GB1322339A - Imidazoline derivatives - Google Patents
Imidazoline derivativesInfo
- Publication number
- GB1322339A GB1322339A GB4694170A GB4694170A GB1322339A GB 1322339 A GB1322339 A GB 1322339A GB 4694170 A GB4694170 A GB 4694170A GB 4694170 A GB4694170 A GB 4694170A GB 1322339 A GB1322339 A GB 1322339A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- alkyl
- butyl
- isoindol
- imidazolin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1322339 2 - (2 - Imidazolin - 2 - yl) - benzyl alcohols AMERICAN HOME PRODUCTS CORP 2 Oct 1970 [10 March 1970] 46941/70 Heading C2C Novel 2 - (2 - imidazolin - 2 - yl) - benzyl alcohols of the general formula wherein R<SP>1</SP> is a phenyl, mono- or di-halophenyl, mono- or di-C 1-4 alkyl (not t-butyl) phenyl, trifluoromethylphenyl, mono- or di-C 1-6 alkoxyphenyl, thienyl, pyridyl, furyl or 5,6,7,8-tetrahydro-2-naphthyl group, R<SP>2</SP> is a hydrogen or halogen atom or an amino, C 1-4 alkyl (not tbutyl) amino, C 1-4 alkyl (not t-butyl) or C 1-6 alkoxy group, R<SP>3</SP> is a hydrogen atom when R<SP>2</SP> and R<SP>3</SP> are dissimilar and when R<SP>2</SP> and R<SP>3</SP> are the same they are both selected from hydrogen and halogen atoms and C 1-4 alkyl (not t-butyl) and C 1-6 alkoxy groups, and R<SP>4</SP> and R<SP>5</SP>, which are attached to the same carbon atom, are each a C 1-4 alkyl (not t-butyl) group, and acid addition salts thereof are prepared by reduction of a 2,3 - dihydro - 5H - imidazo[2,1-a]isoindol- 5 - ol or its tautomer of the respective general formulae followed optionally by salification of the product. 2,3 - Dihydro - 5H - imidazo[2,1-a]isoindol - 5 - ols of the second general formula above are prepared by reaction of a benzoic acid and an ethylenediamine of the respective general formulµ reaction of the resulting 1,2,3,9b-tetrahydro-5H- imidazo[2,1-a]isoindol-5-one of the general formula with a sulphonyl chloride of the general formula R<SP>7</SP>SO 2 Cl, wherein R<SP>7</SP> is an optionally substituted hydrocarbon group, and treatment of the resulting sulphonyl derivative of the general formula with a strong acid, followed by a base. Pharmaceutical compositions having antiinflammatory sctivity comprise, as active ingredient, a 2-(2-imidazolin-2-yl)-benzhydrol of the first general formula above or an acid addition salt thereof, in association with a pharmaceutically acceptable carrier, and may be administered orally or parenterally.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1830970A | 1970-03-10 | 1970-03-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1322339A true GB1322339A (en) | 1973-07-04 |
Family
ID=21787276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4694170A Expired GB1322339A (en) | 1970-03-10 | 1970-10-02 | Imidazoline derivatives |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1322339A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000078726A1 (en) * | 1999-06-18 | 2000-12-28 | Eli Lilly And Company | Imidazoline derivatives for the treatment of diabetes, especially type ii diabetes |
WO2005061513A1 (en) * | 2003-12-24 | 2005-07-07 | Biota Scientific Management Pty Ltd | Polycyclic agents for the treatment of respiratory syncytial virus infections |
AU2004303445B2 (en) * | 2003-12-24 | 2010-09-02 | Biota Scientific Management Pty Ltd | Polycyclic agents for the treatment of respiratory syncytial virus infections |
US8598194B2 (en) | 2006-09-28 | 2013-12-03 | Biota Scientific Management Pty Ltd. | Polycyclic agents for the treatment of respiratory syncytial virus infections |
US8604034B2 (en) | 2010-02-08 | 2013-12-10 | Biota Scientific Management Pty Ltd. | Substituted imidazo[1,2-α]pyrrolo[1,2-d]pyrazines for treating respiratory syncytial virus (RSV) infections |
