EP0923372A4 - Pyridinone thrombin inhibitors - Google Patents

Pyridinone thrombin inhibitors

Info

Publication number
EP0923372A4
EP0923372A4 EP97906633A EP97906633A EP0923372A4 EP 0923372 A4 EP0923372 A4 EP 0923372A4 EP 97906633 A EP97906633 A EP 97906633A EP 97906633 A EP97906633 A EP 97906633A EP 0923372 A4 EP0923372 A4 EP 0923372A4
Authority
EP
European Patent Office
Prior art keywords
pyridinone
thrombin inhibitors
thrombin
inhibitors
pyridinone thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97906633A
Other languages
German (de)
French (fr)
Other versions
EP0923372A1 (en
Inventor
Philip E Sanderson
Terry A Lyle
Joseph P Vacca
William C Lumma
Stephen F Brady
Thomas J Tucker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9605643.7A external-priority patent/GB9605643D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0923372A1 publication Critical patent/EP0923372A1/en
Publication of EP0923372A4 publication Critical patent/EP0923372A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
EP97906633A 1996-02-22 1997-02-18 Pyridinone thrombin inhibitors Withdrawn EP0923372A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1205896P 1996-02-22 1996-02-22
US12058P 1996-02-22
GBGB9605643.7A GB9605643D0 (en) 1996-03-18 1996-03-18 Pyridinone thrombin inhibitors
GB9605643 1996-03-18
PCT/US1997/002408 WO1997030708A1 (en) 1996-02-22 1997-02-18 Pyridinone thrombin inhibitors

Publications (2)

Publication Number Publication Date
EP0923372A1 EP0923372A1 (en) 1999-06-23
EP0923372A4 true EP0923372A4 (en) 2001-09-05

Family

ID=26308947

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97906633A Withdrawn EP0923372A4 (en) 1996-02-22 1997-02-18 Pyridinone thrombin inhibitors

Country Status (5)

Country Link
EP (1) EP0923372A4 (en)
JP (1) JP2000512616A (en)
AU (1) AU720616B2 (en)
CA (1) CA2245811A1 (en)
WO (1) WO1997030708A1 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2277929A1 (en) * 1997-01-22 1998-07-23 Merck & Co., Inc. Thrombin inhibitors
CN1125051C (en) * 1997-11-26 2003-10-22 三维药物公司 Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors
EP1036063B1 (en) 1997-11-26 2006-11-02 Ortho-McNeil Pharmaceuticals, Inc. Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors
JP2001524522A (en) * 1997-12-01 2001-12-04 メルク エンド カムパニー インコーポレーテッド Thrombin inhibitor
AU759427B2 (en) 1998-06-11 2003-04-17 3-Dimensional Pharmaceuticals, Inc. Pyrazinone protease inhibitors
ES2209337T3 (en) 1998-08-14 2004-06-16 Pfizer Inc. ANTITROMBOTIC AGENTS.
CA2348740A1 (en) 1998-12-23 2000-07-06 Ruth R. Wexler Thrombin or factor xa inhibitors
AR023510A1 (en) 1999-04-21 2002-09-04 Astrazeneca Ab A TEAM OF PARTS, PHARMACEUTICAL FORMULATION AND USE OF A THROMBIN INHIBITOR.
US6653316B1 (en) 1999-05-19 2003-11-25 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6664255B1 (en) 1999-05-19 2003-12-16 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
US6458952B1 (en) 1999-05-19 2002-10-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
CA2373509A1 (en) * 1999-05-19 2000-11-23 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US7015230B1 (en) 1999-05-19 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6867217B1 (en) 1999-05-19 2005-03-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US6716838B1 (en) 1999-05-19 2004-04-06 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US6750342B1 (en) 1999-05-19 2004-06-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
CA2372234A1 (en) 1999-05-27 2000-12-07 3-Dimensional Pharmaceuticals, Inc. Oxazaheterocycles as protease inhibitors
FR2795072B1 (en) * 1999-06-15 2001-07-27 Adir NOVEL BICYCLIC DERIVATIVES OF AMINO-PYRAZINONES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WO2001004117A1 (en) 1999-07-09 2001-01-18 3-Dimensional Pharmaceuticals, Inc. Heteroaryl protease inhibitors and diagnostic imaging agents
KR20020027639A (en) 1999-09-13 2002-04-13 3-디멘져널 파마슈티칼즈 인코오포레이티드 Azacycloalkanone serine protease inhibitors
WO2001068605A1 (en) 2000-03-13 2001-09-20 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
ATE289299T1 (en) 2000-04-05 2005-03-15 Pharmacia Corp POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 4-PYRONES USABLE FOR SELECTIVE INHIBITION OF THE COAGULATION PROCESS
EP1268428A2 (en) 2000-04-05 2003-01-02 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
AU2001255399A1 (en) * 2000-04-14 2001-10-30 Corvas International, Inc. Pyridine and pyrazine derivatives as thrombin inhibitors
EP1274676A2 (en) 2000-04-17 2003-01-15 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
CA2415932A1 (en) 2000-07-17 2002-01-24 3-Dimensional Pharmaceuticals, Inc. Cyclic oxyguanidine pyrazinones as protease inhibitors
CA2417914A1 (en) 2000-08-04 2002-02-14 3-Dimensional Pharmaceuticals, Inc. Cyclic oxyguanidine protease inhibitors
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
US7015223B1 (en) 2000-11-20 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
US7119094B1 (en) 2000-11-20 2006-10-10 Warner-Lambert Company Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
WO2002042272A2 (en) 2000-11-20 2002-05-30 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade
CA2462645A1 (en) 2001-10-03 2003-11-13 Pharmacia Corporation Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade
CA2462305A1 (en) 2001-10-03 2003-04-10 Michael S. South 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade
SI21097A (en) 2001-12-04 2003-06-30 Univerza V Ljubljani Thrombine inhibitors
PL218749B1 (en) 2002-02-14 2015-01-30 Pharmacia Corp Substituted pyridinones as modulators of p38 map kinase
FR2867780B1 (en) 2004-03-19 2006-05-19 Servier Lab NOVEL 4-OXO-4,6,7,8-TETRAHYDROPYRROLO (1,2-A) PYRAZINE-6-CARBOXAMIDE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
KR100854584B1 (en) 2006-03-20 2008-08-27 주식회사 엘지생명과학 Selective thrombin inhibitors based on pyridazinone, pyrimidone, or pyridone scaffold
JP6901054B1 (en) * 2020-03-13 2021-07-14 三菱電機株式会社 Elevator door panel structure

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9730708A1 *

Also Published As

Publication number Publication date
EP0923372A1 (en) 1999-06-23
CA2245811A1 (en) 1997-08-28
WO1997030708A1 (en) 1997-08-28
JP2000512616A (en) 2000-09-26
AU720616B2 (en) 2000-06-08
AU2127497A (en) 1997-09-10

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Legal Events

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