EP0923372A4 - Inhibitoren von pyridinone thrombin - Google Patents

Inhibitoren von pyridinone thrombin

Info

Publication number
EP0923372A4
EP0923372A4 EP97906633A EP97906633A EP0923372A4 EP 0923372 A4 EP0923372 A4 EP 0923372A4 EP 97906633 A EP97906633 A EP 97906633A EP 97906633 A EP97906633 A EP 97906633A EP 0923372 A4 EP0923372 A4 EP 0923372A4
Authority
EP
European Patent Office
Prior art keywords
pyridinone
thrombin inhibitors
thrombin
inhibitors
pyridinone thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97906633A
Other languages
English (en)
French (fr)
Other versions
EP0923372A1 (de
Inventor
Philip E Sanderson
Terry A Lyle
Joseph P Vacca
William C Lumma
Stephen F Brady
Thomas J Tucker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9605643.7A external-priority patent/GB9605643D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0923372A1 publication Critical patent/EP0923372A1/de
Publication of EP0923372A4 publication Critical patent/EP0923372A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
EP97906633A 1996-02-22 1997-02-18 Inhibitoren von pyridinone thrombin Withdrawn EP0923372A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1205896P 1996-02-22 1996-02-22
US12058P 1996-02-22
GB9605643 1996-03-18
GBGB9605643.7A GB9605643D0 (en) 1996-03-18 1996-03-18 Pyridinone thrombin inhibitors
PCT/US1997/002408 WO1997030708A1 (en) 1996-02-22 1997-02-18 Pyridinone thrombin inhibitors

Publications (2)

Publication Number Publication Date
EP0923372A1 EP0923372A1 (de) 1999-06-23
EP0923372A4 true EP0923372A4 (de) 2001-09-05

Family

ID=26308947

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97906633A Withdrawn EP0923372A4 (de) 1996-02-22 1997-02-18 Inhibitoren von pyridinone thrombin

Country Status (5)

Country Link
EP (1) EP0923372A4 (de)
JP (1) JP2000512616A (de)
AU (1) AU720616B2 (de)
CA (1) CA2245811A1 (de)
WO (1) WO1997030708A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2277929A1 (en) * 1997-01-22 1998-07-23 Merck & Co., Inc. Thrombin inhibitors
AU751412B2 (en) * 1997-11-26 2002-08-15 3-Dimensional Pharmaceuticals, Inc. Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors
CN1125051C (zh) * 1997-11-26 2003-10-22 三维药物公司 杂环氨基胍和烷氧基胍及其作为蛋白酶抑制剂的用途
AU741766B2 (en) * 1997-12-01 2001-12-06 Merck & Co., Inc. Thrombin inhibitors
DE69942159D1 (de) 1998-06-11 2010-04-29 Ortho Mcneil Pharm Inc Pyrazine Protease Inhibitore
DE69912379T2 (de) 1998-08-14 2004-05-06 Pfizer Inc. Antithrombosemittel
WO2000039102A1 (en) 1998-12-23 2000-07-06 Du Pont Pharmaceuticals Company THROMBIN OR FACTOR Xa INHIBITORS
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
US6750342B1 (en) 1999-05-19 2004-06-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6716838B1 (en) 1999-05-19 2004-04-06 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US6458952B1 (en) 1999-05-19 2002-10-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6653316B1 (en) 1999-05-19 2003-11-25 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US7015230B1 (en) 1999-05-19 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
AU771928B2 (en) * 1999-05-19 2004-04-08 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US6664255B1 (en) 1999-05-19 2003-12-16 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
US6867217B1 (en) 1999-05-19 2005-03-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
MXPA01011956A (es) 1999-05-27 2002-06-21 Dimensional Pharm Inc Oxazaheterociclos como inhibidores de proteasas.
FR2795072B1 (fr) * 1999-06-15 2001-07-27 Adir Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE60005351D1 (de) 1999-07-09 2003-10-23 Dimensional Pharm Inc Heteroaryl protease inhibitoren und diagnostische bilderzeugungsmittel
DK1212300T3 (da) 1999-09-13 2004-03-15 Dimensional Pharm Inc Azacyclololalkanonserinproteaseinhibitorer
US6660885B2 (en) 2000-03-13 2003-12-09 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
EP1268428A2 (de) 2000-04-05 2003-01-02 Pharmacia Corporation Polyzyklische aryl und heteroaryl substituierte 4-pyridon-derivate verwendbar zur selektiven hemmung der blutgerinnungskaskade
ATE289299T1 (de) 2000-04-05 2005-03-15 Pharmacia Corp Polyzyclisch aryl und heteroaryl substituierte 4- pyronen verwendbar als selektive hemmung von dem koagulationsprozess
WO2001079195A2 (en) * 2000-04-14 2001-10-25 Corvas International, Inc. Pyridine and pyrazine derivatives as thrombin inhibitors
US20040171616A9 (en) 2000-04-17 2004-09-02 South Michael S. Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
KR20030015393A (ko) 2000-07-17 2003-02-20 3-디멘져널 파마슈티칼즈 인코오포레이티드 프로테아제 억제제 기능이 있는 시클릭 옥시구아니딘피라지논
AU2001277242A1 (en) 2000-08-04 2002-02-18 3-Dimensional Pharmaceuticals, Inc. Cyclic oxyguanidine protease inhibitors
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
US6624180B2 (en) 2000-11-20 2003-09-23 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade
US7119094B1 (en) 2000-11-20 2006-10-10 Warner-Lambert Company Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
US7015223B1 (en) 2000-11-20 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
WO2003093242A2 (en) 2001-10-03 2003-11-13 Pharmacia Corporation Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade
BR0213092A (pt) 2001-10-03 2004-10-19 Pharmacia Corp Compostos heterocìclicos de 6 elementos úteis para a inibição seletiva da cascata de coagulação
SI21097A (sl) 2001-12-04 2003-06-30 Univerza V Ljubljani Inhibitorji trombina
CN100486576C (zh) 2002-02-14 2009-05-13 法玛西雅公司 作为p38map激酶调节剂的取代吡啶酮类
FR2867780B1 (fr) 2004-03-19 2006-05-19 Servier Lab Nouveaux derives de 4-oxo-4,6,7,8-tetrahydropyrrolo (1,2-a) pyrazine-6-carboxamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR100854584B1 (ko) 2006-03-20 2008-08-27 주식회사 엘지생명과학 피리다지논, 피리미돈 또는 피리돈 구조를 포함하는선택적인 트롬빈 억제제
WO2021181653A1 (ja) * 2020-03-13 2021-09-16 三菱電機株式会社 エレベーターのドアパネル構造

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9730708A1 *

Also Published As

Publication number Publication date
CA2245811A1 (en) 1997-08-28
WO1997030708A1 (en) 1997-08-28
AU720616B2 (en) 2000-06-08
JP2000512616A (ja) 2000-09-26
EP0923372A1 (de) 1999-06-23
AU2127497A (en) 1997-09-10

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Legal Events

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