ATE375330T1 - Enamin-derivate als zell-adhäsionsmoleküle - Google Patents

Enamin-derivate als zell-adhäsionsmoleküle

Info

Publication number
ATE375330T1
ATE375330T1 AT01921580T AT01921580T ATE375330T1 AT E375330 T1 ATE375330 T1 AT E375330T1 AT 01921580 T AT01921580 T AT 01921580T AT 01921580 T AT01921580 T AT 01921580T AT E375330 T1 ATE375330 T1 AT E375330T1
Authority
AT
Austria
Prior art keywords
group
atom
enamine derivatives
alk
cell adhesion
Prior art date
Application number
AT01921580T
Other languages
English (en)
Inventor
Timothy Norman
John Porter
Brian Woodside Hutchinson
Andrew James Ratcliffe
John Head
Rikki Peter Alexander
Barry Langham
Graham Warrellow
Sarah Catherine Archibald
Janeen Linsley
Original Assignee
Ucb Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0009493A external-priority patent/GB0009493D0/en
Priority claimed from GB0018353A external-priority patent/GB0018353D0/en
Priority claimed from GB0018966A external-priority patent/GB0018966D0/en
Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa
Application granted granted Critical
Publication of ATE375330T1 publication Critical patent/ATE375330T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fuel Cell (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT01921580T 2000-04-17 2001-04-12 Enamin-derivate als zell-adhäsionsmoleküle ATE375330T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0009493A GB0009493D0 (en) 2000-04-17 2000-04-17 Chemical compounds
GB0018353A GB0018353D0 (en) 2000-07-26 2000-07-26 Chemical compounds
GB0018966A GB0018966D0 (en) 2000-08-02 2000-08-02 Chemical compounds

Publications (1)

Publication Number Publication Date
ATE375330T1 true ATE375330T1 (de) 2007-10-15

Family

ID=27255675

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01921580T ATE375330T1 (de) 2000-04-17 2001-04-12 Enamin-derivate als zell-adhäsionsmoleküle

Country Status (8)

Country Link
US (2) US6610700B2 (de)
EP (1) EP1332132B1 (de)
JP (1) JP2003531141A (de)
AT (1) ATE375330T1 (de)
AU (1) AU2001248553A1 (de)
DE (1) DE60130910T2 (de)
ES (1) ES2295150T3 (de)
WO (1) WO2001079173A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0021898D0 (en) 2000-09-06 2000-10-25 Celltech Chiroscience Ltd Chemical compounds
PT1370531E (pt) * 2001-02-22 2007-04-30 Celltech R&D Ltd Derivados de fenilalanina-enamida possuindo um grupo ciclobuteno para utilização como inibidores da integrinaa
US7557130B2 (en) 2001-07-26 2009-07-07 Ucb Pharma, S.A. Bicyclic heteroaromatic alanines
GB0216568D0 (en) * 2002-07-17 2002-08-28 Celltech R&D Ltd Chemical compounds
GB0216571D0 (en) * 2002-07-17 2002-08-28 Celltech R&D Ltd Chemical compounds
JP2007530700A (ja) * 2004-03-29 2007-11-01 ユニバーシティ オブ ミシシッピ 新規なシクロペンテンジオン抗真菌性化合物およびその使用方法
TW201422238A (zh) 2004-06-04 2014-06-16 Genentech Inc Ｃｄ２０抗體於治療多發性硬化症之用途及用於該用途之物品
CA2602175C (en) 2005-03-21 2012-11-27 Applera Corporation Alpha ketoamide compounds as cysteine protease inhibitors
MY149159A (en) 2005-11-15 2013-07-31 Hoffmann La Roche Method for treating joint damage
TW201014605A (en) 2008-09-16 2010-04-16 Genentech Inc Methods for treating progressive multiple sclerosis
WO2010075249A2 (en) 2008-12-22 2010-07-01 Genentech, Inc. A method for treating rheumatoid arthritis with b-cell antagonists
US8680152B2 (en) 2011-05-02 2014-03-25 Virobay, Inc. Cathepsin inhibitors for the treatment of bone cancer and bone cancer pain
WO2013101771A2 (en) 2011-12-30 2013-07-04 Genentech, Inc. Compositions and method for treating autoimmune diseases
BR112014018471A2 (pt) 2012-01-31 2017-07-04 Genentech Inc anticorpos anti-ige m1' e métodos para o seu uso
HK1257072A1 (zh) 2015-10-06 2019-10-11 豪夫迈‧罗氏有限公司 治疗多发性硬化的方法
EP4467565A3 (de) 2016-12-21 2025-03-12 Amgen Inc. Anti-tnf-alpha-antikörperformulierungen
CN111349060B (zh) * 2018-12-21 2022-05-03 石家庄圣泰化工有限公司 四氢噻吩-3-酮-1,1-二氧化物的合成方法

