RU2342159C2 - Комбинированная терапия негематологических злокачественных опухолей с использованием анти-igf-1r-антитела - Google Patents

Комбинированная терапия негематологических злокачественных опухолей с использованием анти-igf-1r-антитела Download PDF

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RU2342159C2
RU2342159C2 RU2007101387/14A RU2007101387A RU2342159C2 RU 2342159 C2 RU2342159 C2 RU 2342159C2 RU 2007101387/14 A RU2007101387/14 A RU 2007101387/14A RU 2007101387 A RU2007101387 A RU 2007101387A RU 2342159 C2 RU2342159 C2 RU 2342159C2
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igf
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hematologic malignant
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Антонио ГВАЛЬБЕРТО (US)
Антонио ГВАЛЬБЕРТО
Брюс Дэвид КОЭН (US)
Брюс Дэвид КОЭН
Кэрри Линн МЕЛВИН (US)
Кэрри Линн МЕЛВИН
Мари Луиза РОБЕРТС (US)
Мария Луиза РОБЕРТС
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    • A—HUMAN NECESSITIES
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Abstract

Изобретение относится к медицине, а именно к онкологии, и может быть использовано для лечения негематологических злокачественных опухолей, экспрессирующих инсулиноподобный фактор роста IGF-1R. Предложенные способы лечения включают введение антитела, которое специфически связывается с IGF-1R, а также таксана и карбоплатина. Кроме того, данное изобретение относится к фармацевтической композиции, содержащей это антитело. Изобретение позволяет повысить эффективность лечения за счет способности антител к IGF-1R к ингибированию опухолевого роста и усилению эффективности химиотерапии. 3 н. и 11 з.п. ф-лы, 5 ил.

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Claims (14)

1. Способ лечения негематологической злокачественной опухоли у пациента, нуждающегося в таком лечении, включающий введение пациенту терапевтически эффективного количества антитела, которое специфически связывается с IGF-1R, терапевтически эффективного количества таксана и терапевтически эффективного количества карбоплатина, где негематологическая злокачественная опухоль экспрессирует IGF-1R.
2. Способ по п.1, где антитело выбрано из 2.12.1, 2.13.2, 2.14.3, 4.9.2, 4.17.3 или 6.1.1.
3. Способ по п.2, где таксаном является доцетаксел.
4. Способ по п.2, где таксаном является паклитаксел.
5. Способ по п.3, где антителом является 2.13.2.
6. Способ по п.4, где антителом является 2.13.2.
7. Способ по любому из пп.1-4, где негематологической злокачественной опухолью является рак молочной железы.
8. Способ по любому из пп.1-4, где негематологической злокачественной опухолью является рак легкого.
9. Способ по любому из пп.1-4, где негематологической злокачественной опухолью является рак предстательной железы.
10. Фармацевтическая композиция для лечения негематологической злокачественной опухоли, содержащая терапевтически эффективное количество антитела, которое специфически связывает IGF-1R, терапевтически эффективное количество таксана, терапевтически эффективное количество карбоплатина и фармацевтически приемлемый носитель.
11. Композиция по п.10, где антитело выбрано из группы состоящей из 2.12.1, 2.13.2, 2.14.3, 4.9.2, 4.17.3 или 6.1.1.
12. Композиция по п.11, где это антитело является 2.13.2 и таксаном является паклитаксел.
13. Композиция по п.11, где это антитело является 2.13.2 и таксаном является доцетаксел.
14. Способ лечения рака легких у пациента, нуждающегося в этом, включающий введение пациенту терапевтически эффективного количества антитела, которое специфически связывается с IGF-1R - 2.13.2, терапевтически эффективного количества паклитаксела и терапевтически эффективного количества карбоплатина.
RU2007101387/14A 2004-07-16 2005-07-04 Комбинированная терапия негематологических злокачественных опухолей с использованием анти-igf-1r-антитела RU2342159C2 (ru)

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