EA200900156A1 - Пиридазиновое соединение (варианты), способ его получения (варианты), способ лечения или профилактики инфекционного вирусного гепатита с с его помощью, композиция и лекарственное средство на его основе - Google Patents

Пиридазиновое соединение (варианты), способ его получения (варианты), способ лечения или профилактики инфекционного вирусного гепатита с с его помощью, композиция и лекарственное средство на его основе

Info

Publication number
EA200900156A1
EA200900156A1 EA200900156A EA200900156A EA200900156A1 EA 200900156 A1 EA200900156 A1 EA 200900156A1 EA 200900156 A EA200900156 A EA 200900156A EA 200900156 A EA200900156 A EA 200900156A EA 200900156 A1 EA200900156 A1 EA 200900156A1
Authority
EA
Eurasian Patent Office
Prior art keywords
variants
preparation
treatment
hepatitis
prevention
Prior art date
Application number
EA200900156A
Other languages
English (en)
Other versions
EA019452B1 (ru
Inventor
Стивн С. Бонди
Теренс К. Дал
Дэвид А. О
Ризэ Ольяй
Уинстон К. Тсе
Вахид Зиа
Original Assignee
Джилид Сайэнс, Инк.
К.Ю. Левен Рисеч Энд Дивелопмент
Пуэрштингер, Герхард
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Джилид Сайэнс, Инк., К.Ю. Левен Рисеч Энд Дивелопмент, Пуэрштингер, Герхард filed Critical Джилид Сайэнс, Инк.
Publication of EA200900156A1 publication Critical patent/EA200900156A1/ru
Publication of EA019452B1 publication Critical patent/EA019452B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Abstract

Предложено пиридазиновое соединение формулы (1), его соли и сольваты, лечение или профилактика инфекционного вирусного гепатита С с его помощью, а также способы его получения.
EA200900156A 2006-07-07 2007-07-06 5-({6-[2,4-БИС-(ТРИФТОРМЕТИЛ)ФЕНИЛ]ПИРИДАЗИН-3-ИЛ}МЕТИЛ)-2-(2-ФТОРФЕНИЛ)-5Н-ИМИДАЗО[4,5-c]ПИРИДИН, СПОСОБ ЕГО ПОЛУЧЕНИЯ, СПОСОБ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ ИНФЕКЦИОННОГО ВИРУСНОГО ГЕПАТИТА С С ЕГО ПОМОЩЬЮ, КОМПОЗИЦИЯ И ЛЕКАРСТВЕННОЕ СРЕДСТВО НА ЕГО ОСНОВЕ EA019452B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US81928906P 2006-07-07 2006-07-07
US83240306P 2006-07-21 2006-07-21
US83276906P 2006-07-24 2006-07-24
PCT/US2007/015553 WO2008005519A2 (en) 2006-07-07 2007-07-06 Novel pyridazine compound and use thereof

Publications (2)

Publication Number Publication Date
EA200900156A1 true EA200900156A1 (ru) 2009-06-30
EA019452B1 EA019452B1 (ru) 2014-03-31

Family

ID=38814329

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900156A EA019452B1 (ru) 2006-07-07 2007-07-06 5-({6-[2,4-БИС-(ТРИФТОРМЕТИЛ)ФЕНИЛ]ПИРИДАЗИН-3-ИЛ}МЕТИЛ)-2-(2-ФТОРФЕНИЛ)-5Н-ИМИДАЗО[4,5-c]ПИРИДИН, СПОСОБ ЕГО ПОЛУЧЕНИЯ, СПОСОБ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ ИНФЕКЦИОННОГО ВИРУСНОГО ГЕПАТИТА С С ЕГО ПОМОЩЬЮ, КОМПОЗИЦИЯ И ЛЕКАРСТВЕННОЕ СРЕДСТВО НА ЕГО ОСНОВЕ

Country Status (28)

