ES2054712T3 - Un procedimiento para la preparacion de los derivados de prolinal. - Google Patents
Un procedimiento para la preparacion de los derivados de prolinal.Info
- Publication number
- ES2054712T3 ES2054712T3 ES88101186T ES88101186T ES2054712T3 ES 2054712 T3 ES2054712 T3 ES 2054712T3 ES 88101186 T ES88101186 T ES 88101186T ES 88101186 T ES88101186 T ES 88101186T ES 2054712 T3 ES2054712 T3 ES 2054712T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- procedure
- preparation
- carbon atom
- prolinal derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
UNOS NUEVOS DERIVADOS DEL PROLINAL DE LA FORMULA (I) (DODNE A REPRESENTA UN GRUPO ALQUILENO DE 1 A 4 ATOMO(S) DE CARBONO O UN ANILLO HIDROCARBURO SATURADO CON 3 A 7 ATOMOS DE CARBONO. N REPRESENTA EL NUMERO 2,3 O 4, D REPRESENTA UN ANILLO CARBOCICLICO O HETEROCICLICO SUSTITUIDO O NO SUSTIUIDO POR UNO A TRES ATOMOS HALOGENOS, GRUP ALQUILO O ALCOXI DE 1 A 4 ATOMOS DE CARBONO, UN GRUPO NITRO O UN GRUPO TRIFLUORMETILO. POSEEN ACTIVIDAD INHIBIDORA SOBRE LA ENDOPEPTIDASA PROLIL, Y POR ELLO RESULTAN UTILES PARA TRATAR Y/O PREVENIR LA AMNESIA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2240787 | 1987-02-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2054712T3 true ES2054712T3 (es) | 1994-08-16 |
Family
ID=12081811
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88101186T Expired - Lifetime ES2054712T3 (es) | 1987-02-04 | 1988-01-27 | Un procedimiento para la preparacion de los derivados de prolinal. |
Country Status (6)
Country | Link |
---|---|
US (2) | US4977180A (es) |
EP (1) | EP0277588B1 (es) |
KR (1) | KR960004858B1 (es) |
AT (1) | ATE87306T1 (es) |
DE (1) | DE3879522T2 (es) |
ES (1) | ES2054712T3 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5118811A (en) * | 1989-04-13 | 1992-06-02 | Japan Tobacco Inc. | Amino acid derivatives possessing prolyl endopeptidase-inhibitory activities |
WO1991018891A1 (en) * | 1990-06-04 | 1991-12-12 | Pfizer Inc. | Aromatic pyrrolidine and thiazolidine amides |
ZA200508439B (en) | 2003-05-05 | 2007-03-28 | Probiodrug Ag | Medical use of inhibitors of glutaminyl and glutamate cyclases |
ZA200603165B (en) | 2003-11-03 | 2007-07-25 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
EP1713780B1 (en) | 2004-02-05 | 2012-01-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
US9126987B2 (en) | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
CN101668525A (zh) | 2007-03-01 | 2010-03-10 | 前体生物药物股份公司 | 谷氨酰胺酰环化酶抑制剂的新用途 |
EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
US8524654B2 (en) * | 2007-05-21 | 2013-09-03 | The Uab Research Foundation | Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation |
SG178953A1 (en) | 2009-09-11 | 2012-04-27 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
ES2586231T3 (es) | 2010-03-03 | 2016-10-13 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
DK2545047T3 (da) | 2010-03-10 | 2014-07-28 | Probiodrug Ag | Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5) |
WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
ES2570167T3 (es) | 2011-03-16 | 2016-05-17 | Probiodrug Ag | Derivados de benzimidazol como inhibidores de glutaminil ciclasa |
US9477350B2 (en) | 2011-04-26 | 2016-10-25 | Sentons Inc. | Method and apparatus for active ultrasonic touch devices |
