PE69498A1 - PIRIDINE 3-SULFONAMIDE DERIVATIVES - Google Patents
PIRIDINE 3-SULFONAMIDE DERIVATIVESInfo
- Publication number
- PE69498A1 PE69498A1 PE1997000444A PE00044497A PE69498A1 PE 69498 A1 PE69498 A1 PE 69498A1 PE 1997000444 A PE1997000444 A PE 1997000444A PE 00044497 A PE00044497 A PE 00044497A PE 69498 A1 PE69498 A1 PE 69498A1
- Authority
- PE
- Peru
- Prior art keywords
- compounds
- cycle
- preference
- react
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: "A" Y R ESTAN AUSENTES o "A" ES UN GRUPO METILENO O ETILENO; R ES H, HALOGENO, AZIDA, OR9, NR10R11; R9 ES H, ALQUILO O HIDROXIALQUILO; R10 Y R11 SON H, ALQUILO O JUNTO CON EL ATOMO DE N FORMAN UN CICLO; m ES 0; 1 o 2; n ES 1; 2 o 3; R1 ES DE PREFERENCIA FENILO OPCIONALMENTE SUSTITUIDO CON UNO MAS 0R4, SR5 o NR6R7; R2 ES UN DERIVADO DE AMINOACIDO, TAL COMO FENILALANINA, TIROSINA O DOPA, ENTRE OTROS; SIENDO R2-CH2 DE PREFERENCIA 4-METILAMINOBENCILO, 2-BENZOTIAZOLILMETILO O 4-HIDROXIBENCILO, ENTRE OTROS; R3 PRESENTA 2 o 3 ATOMOS DE CARBONO Y SE ENCUENTRA OPCIONALMENTE SUSTITUIDO POR OH, F O Cl; R4, R5, R6 Y R7 SON H, ALQUILO O HETEROCICLO MONO O BICICLICO, ENTRE OTROS; EN LOS COMPUESTOS EXISTEN Y SE PREFIEREN 2 CENTROS ASIMETRICOS DE CONFIGURACIONES (S). TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DE LOS COMPUESTOS DE FORMULA (I), QUE COMPRENDE: 1. REACCIONAR 4-CLOROPIRIDINA-3-SULFONILCLORURO CON X-CO-CH(CH2-R2)-NH2, EN DONDE "X" ES OH, OPCIONALMENTE PROTEGIDO, 2. REACCIONAR LO OBTENIDO EN (1) CON R1(CH2)m-CH(NH2)-A-R, 3. REACCIONAR LO OBTENIDO EN (2) CON UNA BASE DE AMINA CICLICA. LOS COMPUESTOS OBTENIDOS ACTUAN COMO INHIBIDORES POTENTES DE LAS PROTEASAS DE SERINA (TROMBINA), TIENEN BUENA BIODISPONIBILIDAD Y SON USADOS EN EL TRATAMIENTO DE TROMBOSIS DE VENA, ENTRE OTROSTHEY REFER TO COMPOUNDS OF FORMULA (I), WHERE: "A" AND R ARE ABSENT or "A" IS A METHYLENE OR ETHYLENE GROUP; R IS H, HALOGEN, AZIDA, OR9, NR10R11; R9 IS H, ALKYL OR HYDROXIALKYL; R10 AND R11 ARE H, RENT OR TOGETHER WITH THE ATOM OF N FORM A CYCLE; m IS 0; 1 or 2; n IS 1; 2 or 3; R1 IS OF PREFERENCE FENILE OPTIONALLY REPLACED WITH ONE MORE 0R4, SR5 or NR6R7; R2 IS A DERIVATIVE OF AMINO ACID, SUCH AS PHENYLALANINE, THYROSINE OR DOPA, AMONG OTHERS; PREFERENCE R2-CH2 BEING 4-METHYLAMINOBENCIL, 2-BENZOTIAZOLYLMETHYLL OR 4-HYDROXYBENCIL, AMONG OTHERS; R3 PRESENTS 2 or 3 CARBON ATOMS AND IS OPTIONALLY REPLACED BY OH, F OR Cl; R4, R5, R6 AND R7 ARE H, ALKYL OR HETERO-CYCLE MONO OR BICYCLE, AMONG OTHERS; IN THE COMPOUNDS THERE ARE 2 ASYMMETRIC CONFIGURATION CENTERS AND ARE PREFERRED (S). IT ALSO REFERS TO THE PROCEDURE FOR THE PREPARATION OF FORMULA (I) COMPOUNDS, WHICH INCLUDES: 1. REACTION 4-CHLOROPYRIDINE-3-SULPHONYL CHLORIDE WITH X-CO-CH (CH2-R2) -NH2, WHERE "X" IS OH , OPTIONALLY PROTECTED, 2. REACT THE OBTAINED IN (1) WITH R1 (CH2) m-CH (NH2) -AR, 3. REACT THE OBTAINED IN (2) WITH A CYCLE AMINE BASE. THE COMPOUNDS OBTAINED ACT AS POWERFUL INHIBITORS OF SERINE PROTEASES (THROMBINE), HAVE GOOD BIOAVAILABILITY AND ARE USED IN THE TREATMENT OF VENOMINE THROMBOSIS, AMONG OTHERS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9611461.6A GB9611461D0 (en) | 1996-06-01 | 1996-06-01 | New compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PE69498A1 true PE69498A1 (en) | 1998-11-27 |