Country Link
US (3) US7754720B2 (ru)
EP (1) EP2038275B1 (ru)
JP (1) JP4958974B2 (ru)
KR (1) KR101143596B1 (ru)
CN (1) CN102617571B (ru)
AP (1) AP3430A (ru)
AR (1) AR061969A1 (ru)
AT (1) ATE454384T1 (ru)
AU (1) AU2007269614B2 (ru)
CA (1) CA2656415C (ru)
CY (1) CY1112107T1 (ru)
DE (1) DE602007004220D1 (ru)
DK (1) DK2038275T3 (ru)
EA (1) EA019452B1 (ru)
ES (1) ES2339298T3 (ru)
HK (1) HK1123803A1 (ru)
HR (2) HRP20090078A2 (ru)
IL (1) IL195528A (ru)
MX (1) MX2009000235A (ru)
NO (1) NO20090595L (ru)
NZ (1) NZ574312A (ru)
PL (1) PL2038275T3 (ru)
PT (1) PT2038275E (ru)
RS (1) RS51336B (ru)
SG (1) SG175604A1 (ru)
SI (1) SI2038275T1 (ru)
TW (1) TWI360549B (ru)
WO (1) WO2008005519A2 (ru)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215293D0 (en) * 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
EP1706403B9 (en) * 2003-12-22 2012-07-25 K.U.Leuven Research & Development Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment
WO2006069193A2 (en) * 2004-12-21 2006-06-29 Gilead Sciences, Inc. Imidazo[4,5-c]pyridine compound and method of antiviral treatment
EP2038275B1 (en) 2006-07-07 2010-01-06 Gilead Sciences, Inc. Novel pyridazine compound and use thereof
DK2094702T3 (en) 2006-12-14 2015-12-07 Gilead Sciences Inc viral inhibitors
UA99466C2 (en) * 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
GB0809314D0 (en) * 2008-05-22 2008-07-02 Summit Corp Plc Compounds for treating muscular dystrophy
US20100324060A1 (en) 2009-06-23 2010-12-23 Gilead Sciences, Inc. Pharmaceutical compositions useful for treating hcv
US20100324059A1 (en) 2009-06-23 2010-12-23 Gilead Sciences, Inc. Pharmaceutical compositions useful for treating hcv
TW201111381A (en) 2009-06-23 2011-04-01 Gilead Sciences Inc Pharmaceutical combinations useful for treating HCV
KR20120106942A (ko) 2009-10-30 2012-09-27 베링거 인겔하임 인터내셔날 게엠베하 Ｂｉ２０１３３５, 인터페론 알파 및 리바비린을 포함하는 ｈｃｖ 병용 치료요법을 위한 투여 용법
AU2010333656B2 (en) * 2009-12-18 2015-08-27 Boehringer Ingelheim International Gmbh HCV combination therapy
CA2797872A1 (en) 2010-05-21 2011-11-24 Gilead Sciences, Inc. Heterocyclic flaviviridae virus inhibitors
WO2011156757A1 (en) * 2010-06-10 2011-12-15 Gilead Sciences, Inc. Combination of anti-hcv compounds with ribavirin for the treatment of hcv
CA2822037A1 (en) 2010-12-20 2012-06-28 Gilead Sciences, Inc. Methods for treating hcv
DK3656393T3 (da) 2011-04-28 2022-11-14 Oncopeptides Ab Lyofiliseret præparat af cytotoksiske dipeptider
MD4589C1 (ru) 2011-09-16 2019-03-31 Gilead Pharmasset Llc Фармацевтическая композиция с содержанием софосбувира и ее использование при лечении вирусного гепатита С
CA2889753C (en) 2012-10-26 2021-03-02 Oncopeptides Ab Lyophilized preparations of melphalan flufenamide
NZ625087A (en) 2013-01-31 2017-05-26 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
DK3236972T3 (en) 2014-12-26 2021-10-04 Univ Emory Antivirale N4-hydroxycytidin-derivativer
SG11202004403QA (en) 2017-12-07 2020-06-29 Univ Emory N4-hydroxycytidine and derivatives and anti-viral uses related thereto