US8796303B2 (en) | 2010-11-26 | 2014-08-05 | Biota Scientific Management Pty Ltd. | Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections |
-
1970
- 1970-10-02 GB GB4694170A patent/GB1322339A/en not_active Expired
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000078726A1 (en) * | 1999-06-18 | 2000-12-28 | Eli Lilly And Company | Imidazoline derivatives for the treatment of diabetes, especially type ii diabetes |
WO2005061513A1 (en) * | 2003-12-24 | 2005-07-07 | Biota Scientific Management Pty Ltd | Polycyclic agents for the treatment of respiratory syncytial virus infections |
AU2004303445B2 (en) * | 2003-12-24 | 2010-09-02 | Biota Scientific Management Pty Ltd | Polycyclic agents for the treatment of respiratory syncytial virus infections |
AU2004303445C1 (en) * | 2003-12-24 | 2011-01-20 | Biota Scientific Management Pty Ltd | Polycyclic agents for the treatment of respiratory syncytial virus infections |
US8598193B2 (en) | 2003-12-24 | 2013-12-03 | Biota Scientific Management Pty Ltd. | Polycyclic agents for the treatment of respiratory syncytial virus infections |
US8598194B2 (en) | 2006-09-28 | 2013-12-03 | Biota Scientific Management Pty Ltd. | Polycyclic agents for the treatment of respiratory syncytial virus infections |
US9675694B2 (en) | 2006-09-28 | 2017-06-13 | Biota Scientific Management Pty Ltd | Polycyclic agents for the treatment of respiratory syncytial virus infections |
US8604034B2 (en) | 2010-02-08 | 2013-12-10 | Biota Scientific Management Pty Ltd. | Substituted imidazo[1,2-α]pyrrolo[1,2-d]pyrazines for treating respiratory syncytial virus (RSV) infections |
US9163029B2 (en) | 2010-02-08 | 2015-10-20 | Biota Scientific Management Pty Ltd. | Substituted imidazo[1,2-a]pyrrolo[1,2-d]pyrazines for treating respiratory syncytial virus infections |
US8796303B2 (en) | 2010-11-26 | 2014-08-05 | Biota Scientific Management Pty Ltd. | Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0401819A2 (en) | Pyrazole compounds useful as protein kinase inhibitors and pharmaceutical compositions containing them | |
GB1436771A (en) | Indole derivatives and process for preparing the same | |
GB1234058A (en) | ||
WO1995014007B1 (en) | Phenyl-alkyl imidazoles as h3-receptor antagonists | |
GB1221324A (en) | New processes for the production of benzazepine derivatives | |
GB1242169A (en) | Piperidine derivatives | |
GB1171509A (en) | Pyridine Derivatives | |
GB1167563A (en) | Novel 3-(2-Substituted Ethyl) Indoles and Processes for Their Manufacture | |
GB1294763A (en) | 3-oxo-2,3-dihydro-1,4-benzoxazine derivatives | |
GB1254332A (en) | Amino acids and their derivatives and processes for preparing them | |
GB1322339A (en) | Imidazoline derivatives | |
GB1325065A (en) | Imidazoline derivatives | |
IE40308B1 (en) | 2-acylaminooxauoles, methods for their preparation and their use | |
GB1295228A (en) | ||
GB1343827A (en) | Acylaminotetrazoles and process for preparing them | |
GB1173227A (en) | Amino-Isoquinolines | |
GB1298112A (en) | Phenyl acetyl guanidine derivatives | |
GB1444593A (en) | Imidazoline derivatives | |
GB1174349A (en) | Novel 2-Anilinomethylimidazoline Derivatives and process for the preparation thereof | |
GB1322026A (en) | Benzisoindol-1-ones | |
GB1353508A (en) | Aminoisoquinolines | |
GB1181967A (en) | Novel Picoline Derivatives and a Method for the Production Thereof | |
GB1047245A (en) | ||
GB1341520A (en) | ||
ES311285A1 (en) | í -1,2,4-triazolone-(5) derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PLNP | Patent lapsed through nonpayment of renewal fees |