WO2007084435A8 - Methods for treating hepatitis c - Google Patents

Methods for treating hepatitis c Download PDF

Info

Publication number
WO2007084435A8
WO2007084435A8 PCT/US2007/000996 US2007000996W WO2007084435A8 WO 2007084435 A8 WO2007084435 A8 WO 2007084435A8 US 2007000996 W US2007000996 W US 2007000996W WO 2007084435 A8 WO2007084435 A8 WO 2007084435A8
Authority
WO
WIPO (PCT)
Prior art keywords
methods
treating hepatitis
compounds
compositions
virus
Prior art date
Application number
PCT/US2007/000996
Other languages
French (fr)
Other versions
WO2007084435A2 (en
WO2007084435A3 (en
Inventor
Gary Mitchell Karp
Peter Seongwoo Hwang
James Jan Takasugi
Hongyu Ren
Richard Gerald Wilde
Anthony Allan Turpoff
Alexander Arefolov
Guangming Chen
Jeffrey Allen Campbell
Chunshi Li
Steven Paget
Nanjing Zhang
Xiaoyan Zhang
Jin Zhu
Original Assignee
Ptc Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/331,180 external-priority patent/US7868037B2/en
Application filed by Ptc Therapeutics, Inc. filed Critical Ptc Therapeutics, Inc.
Priority to CA002636916A priority Critical patent/CA2636916A1/en
Priority to EP07716610A priority patent/EP1979315A2/en
Priority to JP2008550455A priority patent/JP2009523732A/en
Publication of WO2007084435A2 publication Critical patent/WO2007084435A2/en
Publication of WO2007084435A3 publication Critical patent/WO2007084435A3/en
Publication of WO2007084435A8 publication Critical patent/WO2007084435A8/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
PCT/US2007/000996 2006-01-13 2007-01-16 Methods for treating hepatitis c WO2007084435A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002636916A CA2636916A1 (en) 2006-01-13 2007-01-16 Methods for treating hepatitis c
EP07716610A EP1979315A2 (en) 2006-01-13 2007-01-16 Methods for treating hepatitis c
JP2008550455A JP2009523732A (en) 2006-01-13 2007-01-16 Treatment method for hepatitis C

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US75852706P 2006-01-13 2006-01-13
US50/758,527 2006-01-13
US11/331,180 US7868037B2 (en) 2004-07-14 2006-01-13 Methods for treating hepatitis C
US11/331,180 2006-01-13
US60/758,527 2006-01-13
US92148307P 2007-01-13 2007-01-13
US11/653,435 2007-01-13
US60/921,483 2007-01-13

Publications (3)

Publication Number Publication Date
WO2007084435A2 WO2007084435A2 (en) 2007-07-26
WO2007084435A3 WO2007084435A3 (en) 2007-11-08
WO2007084435A8 true WO2007084435A8 (en) 2009-11-12

Family

ID=38283923

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/000996 WO2007084435A2 (en) 2006-01-13 2007-01-16 Methods for treating hepatitis c

Country Status (2)

Country Link
JP (1) JP2009523732A (en)
WO (1) WO2007084435A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8546420B2 (en) 2006-12-22 2013-10-01 Merck Sharp & Dohme Corp. 4, 5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections
RU2009127855A (en) 2006-12-22 2011-01-27 Шеринг Корпорейшн (US) 4,5 CYCLOELNELED DERIVATIVES OF INDOLA FOR TREATMENT OR PREVENTION OF HEPATITIS C VIRUS (HCV) AND RELATED VIRAL INFECTIONS
EP2081922B1 (en) 2006-12-22 2012-02-01 Schering Corporation 5,6-Ring annulated indole derivatives and use thereof
AU2008295485B2 (en) * 2007-08-29 2013-09-05 Merck Sharp & Dohme Corp. 2,3-substituted azaindole derivatives for treating viral infections
RU2010111550A (en) 2007-08-29 2011-10-10 Шеринг Корпорейшн (US) 2,3-SUBSTITUTED INDOLIC DERIVATIVES FOR TREATING VIRAL INFECTIONS
EP2408761B1 (en) 2007-08-29 2014-01-01 Merck Sharp & Dohme Corp. Substituted indole derivatives and methods of use thereof
CA2705587A1 (en) 2007-11-16 2009-05-22 Schering Corporation 3-aminosulfonyl substituted indole derivatives and methods of use thereof
CN102099351A (en) 2007-11-16 2011-06-15 先灵公司 3-heterocyclic substituted indole derivatives and methods of use thereof
EP2303893B1 (en) 2008-06-13 2016-12-07 Merck Sharp & Dohme Corp. Tricyclic indole derivatives
TWI438200B (en) * 2009-02-17 2014-05-21 必治妥美雅史谷比公司 Hepatitis c virus inhibitors
JP5572725B2 (en) * 2010-03-10 2014-08-13 ブリストル−マイヤーズ スクイブ カンパニー Compounds for the treatment of hepatitis C
US10568876B2 (en) 2014-09-05 2020-02-25 Merck Sharp & Dohme Corp. Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
WO2016036636A1 (en) 2014-09-05 2016-03-10 Merck Sharp & Dohme Corp. Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2
US9828369B2 (en) 2014-09-05 2017-11-28 Merck Sharpe & Dohme Corp. Isoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
EP3541376B1 (en) 2016-11-18 2023-04-19 Merck Sharp & Dohme LLC Indole derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2
RU2019117556A (en) 2016-11-18 2020-12-18 Мерк Шарп И Доум Корп. INDAZOL DERIVATIVES SUITABLE AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2
EP3860998B1 (en) 2018-10-05 2023-12-27 Annapurna Bio Inc. Compounds and compositions for treating conditions associated with apj receptor activity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2335700A1 (en) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
EP1554271A1 (en) * 2002-10-15 2005-07-20 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
US7223785B2 (en) * 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7098231B2 (en) * 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
GB0323845D0 (en) * 2003-10-10 2003-11-12 Angeletti P Ist Richerche Bio Chemical compounds,compositions and uses
KR20070083484A (en) * 2004-07-14 2007-08-24 피티씨 테라퓨틱스, 인크. Methods for treating hepatitis c

Also Published As

Publication number Publication date
WO2007084435A2 (en) 2007-07-26
JP2009523732A (en) 2009-06-25
WO2007084435A3 (en) 2007-11-08

Similar Documents

Publication Publication Date Title
WO2007084435A8 (en) Methods for treating hepatitis c
WO2007084413A3 (en) Methods for treating hepatitis c
WO2007041632A3 (en) Methods and pharmaceutical compositions for the treatment and prevention of hepatitis c infection
WO2008127364A3 (en) Antiviral compounds and use thereof
WO2009023179A3 (en) Nitrogen containing bicyclic chemical entities for treating viral infections
WO2006039668A3 (en) 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis c infection
WO2008021927A3 (en) Hepatitis c virus inhibitors
WO2008021936A3 (en) Hepatitis c virus inhibitors
WO2008115281A3 (en) Compounds for treating viral infections
WO2008057871A3 (en) Inhibitors of hepatitis c virus
WO2007041487A3 (en) Viral peptides and their use to inhibit viral infections against viruses of the flaviridae family
TW200602064A (en) Nucleoside derivatives for treating hepatitis C virus infection
WO2008057875A3 (en) Inhibitors of hepatitis c virus
WO2008057873A3 (en) Inhibitors of hepatitis c virus
WO2005115398A3 (en) Hiv integrase inhibitors
WO2007140200A3 (en) Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors
WO2007092888A3 (en) Hcv ns5b inhibitors
WO2008060927A3 (en) Hepatitis c virus inhibitors
TW200745035A (en) Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
WO2007044565A3 (en) Composition and synthesis of new reagents for inhibition of hiv replication
WO2007120595A3 (en) Amines for the treatment of hcv
WO2007070556A3 (en) N-(6-membered aromatic ring)-amido anti-viral compounds
TW200720285A (en) Nucleoside compounds for treating viral infections
BRPI0415883A (en) nucleoside compounds and compositions for the treatment of viral infections
MX2009009473A (en) Compounds for the treatment of hepatitis c.

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200780008916.X

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2636916

Country of ref document: CA

Ref document number: MX/a/2008/009059

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2008550455

Country of ref document: JP

NENP Non-entry into the national phase in:

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007716610

Country of ref document: EP