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2191978A (en) 1935-10-10 1940-02-27 Ig Farbenindustrie Ag Quaternary nitrogen compounds and process of preparing them
US2411662A (en) 1943-05-13 1946-11-26 Geigy Ag J R Imino-di-fatty acid amide
US2548863A (en) * 1946-05-29 1951-04-17 Wyeth Corp Substituted glycinamides
US2516674A (en) 1948-10-29 1950-07-25 Wyeth Corp Substituted glycinamide
US3985891A (en) 1973-02-03 1976-10-12 Boehringer Ingelheim Gmbh 2-Phenyl-imidazo (4,5-b)pyridines and salts thereof
SU813921A1 (ru) 1979-10-26 1986-12-23 Институт физико-органической химии и углехимии АН УССР Стирильные производные имидазо(4,5- @ )пиридиний иодида,обладающие фунгицидной активностью
SU851940A1 (ru) 1980-03-20 1988-04-30 Институт физико-органической химии и углехимии АН УССР Четвертичные соли имидазо @ 4,5-с @ пиридини ,обладающие антимикробной и фунгистатической активностью
SU860463A1 (ru) 1980-04-09 1998-05-27 Институт физико-органической химии и углехимии АН Украинской ССР Производные 4-амино-1,3-диметилимидазо [4,5-с] пиридин-2-она, обладающие акарицидным действием
SU1048742A1 (ru) 1981-03-30 1986-12-23 Институт физико-органической химии и углехимии АН УССР 2,4-Дистирилпроизводные имидазо-(4,5- @ )пиридини ,обладающие бактериостатической и фунгистатической активностью
US4358387A (en) 1981-08-10 1982-11-09 Texaco Inc. Cylinder lubricating oil composition
US5137896A (en) 1981-10-01 1992-08-11 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)benzamide derivatives
CA1183847A (en) 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
FR2527608B1 (fr) 1982-05-28 1986-10-10 Sandoz Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments
EP0138552A3 (en) 1983-10-17 1986-03-19 Eli Lilly And Company Improvements on or relating to 3-bicyclicpyridinium-methyl cephalosporins
US4692443A (en) 1983-10-17 1987-09-08 Eli Lilly And Company 3-bicyclicpyridinium-methyl cephalosporins
GB8501542D0 (en) 1985-01-22 1985-02-20 Erba Farmitalia 4 5 6 7-tetrahydro-imidazo(4 5-clpyridine derivatives
GB8530602D0 (en) 1985-12-12 1986-01-22 Fujisawa Pharmaceutical Co Heterocyclic compounds
ES2052544T3 (es) 1986-02-03 1994-07-16 Janssen Pharmaceutica Nv Composiciones anti-histaminicas que contienen n-heterociclil-4-piperidinaminas.
US4804658A (en) * 1986-09-15 1989-02-14 G. D. Searle & Co. Imidazopyridine derivatives and pharmaceutical compositions
IL87149A (en) 1987-07-20 1994-05-30 Merck & Co Inc 6-Piperazinyl derivatives of purine and its 3- and 9-deaza isosteres, their preparation and pharmaceutical compositions containing them
US5057517A (en) 1987-07-20 1991-10-15 Merck & Co., Inc. Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents
US5019581A (en) 1988-03-14 1991-05-28 G. D. Searle & Co. 5-substituted (4,5-c) imidazopyridine compounds which have useful platelet activating factor antagonistic activity
US5227384A (en) * 1988-03-14 1993-07-13 G. D. Searle & Co. 5-substituted [4,5-c] imidazopyridines and pharmaceutical use thereof
US5302601A (en) * 1988-03-14 1994-04-12 G. D. Searle & Co. 5-substituted imidazo[4,5-c]pyridines
US4914108A (en) * 1988-03-14 1990-04-03 G. D. Searle & Co. 5-substituted(4,5-c)imidazopyridine compounds which have useful platelet activating factor antagonistic activity
US5332744A (en) 1989-05-30 1994-07-26 Merck & Co., Inc. Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists
US4990518A (en) 1989-09-13 1991-02-05 G. D. Searle & Co. Pharmacologically active heteroaryl substituted imidazo (4,5-c) pyridines
US4988707A (en) * 1989-09-13 1991-01-29 G. D. Searle & Co. Pharmacologically active phenylalkanoyl substituted imidazo (4,5-C) pyridines
FR2663332B1 (fr) 1990-06-15 1997-11-07 Roussel Uclaf Nouvelles cephalosporines comportant en position 3 un radical propenyle substitue par un ammonium quaternaire, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus.
US5011832A (en) 1990-06-26 1991-04-30 Merck & Co., Inc. 2-biphenyl-carbapenem antibacterial agents
JPH04327587A (ja) 1991-04-26 1992-11-17 Asahi Chem Ind Co Ltd ６’−ｃ−アルキル−３−デアザネプラノシンａ誘導体、その製造法およびその用途
GB9116056D0 (en) 1991-07-24 1991-09-11 British Bio Technology Compounds
US5587372A (en) 1991-12-12 1996-12-24 Roussel Uclaf Cephalosporins
GB9202792D0 (en) 1992-02-11 1992-03-25 British Bio Technology Compounds
DE4211474A1 (de) 1992-04-06 1993-10-07 Merck Patent Gmbh Imidazopyridine
US5208242A (en) 1992-08-26 1993-05-04 G. D. Searle & Co. 5-substituted-4-phenyl-5H-imidazo[4,5-c]pyridine derivatives
DE4230464A1 (de) 1992-09-11 1994-03-17 Merck Patent Gmbh Imidazolderivate
DE4236026A1 (de) 1992-10-24 1994-04-28 Merck Patent Gmbh Imidazopyridine
JP3115455B2 (ja) 1992-12-18 2000-12-04 明治製菓株式会社 新規セファロスポリン誘導体
US5374638A (en) * 1993-03-19 1994-12-20 Merck & Co., Inc. Six membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives used to treat asthma
DE4309969A1 (de) 1993-03-26 1994-09-29 Bayer Ag Substituierte heteroanellierte Imidazole
DE4318813A1 (de) * 1993-06-07 1994-12-08 Merck Patent Gmbh Imidazopyridine
DE4324580A1 (de) * 1993-07-22 1995-01-26 Thomae Gmbh Dr K Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5486525A (en) * 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles
US5563143A (en) 1994-09-21 1996-10-08 Pfizer Inc. Catechol diether compounds as inhibitors of TNF release
US6506876B1 (en) * 1994-10-11 2003-01-14 G.D. Searle & Co. LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
US5585492A (en) 1994-10-11 1996-12-17 G. D. Searle & Co. LTA4 Hydrolase inhibitors
US20100210590A1 (en) * 1995-09-27 2010-08-19 Northwestern University Compositions and treatments for seizure-related disorders
US5939557A (en) * 1996-04-03 1999-08-17 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5854265A (en) * 1996-04-03 1998-12-29 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
US5880140A (en) 1996-04-03 1999-03-09 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
US5883105A (en) 1996-04-03 1999-03-16 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5859035A (en) 1996-04-03 1999-01-12 Merck & Co., Inc. Arylheteroaryl inhibitors of farnesyl-protein transferase
US6080870A (en) 1996-04-03 2000-06-27 Merck & Co., Inc. Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US5872136A (en) 1996-04-03 1999-02-16 Merck & Co., Inc. Arylheteroaryl inhibitors of farnesyl-protein transferase
US5874452A (en) 1996-04-03 1999-02-23 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
US6063930A (en) 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US6329381B1 (en) * 1997-11-28 2001-12-11 Sumitomo Pharmaceuticals Company, Limited Heterocyclic compounds
DE19845153A1 (de) * 1998-10-01 2000-04-06 Merck Patent Gmbh Imidazo[4,5]-pyridin-4-on-derivate
DE19900471A1 (de) 1999-01-08 2000-07-13 Merck Patent Gmbh Imidazo[4,5c]-pyridin-4-on-derivate
WO2000040586A1 (fr) * 1999-01-08 2000-07-13 Chisso Corporation Derives de borane et composes organiques electroluminescents
CA2373073A1 (en) * 1999-05-07 2000-11-16 Takeda Chemical Industries, Ltd. Cyclic compounds and uses thereof
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
US6770666B2 (en) 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
ID30204A (id) 1999-12-27 2001-11-15 Japan Tobacco Inc Senyawa-senyawa cincin terfusi dan penggunaannya sebagai obat
US6376515B2 (en) * 2000-02-29 2002-04-23 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor Xa
EP1132381A1 (en) 2000-03-08 2001-09-12 Cermol S.A. Ester derivatives of dimethylpropionic acid and pharmaceutical compositions containing them
US6448281B1 (en) * 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
CA2444130C (en) 2001-04-17 2010-12-21 Sumitomo Pharmaceuticals Company, Limited Adenine derivatives
AR035543A1 (es) 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
US20030073836A1 (en) 2001-07-05 2003-04-17 Boehringer Ingelheim Pharma Kg Heteroarylcarboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions
US7294457B2 (en) 2001-08-07 2007-11-13 Boehringer Ingelheim (Canada) Ltd. Direct binding assay for identifying inhibitors of HCV polymerase
DE10140246A1 (de) * 2001-08-09 2003-03-06 Forsch Pigmente Und Lacke E V Verfahren zur Behandlung von Oberflächen von Substraten
EP1429759A4 (en) 2001-09-26 2004-12-15 Bristol Myers Squibb Co COMPOUNDS FOR TREATING HEPATITIS C VIRUS
EP1465613A2 (de) 2002-01-10 2004-10-13 Boehringer Ingelheim Pharma GmbH & Co. KG KOMBINATION VON MTP INHIBITOREN ODER apoB-SEKRETIONS-INHIBITOREN MIT FIBRATEN ZUR VERWENDUNG ALS ARZNEIMITTEL
GB0215293D0 (en) * 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
EP2070539A1 (de) 2002-08-21 2009-06-17 Boehringer Ingelheim Pharma GmbH & Co. KG 8-[3-Amino-Piperidin-1-YL]-Xanthine, deren Herstellung und deren Verwendung als Arzneimittel
CN1678306A (zh) 2002-08-29 2005-10-05 贝林格尔·英格海姆药物公司 在炎性、变应性和增生性疾病中用作糖皮质激素模拟物的3－(磺酰氨基乙基)－吲哚衍生物
AU2003269850A1 (en) 2002-10-08 2004-05-04 Novo Nordisk A/S Hemisuccinate salts of heterocyclic dpp-iv inhibitors
WO2004043913A2 (en) 2002-11-08 2004-05-27 Trimeris, Inc. Hetero-substituted benzimidazole compounds and antiviral uses thereof
CA2509711A1 (en) * 2002-12-13 2004-07-01 Smithkline Beecham Corporation Piperidine derivatives as ccr5 antagonists
US7098231B2 (en) * 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
CA2514612A1 (en) 2003-01-30 2004-08-12 Boehringer Ingelheim Pharmaceuticals, Inc. 2,4-diaminopyrimidine derivatives useful as inhibitors of pkc-theta
US20040171108A1 (en) * 2003-02-07 2004-09-02 Fisher Paul B. Human excitatory amino acid transporter-2 gene promoter and uses thereof
CN1771050A (zh) * 2003-02-07 2006-05-10 益安药业 丙型肝炎丝氨酸蛋白酶的大环抑制剂
US7566707B2 (en) * 2003-06-18 2009-07-28 Boehringer Ingelheim International Gmbh Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions
KR20080042188A (ko) * 2003-11-05 2008-05-14 에프. 호프만-라 로슈 아게 Ｐｐａｒ 작용제로서 페닐 유도체
EP1706403B9 (en) * 2003-12-22 2012-07-25 K.U.Leuven Research & Development Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment
CN101027303A (zh) 2004-07-27 2007-08-29 吉里德科学公司 咪唑并[4，5－d]嘧啶类、其应用和制备方法
EP1791932A1 (en) 2004-09-13 2007-06-06 Ciba Specialty Chemicals Holding Inc. Alkylaminoacetamide lubricant additives
WO2006069193A2 (en) 2004-12-21 2006-06-29 Gilead Sciences, Inc. Imidazo[4,5-c]pyridine compound and method of antiviral treatment
WO2007063744A1 (ja) 2005-11-30 2007-06-07 Fujifilm Corporation 平版刷版の後露光方法、後露光装置、露光装置、露光用器具、現像方法、及び現像装置
CN101004515A (zh) * 2006-01-21 2007-07-25 鸿富锦精密工业（深圳）有限公司 直下式背光模组
EP2038275B1 (en) 2006-07-07 2010-01-06 Gilead Sciences, Inc. Novel pyridazine compound and use thereof
UA99466C2 (en) 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
GB0718575D0 (en) * 2007-09-24 2007-10-31 Angeletti P Ist Richerche Bio Nucleoside derivatives as inhibitors of viral polymerases

