EA200600227A1 - Замещённые арилтиомочевины, применимые в качестве ингибиторов репликации вирусов - Google Patents
Замещённые арилтиомочевины, применимые в качестве ингибиторов репликации вирусовInfo
- Publication number
- EA200600227A1 EA200600227A1 EA200600227A EA200600227A EA200600227A1 EA 200600227 A1 EA200600227 A1 EA 200600227A1 EA 200600227 A EA200600227 A EA 200600227A EA 200600227 A EA200600227 A EA 200600227A EA 200600227 A1 EA200600227 A1 EA 200600227A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- substituted
- applicable
- virus replication
- ariltiomaurs
- arylthioureas
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
- C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/14—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of rings other than six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/44—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing eight carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Описываются замещенные арилтиомочевины формулы I и фармацевтически приемлемые соли таких соединений, применимые в качестве противовирусных средств. Некоторые замещенные арилтиомочевины, раскрытые в данном описании, являются сильными и/или селективными ингибиторами репликации вирусов, в частности репликации вируса гепатита С. Также описываются фармацевтические композиции, содержащие одну или несколько замещенных арилтиомочевин и один или несколько фармацевтически приемлемых носителей, эксципиентов или разбавителей. Такие фармацевтические композиции могут содержать замещенную арилтиомочевину как единственное активное вещество или могут содержать сочетание замещенного производного арилтиомочевины и одного или нескольких других фармацевтически активных веществ. Также описываются способы лечения заражений вирусом гепатита С у млекопитающих.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48669703P | 2003-07-10 | 2003-07-10 | |
US49614603P | 2003-08-18 | 2003-08-18 | |
US50669903P | 2003-09-26 | 2003-09-26 | |
US50999503P | 2003-10-08 | 2003-10-08 | |
PCT/US2004/022599 WO2005007601A2 (en) | 2003-07-10 | 2004-07-08 | Substituted arylthiourea derivatives useful as inhibitors of viral replication |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200600227A1 true EA200600227A1 (ru) | 2006-06-30 |
EA010017B1 EA010017B1 (ru) | 2008-06-30 |
Family
ID=34084732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200600227A EA010017B1 (ru) | 2003-07-10 | 2004-07-08 | Замещённые арилтиомочевины, применимые в качестве ингибиторов репликации вирусов |
Country Status (14)
Country | Link |
---|---|
US (1) | US7718671B2 (ru) |
EP (1) | EP1648862A2 (ru) |
JP (1) | JP2007523868A (ru) |
KR (1) | KR20070007759A (ru) |
AU (1) | AU2004257277B2 (ru) |
BR (1) | BRPI0412502A (ru) |
CA (1) | CA2531068A1 (ru) |
EA (1) | EA010017B1 (ru) |
IL (1) | IL172876A0 (ru) |
MX (1) | MXPA06000418A (ru) |
NO (1) | NO20060126L (ru) |
NZ (1) | NZ544674A (ru) |
OA (1) | OA13187A (ru) |
WO (1) | WO2005007601A2 (ru) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
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TW200528459A (en) * | 2004-01-06 | 2005-09-01 | Achillion Pharmaceuticals Inc | Azabenzofuran substituted thioureas; inhibitors of viral replication |
TWI329102B (en) * | 2006-08-15 | 2010-08-21 | Nat Health Research Institutes | Thiourea compounds and method for inhibiting hepatitis c virus infection |
EP1977644A1 (en) * | 2007-04-03 | 2008-10-08 | Bayer CropScience Aktiengesellschaft | Insecticidal derivatives of substituted benzylamines |
CL2008000812A1 (es) * | 2007-04-03 | 2008-10-10 | Bayer Cropscience Ag | Compuestos derivados de bencil-oxazolidin-2-iliden-amina; procedimiento de preparacion; composicion que comprende a dichos compuestos; procedimiento para controlar plagas; y uso de dichos compuestos para controlar plagas |
EP1977645A1 (en) * | 2007-04-03 | 2008-10-08 | Bayer CropScience Aktiengesellschaft | Insecticidal derivates of substituted phenylalkylamines |
CL2008000773A1 (es) * | 2007-04-03 | 2008-10-10 | Bayer Cropscience Ag | Compuestos derivados de bencilaminas sustituidas; procedimiento para la preparacion de dichos compuestos; composicion; procedimiento para controlar plagas; y uso de dichos compuestos. |
WO2008124300A1 (en) * | 2007-04-10 | 2008-10-16 | National Health Research Institutes | Hepatitis c virus inhibitors |
WO2008141227A1 (en) | 2007-05-10 | 2008-11-20 | Intermune, Inc. | Novel peptide inhibitors of hepatitis c virus replication |
US7897764B2 (en) * | 2007-06-08 | 2011-03-01 | National Health Research Institutes | Thiourea derivatives |
TWI361808B (en) * | 2008-01-08 | 2012-04-11 | Nat Health Research Institutes | Imidazolidinone and imidazolidinethione derivatives |
US8198284B2 (en) * | 2008-04-30 | 2012-06-12 | National Health Research Institutes | Treatment of neurodegenerative disorders with thiourea compounds |
AU2011323658A1 (en) | 2010-11-01 | 2013-05-23 | Genoscience Pharma | Novel specific HCV NS3 protease inhibitors |
CN103073455B (zh) * | 2011-10-25 | 2015-08-19 | 中国科学院上海药物研究所 | 一类新型的kcnq钾通道激动剂、其制备方法和用途 |
US9040479B2 (en) | 2012-01-12 | 2015-05-26 | Cocrystal Pharma, Inc. | HCV NS3 protease inhibitors |
KR20180067703A (ko) | 2013-03-05 | 2018-06-20 | 아사히 가세이 케미칼즈 가부시키가이샤 | 이소티오시아네이트를 제조하는 방법, n-치환-o-치환 티오카르바메이트의 이송용 및 저장용 조성물, 그리고 이소티오시아네이트 조성물 |
WO2017026830A1 (ko) * | 2015-08-12 | 2017-02-16 | 서울대학교 산학협력단 | 티오우레아 유도체를 포함하는 자가면역질환 예방 또는 치료용 약학적 조성물 |
US10689354B2 (en) * | 2015-12-11 | 2020-06-23 | Teijin Pharma Limited | Aminoazole derivative |
WO2017197036A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
CN109562107A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
US10702525B1 (en) * | 2019-09-04 | 2020-07-07 | United Arab Emirates University | Pyrimidine derivatives as anti-diabetic agents |
KR20230071841A (ko) * | 2021-11-15 | 2023-05-24 | 서울대학교산학협력단 | RORα의 활성자로서의 신규한 티오우레아 유도체 및 이를 포함하는 약학적 조성물 |
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CA2253502A1 (en) * | 1996-05-06 | 1997-11-13 | Stephen Warren Kaldor | Anti-viral compounds |
AU6421998A (en) | 1997-03-24 | 1998-10-20 | Chugai Seiyaku Kabushiki Kaisha | Hetero-tricyclic compouds exhibiting inhibitory activity against nos |
DE69811062T2 (de) * | 1997-04-10 | 2003-07-17 | Upjohn Co | Polyaromatische antivirale zusammensetzungen |
CA2313004A1 (en) * | 1997-12-12 | 1999-06-24 | David Cavalla | 3-substituted adenines via2-thioxanthines |
JP2002502852A (ja) * | 1998-02-09 | 2002-01-29 | 3−ディメンショナル ファーマシューティカルズ, インコーポレイテッド | プロテアーゼ阻害剤、特にウロキナーゼ阻害剤としてのヘテロアリールアミジン、メチルアミジンおよびグアニジン |
