GB1325065A - Imidazoline derivatives - Google Patents
Imidazoline derivativesInfo
- Publication number
- GB1325065A GB1325065A GB4694070A GB4694070A GB1325065A GB 1325065 A GB1325065 A GB 1325065A GB 4694070 A GB4694070 A GB 4694070A GB 4694070 A GB4694070 A GB 4694070A GB 1325065 A GB1325065 A GB 1325065A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- formula above
- isoindol
- imidazo
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1325065 5 - Aryl - 2,3 - dihydro - 5H- imidazo[2,1-a]isoindol- 5 - ols AMERICAN HOME PRODUCTS CORP 2 Oct 1970 [12 Feb 1970] 46940/70 Heading C2C Novel 5 - aryl - 2,3 - dihydro - 5H - imidazo- [2,1-a]isoindol-5-ols of the general formula and their tautomeric acid addition salts of the general formula wherein R<SP>1</SP> is a phenyl, mono- or di-halophenyl, mono- or di-C 1-4 alkylphenyl, trifluoromethylphenyl, mono- or di-C 1-6 alkoxyphenyl, thienyl, pyridyl, furyl or 5,6,7,8-tetrahydro-2-naphthyl group, R<SP>2</SP> is a hydrogen or halogen atom or an amino, C 1-4 alkylamino, C 1-4 alkyl or C 1-6 alkoxy group, R<SP>3</SP> is a hydrogen atom when R<SP>2</SP> and R<SP>3</SP> are dissimilar, and when R<SP>2</SP> and R<SP>3</SP> are the same they are each a hydrogen or halogen atom or a C 1-4 alkyl or C 1-6 alkoxy group, R<SP>4</SP> and R<SP>5</SP> are each a C 1-4 alkyl group, attached to the same carbon atom, and HX is an acid, are prepared by treatment of a sulphonamide of the general formula wherein each of R<SP>6</SP> and R<SP>7</SP>SO 2 is an organosulphonyl group, with a strong acid, optional treatment of the resulting acid addition salt of the second general formula above with a base and optional salification of the resulting free base of the first general formula above. Sulphonamides of the fourth general formula above are prepared by reaction of the corresponding amine of the general formula with an organosulphonyl halide. Pharmaceutical compositions having antidepressant activity comprise, as active ingredient, a 5 - aryl - 2,3 - dihydro - 5H - imidazo- [2,1-a]isoindol-5-ol of the first general formula above or tautomeric pharmacologically acceptable acid addition salt of the second general formula above, in association with a pharmaceutically acceptable carrier, and may be administered orally or parenterally.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1098470A | 1970-02-12 | 1970-02-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1325065A true GB1325065A (en) | 1973-08-01 |
Family
ID=21748356
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4694070A Expired GB1325065A (en) | 1970-02-12 | 1970-10-02 | Imidazoline derivatives |
| GB2099772A Expired GB1325066A (en) | 1970-02-12 | 1970-10-02 | Phthalimidine compounds |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2099772A Expired GB1325066A (en) | 1970-02-12 | 1970-10-02 | Phthalimidine compounds |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS5542997B1 (en) |
| BE (1) | BE762824A (en) |
| CA (1) | CA936533A (en) |
| CH (2) | CH557350A (en) |
| CY (2) | CY786A (en) |
| DE (1) | DE2106694C2 (en) |
| EG (1) | EG10508A (en) |
| ES (1) | ES388196A1 (en) |
| FR (1) | FR2081505B1 (en) |
| GB (2) | GB1325065A (en) |
| IL (1) | IL36017A (en) |
| MY (2) | MY7500060A (en) |
| NL (1) | NL175722C (en) |
| SE (1) | SE410460B (en) |
| ZA (1) | ZA71337B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8618158B2 (en) | 2008-06-25 | 2013-12-31 | Cancer Research Technology Limited | Therapeutic agents |
| US10526311B2 (en) | 2015-09-29 | 2020-01-07 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity |
| US10544132B2 (en) | 2015-09-29 | 2020-01-28 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity |
| US11236047B2 (en) | 2017-03-28 | 2022-02-01 | Astex Therapeutics Limited | Combination of isoindolinone derivatives with SGI-110 |