US9189109B2 (en) | 2012-07-18 | 2015-11-17 | Sentons Inc. | Detection of type of object used to provide a touch contact input |
US11327599B2 (en) | 2011-04-26 | 2022-05-10 | Sentons Inc. | Identifying a contact type |
US10198097B2 (en) | 2011-04-26 | 2019-02-05 | Sentons Inc. | Detecting touch input force |
US9639213B2 (en) | 2011-04-26 | 2017-05-02 | Sentons Inc. | Using multiple signals to detect touch input |
KR101850680B1 (ko) | 2011-11-18 | 2018-04-20 | 센톤스 아이엔씨. | 터치 입력 힘 검출 |
KR101652744B1 (ko) | 2011-11-18 | 2016-09-09 | 센톤스 아이엔씨. | 국소형 햅틱 피드백 |
US11262253B2 (en) | 2017-08-14 | 2022-03-01 | Sentons Inc. | Touch input detection using a piezoresistive sensor |
US9459715B1 (en) | 2013-09-20 | 2016-10-04 | Sentons Inc. | Using spectral control in detecting touch input |
US10048811B2 (en) | 2015-09-18 | 2018-08-14 | Sentons Inc. | Detecting touch input provided by signal transmitting stylus |
US10908741B2 (en) | 2016-11-10 | 2021-02-02 | Sentons Inc. | Touch input detection along device sidewall |
US10296144B2 (en) | 2016-12-12 | 2019-05-21 | Sentons Inc. | Touch input detection with shared receivers |
US10126877B1 (en) | 2017-02-01 | 2018-11-13 | Sentons Inc. | Update of reference data for touch input detection |
US10585522B2 (en) | 2017-02-27 | 2020-03-10 | Sentons Inc. | Detection of non-touch inputs using a signature |
PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60188317A (ja) * | 1984-03-09 | 1985-09-25 | Yakult Honsha Co Ltd | 抗健忘症剤 |
JPS6137764A (ja) * | 1984-07-31 | 1986-02-22 | Suntory Ltd | 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物 |
JPH0680077B2 (ja) * | 1985-02-08 | 1994-10-12 | サントリー株式会社 | プロリンエンドペプチダ−ゼインヒビタ−活性を有する新規ペプチド化合物 |
JPH0623190B2 (ja) * | 1985-04-16 | 1994-03-30 | サントリー株式会社 | インヒビタ−活性を有するn−アシルピロリジン誘導体及びその製法並びに用途 |
CA1298033C (en) * | 1985-04-16 | 1992-03-24 | Takaharu Tanaka | Dipeptide derivative of fatty acid |
CA1309805C (en) * | 1985-04-16 | 1992-11-03 | Naoki Higuchi | Dipeptide derivative and synthesis and use thereof |
ES2058089T3 (es) * | 1986-11-20 | 1994-11-01 | Ono Pharmaceutical Co | Un procedimiento para la preparacion de un nuevo derivado de prolinal. |
EP0275482B1 (en) * | 1986-12-29 | 1993-01-20 | Ono Pharmaceutical Co., Ltd. | Proline derivatives |
JPH0366162A (ja) * | 1989-08-04 | 1991-03-20 | Hitachi Ltd | 固体撮像装置 |
-
1988
- 1988-01-27 EP EP88101186A patent/EP0277588B1/en not_active Expired - Lifetime
- 1988-01-27 DE DE8888101186T patent/DE3879522T2/de not_active Expired - Fee Related
- 1988-01-27 AT AT88101186T patent/ATE87306T1/de not_active IP Right Cessation
- 1988-01-27 ES ES88101186T patent/ES2054712T3/es not_active Expired - Lifetime
- 1988-02-03 KR KR1019880000965A patent/KR960004858B1/ko not_active IP Right Cessation
- 1988-02-03 US US07/151,862 patent/US4977180A/en not_active Expired - Lifetime
-
1990
- 1990-02-07 US US07/479,493 patent/US5091406A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US4977180A (en) | 1990-12-11 |
KR880009922A (ko) | 1988-10-05 |
ATE87306T1 (de) | 1993-04-15 |
EP0277588B1 (en) | 1993-03-24 |
DE3879522T2 (de) | 1993-09-02 |
EP0277588A1 (en) | 1988-08-10 |
US5091406A (en) | 1992-02-25 |
DE3879522D1 (de) | 1993-04-29 |
KR960004858B1 (ko) | 1996-04-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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