Family Cites Families (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1437781A (en) 1972-04-04 1976-06-03 Beecham Group Ltd Pyridine derivatives having hypoglycaemic activity
US3938367A (en) 1975-03-28 1976-02-17 Nasa Sampler of gas borne particles
JPS609718B2 (ja) 1977-08-25 1985-03-12 塩野義製薬株式会社 チアジアゾリルチオセフアロスポリン類縁抗生物質
JPS5683483A (en) 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
JPS5690045A (en) 1979-12-25 1981-07-21 Tokuyama Soda Co Ltd Alpha*alpha**di substituted amino phenylenediacetic acid
JPS56139455A (en) 1980-04-02 1981-10-30 Santen Pharmaceut Co Ltd Sulfur-containing acylaminoacid
US4470973A (en) 1982-07-19 1984-09-11 E. R. Squibb & Sons, Inc. Substituted peptide compounds
FR2540871B1 (fr) 1983-02-16 1986-01-10 Lipha Amino-2 phenyl-5 benzodiazepines-1,3; procede de preparation et medicaments les contenant
GB8332704D0 (en) 1983-12-07 1984-01-11 Pfizer Ltd Growth promotants for animals
IT1176983B (it) 1984-10-16 1987-08-26 Zambon Spa Dipeptidi ad attivita' farmacologica
CN1030415A (zh) 1987-02-20 1989-01-18 山之内制药株式会社 饱和的杂环碳酰胺衍生物和它的制备方法
JPH0784424B2 (ja) 1987-04-15 1995-09-13 味の素株式会社 チロシン誘導体及びその用途
US5510346A (en) 1987-12-07 1996-04-23 Hoechst Marion Roussel, Inc. 4-heteroaryl-1,3-benzodiazepines and 2-substituted-gamma-(heteroaryl)benzeneethanamines
IT1223565B (it) 1987-12-21 1990-09-19 Zambon Spa Derivati dell'acido tiazolidin 4 carbossilico ad attivita' farmaceutica
US5256812A (en) 1989-01-31 1993-10-26 Hoffmann-La Roche Inc. Carboxamides and sulfonamides
US5164372A (en) 1989-04-28 1992-11-17 Fujisawa Pharmaceutical Company, Ltd. Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
JPH07121917B2 (ja) 1989-07-31 1995-12-25 四国化成工業株式会社 ４（５）―チオカルバモイル―イミダゾール化合物及びその合成方法
US5260277A (en) 1990-09-10 1993-11-09 Tanabe Seiyaku Co., Ltd. Guanidinyl and related cell adhesion modulation compounds
IT1244548B (it) 1991-02-06 1994-07-15 Poli Ind Chimica Spa Derivati della 5-oxo-l-prolina e loro applicazioni farmaceutiche
DE69232854T2 (de) 1991-06-28 2003-09-04 Smith-Kline Beecham Corp., King Of Prussia Bizyklische fibrinogenantagonisten
US5296486A (en) 1991-09-24 1994-03-22 Boehringer Ingelheim Pharmaceuticals, Inc. Leukotriene biosynthesis inhibitors
US5250679A (en) 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
AU3141693A (en) 1991-11-22 1993-06-15 Friedman, Mark M. Non-peptidic surrogates of the arg-gly-asp sequence and pharmaceutical compositions comprising them
US5227490A (en) 1992-02-21 1993-07-13 Merck & Co., Inc. Fibrinogen receptor antagonists
AU686115B2 (en) 1992-11-02 1998-02-05 Fujisawa Pharmaceutical Co., Ltd. Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation
FR2700167B1 (fr) 1993-01-07 1995-02-03 Rhone Poulenc Rorer Sa Dérivés de pyrrolidine et thiazolidine, leur préparation et les médicaments les contenant.