| US11603367B2 (en) | 2017-03-28 | 2023-03-14 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-P53 interaction and process for making them |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2509730A1 (en) * | 1981-07-17 | 1983-01-21 | Carpibem | NOVEL O-HALOGENES AND O-SUBSTITUTED HETEROCYCLE PHENOLS, PROCESS FOR THE PREPARATION THEREOF, MEDICAMENTS CONTAINING SAME, ESPECIALLY ANTI-HYPERTENISERS, AND NOVEL SYNTHETIC INTERMEDIATES |
| DE3403730A1 (en) * | 1984-02-03 | 1985-08-08 | Hoechst Ag, 6230 Frankfurt | ISOINDOLES, METHOD FOR THEIR PRODUCTION AND THEIR USE IN AGRICULTURE |
| ES2052769T3 (en) * | 1987-07-01 | 1994-07-16 | Ciba Geigy Ag | PROCEDURE FOR OBTAINING SUBSTITUTED IMIDAZOLONES WITH HERBICIDE ACTIVITY. |
| GB0419481D0 (en) * | 2004-09-02 | 2004-10-06 | Cancer Rec Tech Ltd | Isoindolin-1-one derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3888846A (en) * | 1967-03-30 | 1975-06-10 | Hoffmann La Roche | Process for 2(2-(1,3-diazacycloalk-2-enyl))benzophenone derivatives and 1,3-diazacycloalkenyl(2,1-a)isoindole derivatives |
-
1970
- 1970-10-02 GB GB4694070A patent/GB1325065A/en not_active Expired
- 1970-10-02 CY CY786A patent/CY786A/en unknown
- 1970-10-02 CY CY787A patent/CY787A/en unknown
- 1970-10-02 GB GB2099772A patent/GB1325066A/en not_active Expired
-
1971
- 1971-01-19 ZA ZA710337A patent/ZA71337B/en unknown
- 1971-01-19 IL IL36017A patent/IL36017A/en unknown
- 1971-01-20 CA CA103212A patent/CA936533A/en not_active Expired
- 1971-02-03 EG EG55/71A patent/EG10508A/en active
- 1971-02-04 JP JP446571A patent/JPS5542997B1/ja active Pending
- 1971-02-09 CH CH1546373A patent/CH557350A/en not_active IP Right Cessation
- 1971-02-09 CH CH192471A patent/CH557366A/en not_active IP Right Cessation
- 1971-02-11 FR FR7104659A patent/FR2081505B1/fr not_active Expired
- 1971-02-11 NL NLAANVRAGE7101847,A patent/NL175722C/en not_active IP Right Cessation
- 1971-02-11 SE SE7101742A patent/SE410460B/en unknown
- 1971-02-11 BE BE762824A patent/BE762824A/en not_active IP Right Cessation
- 1971-02-12 ES ES388196A patent/ES388196A1/en not_active Expired
- 1971-02-12 DE DE2106694A patent/DE2106694C2/en not_active Expired
-
1975
- 1975-12-30 MY MY60/75A patent/MY7500060A/en unknown
- 1975-12-30 MY MY62/75A patent/MY7500062A/en unknown
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8618158B2 (en) | 2008-06-25 | 2013-12-31 | Cancer Research Technology Limited | Therapeutic agents |
| US9358222B2 (en) | 2008-06-25 | 2016-06-07 | Cancer Research Technology Limited | Therapeutic agents |
| US10414726B2 (en) | 2008-06-25 | 2019-09-17 | Cancer Research Technology Limited | Therapeutic agents |
| US10526311B2 (en) | 2015-09-29 | 2020-01-07 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity |
| US10544132B2 (en) | 2015-09-29 | 2020-01-28 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity |
| US10981898B2 (en) | 2015-09-29 | 2021-04-20 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity |
| US11261171B1 (en) | 2015-09-29 | 2022-03-01 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity |
| US11236047B2 (en) | 2017-03-28 | 2022-02-01 | Astex Therapeutics Limited | Combination of isoindolinone derivatives with SGI-110 |
| US11603367B2 (en) | 2017-03-28 | 2023-03-14 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-P53 interaction and process for making them |
Also Published As
| Publication number | Publication date |
|---|---|
| CH557350A (en) | 1974-12-31 |
| ES388196A1 (en) | 1974-03-01 |
| DE2106694A1 (en) | 1971-08-19 |
| CA936533A (en) | 1973-11-06 |
| DE2106694C2 (en) | 1984-04-12 |
| GB1325066A (en) | 1973-08-01 |
| FR2081505A1 (en) | 1971-12-03 |
| SE410460B (en) | 1979-10-15 |
| ZA71337B (en) | 1972-08-30 |
| BE762824A (en) | 1971-08-11 |
| EG10508A (en) | 1976-03-31 |
| MY7500062A (en) | 1975-12-31 |
| NL7101847A (en) | 1971-08-16 |
| JPS5542997B1 (en) | 1980-11-04 |
| NL175722C (en) | 1984-12-17 |
| IL36017A0 (en) | 1971-03-24 |
| CY786A (en) | 1976-06-01 |
| NL175722B (en) | 1984-07-16 |
| MY7500060A (en) | 1975-12-31 |
| CY787A (en) | 1976-06-01 |
| IL36017A (en) | 1975-03-13 |
| FR2081505B1 (en) | 1974-08-30 |
| CH557366A (en) | 1974-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |