EA200400953A1 - Замещённые пиридиноны в качестве модуляторов map-киназы p38 - Google Patents
Замещённые пиридиноны в качестве модуляторов map-киназы p38Info
- Publication number
- EA200400953A1 EA200400953A1 EA200400953A EA200400953A EA200400953A1 EA 200400953 A1 EA200400953 A1 EA 200400953A1 EA 200400953 A EA200400953 A EA 200400953A EA 200400953 A EA200400953 A EA 200400953A EA 200400953 A1 EA200400953 A1 EA 200400953A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- map
- pyridinoes
- modulators
- kinase
- Prior art date
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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Abstract
Описаны соединения формулы I и их фармацевтически приемлемые соли, где R, R, R, Rи Rопределены в описании. Данные соединения могут быть полезны для лечения заболеваний и состояний, индуцирование или обострение которых опосредуется нерегулируемой активностью MAP-киназы p38 и/или TNF-активностью. Также описаны фармацевтические композиции, содержащие указанные соединения; способы их получения и способы лечения с использованием соединений настоящего изобретения.Международная заявка была опубликована вместе с отчетом о международном поиске.
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