PE107999A1 - Derivados 3-amidinoanilina, inhibidores del factor x de coagulacion de la sangre activado e intermediarios de los mismos - Google Patents

Derivados 3-amidinoanilina, inhibidores del factor x de coagulacion de la sangre activado e intermediarios de los mismos

Info

Publication number
PE107999A1
PE107999A1 PE1998000777A PE00077798A PE107999A1 PE 107999 A1 PE107999 A1 PE 107999A1 PE 1998000777 A PE1998000777 A PE 1998000777A PE 00077798 A PE00077798 A PE 00077798A PE 107999 A1 PE107999 A1 PE 107999A1
Authority
PE
Peru
Prior art keywords
alkyl
coagulation factor
intermediaries
inhibitors
rent
Prior art date
Application number
PE1998000777A
Other languages
English (en)
Inventor
Satoshi Akahane
Masahiko Uchida
Hidetoshi Isawa
Norihiko Kikuchi
Tomonaga Ozawa
Hiroaki Kobayashi
Yuichiro Kai
Kenji Akahane
Original Assignee
Kissei Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical filed Critical Kissei Pharmaceutical
Publication of PE107999A1 publication Critical patent/PE107999A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R ES H, ALQUILO, ALQUENILO, ALQUIL-CICLOALQUILO, GRUPO a, ENTRE OTROS; A ES ALQUILENO, EL ANILLO Z ES UN HETEROCICLO AROMATICO CON 1 o 2 N, o UN GRUPO b, B ES H, ALQUILO, ALQUILO-CARBOXI, ENTRE OTROS; D ES H o ALQUILO; R1 ES H, HIDROXI, ALQUILO, ENTRE OTROS; Y ES ENLACE O OXIGENO; R2 ES ALQUILO O UN GRUPO c; DONDE n ES 1 o 2; T ES H, -C(=NH)-W; W ES ALQUILO. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. TAMBIEN SE REFIERE A UN INTERMEDIO QUE ES UN DERIVADO DE 3-CIANOANILINA DE FORMULA II, DONDE R3 ES H, ALQUILO, ALQUENILO, ENTRE OTROS; R4 ES H, ALQUILO, ALCOXI, ENTRE OTROS; R5 ES ALQUILO. EL COMPUESTO I ES UN INHIBIDOR DEL FACTOR X DE LA COAGULACION, POR LO QUE PUEDE SER UTIL PARA LA PREVENCION Y TRATAMIENTO DE ENFERMEDADES TROMBOEMBOLICAS
PE1998000777A 1997-08-27 1998-08-25 Derivados 3-amidinoanilina, inhibidores del factor x de coagulacion de la sangre activado e intermediarios de los mismos PE107999A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP27185397 1997-08-27

Publications (1)

Publication Number Publication Date
PE107999A1 true PE107999A1 (es) 1999-11-24

Family

ID=17505799

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000777A PE107999A1 (es) 1997-08-27 1998-08-25 Derivados 3-amidinoanilina, inhibidores del factor x de coagulacion de la sangre activado e intermediarios de los mismos

Country Status (11)

