease inhibitors, compositions containing the same, their pharmaceutical uses, material for their synthesis
HN2002000136A (es) 2001-06-11 2003-07-31 Basf Ag Inhibidores de la proteasa del virus hiv, compuestos que contienen a los mismos, sus usos farmaceuticos y los materiales para su sintesis
PA8586801A1 (es) 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
CA2513141A1 (en) 2003-01-27 2004-08-12 Pfizer Inc. Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use
US6890942B2 (en) * 2003-05-16 2005-05-10 Bristol-Myers Squibb Company Acyl sulfonamides as inhibitors of HIV integrase
US7776863B2 (en) * 2004-03-24 2010-08-17 Bristol-Myers Squibb Company Methods of treating HIV infection
US20050215544A1 (en) * 2004-03-24 2005-09-29 Pin-Fang Lin Methods of treating HIV infection
MXPA06012342A (es) 2004-04-26 2007-01-17 Pfizer Inhibidores de la enzima integrasa del virus de la inmunodeficiencia humana.
WO2005103003A2 (en) 2004-04-26 2005-11-03 Pfizer Inc. Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors
US7507838B2 (en) * 2004-09-01 2009-03-24 Bristol-Myers Squibb Company Process for the preparation of Z-5-carboxymethylene-1,3-dioxolan-4-ones
US20060058286A1 (en) * 2004-09-16 2006-03-16 Mark Krystal Methods of treating HIV infection
WO2007086584A1 (ja) * 2006-01-30 2007-08-02 Meiji Seika Kaisha, Ltd. 新規ＦａｂＫおよびＦａｂＩ／Ｋ阻害剤
WO2008004100A2 (en) 2006-07-05 2008-01-10 Pfizer Products Inc. Therapeutic compounds
PT2364293E (pt) * 2008-12-05 2013-04-26 Syngenta Participations Ag Novas pirazol-4-n-alcoxicarboxamidas como microbiocidas
US20120316161A1 (en) 2009-12-23 2012-12-13 Katholieke Universiteit Leuven Novel antiviral compounds
US8283366B2 (en) 2010-01-22 2012-10-09 Ambrilia Biopharma, Inc. Derivatives of pyridoxine for inhibiting HIV integrase
CA2817896A1 (en) 2010-11-15 2012-05-24 Viiv Healthcare Uk Limited Inhibitors of hiv replication
EP2640705A2 (en) 2010-11-15 2013-09-25 Katholieke Universiteit Leuven Novel antiviral compounds
CN104245660A (zh) * 2012-04-26 2014-12-24 拜尔农科股份公司 制备n-(5-氯-2-异丙基苄基)-环丙胺的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR029304A1 (es) * 1998-06-26 2003-06-25 Daiichi Seiyaku Co DERIVADOS DE PROPIONILO SUSTITUIDOS, PRODUCTO FARMACEUTICO, USO PARA LA FABRICACION DE UNA COMPOSICION FARMACEUTICA PARA LA PREVENCION Y/O TRATAMIENTO DE HIPERCOLESTEROLEMIA, HIPERLIPEMIA O ARTERIOESCLEROSIS, COMPOSICIoN FARMACÉUTICA Y COMPUESTOS INTERMEDIARIOS

Also Published As

Publication number Publication date
NO20042916L (no) 2004-09-10
CA2469592A1 (en) 2003-06-19
ZA200404628B (en) 2005-09-01
CO5590909A2 (es) 2005-12-30
IL162325A0 (en) 2005-11-20
US20030176495A1 (en) 2003-09-18
WO2003049690A3 (en) 2004-01-22
EP1467695A2 (en) 2004-10-20
MXPA04005623A (es) 2004-12-06
CN1617849A (zh) 2005-05-18
AU2002366604A1 (en) 2003-06-23
CA2469592C (en) 2005-08-23
BR0214842A (pt) 2005-01-11
UY27577A1 (es) 2003-07-31
RU2004119963A (ru) 2006-01-10
NZ533413A (en) 2006-09-29
PL370664A1 (en) 2005-05-30
US6777440B2 (en) 2004-08-17
KR20040065251A (ko) 2004-07-21
TW200301105A (en) 2003-07-01
PE20030763A1 (es) 2003-09-13
WO2003049690A2 (en) 2003-06-19
HRP20040534A2 (en) 2005-04-30
TWI252757B (en) 2006-04-11
JP2005515206A (ja) 2005-05-26
IS7305A (is) 2004-06-10
HUP0402675A2 (hu) 2005-03-29
RU2284315C2 (ru) 2006-09-27

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