HUP9802202A2 - Sejtadhézió inhibitor hatású peptidek és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Sejtadhézió inhibitor hatású peptidek és ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP9802202A2
HUP9802202A2 HU9802202A HUP9802202A HUP9802202A2 HU P9802202 A2 HUP9802202 A2 HU P9802202A2 HU 9802202 A HU9802202 A HU 9802202A HU P9802202 A HUP9802202 A HU P9802202A HU P9802202 A2 HUP9802202 A2 HU P9802202A2
Authority
HU
Hungary
Prior art keywords
cell adhesion
pipe powder
peptides
pharmaceutical compositions
compositions containing
Prior art date
Application number
HU9802202A
Other languages
English (en)
Inventor
Steven P. Adams
Ronald G. Almquist
Mary Beth Carter
Alfredo C. Castro
Julio Hernan Cuervo
Carol Lee Ensinger
Charles E. Hammond
Wen-Cherng Lee
Ko-Chung Lin
Craig N. Zimmerman
Original Assignee
Biogen, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen, Inc. filed Critical Biogen, Inc.
Publication of HUP9802202A2 publication Critical patent/HUP9802202A2/hu
Publication of HUP9802202A3 publication Critical patent/HUP9802202A3/hu

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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
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    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
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Abstract

A találmány tárgyát az Z-(Y1)-(Y2)-(Y3)n-X N>(I) ltalánős képletű, sejtadhéziót gátló vegyületek -, ahől Z acilcsőpőrt, különösen adőtt esetben a gyűrűkben szűbsztitűált (N'-aril- űreidő)-fenil-acetil- vagy (N'-aril-űreidő)-piridil-acetil-csőpőrt, X adőtt esetben szűbsztitűált hidrőxi- vagy aminőcsőpőrt vagynitrőgéntartalmú heterőciklűsős csőpőrt, n = 0-8, de előnyösen 2, és Y1, Y2 és Y3 L-aminősavakból származtatható csőpőrtők vagy azők védettfőrmái, így az adőtt sőrrendet tekintve különösen leűcil- vagymetiőnilcsőpőrt, aszparagilcsőpőrt, valil- és prőlilcsőpőrt - ésszármazékaik, ezeket tartalmazó gyógyszerkészítmények és ezek gyógyászatialkalmazása képezik. ŕ
HU9802202A 1995-07-11 1996-07-11 Peptides having cell adhesion inhibitor effect and pharmaceutical compositions containing them HUP9802202A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/498,237 US6248713B1 (en) 1995-07-11 1995-07-11 Cell adhesion inhibitors

Publications (2)

Publication Number Publication Date
HUP9802202A2 true HUP9802202A2 (hu) 1999-01-28
HUP9802202A3 HUP9802202A3 (en) 1999-03-29

Family

ID=23980177

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802202A HUP9802202A3 (en) 1995-07-11 1996-07-11 Peptides having cell adhesion inhibitor effect and pharmaceutical compositions containing them

Country Status (28)

Country Link
US (2) US6248713B1 (hu)
EP (1) EP0842196B1 (hu)
JP (2) JPH11511124A (hu)
KR (1) KR100531586B1 (hu)
CN (1) CN1195778C (hu)
AU (1) AU716276B2 (hu)
BG (1) BG63876B1 (hu)
BR (1) BR9609782A (hu)
CA (1) CA2226868A1 (hu)
CZ (1) CZ299054B6 (hu)
DE (1) DE69637328T2 (hu)
EA (2) EA003737B1 (hu)
EE (2) EE03694B1 (hu)
FI (1) FI980033A (hu)
HK (1) HK1010888A1 (hu)
HU (1) HUP9802202A3 (hu)
IL (1) IL122783A (hu)
IS (1) IS4648A (hu)
MX (1) MX9800348A (hu)
NO (1) NO980097L (hu)
NZ (1) NZ312950A (hu)
PL (1) PL188446B1 (hu)
RO (1) RO121032B1 (hu)
SK (1) SK3798A3 (hu)
TR (1) TR199800028T1 (hu)
TW (1) TW570927B (hu)
UA (1) UA71888C2 (hu)
WO (1) WO1997003094A1 (hu)

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US6686350B1 (en) 1996-07-25 2004-02-03 Biogen, Inc. Cell adhesion inhibitors
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