DK2097434T3 - Nukleosidarylphosphoramidater og deres anvendelse som antivirale midler til behandlingen af hepatitis C virus - Google Patents

Nukleosidarylphosphoramidater og deres anvendelse som antivirale midler til behandlingen af hepatitis C virus

Info

Publication number
DK2097434T3
DK2097434T3 DK07824684.0T DK07824684T DK2097434T3 DK 2097434 T3 DK2097434 T3 DK 2097434T3 DK 07824684 T DK07824684 T DK 07824684T DK 2097434 T3 DK2097434 T3 DK 2097434T3
Authority
DK
Denmark
Prior art keywords
hepatitis
virus
treatment
nucleosidaryl
phosphoramidates
Prior art date
Application number
DK07824684.0T
Other languages
English (en)
Inventor
Christopher Mcguigan
Plinio Perrone
Original Assignee
Univ Cardiff
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cardiff, Univ Leuven Kath filed Critical Univ Cardiff
Application granted granted Critical
Publication of DK2097434T3 publication Critical patent/DK2097434T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
DK07824684.0T 2006-11-24 2007-11-23 Nukleosidarylphosphoramidater og deres anvendelse som antivirale midler til behandlingen af hepatitis C virus DK2097434T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0623493.4A GB0623493D0 (en) 2006-11-24 2006-11-24 Chemical compounds
PCT/GB2007/004480 WO2008062206A2 (en) 2006-11-24 2007-11-23 Nucleoside aryl phosphoramidates and their use as anti-viral agents for the treatment of hepatitis c virus

Publications (1)

Publication Number Publication Date
DK2097434T3 true DK2097434T3 (da) 2011-08-29

Family

ID=37636469

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07824684.0T DK2097434T3 (da) 2006-11-24 2007-11-23 Nukleosidarylphosphoramidater og deres anvendelse som antivirale midler til behandlingen af hepatitis C virus

Country Status (26)

Country Link
US (1) US8658616B2 (da)
EP (2) EP2412717A1 (da)
JP (1) JP5271913B2 (da)
KR (1) KR20090114356A (da)
CN (1) CN101547932B (da)
AT (1) ATE512973T1 (da)
AU (1) AU2007323220B2 (da)
CA (1) CA2670328C (da)
CO (1) CO6230992A2 (da)
CY (1) CY1112254T1 (da)
DK (1) DK2097434T3 (da)
EC (1) ECSP099462A (da)
ES (1) ES2368012T3 (da)
GB (1) GB0623493D0 (da)
IL (1) IL198610A (da)
MX (1) MX2009005120A (da)
MY (1) MY145856A (da)
NO (1) NO20092399L (da)
NZ (2) NZ577152A (da)
PL (1) PL2097434T3 (da)
PT (1) PT2097434E (da)
RU (1) RU2464272C2 (da)
SG (1) SG171596A1 (da)
SI (1) SI2097434T1 (da)
WO (1) WO2008062206A2 (da)
ZA (1) ZA200904031B (da)

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Also Published As

Publication number Publication date
EP2412717A1 (en) 2012-02-01
WO2008062206A2 (en) 2008-05-29
AU2007323220B2 (en) 2012-09-06
EP2097434A2 (en) 2009-09-09
CA2670328A1 (en) 2008-05-29
GB0623493D0 (en) 2007-01-03
US20110124592A1 (en) 2011-05-26
ATE512973T1 (de) 2011-07-15
SI2097434T1 (sl) 2011-10-28
MY145856A (en) 2012-04-30
CN101547932B (zh) 2014-04-16
CY1112254T1 (el) 2015-12-09
RU2009123104A (ru) 2010-12-27
IL198610A (en) 2013-11-28
PT2097434E (pt) 2011-09-07
ES2368012T3 (es) 2011-11-11
WO2008062206A3 (en) 2008-07-10
NZ593712A (en) 2012-09-28
KR20090114356A (ko) 2009-11-03
ECSP099462A (es) 2009-08-28
CO6230992A2 (es) 2010-12-20
JP5271913B2 (ja) 2013-08-21
PL2097434T3 (pl) 2011-11-30
AU2007323220A1 (en) 2008-05-29
NO20092399L (no) 2009-06-24
CA2670328C (en) 2013-09-24
MX2009005120A (es) 2009-09-23
RU2464272C2 (ru) 2012-10-20
US8658616B2 (en) 2014-02-25
SG171596A1 (en) 2011-06-29
IL198610A0 (en) 2010-02-17
ZA200904031B (en) 2010-04-28
EP2097434B1 (en) 2011-06-15
JP2010510301A (ja) 2010-04-02
CN101547932A (zh) 2009-09-30
WO2008062206A8 (en) 2011-11-10
NZ577152A (en) 2012-01-12

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