Country Link
EP (1) EP1020434A4 (es)
KR (1) KR20010023364A (es)
CN (1) CN1268116A (es)
AR (1) AR016868A1 (es)
AU (1) AU8747598A (es)
CA (1) CA2301559A1 (es)
CO (1) CO4970693A1 (es)
IL (1) IL134394A0 (es)
PE (1) PE107999A1 (es)
WO (1) WO1999010316A1 (es)
ZA (1) ZA987676B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003500383A (ja) 1999-05-24 2003-01-07 コア・セラピューティクス，インコーポレイテッド 第Ｘａ因子阻害剤
US6545055B1 (en) 1999-05-24 2003-04-08 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
DE10041402A1 (de) * 2000-08-23 2002-03-14 Morphochem Ag Neue Verbindungen, die Faktor Xa-Aktivität inhibieren
EP1095933A1 (en) * 1999-10-30 2001-05-02 Aventis Pharma Deutschland GmbH Novel N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them
US20020065303A1 (en) * 2000-02-01 2002-05-30 Bing-Yan Zhu Bivalent phenylene inhibitors of factor Xa
EP1259485B1 (en) 2000-02-29 2005-11-30 Millennium Pharmaceuticals, Inc. BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa
DE10027025A1 (de) * 2000-05-31 2001-12-06 Merck Patent Gmbh Clycinamide
DE10036121A1 (de) * 2000-07-25 2002-02-07 Merck Patent Gmbh N-Substituierte-1-amino-1,1-dialkyl-carbonsäurederivate
DE10040783A1 (de) * 2000-08-21 2002-03-07 Merck Patent Gmbh AZA-Aminosäurederivate (Faktor X¶a¶-Inhibitoren 15)
DE10050723A1 (de) * 2000-10-13 2002-04-25 Merck Patent Gmbh N-Substituierte Aminosäurederivate (Faktor Xa Inhibitoren 12)
US7312235B2 (en) 2001-03-30 2007-12-25 Millennium Pharmaceuticals, Inc. Benzamide inhibitors of factor Xa
DE10130374A1 (de) * 2001-06-23 2003-01-02 Boehringer Ingelheim Pharma Substituierte N-Acyl-anilinderivate, deren Herstellung und deren Verwendung als Arzneimittel
EP1443041A4 (en) * 2001-11-09 2006-06-07 Kissei Pharmaceutical 5-AMIDINO-2-HYDROXYBENZENE-SULFONAMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THEM, THEIR MEDICAL USE AND INTERMEDIATE PRODUCTS USED IN THEIR PRODUCTION
WO2003080038A1 (fr) * 2002-03-22 2003-10-02 Kissei Pharmaceutical Co., Ltd. Agent prophylactique ou therapeutique contre des maladies renales
DE10220048A1 (de) * 2002-05-04 2003-11-13 Merck Patent Gmbh Semicarbazidderivate
US7479502B2 (en) 2002-12-03 2009-01-20 Pharmacyclics, Inc. 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors
EP1678161B1 (en) 2003-10-09 2009-12-30 Millennium Pharmaceuticals, Inc. Thioether-substituted benzamides as inhibitors of factor xa
CA2565437A1 (en) 2004-06-18 2006-01-05 Millennium Pharmaceuticals, Inc. Factor xa inhibitors
US7446204B2 (en) 2004-10-08 2008-11-04 H. Lundbeck A/S Amino substituted aryloxybenzylpiperidine derivatives
US7329656B2 (en) 2004-10-08 2008-02-12 H. Lundbeck A/S Arylthiobenzylpiperidine derivatives
US20080132507A1 (en) * 2004-10-13 2008-06-05 Eisai R&D Management Co., Ltd. Hydrazide Derivatives
WO2006055951A2 (en) 2004-11-19 2006-05-26 Portola Pharmaceuticals, Inc. Tetrahydroisoquinolines as factor xa inhibitors
WO2006063113A2 (en) 2004-12-07 2006-06-15 Portola Pharmaceuticals, Inc. Ureas as factor xa inhibitors
JP4900238B2 (ja) 2005-02-02 2012-03-21 味の素株式会社 新規ベンズアミジン化合物
ATE549317T1 (de) 2005-11-08 2012-03-15 Millennium Pharm Inc Pharmazeutische salze und polymorphe aus n-(5- chloro-2-pyridinyl)-2-ää4- ä(dimethylamino)iminomethylübenzoylüaminoü-5- methoxy-benzamid, einem faktor-xa-hemmer
ATE491694T1 (de) 2006-03-24 2011-01-15 Eisai R&D Man Co Ltd Triazolonderivat
EP2077995B1 (en) 2006-11-02 2012-02-08 Millennium Pharmaceuticals, Inc. Methods of synthesizing pharmaceutical salts of a factor xa inhibitor
EP2202231A4 (en) 2007-09-21 2011-09-28 Eisai R&D Man Co Ltd 2,3-DIHYDROIMINOISOINDOLE DERIVATIVE
KR20110036833A (ko) 2008-07-11 2011-04-11 아지노모토 가부시키가이샤 아미딘 유도체
EA015918B1 (ru) 2010-03-03 2011-12-30 Дмитрий Геннадьевич ТОВБИН УРЕТАНЫ, МОЧЕВИНЫ, АМИДЫ И РОДСТВЕННЫЕ ИНГИБИТОРЫ ФАКТОРА Xa

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2606643B2 (ja) * 1992-04-01 1997-05-07 日東紡績株式会社 安息香酸アミジノフェニルエステル誘導体
JPH07330695A (ja) * 1994-04-11 1995-12-19 Green Cross Corp:The 新規カルボン酸誘導体またはその塩、およびその医薬用途
PT892780E (pt) * 1996-02-22 2003-02-28 Bristol Myers Squibb Pharma Co Analogos de m-amidino fenilo como inibidores do factor xa
JPH101467A (ja) * 1996-06-13 1998-01-06 Banyu Pharmaceut Co Ltd ビフェニルアミジン誘導体

Also Published As

Publication number Publication date
EP1020434A4 (en) 2000-11-15
CO4970693A1 (es) 2000-11-07
EP1020434A1 (en) 2000-07-19
AR016868A1 (es) 2001-08-01
CN1268116A (zh) 2000-09-27
ZA987676B (en) 1999-02-25
IL134394A0 (en) 2001-04-30
KR20010023364A (ko) 2001-03-26
WO1999010316A1 (fr) 1999-03-04
AU8747598A (en) 1999-03-16
CA2301559A1 (en) 1999-03-04

Similar Documents

Publication Publication Date Title
PE107999A1 (es) Derivados 3-amidinoanilina, inhibidores del factor x de coagulacion de la sangre activado e intermediarios de los mismos
PA8463501A1 (es) Derivados de acido hidroxamico como inhibidores de metaloproteasas de matriz (mmp)
PE20001562A1 (es) Derivados de benzamida como inhibidores de la produccion hepatica de la apo proteina b-100
ES2053508T3 (es) Compuestos de acidos 3-pirrolidinil-tio-1-azabiciclo(3.2.0)hept-2-eno-2-carboxilicos.
DK0810209T3 (da) Alpha - and beta-aminosyre-hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser
DK0620215T3 (da) 1H-indol-3-acetamidderivater som sPLA2-inhibitorer
ES2056190T3 (es) Derivados de 4(4-fenil-1-piperazinil)fenoles, inhibidores de 5-lipoxigenasa.
PT94925A (pt) Processo para a preparacao de derivados de tiazol e de composicoes farmaceuticas que os contem
PA8477001A1 (es) Inhibidores no peptidilicos de la union a las celulas dependientes de la vla-4 utiles en el tratamiento de enfermedades inflamatorias autoinmunes y respiratorias
ES2054712T3 (es) Un procedimiento para la preparacion de los derivados de prolinal.
ES2032749T3 (es) Acidos oxoftalazinil-aceticos heterociclicos.
TR200000673T2 (tr) FP agonistleri olarak yararlı aromatik C16-C20- ikameli tetrahidro prostaglandinler.
ES2036562T3 (es) Un procedimiento para produccion de un derivado de pirrolidinamida.
AR002690A1 (es) Derivado de bencimidazol o sales del mismo, composicion farmaceutica, agente inmunosupresor y agente antiinflamatorio que lo contienen yprocedimientos para preparar dicho derivado.
FI88717C (fi) Foerfarande foer framstaellning av som laekemedel anvaendbara cyklopenta/d/pyrimidinderivat
ES2101252T3 (es) Inhibidores de la proteasa del hiv utiles para el tratamiento del sida.
AR000813A1 (es) Procedimiento para la obtencion de n-aril y n-heteroarilhidroxilaminas
PE20021018A1 (es) DERIVADOS DE ß - CARBOLINA
ES2058177T3 (es) Nuevos derivados de alcanosulfonanilida, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.
ES2032752T3 (es) Procedimiento de preparacion de derivados de la 1-bencenosulfonil-2-oxo-5-alcoxi-pirrolidina.
IT1196423B (it) Benzotiazolin-composti
EA200500133A1 (ru) Производные пирролидина в качестве антагонистов окситоцина
SE8501988L (sv) Iminotiazolidinderivat
PT92189A (pt) Processo para a preparacao de derivados de difenilacetamidas e de composicoes farmaceuticas que os contem
ES2183500T3 (es) Nuevos compuestos y composiciones farmaceuticas que los contienen.

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed