AR061969A1 - Derivados halogenados de imidazo-piridino, metodo de preparacion, composiciones farmaceuticas que los contienen y usos como agentes anti vhc - Google Patents

Derivados halogenados de imidazo-piridino, metodo de preparacion, composiciones farmaceuticas que los contienen y usos como agentes anti vhc

Info

Publication number
AR061969A1
AR061969A1 ARP070103028A ARP070103028A AR061969A1 AR 061969 A1 AR061969 A1 AR 061969A1 AR P070103028 A ARP070103028 A AR P070103028A AR P070103028 A ARP070103028 A AR P070103028A AR 061969 A1 AR061969 A1 AR 061969A1
Authority
AR
Argentina
Prior art keywords
imidazo
piridino
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
ARP070103028A
Other languages
English (en)
Original Assignee
Gilead Sciences Inc
Leuven K U Res & Dev
Puerstinger Gerhard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc, Leuven K U Res & Dev, Puerstinger Gerhard filed Critical Gilead Sciences Inc
Publication of AR061969A1 publication Critical patent/AR061969A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Reivindicación 1: Un método para preparar un compuesto de fórmula (1) que comprende (a) hacer reaccionar 5-[6-cloro-piridazin-3-ilmetil]-2-(fluoro-fenil)-5H-imidazo[4,5-c]piridina con ácido 2,4-bis(trifluorometil)fenilborónico en presencia de un solvente que tiene la estructura R¹OR²O(R⁴O)ₐR³ donde cada R¹, R², R³ y R⁴ se seleccionan en forma independiente de alquilo C₁₋₆ y a es 0 ó 1, y (b) recuperar el compuesto (1). Reivindicación 5: Un compuesto que tiene la fórmula (1) y las sales y solvatos del mismo.
ARP070103028A 2006-07-07 2007-07-06 Derivados halogenados de imidazo-piridino, metodo de preparacion, composiciones farmaceuticas que los contienen y usos como agentes anti vhc AR061969A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81928906P 2006-07-07 2006-07-07
US83240306P 2006-07-21 2006-07-21
US83276906P 2006-07-24 2006-07-24

Publications (1)

Publication Number Publication Date
AR061969A1 true AR061969A1 (es) 2008-08-10

Family

ID=38814329

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070103028A AR061969A1 (es) 2006-07-07 2007-07-06 Derivados halogenados de imidazo-piridino, metodo de preparacion, composiciones farmaceuticas que los contienen y usos como agentes anti vhc

Country Status (28)

Country Link
US (3) US7754720B2 (es)
EP (1) EP2038275B1 (es)
JP (1) JP4958974B2 (es)
KR (1) KR101143596B1 (es)
CN (1) CN102617571B (es)
AP (1) AP3430A (es)
AR (1) AR061969A1 (es)
AT (1) ATE454384T1 (es)
AU (1) AU2007269614B2 (es)
CA (1) CA2656415C (es)
CY (1) CY1112107T1 (es)
DE (1) DE602007004220D1 (es)
DK (1) DK2038275T3 (es)
EA (1) EA019452B1 (es)
ES (1) ES2339298T3 (es)
HK (1) HK1123803A1 (es)
HR (2) HRP20090078A2 (es)
IL (1) IL195528A (es)
MX (1) MX2009000235A (es)
NO (1) NO20090595L (es)
NZ (1) NZ574312A (es)
PL (1) PL2038275T3 (es)
PT (1) PT2038275E (es)
RS (1) RS51336B (es)
SG (1) SG175604A1 (es)
SI (1) SI2038275T1 (es)
TW (1) TWI360549B (es)
WO (1) WO2008005519A2 (es)

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CN102596201A (zh) 2009-10-30 2012-07-18 贝林格尔.英格海姆国际有限公司 包含BI201335、干扰素α和利巴韦林的HCV组合治疗的用药方案
CN102753173A (zh) * 2009-12-18 2012-10-24 贝林格尔.英格海姆国际有限公司 Hcv组合疗法
CA2797872A1 (en) 2010-05-21 2011-11-24 Gilead Sciences, Inc. Heterocyclic flaviviridae virus inhibitors
UY33445A (es) * 2010-06-10 2012-01-31 Gilead Sciences Inc Un régimen de dosificación, métodos para tratar el virus de la hepatitis c, composición farmacéutica, compuesta, compuestos anti-hcv y kit
TW201701876A (zh) * 2010-12-20 2017-01-16 吉李德科學股份有限公司 治療ｃ型肝炎病毒（ｈｃｖ）之方法
CA3024230C (en) 2011-04-28 2022-10-18 Oncopeptides Ab Lyophilized preparation of cytotoxic dipeptides
ME03009B (me) 2011-09-16 2018-10-20 Gilead Pharmasset Llc Metode za lecenje hcv-a
MX365205B (es) * 2012-10-26 2019-05-27 Oncopeptides Ab Preparaciones liofilizadas de melfalán flufenamida.
JP2015508418A (ja) 2013-01-31 2015-03-19 ギリアド ファーマセット エルエルシー ２種の抗ウイルス化合物のコンビナトリアル製剤
HRP20211456T1 (hr) 2014-12-26 2021-12-24 Emory University Protuvirusni derivati n4-hidroksicitidina
JP6804790B1 (ja) 2017-12-07 2020-12-23 エモリー ユニバーシティー Ｎ４−ヒドロキシシチジンおよび誘導体ならびにそれらに関連する抗ウイルス用途

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