IL139884A0 (en) * | 1998-05-26 | 2002-02-10 | Natural Drug Sciences Llc | N-substituted derivatives of 5-oximinobarbituric acid |
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JP2002531557A (ja) * | 1998-12-09 | 2002-09-24 | ワイス | ヘルペスウイルスのチオ尿素インヒビター |
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WO2000047194A2 (en) * | 1999-02-09 | 2000-08-17 | 3-Dimensional Pharmaceuticals, Inc. | METHODS OF TREATING C1s-MEDIATED DISEASES AND CONDITIONS, AND COMPOUNDS AND COMPOSITIONS THEREFOR |
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CA2367857A1 (en) * | 1999-03-19 | 2000-09-28 | Fatih M. Uckun | Thiourea and urea liquid-phase combinatorial libraries: synthesis and apoptosis induction |
AU2001252648A1 (en) | 2000-04-28 | 2001-11-12 | Chugai Seiyaku Kabushiki Kaisha | Aniline derivatives |
JP2001316314A (ja) * | 2000-05-09 | 2001-11-13 | Euro Celtique Sa | 増強されたホスホジエステラーゼiv阻害活性を有する6,5−融合芳香環系 |
YU96502A (sh) | 2000-06-21 | 2006-01-16 | F. Hoffmann-La Roche Ag. | Derivati benzotiazola |
FR2812633A1 (fr) | 2000-08-04 | 2002-02-08 | Aventis Cropscience Sa | Derives de phenyl(thio)urees et phenyl(thio)carbamates fongicides |
JP2002255964A (ja) * | 2000-10-24 | 2002-09-11 | Sankyo Co Ltd | イミダゾピリジン誘導体 |
BR0209537A (pt) | 2001-05-09 | 2004-03-09 | Bayer Cropscience Ag | Arilcetonas substituìdas |
-
2004
- 2004-07-08 JP JP2006518982A patent/JP2007523868A/ja active Pending
- 2004-07-08 EP EP04756991A patent/EP1648862A2/en not_active Withdrawn
- 2004-07-08 EA EA200600227A patent/EA010017B1/ru not_active IP Right Cessation
- 2004-07-08 MX MXPA06000418A patent/MXPA06000418A/es not_active Application Discontinuation
- 2004-07-08 CA CA002531068A patent/CA2531068A1/en not_active Abandoned
- 2004-07-08 NZ NZ544674A patent/NZ544674A/en not_active IP Right Cessation
- 2004-07-08 US US10/887,227 patent/US7718671B2/en not_active Expired - Fee Related
- 2004-07-08 AU AU2004257277A patent/AU2004257277B2/en not_active Ceased
- 2004-07-08 KR KR1020067000589A patent/KR20070007759A/ko not_active Application Discontinuation
- 2004-07-08 BR BRPI0412502-9A patent/BRPI0412502A/pt not_active IP Right Cessation
- 2004-07-08 OA OA1200600003A patent/OA13187A/en unknown
- 2004-07-08 WO PCT/US2004/022599 patent/WO2005007601A2/en active Application Filing
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2005
- 2005-12-28 IL IL172876A patent/IL172876A0/en unknown
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2006
- 2006-01-09 NO NO20060126A patent/NO20060126L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
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OA13187A (en) | 2006-12-13 |
AU2004257277B2 (en) | 2011-03-31 |
NZ544674A (en) | 2009-03-31 |
AU2004257277A1 (en) | 2005-01-27 |
JP2007523868A (ja) | 2007-08-23 |
IL172876A0 (en) | 2006-06-11 |
US20050032849A1 (en) | 2005-02-10 |
MXPA06000418A (es) | 2006-04-05 |
EP1648862A2 (en) | 2006-04-26 |
WO2005007601A2 (en) | 2005-01-27 |
KR20070007759A (ko) | 2007-01-16 |
US7718671B2 (en) | 2010-05-18 |
CA2531068A1 (en) | 2005-01-27 |
WO2005007601A3 (en) | 2005-06-23 |
EA010017B1 (ru) | 2008-06-30 |
BRPI0412502A (pt) | 2006-09-19 |
NO20060126L (no) | 2006-02-08 |
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