EA200000096A1 - Производные арилоксиарилсульфониламиногидроксамовой кислоты - Google Patents

Производные арилоксиарилсульфониламиногидроксамовой кислоты

Info

Publication number
EA200000096A1
EA200000096A1 EA200000096A EA200000096A EA200000096A1 EA 200000096 A1 EA200000096 A1 EA 200000096A1 EA 200000096 A EA200000096 A EA 200000096A EA 200000096 A EA200000096 A EA 200000096A EA 200000096 A1 EA200000096 A1 EA 200000096A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
substituent
arylsulfonyl
aryloxy
derivatives
Prior art date
Application number
EA200000096A
Other languages
English (en)
Other versions
EA002490B1 (ru
Inventor
Ральф Пелтон Робинсон
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200000096A1 publication Critical patent/EA200000096A1/ru
Publication of EA002490B1 publication Critical patent/EA002490B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Surgery (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrane Compounds (AREA)

Abstract

Соединение формулы (I) или его фармацевтически приемлемые соли, где Rпредставляет собой (C-C)алкил; Rпредставляет собой (C-C)алкил; или Rи R, взятые вместе с атомом углерода, к которому они присоединены, образуют кольцо, выбранное из (C-C)циклоалкила, 4-тетрагидропиранила и 4-пиперидинила; Rпредставляет собой водород или (C-C)алкил; a Y представляет собой заместитель по любому из атомов углерода фенильного кольца, способного нести дополнительную связь, предпочтительно от 1 до 2 заместителей (более предпочтительно один заместитель, наиболее предпочтительно один заместитель в положении 4) фенильного кольца, независимо выбранный из водорода, фторо, хлоро, трифторметила, (C-C)алкокси, трифторметокси, дифторметокси и (C-C)алкила.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000096A 1997-08-08 1998-07-21 Производные арилоксиарилсульфониламиногидроксамовой кислоты EA002490B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5520797P 1997-08-08 1997-08-08
PCT/IB1998/001113 WO1999007675A1 (en) 1997-08-08 1998-07-21 Aryloxyarylsulfonylamino hydroxamic acid derivatives

Publications (2)

Publication Number Publication Date
EA200000096A1 true EA200000096A1 (ru) 2000-10-30
EA002490B1 EA002490B1 (ru) 2002-06-27

Family

ID=21996358

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000096A EA002490B1 (ru) 1997-08-08 1998-07-21 Производные арилоксиарилсульфониламиногидроксамовой кислоты

Country Status (43)

Country Link
US (1) US6214872B1 (ru)
EP (1) EP1003720B1 (ru)
JP (1) JP3448275B2 (ru)
KR (1) KR100372138B1 (ru)
CN (1) CN1171866C (ru)
AP (1) AP1220A (ru)
AR (1) AR015419A1 (ru)
AT (1) ATE263147T1 (ru)
AU (1) AU730248B2 (ru)
BG (1) BG104118A (ru)
BR (1) BR9811868A (ru)
CA (1) CA2299355C (ru)
CO (1) CO4960658A1 (ru)
DE (1) DE69822839T2 (ru)
DK (1) DK1003720T3 (ru)
DZ (1) DZ2581A1 (ru)
EA (1) EA002490B1 (ru)
ES (1) ES2216293T3 (ru)
GT (1) GT199800124A (ru)
HK (1) HK1029575A1 (ru)
HR (1) HRP980438B1 (ru)
HU (1) HUP0002960A3 (ru)
ID (1) ID23668A (ru)
IL (1) IL134300A (ru)
IS (1) IS5340A (ru)
MA (1) MA26530A1 (ru)
MY (1) MY120235A (ru)
NO (1) NO313189B1 (ru)
NZ (1) NZ502309A (ru)
OA (1) OA11284A (ru)
PA (1) PA8456801A1 (ru)
PE (1) PE110899A1 (ru)
PL (1) PL338633A1 (ru)
PT (1) PT1003720E (ru)
SK (1) SK1362000A3 (ru)
TN (1) TNSN98150A1 (ru)
TR (1) TR200000368T2 (ru)
TW (1) TW426662B (ru)
UA (1) UA61963C2 (ru)
UY (2) UY25131A1 (ru)
WO (1) WO1999007675A1 (ru)
YU (1) YU1900A (ru)
ZA (1) ZA987126B (ru)

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