ATE523498T1 - Hiv-inhibierende 2-(4- cyanophenylamino)pyrimidinderivate - Google Patents
Hiv-inhibierende 2-(4- cyanophenylamino)pyrimidinderivateInfo
- Publication number
- ATE523498T1 ATE523498T1 AT06707872T AT06707872T ATE523498T1 AT E523498 T1 ATE523498 T1 AT E523498T1 AT 06707872 T AT06707872 T AT 06707872T AT 06707872 T AT06707872 T AT 06707872T AT E523498 T1 ATE523498 T1 AT E523498T1
- Authority
- AT
- Austria
- Prior art keywords
- hiv
- cyanophenylamino
- inhibiting
- pyrimidine derivatives
- compounds
- Prior art date
Links
- LEVKDNUAUGWBDW-UHFFFAOYSA-N 4-(pyrimidin-2-ylamino)benzonitrile Chemical class C1=CC(C#N)=CC=C1NC1=NC=CC=N1 LEVKDNUAUGWBDW-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05100521 | 2005-01-27 | ||
| PCT/EP2006/050490 WO2006079656A1 (en) | 2005-01-27 | 2006-01-27 | Hiv inhibiting 2-( 4-cyanophenylamino) pyrimidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE523498T1 true ATE523498T1 (de) | 2011-09-15 |
Family
ID=34938584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06707872T ATE523498T1 (de) | 2005-01-27 | 2006-01-27 | Hiv-inhibierende 2-(4- cyanophenylamino)pyrimidinderivate |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20090124644A1 (de) |
| EP (2) | EP2388249A1 (de) |
| JP (2) | JP5190272B2 (de) |
| CN (1) | CN101107234B (de) |
| AT (1) | ATE523498T1 (de) |
| AU (1) | AU2006208778B2 (de) |
| BR (1) | BRPI0607214B8 (de) |
| CA (1) | CA2599228C (de) |
| ES (1) | ES2373820T3 (de) |
| MX (1) | MX2007009015A (de) |
| RU (1) | RU2403245C2 (de) |
| WO (1) | WO2006079656A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7935711B2 (en) * | 2005-02-18 | 2011-05-03 | Tibotec Pharmaceuticals Ltd. | HIV inhibiting 2-(4-cyanophenylamino) pyrimidine oxide derivatives |
| EP1947097A1 (de) * | 2005-10-27 | 2008-07-23 | Teijin Pharma Limited | Benzo[b]thiophenderivat und verfahren zu dessen herstellung |
| ES2523863T3 (es) * | 2006-12-29 | 2014-12-02 | Janssen R&D Ireland | Pirimidinas 5,6-sustituidas inhibidoras del VIH |
| BRPI0720858B8 (pt) * | 2006-12-29 | 2021-05-25 | Janssen R & D Ireland | pirimidinas 6-substituídas inibidoras de hiv e composição farmacêutica que as compreende |
| US20110196156A1 (en) * | 2009-06-22 | 2011-08-11 | Mukund Keshav Gurjar | Process for synthesis of diarylpyrimidine non-nucleoside reverse transcriptase inhibitor |
| US8153790B2 (en) | 2009-07-27 | 2012-04-10 | Krizmanic Irena | Process for the preparation and purification of etravirine and intermediates thereof |
| CN102731414B (zh) * | 2012-07-04 | 2014-11-26 | 宁波九胜创新医药科技有限公司 | 4-[(4-氯-2-嘧啶基)氨基]苯腈的制备方法 |
| CN102718720B (zh) * | 2012-07-04 | 2015-01-07 | 宁波九胜创新医药科技有限公司 | 4-[(4,6-二氯-2-嘧啶基)氨基]苯腈的制备方法 |
| WO2014072419A1 (en) | 2012-11-08 | 2014-05-15 | Universiteit Antwerpen | Novel anti-hiv compounds |
| RU2729792C1 (ru) * | 2019-07-29 | 2020-08-12 | Акционерное общество "Научно-производственное объединение "ДОМ ФАРМАЦИИ" | Способы повышения растворимости лекарственного средства на основе пиримидинового производного бензофенона |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3459731A (en) | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
| EP0862463A1 (de) | 1995-11-23 | 1998-09-09 | Janssen Pharmaceutica N.V. | Feste mischungen von cyclodextrinen, hergestellt durch schmelzextrusionsverfahren |
| SK287269B6 (sk) * | 1998-11-10 | 2010-05-07 | Janssen Pharmaceutica N. V. | Derivát pyrimidínu, jeho použitie, spôsob jeho prípravy a farmaceutická kompozícia, kombinácia a produkt s jeho obsahom |
| US20050239054A1 (en) * | 2002-04-26 | 2005-10-27 | Arimilli Murty N | Method and compositions for identifying anti-HIV therapeutic compounds |
-
2006
- 2006-01-27 EP EP11177764A patent/EP2388249A1/de not_active Ceased
- 2006-01-27 CN CN2006800031094A patent/CN101107234B/zh not_active Expired - Fee Related
- 2006-01-27 EP EP06707872A patent/EP1853568B1/de not_active Expired - Lifetime
- 2006-01-27 US US11/813,772 patent/US20090124644A1/en not_active Abandoned
- 2006-01-27 JP JP2007552651A patent/JP5190272B2/ja not_active Expired - Fee Related
- 2006-01-27 CA CA2599228A patent/CA2599228C/en not_active Expired - Fee Related
- 2006-01-27 MX MX2007009015A patent/MX2007009015A/es active IP Right Grant
- 2006-01-27 AT AT06707872T patent/ATE523498T1/de not_active IP Right Cessation
- 2006-01-27 WO PCT/EP2006/050490 patent/WO2006079656A1/en not_active Ceased
- 2006-01-27 ES ES06707872T patent/ES2373820T3/es not_active Expired - Lifetime
- 2006-01-27 BR BRPI0607214A patent/BRPI0607214B8/pt not_active IP Right Cessation
- 2006-01-27 RU RU2007132179/04A patent/RU2403245C2/ru active
- 2006-01-27 AU AU2006208778A patent/AU2006208778B2/en not_active Ceased
-
2012
- 2012-12-17 JP JP2012274674A patent/JP2013082722A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2388249A1 (de) | 2011-11-23 |
| MX2007009015A (es) | 2007-09-18 |
| JP2008528554A (ja) | 2008-07-31 |
| CN101107234A (zh) | 2008-01-16 |
| EP1853568B1 (de) | 2011-09-07 |
| EP1853568A1 (de) | 2007-11-14 |
| RU2007132179A (ru) | 2009-03-10 |
| ES2373820T3 (es) | 2012-02-09 |
| AU2006208778B2 (en) | 2012-08-09 |
| JP5190272B2 (ja) | 2013-04-24 |
| AU2006208778A1 (en) | 2006-08-03 |
| CN101107234B (zh) | 2013-06-19 |
| BRPI0607214A2 (pt) | 2009-08-18 |
| JP2013082722A (ja) | 2013-05-09 |
| CA2599228A1 (en) | 2006-08-03 |
| CA2599228C (en) | 2014-05-13 |
| US20090124644A1 (en) | 2009-05-14 |
| WO2006079656A1 (en) | 2006-08-03 |
| BRPI0607214B1 (pt) | 2019-09-10 |
| BRPI0607214B8 (pt) | 2021-05-25 |
| RU2403245C2 (ru) | 2010-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |