BRPI0418127A - uso de um composto, seus sais, e derivados farmaceuticamente aceitáveis dos mesmos, método para o tratamento de infecções envolvendo vìrus da sub-famìlia pneumovirinae, formulação farmacêutica, métodos para tratar mamìferos infectados e para prevenir a infecção de mamìferos com vìrus da sub-famìlia pneumovirinae, composto, seus sais, e derivados farmaceuticamente aceitáveis dos mesmos, composto e a forma n-óxido e sal piridìnio do mesmo, e, método de separação de enantiÈmeros de um composto - Google Patents

uso de um composto, seus sais, e derivados farmaceuticamente aceitáveis dos mesmos, método para o tratamento de infecções envolvendo vìrus da sub-famìlia pneumovirinae, formulação farmacêutica, métodos para tratar mamìferos infectados e para prevenir a infecção de mamìferos com vìrus da sub-famìlia pneumovirinae, composto, seus sais, e derivados farmaceuticamente aceitáveis dos mesmos, composto e a forma n-óxido e sal piridìnio do mesmo, e, método de separação de enantiÈmeros de um composto

Info

Publication number
BRPI0418127A
BRPI0418127A BRPI0418127-1A BRPI0418127A BRPI0418127A BR PI0418127 A BRPI0418127 A BR PI0418127A BR PI0418127 A BRPI0418127 A BR PI0418127A BR PI0418127 A BRPI0418127 A BR PI0418127A
Authority
BR
Brazil
Prior art keywords
compound
salts
pharmaceutically acceptable
pneumovirinae
acceptable derivatives
Prior art date
Application number
BRPI0418127-1A
Other languages
English (en)
Inventor
Silas Bond
Vanessa Anne Sanford
John Nicholas Lambert
Chin Yu Lim
Jeffrey Peter Mitchell
Alistair George Draffan
Roland Henry Nearn
Original Assignee
Biota Scient Management
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2003907196A external-priority patent/AU2003907196A0/en
Application filed by Biota Scient Management filed Critical Biota Scient Management
Publication of BRPI0418127A publication Critical patent/BRPI0418127A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"USO DE UM COMPOSTO, SEUS SAIS, E DERIVADOS FARMACEUTICAMENTE ACEITáVEIS DOS MESMOS, MéTODO PARA O TRATAMENTO DE INFECçõES ENVOLVENDO VìRUS DA SUB-FAMìLIA PNEUMOVIRINAE, FORMULAçãO FARMACêUTICA, MéTODOS PARA TRATAR MAMìFEROS INFECTADOS E PARA PREVENIR A INFECçãO DE MAMìFEROS COM VìRUS DA SUBFAMìLIA PNEUMOVIRINAE, COMPOSTO, SEUS SAIS, E DERIVADOS FARMACEUTICAMENTE ACEITáVEIS DOS MESMOS, COMPOSTO E A FORMA N-óXIDO E SAL PIRIDìNIO DO MESMO, E, MéTODO DE SEPARAçãO DE ENANTIÈMEROS DE UM COMPOSTO". Compostos de fórmula (I), Fórmula I e seu uso como no tratamento de infecções envolvendo vírus da sub-família Pneumovirinae (RSV) são descritos. Na fórmula, anel (A) pode ser fenila, piridila, etc. (B-C) pode ser CH~ 2~-CH~ 2~ etc., (R~ 1~) pode ser fenila e formas substituídas da mesma, (R~ 2~) podem ser substituintes variados.
BRPI0418127-1A 2003-12-24 2004-12-24 uso de um composto, seus sais, e derivados farmaceuticamente aceitáveis dos mesmos, método para o tratamento de infecções envolvendo vìrus da sub-famìlia pneumovirinae, formulação farmacêutica, métodos para tratar mamìferos infectados e para prevenir a infecção de mamìferos com vìrus da sub-famìlia pneumovirinae, composto, seus sais, e derivados farmaceuticamente aceitáveis dos mesmos, composto e a forma n-óxido e sal piridìnio do mesmo, e, método de separação de enantiÈmeros de um composto BRPI0418127A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2003907196A AU2003907196A0 (en) 2003-12-24 Polycyclic agents for the treatment of respiratory syncytial virus infections
PCT/AU2004/001830 WO2005061513A1 (en) 2003-12-24 2004-12-24 Polycyclic agents for the treatment of respiratory syncytial virus infections

Publications (1)

Publication Number Publication Date
BRPI0418127A true BRPI0418127A (pt) 2007-04-27

Family

ID=34705575

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0418127-1A BRPI0418127A (pt) 2003-12-24 2004-12-24 uso de um composto, seus sais, e derivados farmaceuticamente aceitáveis dos mesmos, método para o tratamento de infecções envolvendo vìrus da sub-famìlia pneumovirinae, formulação farmacêutica, métodos para tratar mamìferos infectados e para prevenir a infecção de mamìferos com vìrus da sub-famìlia pneumovirinae, composto, seus sais, e derivados farmaceuticamente aceitáveis dos mesmos, composto e a forma n-óxido e sal piridìnio do mesmo, e, método de separação de enantiÈmeros de um composto

Country Status (17)

Country Link
US (2) US8598193B2 (pt)
EP (2) EP2287167A1 (pt)
JP (2) JP5384793B2 (pt)
KR (1) KR20060127909A (pt)
CN (2) CN100582109C (pt)
AT (1) ATE496920T1 (pt)
BR (1) BRPI0418127A (pt)
CA (1) CA2551178C (pt)
DE (1) DE602004031258D1 (pt)
ES (1) ES2360222T3 (pt)
HK (1) HK1088607A1 (pt)
IL (1) IL176155A0 (pt)
NO (1) NO20062758L (pt)
NZ (1) NZ551468A (pt)
RU (1) RU2422444C2 (pt)
WO (1) WO2005061513A1 (pt)
ZA (1) ZA200604528B (pt)

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DK3187225T3 (da) 2005-04-28 2022-02-28 Viiv Healthcare Co Polycyklisk carbamoylpyridonderivat med hiv-integrasehæmmende aktivitet
TWI423972B (zh) * 2006-09-28 2014-01-21 Biota Scient Management 治療呼吸系融合細胞病毒感染之多環劑

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NO20062758L (no) 2006-07-17
CA2551178C (en) 2012-11-06
ZA200604528B (en) 2007-06-27
CA2551178A1 (en) 2005-07-07
EP1697377B1 (en) 2011-01-26
RU2006126663A (ru) 2008-01-27
EP1697377A1 (en) 2006-09-06
US8598193B2 (en) 2013-12-03
WO2005061513A1 (en) 2005-07-07
JP5536842B2 (ja) 2014-07-02
CN1898247A (zh) 2007-01-17
JP2012246318A (ja) 2012-12-13
NZ551468A (en) 2010-05-28
US20070287700A1 (en) 2007-12-13
HK1088607A1 (en) 2006-11-10
JP5384793B2 (ja) 2014-01-08
JP2007516983A (ja) 2007-06-28
CN100582109C (zh) 2010-01-20
CN101723949B (zh) 2013-10-23
KR20060127909A (ko) 2006-12-13
EP1697377A4 (en) 2008-03-19
CN101723949A (zh) 2010-06-09
EP2287167A1 (en) 2011-02-23
DE602004031258D1 (de) 2011-03-10
ATE496920T1 (de) 2011-02-15
ES2360222T3 (es) 2011-06-02
RU2422444C2 (ru) 2011-06-27

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