AU2908197A - Thrombin inhibitors - Google Patents

Thrombin inhibitors

Info

Publication number
AU2908197A
AU2908197A AU29081/97A AU2908197A AU2908197A AU 2908197 A AU2908197 A AU 2908197A AU 29081/97 A AU29081/97 A AU 29081/97A AU 2908197 A AU2908197 A AU 2908197A AU 2908197 A AU2908197 A AU 2908197A
Authority
AU
Australia
Prior art keywords
thrombin inhibitors
thrombin
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU29081/97A
Inventor
Mark Christopher Allen
Lyndon Nigel Brown
Derek Edward Brundish
Paul Ian Butler
Xiao-Ling Cockroft
Darren Mark Le Grand
Ian Timothy William Matthews
Keith Allan Menear
Garrick Paul Smith
Clive Victor Walker
William Bernard Wathey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG, Novartis AG filed Critical Ciba Geigy AG
Publication of AU2908197A publication Critical patent/AU2908197A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU29081/97A 1996-06-01 1997-05-21 Thrombin inhibitors Abandoned AU2908197A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9611461 1996-06-01
GBGB9611461.6A GB9611461D0 (en) 1996-06-01 1996-06-01 New compounds
PCT/GB1997/001385 WO1997046553A1 (en) 1996-06-01 1997-05-21 Thrombin inhibitors

Publications (1)

Publication Number Publication Date
AU2908197A true AU2908197A (en) 1998-01-05

Family

ID=10794610

Family Applications (1)

Application Number Title Priority Date Filing Date
AU29081/97A Abandoned AU2908197A (en) 1996-06-01 1997-05-21 Thrombin inhibitors

Country Status (8)

Country Link
AR (1) AR008376A1 (en)
AU (1) AU2908197A (en)
CO (1) CO4940504A1 (en)
GB (1) GB9611461D0 (en)
ID (1) ID16990A (en)
PE (1) PE69498A1 (en)
WO (1) WO1997046553A1 (en)
ZA (1) ZA974779B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004537531A (en) * 2001-06-12 2004-12-16 エスケー コーポレイション New phenylalkyldiamine and amide analogs
AU2002331064B2 (en) * 2001-08-10 2007-08-23 Palatin Technologies, Inc. Peptidomimetics of biologically active metallopeptides
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
JP2011522801A (en) * 2008-05-22 2011-08-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Alpha-substituted N-sulfonylglycine (GYLCINE) amide antagonists of CCR10, compositions containing them and methods for using them
US20140066431A1 (en) 2010-11-15 2014-03-06 Exelixis, Inc. Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture
WO2012071509A2 (en) 2010-11-24 2012-05-31 Exelixis, Inc. Benzoxazepines as inhibitors of p13k/mtor and methods of their use and manufacture
CN112679448B (en) * 2020-12-31 2022-08-19 苏州昊帆生物股份有限公司 Preparation method of N- (2-aminoethyl) morpholine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH31294A (en) * 1992-02-13 1998-07-06 Thomae Gmbh Dr K Benzimidazolyl derivatives, pharmaceutical compositions containing these compounds and process for preparing them.
EP0673247A4 (en) * 1992-12-01 1996-05-01 Merck & Co Inc Fibrinogen receptor antagonists.
FR2727413B1 (en) * 1994-11-25 1996-12-20 Synthelabo DERIVATIVES OF 5- (1H-IMIDAZOL-4-YL) -1-OXO-2- (PHENYLSULFONAMINO) - PENTYLPIPERIDINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Also Published As

Publication number Publication date
PE69498A1 (en) 1998-11-27
ZA974779B (en) 1997-12-01
GB9611461D0 (en) 1996-08-07
AR008376A1 (en) 2000-01-19
ID16990A (en) 1997-11-27
CO4940504A1 (en) 2000-07-24
WO1997046553A1 (en) 1997-12-11

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