EA200001176A1 - Гетероциклические ингибиторы p38 - Google Patents

Гетероциклические ингибиторы p38

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Publication number
EA200001176A1
EA200001176A1 EA200001176A EA200001176A EA200001176A1 EA 200001176 A1 EA200001176 A1 EA 200001176A1 EA 200001176 A EA200001176 A EA 200001176A EA 200001176 A EA200001176 A EA 200001176A EA 200001176 A1 EA200001176 A1 EA 200001176A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
relates
compositions
heterocyclic inhibitors
prevention
Prior art date
Application number
EA200001176A
Other languages
English (en)
Inventor
Франческо Салитуро
Винсент Галулло
Стивен Беллон
Гай Бемиз
Джон Кочран
Original Assignee
Вертекс Фармасьютикалз Инкорпорейтед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вертекс Фармасьютикалз Инкорпорейтед filed Critical Вертекс Фармасьютикалз Инкорпорейтед
Publication of EA200001176A1 publication Critical patent/EA200001176A1/ru

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

Данное изобретение относится к ингибиторам p38, протеинкиназы млекопитающих, вовлеченной в клеточную пролиферацию, гибель клеток и ответ на внеклеточные сигналы. Изобретение относится также к способу получения этих ингибиторов. Кроме того, изобретение предоставляет фармацевтические композиции, включающие ингибиторы данного изобретения, и способы применения этих композиций для лечения и профилактики различных расстройств.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200001176A 1998-05-11 1999-05-11 Гетероциклические ингибиторы p38 EA200001176A1 (ru)

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HUP0105174A3 (en) 2002-06-28
EP2336111A1 (en) 2011-06-22
BG65025B1 (bg) 2006-12-29
CN1306512A (zh) 2001-08-01
PL344046A1 (en) 2001-09-24
AP2000001996A0 (en) 2000-12-31
US7423049B2 (en) 2008-09-09
AU3792399A (en) 1999-11-29
SK16882000A3 (sk) 2001-05-10
EP2062879A1 (en) 2009-05-27
NO20005673D0 (no) 2000-11-10

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