EP1017393A4 - Pyrazinon thrombininhibitoren - Google Patents

Pyrazinon thrombininhibitoren

Info

Publication number
EP1017393A4
EP1017393A4 EP98946835A EP98946835A EP1017393A4 EP 1017393 A4 EP1017393 A4 EP 1017393A4 EP 98946835 A EP98946835 A EP 98946835A EP 98946835 A EP98946835 A EP 98946835A EP 1017393 A4 EP1017393 A4 EP 1017393A4
Authority
EP
European Patent Office
Prior art keywords
thrombin inhibitors
pyrazinone
pyrazinone thrombin
inhibitors
thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98946835A
Other languages
English (en)
French (fr)
Other versions
EP1017393A1 (de
Inventor
Philip E Sanderson
Terry A Lyle
Bruce D Dorsey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9801005.1A external-priority patent/GB9801005D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1017393A1 publication Critical patent/EP1017393A1/de
Publication of EP1017393A4 publication Critical patent/EP1017393A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP98946835A 1997-09-05 1998-09-03 Pyrazinon thrombininhibitoren Withdrawn EP1017393A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5805897P 1997-09-05 1997-09-05
US58058P 1997-09-05
GB9801005 1998-01-16
GBGB9801005.1A GB9801005D0 (en) 1998-01-16 1998-01-16 Pyrazinone thrombin inhibitors
PCT/US1998/018417 WO1999011267A1 (en) 1997-09-05 1998-09-03 Pyrazinone thrombin inhibitors

Publications (2)

Publication Number Publication Date
EP1017393A1 EP1017393A1 (de) 2000-07-12
EP1017393A4 true EP1017393A4 (de) 2002-01-23

Family

ID=26312966

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98946835A Withdrawn EP1017393A4 (de) 1997-09-05 1998-09-03 Pyrazinon thrombininhibitoren

Country Status (4)

Country Link
EP (1) EP1017393A4 (de)
JP (1) JP2001514227A (de)
CA (1) CA2301520A1 (de)
WO (1) WO1999011267A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9710809D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
US6147078A (en) * 1998-05-19 2000-11-14 Merck & Co., Inc. Pyrazinone thrombin inhibitors
AU759427B2 (en) 1998-06-11 2003-04-17 3-Dimensional Pharmaceuticals, Inc. Pyrazinone protease inhibitors
EP0997474B1 (de) 1998-08-14 2003-10-29 Pfizer Inc. Antithrombosemittel
AU747776B2 (en) 1998-10-30 2002-05-23 Merck & Co., Inc. Thrombin inhibitors
EP1124823A1 (de) 1998-10-30 2001-08-22 Merck & Co., Inc. Thrombin inhibitoren
US6750342B1 (en) 1999-05-19 2004-06-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
AU771928B2 (en) * 1999-05-19 2004-04-08 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US7015230B1 (en) 1999-05-19 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6867217B1 (en) 1999-05-19 2005-03-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US6716838B1 (en) 1999-05-19 2004-04-06 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US6653316B1 (en) 1999-05-19 2003-11-25 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6664255B1 (en) * 1999-05-19 2003-12-16 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
EP1586565A1 (de) * 1999-05-19 2005-10-19 Pharmacia Corporation Substituierte polycyclische aryl und heteroarylpyrazinone zur selektiven Hemmung von der Blutgerinnungskaskade
US6458952B1 (en) 1999-05-19 2002-10-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
CA2372617A1 (en) * 1999-05-19 2000-11-23 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
UA58636C2 (uk) * 1999-06-04 2003-08-15 Мерк Енд Ко., Інк. Піразинонові інгібітори тромбіну, фармацевтична композиція, спосіб інгібування утворення тромбів у крові, спосіб лікування станів, пов'язаних із тромбоутворенням
DE60031686T2 (de) 1999-07-19 2007-08-30 Merck Frosst Canada Ltd., Kirkland Pyrazinone, diese verbindungen enthaltende zusammenstellungen
WO2001038323A1 (en) * 1999-11-23 2001-05-31 Merck & Co., Inc. Pyrazinone thrombin inhibitors
WO2001068605A1 (en) 2000-03-13 2001-09-20 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
EP1267876A1 (de) 2000-03-23 2003-01-02 Merck & Co., Inc. Thrombinhemmer
EP1268463B1 (de) 2000-04-05 2005-02-16 Pharmacia Corporation Polyzyclisch aryl und heteroaryl substituierte 4-pyronen verwendbar als selektive hemmung von dem koagulationsprozess
WO2001077079A2 (en) * 2000-04-05 2001-10-18 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
AU2001255399A1 (en) * 2000-04-14 2001-10-30 Corvas International, Inc. Pyridine and pyrazine derivatives as thrombin inhibitors
US6506754B1 (en) * 2000-04-14 2003-01-14 Corvas International, Inc. Non-covalent thrombin inhibitors
AU2001253363A1 (en) 2000-04-17 2001-10-30 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
WO2001092234A1 (en) 2000-06-01 2001-12-06 Merck & Co., Inc. Pyrazinone thrombin inhibitors
WO2002006248A2 (en) * 2000-07-17 2002-01-24 3-Dimensional Pharmaceuticals, Inc. Cyclic oxyguanidine pyrazinones as protease inhibitors
AU2001278997A1 (en) * 2000-07-28 2002-02-13 Merck And Co., Inc. Thrombin inhibitors
MXPA03004458A (es) 2000-11-20 2005-01-25 Pharmacia Corp Arilpiridinas y heteroarilpiridinas sustituidas utiles para inhibicion selectiva de la cascada de coagulacion.
US7119094B1 (en) 2000-11-20 2006-10-10 Warner-Lambert Company Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
US7015223B1 (en) 2000-11-20 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
WO2002046160A2 (en) * 2000-12-06 2002-06-13 Merck & Co., Inc. Process for making a thrombin inhibitor
CA2436068A1 (en) * 2001-02-09 2002-08-22 Merck & Co., Inc. Thrombin inhibitors
WO2003029216A1 (en) 2001-10-03 2003-04-10 Pharmacia Corporation 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade
WO2003093242A2 (en) 2001-10-03 2003-11-13 Pharmacia Corporation Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001338A1 (en) * 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5668289A (en) * 1996-06-24 1997-09-16 Merck & Co., Inc. Pyridinone thrombin inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001338A1 (en) * 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9911267A1 *

