EA199800119A1 - Ингибиторы адгезии клеток - Google Patents

Ингибиторы адгезии клеток

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Publication number
EA199800119A1
EA199800119A1 EA199800119A EA199800119A EA199800119A1 EA 199800119 A1 EA199800119 A1 EA 199800119A1 EA 199800119 A EA199800119 A EA 199800119A EA 199800119 A EA199800119 A EA 199800119A EA 199800119 A1 EA199800119 A1 EA 199800119A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cell adhesion
compounds
inhibiting
pharmaceutical compositions
present
Prior art date
Application number
EA199800119A
Other languages
English (en)
Other versions
EA001594B1 (ru
Inventor
Ко-Чунг Лин
Стивен П. Адамс
Альфредо К. Кастро
Крейг Н. Зиммерман
Хулио Хернан Куэрво
Вен-Чернг Ли
Чарльз И. Хаммонд
Мэри Бет Картер
Рональд А. Олмквист
Кэрол Ли Энсингер
Original Assignee
Байоджен, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байоджен, Инк. filed Critical Байоджен, Инк.
Publication of EA199800119A1 publication Critical patent/EA199800119A1/ru
Publication of EA001594B1 publication Critical patent/EA001594B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/06—Antipsoriatics
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    • A—HUMAN NECESSITIES
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/02—Immunomodulators
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
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    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
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    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
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    • C07K5/10—Tetrapeptides
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    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
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    • C07K5/10—Tetrapeptides
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    • C07K5/10—Tetrapeptides
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
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  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pulmonology (AREA)
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  • Dermatology (AREA)
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  • Neurosurgery (AREA)
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Abstract

Настоящее изобретение касается новых соединений, которые пригодны для ингибирования и предотвращения адгезии клеток и обусловленных ею патологией. Изобретение включает также фармацевтические композиции, включающие эти соединения и способы их применения для ингибирования и предотвращения адгезии клеток и обусловленных ею патологий. Соединения и фармацевтические композиции согласно настоящему изобретению могут использоваться в качестве терапевтических или профилактических средств. Они особенно полезны для лечения многих заболеваний воспалительного и аутоиммунного характера.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800119A 1995-07-11 1996-07-11 Ингибиторы адгезии клеток EA001594B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/498,237 US6248713B1 (en) 1995-07-11 1995-07-11 Cell adhesion inhibitors
PCT/US1996/011570 WO1997003094A1 (en) 1995-07-11 1996-07-11 Cell adhesion inhibitors

Publications (2)

Publication Number Publication Date
EA199800119A1 true EA199800119A1 (ru) 1998-08-27
EA001594B1 EA001594B1 (ru) 2001-06-25

Family

ID=23980177

Family Applications (2)

Application Number Title Priority Date Filing Date
EA199800119A EA001594B1 (ru) 1995-07-11 1996-07-11 Ингибиторы адгезии клеток
EA200100103A EA003737B1 (ru) 1995-07-11 1996-07-11 Ингибиторы адгезии клеток

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200100103A EA003737B1 (ru) 1995-07-11 1996-07-11 Ингибиторы адгезии клеток

Country Status (28)

Country Link
US (2) US6248713B1 (ru)
EP (1) EP0842196B1 (ru)
JP (2) JPH11511124A (ru)
KR (1) KR100531586B1 (ru)
CN (1) CN1195778C (ru)
AU (1) AU716276B2 (ru)
BG (1) BG63876B1 (ru)
BR (1) BR9609782A (ru)
CA (1) CA2226868A1 (ru)
CZ (1) CZ299054B6 (ru)
DE (1) DE69637328T2 (ru)
EA (2) EA001594B1 (ru)
EE (2) EE03694B1 (ru)
FI (1) FI980033A (ru)
HK (1) HK1010888A1 (ru)
HU (1) HUP9802202A3 (ru)
IL (1) IL122783A (ru)
IS (1) IS4648A (ru)
MX (1) MX9800348A (ru)
NO (1) NO980097L (ru)
NZ (1) NZ312950A (ru)
PL (1) PL188446B1 (ru)
RO (1) RO121032B1 (ru)
SK (1) SK3798A3 (ru)
TR (1) TR199800028T1 (ru)
TW (1) TW570927B (ru)
UA (1) UA71888C2 (ru)
WO (1) WO1997003094A1 (ru)

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US6037324A (en) 1996-01-04 2000-03-14 Leukosite, Inc. Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor
JP2002515043A (ja) 1996-07-25 2002-05-21 バイオジェン，インコーポレイテッド Ｖｌａ―４インヒビターのための分子モデル
US6686350B1 (en) 1996-07-25 2004-02-03 Biogen, Inc. Cell adhesion inhibitors
US6291511B1 (en) 1997-05-29 2001-09-18 Merck & Co., Inc. Biarylalkanoic acids as cell adhesion inhibitors
DE69833654T2 (de) * 1997-05-29 2006-12-14 Merck & Co., Inc. (A New Jersey Corp.) Biarylalkansäuren in der verwendung als zelladhäsionsinhibitoren
US6903075B1 (en) 1997-05-29 2005-06-07 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
US6221888B1 (en) 1997-05-29 2001-04-24 Merck & Co., Inc. Sulfonamides as cell adhesion inhibitors
DE69820614T2 (de) * 1997-05-30 2004-09-30 Celltech Therapeutics Ltd., Slough Entzündungshemmende tyrosin-derivate
US6939855B2 (en) * 1997-07-31 2005-09-06 Elan Pharmaceuticals, Inc. Anti-inflammatory compositions and method
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AR016133A1 (es) * 1997-07-31 2001-06-20 Wyeth Corp Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria
US7030114B1 (en) 1997-07-31 2006-04-18 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6362341B1 (en) 1997-07-31 2002-03-26 Athena Neurosciences, Inc. Benzyl compounds which inhibit leukocyte adhesion mediated by VLA-4
US6291453B1 (en) 1997-07-31 2001-09-18 Athena Neurosciences, Inc. 4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
US6492421B1 (en) 1997-07-31 2002-12-10 Athena Neurosciences, Inc. Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
US6583139B1 (en) 1997-07-31 2003-06-24 Eugene D. Thorsett Compounds which inhibit leukocyte adhesion mediated by VLA-4
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DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
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