CY1112254T1 - Αρυλικοι φωσφοραμιδικοι εστερες νουκλεοζιτων και οι χρησεις τους ως αντι-ιικοι παραγοντες για την αντιμετωπιση του ιου της ηπατιτιδας c - Google Patents

Αρυλικοι φωσφοραμιδικοι εστερες νουκλεοζιτων και οι χρησεις τους ως αντι-ιικοι παραγοντες για την αντιμετωπιση του ιου της ηπατιτιδας c

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Publication number
CY1112254T1
CY1112254T1 CY20111100875T CY111100875T CY1112254T1 CY 1112254 T1 CY1112254 T1 CY 1112254T1 CY 20111100875 T CY20111100875 T CY 20111100875T CY 111100875 T CY111100875 T CY 111100875T CY 1112254 T1 CY1112254 T1 CY 1112254T1
Authority
CY
Cyprus
Prior art keywords
virus
treatment
phosphoramide
aryl
viral agents
Prior art date
Application number
CY20111100875T
Other languages
English (en)
Inventor
Christopher Mcguigan
Plinio Perrone
Original Assignee
University College Cardiff Consultants Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College Cardiff Consultants Limited filed Critical University College Cardiff Consultants Limited
Publication of CY1112254T1 publication Critical patent/CY1112254T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Φωσφοραμιδικά παράγωγα νουκλεοζιτικών ενώσεων προερχόμενων από βάσεις όπως αδενίνη και γουανίνη έχουν ενισχυμένη θεραπευτική ισχύ, συγκεκριμένα ενισχυμένη ισχύ όσον αφορά την προφύλαξη ή αντιμετώπιση μιας ιικής μόλυνσης όπως από ιό της ηπατίτιδας C. Το γλυκοζιτικό τμήμα της νουκλεοζιτικής ένωσης είναι κατάλληλα υποκατεστημένο στην β-2' θέση με μεθύλιο και η φωσφοραμιδική ομάδα καταλλήλως περιλαμβάνει 1-ναφθύλιο συνδεδεμένο μέσω -Ο- με το Ρ άτομο.
CY20111100875T 2006-11-24 2011-09-13 Αρυλικοι φωσφοραμιδικοι εστερες νουκλεοζιτων και οι χρησεις τους ως αντι-ιικοι παραγοντες για την αντιμετωπιση του ιου της ηπατιτιδας c CY1112254T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0623493.4A GB0623493D0 (en) 2006-11-24 2006-11-24 Chemical compounds
EP07824684A EP2097434B1 (en) 2006-11-24 2007-11-23 Nucleoside aryl phosphoramidates and their use as anti-viral agents for the treatment of hepatitis c virus

Publications (1)

Publication Number Publication Date
CY1112254T1 true CY1112254T1 (el) 2015-12-09

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100875T CY1112254T1 (el) 2006-11-24 2011-09-13 Αρυλικοι φωσφοραμιδικοι εστερες νουκλεοζιτων και οι χρησεις τους ως αντι-ιικοι παραγοντες για την αντιμετωπιση του ιου της ηπατιτιδας c

Country Status (26)

Country Link
US (1) US8658616B2 (el)
EP (2) EP2412717A1 (el)
JP (1) JP5271913B2 (el)
KR (1) KR20090114356A (el)
CN (1) CN101547932B (el)
AT (1) ATE512973T1 (el)
AU (1) AU2007323220B2 (el)
CA (1) CA2670328C (el)
CO (1) CO6230992A2 (el)
CY (1) CY1112254T1 (el)
DK (1) DK2097434T3 (el)
EC (1) ECSP099462A (el)
ES (1) ES2368012T3 (el)
GB (1) GB0623493D0 (el)
IL (1) IL198610A (el)
MX (1) MX2009005120A (el)
MY (1) MY145856A (el)
NO (1) NO20092399L (el)
NZ (2) NZ577152A (el)
PL (1) PL2097434T3 (el)
PT (1) PT2097434E (el)
RU (1) RU2464272C2 (el)
SG (1) SG171596A1 (el)
SI (1) SI2097434T1 (el)
WO (1) WO2008062206A2 (el)
ZA (1) ZA200904031B (el)

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SG171596A1 (en) 2011-06-29
RU2009123104A (ru) 2010-12-27
DK2097434T3 (da) 2011-08-29
MX2009005120A (es) 2009-09-23
EP2097434B1 (en) 2011-06-15
NZ593712A (en) 2012-09-28
CN101547932B (zh) 2014-04-16
NZ577152A (en) 2012-01-12
AU2007323220B2 (en) 2012-09-06
IL198610A0 (en) 2010-02-17
ATE512973T1 (de) 2011-07-15
ZA200904031B (en) 2010-04-28
PT2097434E (pt) 2011-09-07
NO20092399L (no) 2009-06-24
ES2368012T3 (es) 2011-11-11
ECSP099462A (es) 2009-08-28
JP5271913B2 (ja) 2013-08-21
CO6230992A2 (es) 2010-12-20
KR20090114356A (ko) 2009-11-03
JP2010510301A (ja) 2010-04-02
US20110124592A1 (en) 2011-05-26
EP2097434A2 (en) 2009-09-09
RU2464272C2 (ru) 2012-10-20
EP2412717A1 (en) 2012-02-01
WO2008062206A8 (en) 2011-11-10
IL198610A (en) 2013-11-28
SI2097434T1 (sl) 2011-10-28
PL2097434T3 (pl) 2011-11-30
CA2670328A1 (en) 2008-05-29
CN101547932A (zh) 2009-09-30
WO2008062206A3 (en) 2008-07-10
MY145856A (en) 2012-04-30
AU2007323220A1 (en) 2008-05-29
GB0623493D0 (en) 2007-01-03
CA2670328C (en) 2013-09-24
US8658616B2 (en) 2014-02-25
WO2008062206A2 (en) 2008-05-29

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