YU1900A - Derivati ariloksiarilsulfonilamino hidroksaminske kiseline - Google Patents

Derivati ariloksiarilsulfonilamino hidroksaminske kiseline

Info

Publication number
YU1900A
YU1900A YU1900A YU1900A YU1900A YU 1900 A YU1900 A YU 1900A YU 1900 A YU1900 A YU 1900A YU 1900 A YU1900 A YU 1900A YU 1900 A YU1900 A YU 1900A
Authority
YU
Yugoslavia
Prior art keywords
alkyl
substituent
acid derivatives
hydroxamic acid
hydrogen
Prior art date
Application number
YU1900A
Other languages
English (en)
Inventor
Ralph Pelton Robinson
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of YU1900A publication Critical patent/YU1900A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Surgery (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrane Compounds (AREA)

Abstract

Jedinjenje formule (I) njegove farmaceutski prihvatljive soli, gde R1 je (C1-C6)alkil; R2 je (C1-C6)alkil; ili R1 i R2 uzeti zajedno sa atomom ugljenika na koji su vezani formiraju prsten odabran od (C5-C7)cikloalkila, 4-tetrahidropiranila i 4-piperidinila; R3 je vodonik ili (C1-C6)alkil; i Y je supstituent na bilo kom atomu ugljenika fenil prstena sposoban da podrži dodatnu vezu, poželjno od 1 do 2 supstituenta (poželjnije jedan supsitituent, najpoželjnije jedan supstituent na 4-položaju) na fenil prstenu, nezavisno odabran od vodonika, fluoro, hloro, trifluorometila, (C1-C6)alkoksi, trifluorometoksi, difluorometoksi i (C1-C6)alkila.[A compound of formula (I) or the pharmaceutically acceptable salts thereof, wherein R1 is (C1-C6)alkyl; R2 is (C1-C6)alkyl; or R1 and R2 taken together with the carbon atom to which they are attached form a ring selected from (C5-C7)cycloalkyl, 4-tetrahydropyranyl and 4-piperidinyl; R3 is hydrogen or (C1-C6)alkyl; and Y is a substituent of any of the carbon atoms of the phenyl ring capable of supporting an additional bond, preferably from 1 to 2 substituents (more preferably one substituent, most preferably one substituent in the 4-position) on the phenyl ring, independently selected from hydrogen, fluoro, chloro, trifluoromethyl, (C1-C6)alkoxy, trifluoromethoxy, difluoromethoxy and (C1-C6)alkyl.
YU1900A 1997-08-08 1998-07-21 Derivati ariloksiarilsulfonilamino hidroksaminske kiseline YU1900A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5520797P 1997-08-08 1997-08-08

Publications (1)

Publication Number Publication Date
YU1900A true YU1900A (sh) 2002-08-12

Family

ID=21996358

Family Applications (1)

Application Number Title Priority Date Filing Date
YU1900A YU1900A (sh) 1997-08-08 1998-07-21 Derivati ariloksiarilsulfonilamino hidroksaminske kiseline

Country Status (42)

Country Link
US (1) US6214872B1 (sh)
EP (1) EP1003720B1 (sh)
JP (1) JP3448275B2 (sh)
KR (1) KR100372138B1 (sh)
CN (1) CN1171866C (sh)
AP (1) AP1220A (sh)
AR (1) AR015419A1 (sh)
AT (1) ATE263147T1 (sh)
AU (1) AU730248B2 (sh)
BG (1) BG104118A (sh)
BR (1) BR9811868A (sh)
CA (1) CA2299355C (sh)
CO (1) CO4960658A1 (sh)
DE (1) DE69822839T2 (sh)
DK (1) DK1003720T3 (sh)
DZ (1) DZ2581A1 (sh)
EA (1) EA002490B1 (sh)
ES (1) ES2216293T3 (sh)
GT (1) GT199800124A (sh)
HR (1) HRP980438B1 (sh)
HU (1) HUP0002960A3 (sh)
ID (1) ID23668A (sh)
IL (1) IL134300A (sh)
IS (1) IS5340A (sh)
MA (1) MA26530A1 (sh)
MY (1) MY120235A (sh)
NO (1) NO313189B1 (sh)
NZ (1) NZ502309A (sh)
OA (1) OA11284A (sh)
PA (1) PA8456801A1 (sh)
PE (1) PE110899A1 (sh)
PL (1) PL338633A1 (sh)
PT (1) PT1003720E (sh)
SK (1) SK1362000A3 (sh)
TN (1) TNSN98150A1 (sh)
TR (1) TR200000368T2 (sh)
TW (1) TW426662B (sh)
UA (1) UA61963C2 (sh)
UY (2) UY25131A1 (sh)
WO (1) WO1999007675A1 (sh)
YU (1) YU1900A (sh)
ZA (1) ZA987126B (sh)

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