FR2700168B1 (fr) 1993-01-07 1995-02-03 Rhone Poulenc Rorer Sa Dérivés de thiazolidine, leur préparation et les médicaments les contenant.
GB9311661D0 (en) 1993-06-05 1993-07-21 Smithkline Beecham Plc Novel compounds
AU678503B2 (en) 1993-09-24 1997-05-29 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds and their use as squalene synthetase inhibitors
AU8107694A (en) 1993-11-17 1995-06-06 Byk Nederland Bv Use of substituted thiazolidine derivatives in the treatment of raised intraocular pressure
WO1995015973A1 (en) 1993-12-06 1995-06-15 Cytel Corporation Cs-1 peptidomimetics, compositions and methods of using the same
JP2973271B2 (ja) 1994-01-18 1999-11-08 参天製薬株式会社 エンドペプチダーゼ２４．１５阻害剤
FR2721608B1 (fr) 1994-06-22 1996-07-19 Rhone Poulenc Rorer Sa Dérivés de thiazolidine, leur préparation et les médicaments les contenant.
WO1996001644A1 (en) 1994-07-11 1996-01-25 Athena Neurosciences, Inc. Inhibitors of leukocyte adhesion
ES2123889T3 (es) 1994-11-02 1999-01-16 Merck Patent Gmbh Antagonistas de receptores de adhesion.
TW403748B (en) 1994-11-02 2000-09-01 Takeda Chemical Industries Ltd An oxazolidinedione derivative, its production and a pharmaceutical composition for lowering blood sugar and lipid in blood comprising the same
US6306840B1 (en) 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
WO1996026190A1 (en) 1995-02-22 1996-08-29 Smithkline Beecham Corporation Integrin receptor antagonists
US6248713B1 (en) 1995-07-11 2001-06-19 Biogen, Inc. Cell adhesion inhibitors
GB9515073D0 (en) 1995-07-22 1995-09-20 Blair Neil Securement device and method
AU702487B2 (en) 1995-08-30 1999-02-25 G.D. Searle & Co. Meta-guanidine, urea, thiourea or azacyclic amino benzoic acid derivatives as integrin antagonists
US5714488A (en) 1995-10-03 1998-02-03 Abbott Laboratories Bis-heteroarylylmethoxyphenyl ketone derivatives as inhibitors of leukotriene biosynthesis
JP2000501105A (ja) 1995-12-22 2000-02-02 デュポン ファーマシューティカルズ カンパニー 新規なインテグリン受容体アンタゴニスト
JP2000502704A (ja) 1995-12-29 2000-03-07 スミスクライン・ビーチャム・コーポレイション ビトロネクチン受容体拮抗物質
GB9604242D0 (en) 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
EP0889876B1 (de) 1996-03-29 2001-07-25 G.D. SEARLE & CO. Meta-substituierte phenylsulphonamidderivate
JP2000507575A (ja) 1996-03-29 2000-06-20 ジー．ディー．サール アンド カンパニー シクロプロピルアルカノイック酸誘導体
ES2162676T3 (es) 1996-03-29 2002-01-01 Searle & Co Derivados de fenileno sustituidos en meta y su uso como antagonistas o inhibidores de integrina alfav,beta3.
ES2172780T3 (es) * 1996-03-29 2002-10-01 Searle & Co Derivados de acido fenilpropanoico sustituidos en para como antagonistas de integrina.
DE19620041A1 (de) 1996-05-17 1998-01-29 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