Family
ID=10794610
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1997000444A PE69498A1 (en) | 1996-06-01 | 1997-05-29 | PIRIDINE 3-SULFONAMIDE DERIVATIVES |
Country Status (8)
Country | Link |
---|---|
AR (1) | AR008376A1 (en) |
AU (1) | AU2908197A (en) |
CO (1) | CO4940504A1 (en) |
GB (1) | GB9611461D0 (en) |
ID (1) | ID16990A (en) |
PE (1) | PE69498A1 (en) |
WO (1) | WO1997046553A1 (en) |
ZA (1) | ZA974779B (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1401821A4 (en) * | 2001-06-12 | 2006-05-31 | Sk Corp | Novel phenylalkyl diamine and amide analogs |
AU2002331064B2 (en) * | 2001-08-10 | 2007-08-23 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
EP2294051B1 (en) * | 2008-05-22 | 2014-08-13 | Boehringer Ingelheim International GmbH | Alpha-substituted n-sulfonyl gylcine amides antagonists of ccr10, compositions containing the same and methods for using them |
WO2012068106A2 (en) | 2010-11-15 | 2012-05-24 | Exelixis, Inc. | Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture |
EP2643316A2 (en) | 2010-11-24 | 2013-10-02 | Exelixis, Inc. | Benzoxazepines as inhibitors of p13k/mtor and methods of their use and manufacture |
CN112679448B (en) * | 2020-12-31 | 2022-08-19 | 苏州昊帆生物股份有限公司 | Preparation method of N- (2-aminoethyl) morpholine |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH31294A (en) * | 1992-02-13 | 1998-07-06 | Thomae Gmbh Dr K | Benzimidazolyl derivatives, pharmaceutical compositions containing these compounds and process for preparing them. |
CA2150550A1 (en) * | 1992-12-01 | 1994-06-09 | Melissa S. Egbertson | Fibrinogen receptor antagonists |
FR2727413B1 (en) * | 1994-11-25 | 1996-12-20 | Synthelabo | DERIVATIVES OF 5- (1H-IMIDAZOL-4-YL) -1-OXO-2- (PHENYLSULFONAMINO) - PENTYLPIPERIDINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
-
1996
- 1996-06-01 GB GBGB9611461.6A patent/GB9611461D0/en active Pending
-
1997
- 1997-05-21 WO PCT/GB1997/001385 patent/WO1997046553A1/en active Application Filing
- 1997-05-21 AU AU29081/97A patent/AU2908197A/en not_active Abandoned
- 1997-05-28 AR ARP970102270A patent/AR008376A1/en unknown
- 1997-05-29 CO CO97029802A patent/CO4940504A1/en unknown
- 1997-05-29 PE PE1997000444A patent/PE69498A1/en not_active Application Discontinuation
- 1997-05-30 ID IDP971834A patent/ID16990A/en unknown
- 1997-05-30 ZA ZA9704779A patent/ZA974779B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ID16990A (en) | 1997-11-27 |
WO1997046553A1 (en) | 1997-12-11 |
AU2908197A (en) | 1998-01-05 |
AR008376A1 (en) | 2000-01-19 |
CO4940504A1 (en) | 2000-07-24 |
ZA974779B (en) | 1997-12-01 |
GB9611461D0 (en) | 1996-08-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |