MX342153B - Compuestos para el tratamiento y profilaxis de enfermedad por el virus sincitial respiratorio. - Google Patents

Compuestos para el tratamiento y profilaxis de enfermedad por el virus sincitial respiratorio.

Info

Publication number
MX342153B
MX342153B MX2014003701A MX2014003701A MX342153B MX 342153 B MX342153 B MX 342153B MX 2014003701 A MX2014003701 A MX 2014003701A MX 2014003701 A MX2014003701 A MX 2014003701A MX 342153 B MX342153 B MX 342153B
Authority
MX
Mexico
Prior art keywords
prophylaxis
compounds
treatment
respiratory syncytial
syncytial virus
Prior art date
Application number
MX2014003701A
Other languages
English (en)
Other versions
MX2014003701A (es
Inventor
Liang Chungen
Wang Lisha
Yun Hongying
Zheng Xiufang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2014003701A publication Critical patent/MX2014003701A/es
Publication of MX342153B publication Critical patent/MX342153B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describe un compuesto de fórmula (I) (ver fórmula) también como una sal aceptable farmacéuticamente del mismo, en donde R1, R2 y X son como se definen en la descripción y en las reivindicaciones, que pueden ser usadas como medicamento.
MX2014003701A 2011-10-11 2012-10-08 Compuestos para el tratamiento y profilaxis de enfermedad por el virus sincitial respiratorio. MX342153B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2011080627 2011-10-11
PCT/EP2012/069813 WO2013053658A1 (en) 2011-10-11 2012-10-08 Compounds for the treatment and prophylaxis of respiratory syncytial virus disease

Publications (2)

Publication Number Publication Date
MX2014003701A MX2014003701A (es) 2015-04-14
MX342153B true MX342153B (es) 2016-09-15

Family

ID=47018191

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014003701A MX342153B (es) 2011-10-11 2012-10-08 Compuestos para el tratamiento y profilaxis de enfermedad por el virus sincitial respiratorio.

Country Status (11)

Country Link
US (1) US8604019B2 (es)
EP (1) EP2766370B1 (es)
JP (1) JP2014530225A (es)
KR (1) KR20140088555A (es)
CN (1) CN103748098B (es)
BR (1) BR112014008783A2 (es)
CA (1) CA2847071A1 (es)
ES (1) ES2593059T3 (es)
MX (1) MX342153B (es)
RU (1) RU2014118330A (es)
WO (1) WO2013053658A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040175384A1 (en) * 2003-12-12 2004-09-09 Mohapatra Shyam S. Protein kinase C as a target for the treatment of respiratory syncytial virus
US10184942B2 (en) 2011-03-17 2019-01-22 University Of South Florida Natriuretic peptide receptor as a biomarker for diagnosis and prognosis of cancer
CA2921294C (en) 2013-08-21 2023-05-16 Alios Biopharma, Inc. Antiviral compounds
AR099134A1 (es) 2014-01-24 2016-06-29 Hoffmann La Roche Procedimiento para la preparación de n-[(3-aminooxetán-3-il)metil]-2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepín-4-il)-6-metil-quinazolín-4-amina
TWI678369B (zh) * 2014-07-28 2019-12-01 美商基利科學股份有限公司 用於治療呼吸道合胞病毒感染之噻吩並［３,２-ｄ］嘧啶、呋喃並［３,２-ｄ］嘧啶及吡咯並［３,２-ｄ］嘧啶化合物類
MA41614A (fr) 2015-02-25 2018-01-02 Alios Biopharma Inc Composés antiviraux
WO2017009316A1 (en) 2015-07-16 2017-01-19 F. Hoffmann-La Roche Ag Crystalline forms of n-[(3-amino-3-oxetanyl)methyl]-2-(2,3-dihydro-1,1 -dioxido-1,4-benzothiazepin-4(5 h)-yl)-6-methyl-4-quinazolinamine for the treatment of respiratory syncytial virus (rsv) infections
CN111386118B (zh) 2017-09-29 2023-05-09 英安塔制药有限公司 作为rsv抑制剂的组合药物剂
EP4745139A1 (en) * 2023-07-10 2026-05-20 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. COMPOUND FOR THE TREATMENT AND PREVENTION OF INFECTIOUS DISEASES CAUSED BY THE RESPIRATORY SYNCYTIAL VIRUS
CN117865910A (zh) * 2023-12-15 2024-04-12 山东盛安贝新材料有限公司南京分公司 一种齐瑞索韦中间体的合成方法
CN120794971A (zh) * 2024-04-10 2025-10-17 广州医科大学 二氨基嘧啶化合物及其用途
WO2025252264A1 (zh) * 2024-06-07 2025-12-11 武汉武药科技有限公司 用于治疗或预防呼吸道合胞病毒疾病的化合物
WO2026149524A1 (zh) * 2025-01-09 2026-07-16 石药集团中奇制药技术（石家庄）有限公司 氨基吡咯烷类衍生物及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774134B2 (en) * 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
CA2551178C (en) * 2003-12-24 2012-11-06 Biota Scientific Management Pty Ltd Polycyclic agents for the treatment of respiratory syncytial virus infections
WO2009008906A2 (en) * 2007-02-06 2009-01-15 The Trustees Of The University Of Pennsylvania Therapeutic compounds for blocking dna synthesis of pox viruses

Also Published As

Publication number Publication date
RU2014118330A (ru) 2015-11-20
CA2847071A1 (en) 2013-04-18
WO2013053658A1 (en) 2013-04-18
HK1197058A1 (en) 2015-01-02
US20130090328A1 (en) 2013-04-11
CN103748098B (zh) 2016-06-29
EP2766370B1 (en) 2016-08-03
EP2766370A1 (en) 2014-08-20
US8604019B2 (en) 2013-12-10
BR112014008783A2 (pt) 2017-04-25
CN103748098A (zh) 2014-04-23
JP2014530225A (ja) 2014-11-17
KR20140088555A (ko) 2014-07-10
ES2593059T3 (es) 2016-12-05
MX2014003701A (es) 2015-04-14

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