IE35727L - Benzodiazepines. - Google Patents
Benzodiazepines.Info
- Publication number
- IE35727L IE35727L IE700753A IE75370A IE35727L IE 35727 L IE35727 L IE 35727L IE 700753 A IE700753 A IE 700753A IE 75370 A IE75370 A IE 75370A IE 35727 L IE35727 L IE 35727L
- Authority
- IE
- Ireland
- Prior art keywords
- group
- general formula
- benzodiazepin
- tetrahydro
- reaction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1317475 1 H - 2,3,4,5 - Tetrahydro - 1,5- benzodiazepin - 4 - ones BOEHRINGER INGELHEIM GmbH 10 June 1970 [11 June 1969 13 Feb 1970 23 April 1970] 28197/70 Heading C2C Novel 1H - 2,3,4,5 - tetrahydro - 1,5 - benzodiazepin-4-ones of the general formula wherein R 1 is a hydrogen atom or a straight or branched chain C 1-6 alkyl group, an unsaturated aliphatic C 2-6 hydrocarbon group, a C 2-3 alkyl group substituted by a hydroxy group in the terminal position, or a C 4-7 cycloalkylmethyl or formyl group, R 2 is an α-pyridyl group, or a phenyl group optionally substituted in the oposition thereof by a halogen atom or a nitro or trifluoromethyl group and R 3 is a hydrogen or halogen atom or a hydroxy, trifluoromethyl, nitro or cyano group, and, except when R 1 is a formyl group and R 2 is other than an α-pyridyl group, physiologically acceptable acid addition salts thereof are prepared (a) when R 1 is other than a formyl group, by reaction of a 1H-2,3,4,5- tetrahydro - 1,5 - benzodiazepin - 4 - one of the general formula wherein R 4 is as R 1 with the exception of a formyl group, with an aryl or heteroaryl halide of the general formula R 2 X, wherein X is a halogen atom; (b) when R 1 is other than a formyl group, by cyclization of an N-(2-anilinophenyl)-#-alanine of the general formula (c) when R 1 is other than a formyl group, by cyclization of an N-acyl-o-phenylenediamine of the general formula wherein Y is a vinyl or 2-haloethyl group; (d) when R 1 is other than a hydrogen atom, by reaction of a lH-2,3,4,5-tetrahydro-1,5-benzodiazepin-4-one of the general formula with a compound of the general formula R 5 Y, wherein R 5 is as R 1 with the exception of a hydrogen atom and Y is an atom or group readily removable as an anion; (e) when R 1 is a 2-hydroxyethyl group, by reaction of a 1H-2,3,4,5 - tetrahydro - 1,5 - benzodiazepin-4- one of the sixth general formula above with ethylene oxide, and (f) when R 1 is a formyl group, by reaction of a 1H-2,3,4,5-tetrahydro- 1,5 - benzodiazepin - 4 - one of the sixth general formula above with formic acid; followed optionally, where appropriate, by salification of the product. Pharmaceutical compositions having tranquillizing activity comprise, as active ingredient, at least one lH-2,3,4,5-tetrahydro-1,5-benzodiazepin-4-one of the first general formula above or physiologically acceptable acid addition salt thereof, in association with a pharmaceutical carrier or excipient, and may be administered orally, parenterally or rectally.
[GB1317475A]
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19691929656 DE1929656A1 (en) | 1969-06-11 | 1969-06-11 | Tetrahydro-1,5-benzodiazepine-4-ones |
DE19702006600 DE2006600A1 (en) | 1970-02-13 | 1970-02-13 | Tetrahydro-1,5-benzodiazepine-4-ones |
DE19702019627 DE2019627A1 (en) | 1969-06-11 | 1970-04-23 | Tetrahydro-1,5-benzodiazepine-4-ones |
Publications (2)
Publication Number | Publication Date |
---|---|
IE35727L true IE35727L (en) | 1970-12-11 |
IE35727B1 IE35727B1 (en) | 1976-05-12 |
Family
ID=27181978
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE753/70A IE35727B1 (en) | 1969-06-11 | 1970-06-10 | Novel benzodiazepines the preparation thereof and compositions containing the same |
Country Status (16)
Country | Link |
---|---|
JP (3) | JPS5031158B1 (en) |
AT (2) | AT303746B (en) |
BE (1) | BE751834A (en) |
BG (4) | BG17602A3 (en) |
CA (1) | CA967154A (en) |
CH (1) | CH549582A (en) |
ES (4) | ES380557A1 (en) |
FR (1) | FR2052950B1 (en) |
GB (1) | GB1317475A (en) |
IE (1) | IE35727B1 (en) |
IL (1) | IL34689A (en) |
NL (1) | NL7008404A (en) |
NO (1) | NO129524B (en) |
RO (4) | RO58405A (en) |
SE (1) | SE381873B (en) |
SU (1) | SU423299A3 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110256365B (en) * | 2019-06-24 | 2022-06-07 | 陕西师范大学 | Method for preparing benzodiazepine derivative by catalysis of dichlorotitanocene |