Also Published As

Publication number Publication date
AP3430A (en) 2015-09-30
WO2008005519A2 (en) 2008-01-10
NZ574312A (en) 2012-02-24
EP2038275A2 (en) 2009-03-25
CA2656415A1 (en) 2008-01-10
US20080199427A1 (en) 2008-08-21
AP2008004717A0 (en) 2008-12-31
PT2038275E (pt) 2010-04-08
KR20090028813A (ko) 2009-03-19
EP2038275B1 (en) 2010-01-06
HRP20090078A2 (en) 2009-06-30
ATE454384T1 (de) 2010-01-15
JP4958974B2 (ja) 2012-06-20
KR101143596B1 (ko) 2012-05-11
SG175604A1 (en) 2011-11-28
RS51336B (en) 2011-02-28
US7956184B2 (en) 2011-06-07
CA2656415C (en) 2012-05-22
WO2008005519A3 (en) 2008-04-24
DE602007004220D1 (de) 2010-02-25
IL195528A (en) 2014-07-31
IL195528A0 (en) 2009-09-01
US20100063059A1 (en) 2010-03-11
TWI360549B (en) 2012-03-21
CY1112107T1 (el) 2015-11-04
CN102617571B (zh) 2015-06-10
PL2038275T3 (pl) 2010-08-31
EA019452B1 (ru) 2014-03-31
US7754720B2 (en) 2010-07-13
AU2007269614A1 (en) 2008-01-10
CN102617571A (zh) 2012-08-01
AR061969A1 (es) 2008-08-10
NO20090595L (no) 2009-04-07
JP2009542692A (ja) 2009-12-03
US8569487B2 (en) 2013-10-29
AU2007269614B2 (en) 2011-09-08
HK1123803A1 (en) 2009-06-26
SI2038275T1 (sl) 2010-06-30
HRP20100180T1 (hr) 2010-06-30
DK2038275T3 (da) 2010-05-10
ES2339298T3 (es) 2010-05-18
TW200811180A (en) 2008-03-01
MX2009000235A (es) 2009-01-23
US20100152444A1 (en) 2010-06-17

Similar Documents

Publication Publication Date Title
EA200900156A1 (ru) Пиридазиновое соединение (варианты), способ его получения (варианты), способ лечения или профилактики инфекционного вирусного гепатита с с его помощью, композиция и лекарственное средство на его основе
EA201270275A1 (ru) Кристаллическое соединение пиридазина
EA200800932A1 (ru) Модифицированные 4`-нуклеозиды в качестве противовирусных агентов
EA200500584A1 (ru) Нуклеозидные производные для лечения инфекционных заболеваний, вызванных вирусом гепатита c
EA200901241A1 (ru) Соединения для лечения гепатита с
WO2006027628A3 (en) Naphthalimide derivatives as antiviral agents
EP2041159B8 (en) Macrocyclic compounds as antiviral agents
TW200602064A (en) Nucleoside derivatives for treating hepatitis C virus infection
ATE530561T1 (de) 3-ether- und 3-thioether-substituierte ciclosporinderivate zur behandlung und prävention einer hepatitis-c-infektion
TW200730478A (en) N-(6-membered aromatic ring)-amido anti-viral compounds
MX2010001733A (es) Compustos de imidazo[1,2-a]pirazina para tratamiento de infecciones virales tales como hepatitis.
WO2005084192A3 (en) Novel 2’-c-methyl nucleoside derivatives
NO341663B1 (no) Cyklopropyl-kondenserte indolobenzaepin HCV NS5B inhibitorer
TW200745035A (en) Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
MY159958A (en) 5,5-fused arylene or heteroarylene hepatitis c virus inhibitors
EA201200890A1 (ru) Комбинированная терапия hcv
BR0309581A (pt) Derivados de nucleosìdeo para tratamento de infecção por vìrus de hepatite c
EA201170241A1 (ru) Макроциклические хиноксалиновые соединения в качестве ингибиторов протеазы вгс ns3
EA201000201A1 (ru) Азотсодержащие бициклические химические вещества для лечения вирусных инфекций
EA200970805A1 (ru) Ингибиторы серинпротеаз для лечения hcv инфекций
MX337050B (es) Compuestos 4'-azido-nucleósidos como anti-vhc.
EA201100795A1 (ru) Фармацевтическая композиция эффективного ингибитора всг для перорального введения
DK1569929T3 (da) Forbindelser og fremgangsmåder til behandling eller forebyggelse af flavi-virusinfektioner
WO2007084435A8 (en) Methods for treating hepatitis c
EA201000277A1 (ru) Соединения для лечения гепатита с

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU