AR037698A1 - N-[4-(1h-imidazol-1-il)-2-fluorofenil]-3-(trifluorometil)-1h-pirazol-5-carboxamidas como inhibidores del factor xa - Google Patents

N-[4-(1h-imidazol-1-il)-2-fluorofenil]-3-(trifluorometil)-1h-pirazol-5-carboxamidas como inhibidores del factor xa

Info

Publication number
AR037698A1
AR037698A1 ARP020104702A ARP020104702A AR037698A1 AR 037698 A1 AR037698 A1 AR 037698A1 AR P020104702 A ARP020104702 A AR P020104702A AR P020104702 A ARP020104702 A AR P020104702A AR 037698 A1 AR037698 A1 AR 037698A1
Authority
AR
Argentina
Prior art keywords
alkyl
imidazol
phenyl substituted
inhibitors
factor
Prior art date
Application number
ARP020104702A
Other languages
English (en)
Inventor
Mimi L Quan
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR037698A1 publication Critical patent/AR037698A1/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención describe N-[4-(1H-imidazol-1-il)-2-fluorofenil-3-(trifluorometil)-1H-pirazol-5-carboxamidas y derivados de las mismas, los cuales son útiles como inhibidores del factor Xa. Reivindicación 1: Un compuesto formado porque es de fórmula (1): o una sal del mismo farmacéuticamente aceptable, en donde: R es H alquilo C1-6; R1 es selecciona del grupo: H; alquenileno(C1-6)-C(O)-alquilo(C1-6; C(O)-alquiloC1-6; C(O)-alquilo(C1-6)-NraRaRa, en donde Ra es independientemente H o alquilo C1-6; C(O)CH2CH2CH(NraRa)C(O)Ora, en donde Ra es independientemente H o alquilo C1-6; C(O)-fenilo sustituido con 0-2 R2; C(O)-OCH2OPO3H; C(O)-OCH2O-alquiloC1-6; CH"OC(O)-fenilo sustituidocon 0-2 R2; CH2OC(O)CH2-heterociclo de 5-6 elementos que consiste de átomos de carbono y 1-2 heteroátomos seleccionados de O y N, y sustituido con 0-2 R2; y, un resto de fórmula (2), en donde el asterisco define un punto de unión; R2 es seleccionado de CL, F, Br, I, OH, alquilo C1-6, alquiloC1-6-OH; alcoxi C1-6, y alquileno (C1-4-OC(O)-alquiloC1-6; y, R3 es seleccionado de alquilo C1-6 y fenilo sustituido con 0-2 R2.
ARP020104702A 2001-12-04 2002-12-04 N-[4-(1h-imidazol-1-il)-2-fluorofenil]-3-(trifluorometil)-1h-pirazol-5-carboxamidas como inhibidores del factor xa AR037698A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33697201P 2001-12-04 2001-12-04

Publications (1)

Publication Number Publication Date
AR037698A1 true AR037698A1 (es) 2004-12-01

Family

ID=23318529

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020104702A AR037698A1 (es) 2001-12-04 2002-12-04 N-[4-(1h-imidazol-1-il)-2-fluorofenil]-3-(trifluorometil)-1h-pirazol-5-carboxamidas como inhibidores del factor xa

Country Status (10)

Country Link
US (1) US6730689B2 (es)
EP (1) EP1460996A4 (es)
JP (1) JP2005527485A (es)
AR (1) AR037698A1 (es)
AU (1) AU2002352962A1 (es)
HU (1) HUP0402515A2 (es)
PE (1) PE20030661A1 (es)
PL (1) PL373907A1 (es)
TW (1) TW200303309A (es)
WO (1) WO2003047517A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
GB0128996D0 (en) 2001-12-04 2002-01-23 Novartis Ag Organic compounds
US20030220383A1 (en) * 2002-02-14 2003-11-27 Aventis Pharma Deutschland Gmbh Use of inhibitors of the sodium-dependent chloride/bicarbonate exchanger for the treatment of thrombotic and inflammatory disorders
AU2003270861A1 (en) * 2002-10-02 2004-04-23 Bristol-Myers Squibb Company Novel combination of a factor xa inhibitor and clopidogrel
EP1734963A4 (en) 2004-04-02 2008-06-18 Merck & Co Inc METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
ATE493973T1 (de) 2004-06-04 2011-01-15 Teva Pharma Irbesartan enthaltende pharmazeutische zusammensetzung
TWI277432B (en) * 2004-09-20 2007-04-01 Therapyzone Inc Exercise handle and methods of use
EP2196461A1 (de) 2008-12-15 2010-06-16 Bayer CropScience AG 4-Amino-1,2,3-benzoxathiazin-Derivate als Pestizide
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
MX2016011468A (es) 2014-03-07 2017-01-23 Biocryst Pharm Inc Inhibidores de calicreína plasmática humana.
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
KR20200035035A (ko) 2017-07-31 2020-04-01 노파르티스 아게 코카인 사용 감소 또는 코카인 사용 재발 예방에 있어서 마보글루란트의 용도

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5342851A (en) 1992-10-07 1994-08-30 Mcneil-Ppc, Inc. Substituted thiazole derivatives useful as platelet aggregation inhibitors
US5925635A (en) * 1996-04-17 1999-07-20 Dupont Pharmaceuticals Company N-(amidinophenyl) cyclourea analogs as factor XA inhibitors
AU730224B2 (en) 1996-12-23 2001-03-01 Du Pont Pharmaceuticals Company Nitrogen containing heteroaromatics as factor Xa inhibitors
US6020357A (en) 1996-12-23 2000-02-01 Dupont Pharmaceuticals Company Nitrogen containing heteroaromatics as factor Xa inhibitors
ZA985247B (en) * 1997-06-19 1999-12-17 Du Pont Merck Pharma Guanidine mimics as factor Xa inhibitors.
US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
US6271237B1 (en) 1997-12-22 2001-08-07 Dupont Pharmaceuticals Company Nitrogen containing heteromatics with ortho-substituted P1s as factor Xa inhabitors
TW200302225A (en) * 2001-12-04 2003-08-01 Bristol Myers Squibb Co Substituted amino methyl factor Xa inhibitors

Also Published As

Publication number Publication date
TW200303309A (en) 2003-09-01
EP1460996A4 (en) 2005-11-16
WO2003047517A3 (en) 2004-02-26
EP1460996A2 (en) 2004-09-29
PE20030661A1 (es) 2003-08-08
HUP0402515A2 (hu) 2005-03-29
JP2005527485A (ja) 2005-09-15
PL373907A1 (en) 2005-09-19
AU2002352962A8 (en) 2003-06-17
WO2003047517A2 (en) 2003-06-12
US6730689B2 (en) 2004-05-04
AU2002352962A1 (en) 2003-06-17
US20030144287A1 (en) 2003-07-31

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