GB1186062A - Benzonaphthyridine Derivatives - Google Patents
Benzonaphthyridine DerivativesInfo
- Publication number
- GB1186062A GB1186062A GB5064369A GB5064369A GB1186062A GB 1186062 A GB1186062 A GB 1186062A GB 5064369 A GB5064369 A GB 5064369A GB 5064369 A GB5064369 A GB 5064369A GB 1186062 A GB1186062 A GB 1186062A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pharmaceutically acceptable
- acid addition
- acceptable acid
- benzonaphthyridines
- alkoxyphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
1,186,062. Benzonaphthyridines. AMERICAN HOME PRODUCTS CORP. 13 March, 1967 [14 March, 1966], No. 50643/69. Divided out of 1,186,061. Heading C2C. Novel benzonaphthyridines of the general formula wherein R<SP>1</SP> is a hydrogen or halogen atom or a nitro, alkyl or alkoxy group; R<SP>3</SP> is a hydrogen atom or an alkyl, phenyl, alkylphenyl, halophenyl, alkoxyphenyl, benzyl, halobenzyl, alkylbenzyl or alkoxybenzyl group; and R<SP>5</SP> is a hydrogen atom or a phenyl, halophenyl, alkylphenyl, alkoxyphenyl, pyridyl, furyl or thienyl group, and pharmaceutically acceptable acid addition salts thereof are prepared by reaction of an aniline derivative and a 3-quinuclidinone (or an acid addition salt thereof) of the respective general formulµ followed optionally by saliflcation of the product with a pharmaceutically acceptable acid. Pharmaceutical compositions having central nervous system depressant activity comprise, as active ingredient a benzonaphthyridine of the first general formula above or a pharmaceutically acceptable acid addition salt thereof, together with a pharmaceutically acceptable carrier, and may be administered orally or parenterally.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53379366A | 1966-03-14 | 1966-03-14 | |
| US53380266A | 1966-03-14 | 1966-03-14 | |
| US53381666A | 1966-03-14 | 1966-03-14 | |
| US58175666A | 1966-09-26 | 1966-09-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1186062A true GB1186062A (en) | 1970-04-02 |
Family
ID=27504644
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB50644/67D Expired GB1186063A (en) | 1966-03-14 | 1967-03-13 | Benzonaphthyridine Derivatives |
| GB01601/67A Expired GB1186061A (en) | 1966-03-14 | 1967-03-13 | Benzonaphthyridine Derivatives |
| GB5064369A Expired GB1186062A (en) | 1966-03-14 | 1967-03-13 | Benzonaphthyridine Derivatives |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB50644/67D Expired GB1186063A (en) | 1966-03-14 | 1967-03-13 | Benzonaphthyridine Derivatives |
| GB01601/67A Expired GB1186061A (en) | 1966-03-14 | 1967-03-13 | Benzonaphthyridine Derivatives |
Country Status (3)
| Country | Link |
|---|---|
| DE (2) | DE1795616A1 (en) |
| FR (2) | FR1514010A (en) |
| GB (3) | GB1186063A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4511568A (en) * | 1982-05-12 | 1985-04-16 | Ici Americas Inc. | CNS-Depressant pyrazolopyridines |
| WO1989002739A1 (en) * | 1987-10-05 | 1989-04-06 | Pfizer Inc. | 4-aminopyridine derivatives |
| EP2552914B1 (en) * | 2010-03-26 | 2015-11-11 | Merck Patent GmbH | Benzonaphthyridinamines as autotaxin inhibitors |
-
1967
- 1967-03-13 GB GB50644/67D patent/GB1186063A/en not_active Expired
- 1967-03-13 FR FR98542A patent/FR1514010A/en not_active Expired
- 1967-03-13 DE DE19671795616 patent/DE1795616A1/en active Pending
- 1967-03-13 GB GB01601/67A patent/GB1186061A/en not_active Expired
- 1967-03-13 DE DE19671645957 patent/DE1645957A1/en active Pending
- 1967-03-13 GB GB5064369A patent/GB1186062A/en not_active Expired
- 1967-06-06 FR FR109287A patent/FR6519M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR1514010A (en) | 1968-02-16 |
| GB1186063A (en) | 1970-04-02 |
| DE1795616A1 (en) | 1972-03-30 |
| GB1186061A (en) | 1970-04-02 |
| DE1645957A1 (en) | 1970-06-04 |
| FR6519M (en) | 1968-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |