HK1088607A1 - Polycyclic agents for the treatment of respiratory syncytial virus infections - Google Patents

Polycyclic agents for the treatment of respiratory syncytial virus infections

Info

Publication number
HK1088607A1
HK1088607A1 HK06110690.6A HK06110690A HK1088607A1 HK 1088607 A1 HK1088607 A1 HK 1088607A1 HK 06110690 A HK06110690 A HK 06110690A HK 1088607 A1 HK1088607 A1 HK 1088607A1
Authority
HK
Hong Kong
Prior art keywords
treatment
respiratory syncytial
syncytial virus
virus infections
agents
Prior art date
Application number
HK06110690.6A
Other languages
English (en)
Inventor
Silas Bond
Vanessa Anne Sanford
John Nicholas Lambert
Chin Yu Lim
Jeffrey Peter Mitchell
Alistair George Draffan
Roland Henry Nearn
Original Assignee
Biota Scient Management
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2003907196A external-priority patent/AU2003907196A0/en
Application filed by Biota Scient Management filed Critical Biota Scient Management
Publication of HK1088607A1 publication Critical patent/HK1088607A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41881,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/424Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK06110690.6A 2003-12-24 2006-09-26 Polycyclic agents for the treatment of respiratory syncytial virus infections HK1088607A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2003907196A AU2003907196A0 (en) 2003-12-24 Polycyclic agents for the treatment of respiratory syncytial virus infections
PCT/AU2004/001830 WO2005061513A1 (en) 2003-12-24 2004-12-24 Polycyclic agents for the treatment of respiratory syncytial virus infections

Publications (1)

Publication Number Publication Date
HK1088607A1 true HK1088607A1 (en) 2006-11-10

Family

ID=34705575

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06110690.6A HK1088607A1 (en) 2003-12-24 2006-09-26 Polycyclic agents for the treatment of respiratory syncytial virus infections

Country Status (17)

Country Link
US (2) US8598193B2 (xx)
EP (2) EP2287167A1 (xx)
JP (2) JP5384793B2 (xx)
KR (1) KR20060127909A (xx)
CN (2) CN100582109C (xx)
AT (1) ATE496920T1 (xx)
BR (1) BRPI0418127A (xx)
CA (1) CA2551178C (xx)
DE (1) DE602004031258D1 (xx)
ES (1) ES2360222T3 (xx)
HK (1) HK1088607A1 (xx)
IL (1) IL176155A0 (xx)
NO (1) NO20062758L (xx)
NZ (1) NZ551468A (xx)
RU (1) RU2422444C2 (xx)
WO (1) WO2005061513A1 (xx)
ZA (1) ZA200604528B (xx)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2287167A1 (en) 2003-12-24 2011-02-23 Biota Scientific Management Pty. Ltd. Polycyclic agents for the treatment of respiratory syncytial virus infections
US20090005363A1 (en) * 2005-12-20 2009-01-01 Ralf Glatthar Organic Compounds
RU2009110254A (ru) 2006-08-24 2010-09-27 Новартис АГ (CH) Производные 2-(пиразин-2-ил)тиазола и 2-(1н-пиразол-3-ил)тиразола и связанные с ним соединения в качестве ингибиторов стеароил-соа десатуразы для лечения метаболических, сердечно-сосудистых и других нарушений
KR20090053923A (ko) 2006-09-22 2009-05-28 노파르티스 아게 헤테로시클릭 유기 화합물
TWI423972B (zh) * 2006-09-28 2014-01-21 Biota Scient Management 治療呼吸系融合細胞病毒感染之多環劑
KR20090091337A (ko) 2006-12-20 2009-08-27 노파르티스 아게 Scd 억제제로서의 2-치환 5-원 헤테로사이클
TWI508968B (zh) 2010-02-08 2015-11-21 Biota Scient Management 用於治療呼吸道融合性病毒感染的化合物
ES2700542T3 (es) * 2010-06-24 2019-02-18 Gilead Sciences Inc Composición farmacéutica que comprende un derivado de pirazolo[1,5-A]pirimidina como un agente antiviral
AU2015200638B2 (en) * 2010-06-24 2016-11-10 Gilead Sciences, Inc. Pyrazolo [1, 5 -a] pyrimidines as antiviral agents
US8796303B2 (en) 2010-11-26 2014-08-05 Biota Scientific Management Pty Ltd. Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections
US8871756B2 (en) * 2011-08-11 2014-10-28 Hoffmann-La Roche Inc. Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease
BR112014008783A2 (pt) 2011-10-11 2017-04-25 Hoffmann La Roche compostos para o tratamento e profilaxia da doença causada por vírus sincicial respiratório
CN103748098B (zh) * 2011-10-11 2016-06-29 弗·哈夫曼-拉罗切有限公司 用于治疗或预防呼吸道合胞病毒疾病的化合物
GB201119538D0 (en) * 2011-11-10 2011-12-21 Viral Ltd Pharmaceutical compounds
PT2794611T (pt) 2011-12-22 2017-12-06 Gilead Sciences Inc Pirazolo[1,5-a]pirimidinas como agentes antivirais
IN2014DN09173A (xx) 2012-04-17 2015-07-10 Gilead Sciences Inc
CN104311559A (zh) * 2014-09-12 2015-01-28 中山大学 一类光学纯手性环状n,n-缩醛的合成方法
WO2016057931A1 (en) 2014-10-10 2016-04-14 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
WO2016133888A1 (en) * 2015-02-16 2016-08-25 Biota Pharmaceuticals, Inc. Compounds for treating respiratory syncytial virus infections
JO3637B1 (ar) 2015-04-28 2020-08-27 Janssen Sciences Ireland Uc مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv
JP6749343B2 (ja) 2015-05-20 2020-09-02 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 脊髄性筋萎縮症を処置するための化合物
CN108290882B (zh) 2015-07-16 2021-07-06 豪夫迈·罗氏有限公司 用于治疗呼吸道合胞病毒感染的4-喹唑啉胺衍生物的晶形
EA036399B1 (ru) 2015-11-12 2020-11-06 Ф. Хоффманн-Ля Рош Аг Композиции для лечения спинальной мышечной атрофии
JP2019500352A (ja) 2015-12-10 2019-01-10 ピーティーシー セラピューティクス, インコーポレイテッド ハンチントン病の治療方法
WO2017097728A1 (en) 2015-12-10 2017-06-15 F. Hoffmann-La Roche Ag Bridged piperidine derivatives
CA3023922C (en) * 2016-05-10 2023-04-18 Georgia State University Research Foundation, Inc. Heterocyclic derivatives for the treatment of rsv
BR112019025740A2 (pt) 2017-06-05 2020-06-23 Ptc Therapeutics, Inc. Compostos para tratar a doença de huntington
CN110891592A (zh) 2017-06-14 2020-03-17 维罗米蒂克斯股份公司 用于保护免受呼吸道合胞病毒的环状肽
CA3067592A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. Methods for treating huntington's disease
US11382918B2 (en) 2017-06-28 2022-07-12 Ptc Therapeutics, Inc. Methods for treating Huntington's Disease
TW201932470A (zh) 2017-11-29 2019-08-16 愛爾蘭商健生科學愛爾蘭無限公司 具有抗rsv活性之吡唑并嘧啶
US11491157B2 (en) 2018-01-31 2022-11-08 Janssen Sciences Ireland Unlimited Company Co Cork, IE Cycloalkyl substituted pyrazolopyrimidines having activity against RSV
US11760701B2 (en) 2018-02-27 2023-09-19 The Research Foundation For The State University Of New Yrok Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same
MX2020009957A (es) 2018-03-27 2021-01-15 Ptc Therapeutics Inc Compuestos para el tratamiento de enfermedad de hungtinton.
WO2019206828A1 (en) 2018-04-23 2019-10-31 Janssen Sciences Ireland Unlimited Company Heteroaromatic compounds having activity against rsv
US11858941B2 (en) 2018-06-27 2024-01-02 Ptc Therapeutics, Inc. Heterocyclic and heteroaryl compounds for treating Huntington's disease
WO2020005882A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
CN108997354B (zh) * 2018-08-08 2021-12-31 青岛大学附属医院 二氢嘧啶并异吲哚酮类化合物及其乳膏剂和在治疗高尿酸血症中的用途

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1058529A (en) 1910-12-24 1913-04-08 Harry T Hickey Car-door.
NL137586C (xx) 1963-04-11
US3507863A (en) 1963-12-18 1970-04-21 Sandoz Ag Isoindolones and method for preparing same
NL126596C (xx) * 1964-02-11
NL129866C (xx) 1965-09-21
CH480350A (de) 1965-09-21 1969-10-31 Geigy Ag J R Verfahren zur Herstellung von neuen, kondensierten heterocyclischen Verbindungen
US3379733A (en) 1965-12-07 1968-04-23 Sandoz Ag N-(omega-aminoalkyl)isoindoles and method for preparing same
CH481123A (de) 1966-09-21 1969-11-15 Geigy Ag J R Verfahren zur Herstellung von neuen, kondensierten heterocyclischen Verbindungen
JPS4939677B1 (xx) 1967-03-14 1974-10-28
CH482697A (de) 1967-03-17 1969-12-15 Geigy Ag J R Verfahren zur Herstellung von neuen, kondensierten heterocyclischen Verbindungen
US3935218A (en) 1968-09-05 1976-01-27 American Home Products Corporation Imidazolinyl phenyl carbonyl compounds acid addition salts and related compounds
US3885037A (en) 1968-09-05 1975-05-20 American Home Prod Method of producing anorexia using imidazolinyl phenyl carbonyl compounds, their acid addition salts and related compounds
US3657221A (en) * 1969-02-19 1972-04-18 American Home Prod Process for preparing 9b-substituted-1 - sulfonyl - 1 2 3 9b - tetrahydro-5h-imidazo(2 1-a)isoindol-5-ones
US3770766A (en) 1970-03-10 1973-11-06 American Home Prod 2-(2-amino-2,2-dialkylamino-3-hydroxy-3-phenyl-1h-benz(f)isoindole-1-ones
GB1322339A (en) 1970-03-10 1973-07-04 American Home Prod Imidazoline derivatives
US3624101A (en) 1970-03-10 1971-11-30 American Home Prod 2,3-DIHYDRO-5-ARYL-5H-BENZ{8 f{9 IMIDAZO{8 2,1-a{9 ISOINDOL-5-OLS
US3966955A (en) 1974-08-07 1976-06-29 American Home Products Corporation Anti-ulcer therapy
US4056536A (en) 1976-06-29 1977-11-01 Merck & Co., Inc. Pyrrolo[2,1-b][3]benzazepines
US4258529A (en) * 1978-07-21 1981-03-31 Phillips Petroleum Company Method of sealing a container
US4701208A (en) 1983-08-02 1987-10-20 American Cyanamid Company Dihydroimidazopyrrolopyridine, quinoline, thieno- and furo[2,3-b]pyridine, dihydrothieno- and furo[2,3-b]-pyridine, thieno- and furo[3,2-b]pyridine and dihydrothieno- and furo[3,2-b]pyridine herbicides and method for preparation thereof
DE3520390A1 (de) 1984-07-07 1986-02-06 Bayer Ag, 5090 Leverkusen Imidazo-pyrrolo-pyridin-derivate
EP0183993A3 (de) 1984-11-16 1987-12-09 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 2H-Imidazo[1',2':1,2]pyrrolo[3,4-b]pyridine und deren Verwendung als Unkrautbekämpfungsmittel
DE3674028D1 (de) 1985-03-12 1990-10-18 Ciba Geigy Ag Heterocyclisch kondensierte pyridin-verbindungen als herbizide.
DE3534948A1 (de) 1985-10-01 1987-04-09 Bayer Ag Fungizide und wachstumsregulatorische mittel
US4717414A (en) 1986-08-08 1988-01-05 Ppg Industries, Inc. Herbicidally active imidazopyrrolo-pyridine (or benzene) derivatives
DE3634952A1 (de) 1986-10-14 1988-04-21 Bayer Ag Imidazo-pyrrolo-pyridin-derivate
EP0475908A1 (de) 1990-09-14 1992-03-18 Ciba-Geigy Ag Chromogene Lactamverbindungen und ihre Herstellung und Verwendung
DE4103177A1 (de) 1991-02-02 1992-08-06 Boehringer Mannheim Gmbh Thiazolo-(2,3-a)isoindol-derivate und diese enthaltende arzneimittel
AU1251192A (en) * 1991-02-28 1992-10-06 Boehringer Mannheim Gmbh Use of tricyclic isoindolinones as antiviral drugs, and new, optically active isoindolinones
DE4108395A1 (de) 1991-03-15 1993-01-28 Boehringer Mannheim Gmbh Verwendung von oxazolo-(2,3-a)isoindol-und imidazo(2,1-a)-isoindol-derivaten als antivirale arzneimittel sowie neue oxazolo(2,3-a)isoindol-derivaten
DE4129779A1 (de) 1991-09-07 1993-03-11 Boehringer Mannheim Gmbh Neue tricyclische thiazol- und oxazol-derivate und diese enthaltende arzneimittel
ATE316089T1 (de) 1999-08-25 2006-02-15 Banyu Pharma Co Ltd Isoindolderivate
US6489338B2 (en) 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
US6506738B1 (en) * 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
AU2002223275A1 (en) 2000-11-22 2002-06-03 Biota Scientific Management Pty Ltd A method of expression and agents identified thereby
WO2002066479A1 (fr) * 2001-02-23 2002-08-29 Banyu Pharmaceutical Co.,Ltd. Derives de l'isoindole
JP2002310962A (ja) * 2001-04-19 2002-10-23 Hitachi Ltd 画像分類方法並びに観察方法及びその装置
AUPR878401A0 (en) 2001-11-09 2001-12-06 Biota Holdings Ltd Methods for identifying or screening anti-viral agents
EP2287167A1 (en) 2003-12-24 2011-02-23 Biota Scientific Management Pty. Ltd. Polycyclic agents for the treatment of respiratory syncytial virus infections
SI3045206T1 (en) 2005-04-28 2018-07-31 Viiv Healthcare Company A polycyclic carbamoylpyridone derivative with inhibitory activity for the HIV integrase
TWI423972B (zh) 2006-09-28 2014-01-21 Biota Scient Management 治療呼吸系融合細胞病毒感染之多環劑

Also Published As

Publication number Publication date
IL176155A0 (en) 2006-10-05
CN1898247A (zh) 2007-01-17
CN100582109C (zh) 2010-01-20
NO20062758L (no) 2006-07-17
EP1697377A1 (en) 2006-09-06
EP1697377A4 (en) 2008-03-19
KR20060127909A (ko) 2006-12-13
CA2551178C (en) 2012-11-06
ES2360222T3 (es) 2011-06-02
NZ551468A (en) 2010-05-28
JP5384793B2 (ja) 2014-01-08
CA2551178A1 (en) 2005-07-07
JP2012246318A (ja) 2012-12-13
ZA200604528B (en) 2007-06-27
WO2005061513A1 (en) 2005-07-07
JP5536842B2 (ja) 2014-07-02
DE602004031258D1 (de) 2011-03-10
US20140051689A1 (en) 2014-02-20
US8598193B2 (en) 2013-12-03
CN101723949B (zh) 2013-10-23
US20070287700A1 (en) 2007-12-13
RU2422444C2 (ru) 2011-06-27
CN101723949A (zh) 2010-06-09
ATE496920T1 (de) 2011-02-15
BRPI0418127A (pt) 2007-04-27
EP1697377B1 (en) 2011-01-26
EP2287167A1 (en) 2011-02-23
RU2006126663A (ru) 2008-01-27
JP2007516983A (ja) 2007-06-28

Similar Documents

Publication Publication Date Title
IL176155A0 (en) Polycyclic agents for the treatment of respiratory syncytial virus infections
AP1753A (en) Thiophene derivatives as antiviral agents for flavvivirus infection
MX2007004979A (es) Derivados de indol tetraciclicos como agentes antiviricos.
CY1112254T1 (el) Αρυλικοι φωσφοραμιδικοι εστερες νουκλεοζιτων και οι χρησεις τους ως αντι-ιικοι παραγοντες για την αντιμετωπιση του ιου της ηπατιτιδας c
CY1109183T1 (el) Συντηγμενες ετεροκυκλικες ενωσεις και χρηση αυτων ως αναστολεας hcv πολυμερασης
DE602005023015D1 (de) Indolderivate als viruzide
WO2006027628A3 (en) Naphthalimide derivatives as antiviral agents
EP2041159B8 (en) Macrocyclic compounds as antiviral agents
DK2314582T3 (da) Heterocykliske forbindelser som antivirusmidler
WO2008114819A1 (ja) 新規アデニン化合物
BRPI0409938A (pt) derivados de azetidinacarboxamida e seu uso em terapia
RS54260B1 (en) AMINODIHYDROTIAZINE DERIVATIVES AS BACE INHIBITORS FOR ALZHEIMER DISEASE TREATMENT
MY141789A (en) Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
NZ609146A (en) Modified 4’-nucleosides as antiviral agents
HRP20110726T1 (en) Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity
MX2010001566A (es) Derivado de aminopirazolamida.
ATE523498T1 (de) Hiv-inhibierende 2-(4- cyanophenylamino)pyrimidinderivate
BR112012013861A2 (pt) ibidores da cisteína protease
IL160874A0 (en) 4-imidazolin-2-one derivatives
WO2007092558A3 (en) Sulfonamide derivatives to treat infection with hepatitis c virus
EA200700322A1 (ru) Оксазолидиноны, содержащие оксиндолы, в качестве антибактериальных агентов
EP1908755A4 (en) THERAPEUTIC AGENT AGAINST RESTENOSIS
NO20075505L (no) 7-fluor-1,3-dihydro-indol-2-on oksazolidinoner som antibakterielle forbindelser
NO20075547L (no) Et oksindol oksazolidinon som et antibakterielt middel
UA96296C2 (xx) Піридазинові сполуки і їх застосування[пиридазиновые соединения и их применение

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20141224