ZA974779B - Thrombin inhibitors. - Google Patents

Thrombin inhibitors.

Info

Publication number
ZA974779B
ZA974779B ZA9704779A ZA974779A ZA974779B ZA 974779 B ZA974779 B ZA 974779B ZA 9704779 A ZA9704779 A ZA 9704779A ZA 974779 A ZA974779 A ZA 974779A ZA 974779 B ZA974779 B ZA 974779B
Authority
ZA
South Africa
Prior art keywords
thrombin inhibitors
thrombin
inhibitors
Prior art date
Application number
ZA9704779A
Inventor
Derek Edward Brundish
Lyndon Nigel Brown
Darren Mark Le Grand
Keith Allan Menear
Garrick Paul Smith
Mark Christopher Allen Butler
Xiao-Ling Cockroft
Ian Timothy William Matthews
Clive Victor Walker
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ZA974779B publication Critical patent/ZA974779B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
ZA9704779A 1996-06-01 1997-05-30 Thrombin inhibitors. ZA974779B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9611461.6A GB9611461D0 (en) 1996-06-01 1996-06-01 New compounds

Publications (1)

Publication Number Publication Date
ZA974779B true ZA974779B (en) 1997-12-01

Family

ID=10794610

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9704779A ZA974779B (en) 1996-06-01 1997-05-30 Thrombin inhibitors.

Country Status (8)

Country Link
AR (1) AR008376A1 (en)
AU (1) AU2908197A (en)
CO (1) CO4940504A1 (en)
GB (1) GB9611461D0 (en)
ID (1) ID16990A (en)
PE (1) PE69498A1 (en)
WO (1) WO1997046553A1 (en)
ZA (1) ZA974779B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112679448A (en) * 2020-12-31 2021-04-20 苏州昊帆生物股份有限公司 Preparation method of N- (2-aminoethyl) morpholine

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1547575A (en) * 2001-06-12 2004-11-17 Sk��ʽ���� Novel phenylalkyl diamine and amide analogs
AU2002331064B2 (en) * 2001-08-10 2007-08-23 Palatin Technologies, Inc. Peptidomimetics of biologically active metallopeptides
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
CA2725140A1 (en) * 2008-05-22 2009-11-26 Boehringer Ingelheim International Gmbh Alpha-substituted n-sulfonyl gylcine amides antagonists of ccr10, compositions containing the same and methods for using them
EP2640367A2 (en) 2010-11-15 2013-09-25 Exelixis, Inc. Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture
WO2012071509A2 (en) 2010-11-24 2012-05-31 Exelixis, Inc. Benzoxazepines as inhibitors of p13k/mtor and methods of their use and manufacture

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH31294A (en) * 1992-02-13 1998-07-06 Thomae Gmbh Dr K Benzimidazolyl derivatives, pharmaceutical compositions containing these compounds and process for preparing them.
EP0673247A4 (en) * 1992-12-01 1996-05-01 Merck & Co Inc Fibrinogen receptor antagonists.
FR2727413B1 (en) * 1994-11-25 1996-12-20 Synthelabo DERIVATIVES OF 5- (1H-IMIDAZOL-4-YL) -1-OXO-2- (PHENYLSULFONAMINO) - PENTYLPIPERIDINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112679448A (en) * 2020-12-31 2021-04-20 苏州昊帆生物股份有限公司 Preparation method of N- (2-aminoethyl) morpholine

Also Published As

Publication number Publication date
ID16990A (en) 1997-11-27
AR008376A1 (en) 2000-01-19
PE69498A1 (en) 1998-11-27
GB9611461D0 (en) 1996-08-07
WO1997046553A1 (en) 1997-12-11
AU2908197A (en) 1998-01-05
CO4940504A1 (en) 2000-07-24

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