CN110183397B (en) * | 2019-06-24 | 2022-08-23 | 陕西师范大学 | Method for preparing 1, 5-benzothiazine compound by catalysis of zirconocene dichloride |
-
1970
- 1970-04-10 BG BG014913A patent/BG17602A3/en unknown
- 1970-06-05 CA CA084,760A patent/CA967154A/en not_active Expired
- 1970-06-05 RO RO63562A patent/RO58405A/ro unknown
- 1970-06-05 RO RO69785A patent/RO58887A/ro unknown
- 1970-06-05 RO RO69784A patent/RO58641A/ro unknown
- 1970-06-05 RO RO69783A patent/RO58640A/ro unknown
- 1970-06-05 SU SU701666624A patent/SU423299A3/en active
- 1970-06-09 IL IL34689A patent/IL34689A/en unknown
- 1970-06-09 ES ES380557A patent/ES380557A1/en not_active Expired
- 1970-06-09 CH CH863170A patent/CH549582A/en not_active IP Right Cessation
- 1970-06-10 BG BG017287A patent/BG17973A3/en unknown
- 1970-06-10 IE IE753/70A patent/IE35727B1/en unknown
- 1970-06-10 NO NO02256/70A patent/NO129524B/no unknown
- 1970-06-10 AT AT00409/72A patent/AT303746B/en not_active IP Right Cessation
- 1970-06-10 NL NL7008404A patent/NL7008404A/xx unknown
- 1970-06-10 GB GB2819770A patent/GB1317475A/en not_active Expired
- 1970-06-10 AT AT522570A patent/AT303737B/en not_active IP Right Cessation
- 1970-06-10 BG BG017289A patent/BG17974A3/en unknown
- 1970-06-11 BE BE751834D patent/BE751834A/en unknown
- 1970-06-11 FR FR7021448A patent/FR2052950B1/fr not_active Expired
- 1970-06-11 SE SE7008152A patent/SE381873B/en unknown
-
1971
- 1971-01-11 ES ES387138A patent/ES387138A1/en not_active Expired
- 1971-01-11 ES ES387136A patent/ES387136A1/en not_active Expired
- 1971-01-11 ES ES71387137A patent/ES387137A1/en not_active Expired
- 1971-04-07 BG BG017288A patent/BG17603A3/en unknown
- 1971-10-01 JP JP46077048A patent/JPS5031158B1/ja active Pending
- 1971-10-01 JP JP46077046A patent/JPS49192B1/ja active Pending
- 1971-10-01 JP JP46077047A patent/JPS5013273B1/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
SU423299A3 (en) | 1974-04-05 |
GB1317475A (en) | 1973-05-16 |
ES387137A1 (en) | 1974-01-01 |
BE751834A (en) | 1970-12-11 |
JPS5031158B1 (en) | 1975-10-07 |
CH549582A (en) | 1974-05-31 |
JPS5013273B1 (en) | 1975-05-19 |
ES387138A1 (en) | 1973-05-01 |
RO58887A (en) | 1975-10-15 |
BG17974A3 (en) | 1974-03-05 |
IL34689A0 (en) | 1970-08-19 |
IL34689A (en) | 1973-03-30 |
JPS49192B1 (en) | 1974-01-05 |
RO58405A (en) | 1975-11-15 |
CA967154A (en) | 1975-05-06 |
NO129524B (en) | 1974-04-22 |
AT303746B (en) | 1972-11-15 |
ES380557A1 (en) | 1973-04-01 |
RO58640A (en) | 1975-10-15 |
RO58641A (en) | 1975-09-15 |
SE381873B (en) | 1975-12-22 |
FR2052950B1 (en) | 1974-08-30 |
BG17973A3 (en) | 1974-03-05 |
ES387136A1 (en) | 1974-01-01 |
NL7008404A (en) | 1970-12-15 |
AT303737B (en) | 1972-12-11 |
FR2052950A1 (en) | 1971-04-16 |
BG17602A3 (en) | 1973-11-10 |
IE35727B1 (en) | 1976-05-12 |
BG17603A3 (en) | 1973-11-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1222708A (en) | Novel 5-(n-substituted aminomethyl)-2-oxazolidinones and their process of preparation | |
GB1205957A (en) | Pharmaceutical compositions comprising 1-pnenoxy-2-aminopropanes | |
GB1294763A (en) | 3-oxo-2,3-dihydro-1,4-benzoxazine derivatives | |
IE780515L (en) | Morphine derivatives | |
GB1180766A (en) | 2-Arylamine-1,3-Diazacycloalkenes-(2) and the Preparation Thereof | |
GB1301431A (en) | ||
GB1456627A (en) | Pyridobenzodiazepinones | |
GB1513320A (en) | N-propargyl-2-phenylamino-2-imidazolines | |
IE35727L (en) | Benzodiazepines. | |
IE39481B1 (en) | Imidazoline derivatives | |
GB1337371A (en) | 3-amino-imidazo-1,5-a- pyridines processes for their preparation and pharmaceutical compositions incorporating them | |
GB1394504A (en) | 1,2-bis-4-phenyl-1-piperazinyl-ethane derivatives | |
GB1409648A (en) | Substituted pyrrolidinemethanol compounds and pharmaceutical compositions thereof | |
GB1353508A (en) | Aminoisoquinolines | |
GB1254270A (en) | Benzoxazepine derivatives | |
GB1305725A (en) | ||
GB1229996A (en) | ||
GB1245155A (en) | NOVEL 5-SUBSTITUTED-gamma-CARBOLINE DERIVATIVES AND THE SALTS THEREOF | |
GB1321390A (en) | Basic quinobenzazepines | |
GB1276719A (en) | Benzomorphan derivatives and their salts | |
GB1453910A (en) | Benzazepine derivatives | |
GB1186062A (en) | Benzonaphthyridine Derivatives | |
GB1322069A (en) | Aminoalkanoylaminocyclohexane derivatives | |
GB1273399A (en) | Novel formamido-cycloalkane derivatives | |
GB1225412A (en) |