Also Published As

Publication number Publication date
EP1017393A1 (de) 2000-07-12
WO1999011267A1 (en) 1999-03-11
JP2001514227A (ja) 2001-09-11
CA2301520A1 (en) 1999-03-11

Similar Documents

Publication Publication Date Title
EP1017393A4 (de) Pyrazinon thrombininhibitoren
EP0969840A4 (de) Thrombin inhibitoren
EP1124822A4 (de) Thrombin inhibitoren
EP0971891A4 (de) Thrombin-inhibitoren
EP0923372A4 (de) Inhibitoren von pyridinone thrombin
EP0927035A4 (de) Thrombin inhibitoren
EP0991753A4 (de) Proteaseinhibitoren
EP1079835A4 (de) Pyrazinone als thrombininhibitoren
IL127751A0 (en) Thrombin inhibitors
EP1003846A4 (de) Proteaseinhibitoren
EP0983228A4 (de) Proteaseinhibitoren
EP1117660A4 (de) Thrombin-inhibitoren
EP1019046A4 (de) Proteaseinhibitoren
IL136139A0 (en) Thrombin inhibitors
HUP0202366A3 (en) Pyrazinone thrombin inhibitors
GB9613718D0 (en) Thrombin inhibitors
EP1015438A4 (de) Protease inhibitoren
IL121474A0 (en) Thrombin inhibitors
EP1017383A4 (de) Thrombininhibitoren
ZA974779B (en) Thrombin inhibitors.
EP1039907A4 (de) Thrombin hemmer
EP0975612A4 (de) Proteaseinhibitoren
EP1027333A4 (de) Thrombin-inhibitoren
GB9813580D0 (en) Pyrazinone thrombin inhibitors
GB9801005D0 (en) Pyrazinone thrombin inhibitors

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20000405

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

AX Request for extension of the european patent

Free format text: AL PAYMENT 20000405;LT PAYMENT 20000405;LV PAYMENT 20000405;MK PAYMENT 20000405;RO PAYMENT 20000405;SI PAYMENT 20000405

A4 Supplementary search report drawn up and despatched

Effective date: 20011207

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7C 07D 401/12 A, 7C 07D 401/14 B, 7C 07D 405/12 B, 7C 07D 405/14 B

17Q First examination report despatched

Effective date: 20020418

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20040108