ATE557010T1 - Triazolonderivat - Google Patents
TriazolonderivatInfo
- Publication number
- ATE557010T1 ATE557010T1 AT10157326T AT10157326T ATE557010T1 AT E557010 T1 ATE557010 T1 AT E557010T1 AT 10157326 T AT10157326 T AT 10157326T AT 10157326 T AT10157326 T AT 10157326T AT E557010 T1 ATE557010 T1 AT E557010T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- independently represent
- represent hydrogen
- represents optionally
- triazolone derivative
- Prior art date
Links
- FFSJPOPLSWBGQY-UHFFFAOYSA-N triazol-4-one Chemical class O=C1C=NN=N1 FFSJPOPLSWBGQY-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006083486 | 2006-03-24 | ||
| US78668706P | 2006-03-29 | 2006-03-29 | |
| JP2006162594 | 2006-06-12 | ||
| US80487806P | 2006-06-15 | 2006-06-15 | |
| JP2006218819 | 2006-08-10 | ||
| US83841806P | 2006-08-18 | 2006-08-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE557010T1 true ATE557010T1 (de) | 2012-05-15 |
Family
ID=38950011
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT10157326T ATE557010T1 (de) | 2006-03-24 | 2007-03-22 | Triazolonderivat |
| AT07739256T ATE491694T1 (de) | 2006-03-24 | 2007-03-22 | Triazolonderivat |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07739256T ATE491694T1 (de) | 2006-03-24 | 2007-03-22 | Triazolonderivat |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US7816522B2 (de) |
| EP (2) | EP2000465B1 (de) |
| JP (1) | JP5016592B2 (de) |
| KR (1) | KR101362024B1 (de) |
| AT (2) | ATE557010T1 (de) |
| AU (1) | AU2007230346B2 (de) |
| BR (1) | BRPI0709101A2 (de) |
| CA (1) | CA2647423C (de) |
| CY (1) | CY1111271T1 (de) |
| DE (1) | DE602007011231D1 (de) |
| DK (1) | DK2000465T3 (de) |
| HR (1) | HRP20110054T1 (de) |
| IL (1) | IL194188A (de) |
| MX (1) | MX2008012031A (de) |
| MY (1) | MY146537A (de) |
| NO (1) | NO20084441L (de) |
| NZ (1) | NZ571441A (de) |
| PL (1) | PL2000465T3 (de) |
| PT (1) | PT2000465E (de) |
| RS (1) | RS52030B (de) |
| SA (1) | SA07280131B1 (de) |
| SI (1) | SI2000465T1 (de) |
| TW (1) | TWI389894B (de) |
| WO (1) | WO2007111212A1 (de) |
| ZA (1) | ZA200805758B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006041119A1 (ja) * | 2004-10-13 | 2006-04-20 | Eisai R & D Management Co., Ltd. | ヒドラジド誘導体 |
| WO2007111212A1 (ja) | 2006-03-24 | 2007-10-04 | Eisai R & D Management Co., Ltd. | トリアゾロン誘導体 |
| JPWO2009038157A1 (ja) * | 2007-09-21 | 2011-01-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ２，３−ジヒドロ−イミノイソインドール誘導体 |
| EA201000656A1 (ru) * | 2007-10-26 | 2010-12-30 | Астразенека Аб | Аминопроизводные 1,2,4-триазола в качестве модуляторов mglur5 |
| WO2009054791A1 (en) * | 2007-10-26 | 2009-04-30 | Astrazeneca Ab | Fused pyrrolidine 1,2,4-triazole derivatives as modulators of mglur5 |
| TW201206905A (en) * | 2010-05-20 | 2012-02-16 | Eisai R & Amp D Man Co Ltd | Prodrug of triazolone compound |
| WO2013134562A1 (en) * | 2012-03-09 | 2013-09-12 | Inception 2, Inc. | Triazolone compounds and uses thereof |
| CN102993109A (zh) * | 2012-12-03 | 2013-03-27 | 浙江工业大学 | 一种脒化合物的制备方法 |
| JP6404230B2 (ja) | 2012-12-20 | 2018-10-10 | インセプション ２、 インコーポレイテッド | トリアゾロン化合物およびその使用 |
| EA201690230A1 (ru) | 2013-09-06 | 2016-07-29 | Инсепшн 2, Инк. | Соединения триазолона и их применения |
| EP3588064B1 (de) * | 2017-02-23 | 2022-09-07 | IHI Corporation | Oh radikaldetektionssonde, oh-radikalmessvorrichtung und oh-radikalmessverfahren |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2005000A (en) * | 1931-07-18 | 1935-06-18 | L N Miller Engineering Corp | Differential motor |
| EP0019586A1 (de) | 1979-05-11 | 1980-11-26 | Ciba-Geigy Ag | Neue antithrombotische Kombinationspräparate |
| SU1512055A1 (ru) | 1987-12-04 | 1992-07-23 | Пермский фармацевтический институт | Дигидрохлорид гидразида N-ацетил-N-аллилантраниловой кислоты, про вл ющий антиагрегатную активность по отношению к тромбоцитам плазмы крови |
| CN1268116A (zh) | 1997-08-27 | 2000-09-27 | 橘生药品工业株式会社 | 3－脒基苯胺衍生物,活化血凝固因子x抑制剂和制备这些物质的中间体 |
| KR20010082515A (ko) | 1998-02-17 | 2001-08-30 | 우에노 도시오 | 아미디노 유도체 및 그 유도체를 유효 성분으로서함유하는 약제 |
| CA2321538A1 (en) | 1998-03-27 | 1999-10-07 | Dupont Pharmaceuticals Company | Disubstituted pyrazolines and triazolines as factor xa inhibitors |
| HK1043106A1 (zh) | 1998-12-14 | 2002-09-06 | F. Hoffmann-La Roche Ag | 苯基甘氨酸衍生物 |
| EP1144373B1 (de) * | 1999-01-13 | 2005-10-19 | Genentech, Inc. | Serinprotease-inhibitoren |
| FR2791683A1 (fr) | 1999-03-30 | 2000-10-06 | Synthelabo | Derives de n-sulfonyl-dipeptides, leur preparation et leur application en therapeutique |
| FR2793247B1 (fr) | 1999-05-04 | 2001-06-22 | Synthelabo | Derives de 6-[[(aryl et heteroaryl)oxy]methyl]naphtalene-2- carboximidamide, leur preparation et leur application en therapeutique |
| US6548694B2 (en) | 2000-05-23 | 2003-04-15 | Hoffman-La Roche Inc. | N-(4-carbamimidoyl-phenyl)-glycine derivatives |
| EP1162194A1 (de) | 2000-06-06 | 2001-12-12 | Aventis Pharma Deutschland GmbH | Auf Faktor VIIa inhibitorisch wirkende (Thio)-Harnstoff Verbindungen, Verfahren zu deren Herstellung und deren Verwendung |
| US7476688B2 (en) | 2001-04-19 | 2009-01-13 | Eisai R&D Management Co., Ltd. | Cyclic amidine derivatives |
| EP1312602A1 (de) | 2001-11-15 | 2003-05-21 | Eisai Co., Ltd. | Amidinoderivate und diese enthaltende antikoagulierende und antithrombotische Wirkstoffe |
| JP4209659B2 (ja) | 2001-11-15 | 2009-01-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | アミジノ誘導体並びにそれを用いた抗血液凝固剤および血栓症治療剤 |
| AU2003284001A1 (en) * | 2002-10-07 | 2004-05-04 | Bristol-Myers Squibb Company | Triazolone and triazolethione derivatives |
| EP1479679A1 (de) * | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Triazolderivate als Faktor-Xa-Inhibitoren |
| WO2006041119A1 (ja) | 2004-10-13 | 2006-04-20 | Eisai R & D Management Co., Ltd. | ヒドラジド誘導体 |
| US7576098B2 (en) | 2004-12-08 | 2009-08-18 | Bristol-Myers Squibb Company | Heterocyclic compounds as inhibitors of factor VIIa |
| WO2007111212A1 (ja) | 2006-03-24 | 2007-10-04 | Eisai R & D Management Co., Ltd. | トリアゾロン誘導体 |
| JPWO2009038157A1 (ja) | 2007-09-21 | 2011-01-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ２，３−ジヒドロ−イミノイソインドール誘導体 |
-
2007
- 2007-03-22 WO PCT/JP2007/055813 patent/WO2007111212A1/ja not_active Ceased
- 2007-03-22 MY MYPI20083555A patent/MY146537A/en unknown
- 2007-03-22 EP EP07739256A patent/EP2000465B1/de active Active
- 2007-03-22 DK DK07739256.1T patent/DK2000465T3/da active
- 2007-03-22 EP EP10157326A patent/EP2194046B1/de active Active
- 2007-03-22 CA CA2647423A patent/CA2647423C/en not_active Expired - Fee Related
- 2007-03-22 HR HR20110054T patent/HRP20110054T1/hr unknown
- 2007-03-22 AU AU2007230346A patent/AU2007230346B2/en not_active Ceased
- 2007-03-22 SI SI200730515T patent/SI2000465T1/sl unknown
- 2007-03-22 MX MX2008012031A patent/MX2008012031A/es active IP Right Grant
- 2007-03-22 RS RS20110118A patent/RS52030B/sr unknown
- 2007-03-22 DE DE602007011231T patent/DE602007011231D1/de active Active
- 2007-03-22 KR KR1020087025698A patent/KR101362024B1/ko not_active Expired - Fee Related
- 2007-03-22 US US11/723,893 patent/US7816522B2/en not_active Expired - Fee Related
- 2007-03-22 AT AT10157326T patent/ATE557010T1/de active
- 2007-03-22 JP JP2008507453A patent/JP5016592B2/ja not_active Expired - Fee Related
- 2007-03-22 PT PT07739256T patent/PT2000465E/pt unknown
- 2007-03-22 BR BRPI0709101-0A patent/BRPI0709101A2/pt not_active IP Right Cessation
- 2007-03-22 NZ NZ571441A patent/NZ571441A/en not_active IP Right Cessation
- 2007-03-22 PL PL07739256T patent/PL2000465T3/pl unknown
- 2007-03-22 AT AT07739256T patent/ATE491694T1/de active
- 2007-03-23 TW TW096110040A patent/TWI389894B/zh not_active IP Right Cessation
- 2007-03-24 SA SA7280131A patent/SA07280131B1/ar unknown
-
2008
- 2008-07-01 ZA ZA2008/05758A patent/ZA200805758B/en unknown
- 2008-09-17 IL IL194188A patent/IL194188A/en not_active IP Right Cessation
- 2008-10-22 NO NO20084441A patent/NO20084441L/no not_active Application Discontinuation
-
2010
- 2010-03-29 US US12/748,806 patent/US7928228B2/en not_active Expired - Fee Related
-
2011
- 2011-01-13 US US13/006,004 patent/US8163787B2/en not_active Expired - Fee Related
- 2011-02-28 CY CY20111100231T patent/CY1111271T1/el unknown
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