EA200400616A1 - ПРОИЗВОДНЫЕ АМИНОБЕНЗАМИДОВ В КАЧЕСТВЕ ИНГИБИТОРОВ ГЛИКОГЕНСИНТАЗА-КИНАЗЫ 3β - Google Patents

ПРОИЗВОДНЫЕ АМИНОБЕНЗАМИДОВ В КАЧЕСТВЕ ИНГИБИТОРОВ ГЛИКОГЕНСИНТАЗА-КИНАЗЫ 3β

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Publication number
EA200400616A1
EA200400616A1 EA200400616A EA200400616A EA200400616A1 EA 200400616 A1 EA200400616 A1 EA 200400616A1 EA 200400616 A EA200400616 A EA 200400616A EA 200400616 A EA200400616 A EA 200400616A EA 200400616 A1 EA200400616 A1 EA 200400616A1
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Eurasian Patent Office
Prior art keywords
hydrogen
alkyl
optionally substituted
6alkyloxy
nrr
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EA200400616A
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EA007063B1 (ru
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Эдди Жан Эдгар Фрейн
Петер Якобус Йоханнес Антониус Бейнстерс
Марк Виллемс
Вернер Констант Йохан Эмбрехтс
Поль Адриан Ян Жанссен
Паулус Йоаннес Леви
Ян Херес
Марк Рене Де Жонж
Люсьен Мария Хенрикус Койманс
Фредерик Франс Дезире Дайер
Майкл Джозеф Кукла
Юго Альфонс Габриель Гертс
Рони Мария Нюйденс
Марк Юбер Меркен
Дональд Вилльям Лудовики
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Янссен Фармацевтика Н.В.
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Publication of EA200400616A1 publication Critical patent/EA200400616A1/ru
Publication of EA007063B1 publication Critical patent/EA007063B1/ru

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Abstract

Данное изобретение относится к соединению формулы (I'), его N-оксиду, фармацевтически приемлемой аддитивной соли, четвертичному амину и стереохимически изомерной форме, где кольцо A является 6-членным гетероциклом; Rозначает водород; арил; формил; Cалкилкарбонил; необязательно замещенный Cалкил; Cалкилоксикарбонил; необязательно замещенный Cалкилокси-Cалкилкарбонил; X означает прямую связь, или линкерный атом, или линкерную группу; Z представляет O или S; Rозначает водород, Cалкил, Cалкенил, Cалкинил, карбоцикл или гетероцикл, причем каждая из указанных групп может быть необязательно замещена; Rозначает водород; гидрокси; галоген; необязательно замещенный Cалкил, или Cалкенил, или Cалкинил; Cалкилокси; Cалкилтио; Cалкилоксикарбонил; Cалкилкарбонилокси; карбоксил; циано; нитро; амино; моно- или ди(Cалкил)амино; полигалоген-Cалкил; полигалоген-Cалкилокси; полигалоген-Cалкилтио; R; R-Cалкил; R-O-; R-S-; R-C(=O)-; R-S(=O)-; R-S(=O)-; R-S(=O)-NH-; R-S(=O)-NH-; R-C(=O)-; -NHC(=O)H; -C(=O)NHNH; R-C(=O)-NH-; R-C(=O)-NH-; -C(=NH)R; -C(=NH)R; Rили R, каждый независимо, означает водород, R, -Y-NR-Y-NRR, -Y-NR-Y-R, -Y-NRR; при условии, что -X-Rи/или Rявляется другим, чем водород; их применению, содержащим их фармацевтическим композициям и способам их получения.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400616A 2001-11-01 2002-10-29 ПРОИЗВОДНЫЕ АМИНОБЕНЗАМИДОВ В КАЧЕСТВЕ ИНГИБИТОРОВ ГЛИКОГЕНСИНТАЗА-КИНАЗЫ 3β; EA007063B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01204192 2001-11-01
PCT/EP2002/012079 WO2003037877A1 (en) 2001-11-01 2002-10-29 AMINOBENZAMIDE DERIVATIVES AS GLYCOGEN SYNTHASE KINASE 3β INHIBITORS

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EA200400616A1 true EA200400616A1 (ru) 2004-08-26
EA007063B1 EA007063B1 (ru) 2006-06-30

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US (1) US20060063789A1 (ru)
EP (1) EP1442024B1 (ru)
JP (1) JP2005507420A (ru)
KR (1) KR20040062557A (ru)
CN (1) CN100436427C (ru)
AT (1) ATE389638T1 (ru)
AU (1) AU2002363177B2 (ru)
BR (1) BR0213790A (ru)
CA (1) CA2463823A1 (ru)
DE (1) DE60225709T2 (ru)
DK (1) DK1442024T3 (ru)
EA (1) EA007063B1 (ru)
ES (1) ES2303565T3 (ru)
HU (1) HUP0402245A3 (ru)
IL (1) IL161663A0 (ru)
MX (1) MXPA04004176A (ru)
NO (1) NO326889B1 (ru)
NZ (1) NZ531854A (ru)
PL (1) PL368920A1 (ru)
PT (1) PT1442024E (ru)
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HUP0402245A2 (hu) 2005-02-28
CA2463823A1 (en) 2003-05-08
WO2003037877A1 (en) 2003-05-08
DE60225709D1 (de) 2008-04-30
JP2005507420A (ja) 2005-03-17
ES2303565T3 (es) 2008-08-16
AU2002363177B2 (en) 2008-09-18
EP1442024A1 (en) 2004-08-04
PL368920A1 (en) 2005-04-04
CN1703405A (zh) 2005-11-30
IL161663A0 (en) 2004-09-27
HUP0402245A3 (en) 2010-03-29
KR20040062557A (ko) 2004-07-07
MXPA04004176A (es) 2004-09-06
DK1442024T3 (da) 2008-06-30
EA007063B1 (ru) 2006-06-30
NO20042253L (no) 2004-06-01
NZ531854A (en) 2006-03-31
PT1442024E (pt) 2008-06-12
BR0213790A (pt) 2004-12-07
NO326889B1 (no) 2009-03-16
US20060063789A1 (en) 2006-03-23
ATE389638T1 (de) 2008-04-15
EP1442024B1 (en) 2008-03-19
CN100436427C (zh) 2008-11-26

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