DE69733135T2 (de) 1996-06-10 2006-03-02 Merck & Co., Inc. Substituierte imidazole mit cytokinin-inhibirender wirkung
KR20000022190A (ko) 1996-06-28 2000-04-25 플레믹 크리스티안 인테그린 저해제로서의 페닐알라닌 유도체
DE19654483A1 (de) 1996-06-28 1998-01-02 Merck Patent Gmbh Phenylalanin-Derivate
WO1998004247A1 (en) 1996-07-25 1998-02-05 Biogen, Inc. Cell adhesion inhibitors
CA2268940A1 (en) 1996-10-30 1998-05-07 Merck & Co., Inc. Integrin antagonists
DE19647380A1 (de) 1996-11-15 1998-05-20 Hoechst Ag 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
DE19647381A1 (de) 1996-11-15 1998-05-20 Hoechst Ag Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
ATE234812T1 (de) 1996-12-09 2003-04-15 Lilly Co Eli Integrin antagonisten
WO1998031359A1 (en) 1997-01-17 1998-07-23 Merck & Co., Inc. Integrin antagonists
US6034136A (en) 1997-03-20 2000-03-07 Novartis Ag Certain cyclic thio substituted acylaminoacid amide derivatives
AU726585B2 (en) 1997-05-29 2000-11-09 Merck & Co., Inc. Biarylalkanoic acids as cell adhesion inhibitors
EP1001764A4 (de) 1997-05-29 2005-08-24 Merck & Co Inc Heterozyklische amide als zelladhäsionshemmern
JP2002501537A (ja) 1997-05-29 2002-01-15 メルク エンド カンパニー インコーポレーテッド 細胞接着阻害薬としてのスルホンアミド類
DE69820614T2 (de) 1997-05-30 2004-09-30 Celltech Therapeutics Ltd., Slough Entzündungshemmende tyrosin-derivate
JP2001517246A (ja) 1997-06-23 2001-10-02 田辺製薬株式会社 α▲下４▼β▲下１▼媒介細胞接着の阻止剤
AU8585198A (en) 1997-07-31 1999-02-22 American Home Products Corporation Benzyl compounds which inhibit leukocyte adhesion mediated by vla-4
EP0994895A1 (de) 1997-07-31 2000-04-26 Elan Pharmaceuticals, Inc. Dipeptide, die die vla-4 vermittelte adhäsion von leukozyten inhibieren
JP2001512139A (ja) 1997-07-31 2001-08-21 エラン・ファーマシューティカルズ・インコーポレーテッド Ｖｌａ−４が介在する白血球接着を阻害するスルホニル化ジペプチド化合物
AR016133A1 (es) 1997-07-31 2001-06-20 Wyeth Corp Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria
CA2290750A1 (en) 1997-07-31 1999-02-11 Elan Pharmaceuticals, Inc. 4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by vla-4
AU8585098A (en) 1997-07-31 1999-02-22 American Home Products Corporation Dipeptide and related compounds which inhibit leukocyte adhesion mediated by vla-4
BR9812114A (pt) 1997-07-31 2000-07-18 Elan Pharm Inc Compostos do tipo fenilalanina substituìda que inibem a adesão de leucócito mediada por vla-4
AU8678698A (en) 1997-07-31 1999-02-22 American Home Products Corporation Compounds which inhibit leukocyte adhesion mediated by vla-4
JP3727536B2 (ja) * 1997-08-22 2005-12-14 エフ．ホフマン−ラ ロシュ アーゲー Ｎ−アルカノイルフェニルアラニン誘導体
DK1005445T3 (da) 1997-08-22 2004-10-04 Hoffmann La Roche N-alkanoylphenylaninderivater
WO1999020272A1 (en) 1997-10-21 1999-04-29 Merck & Co., Inc. Azapeptide acids as cell adhesion inhibitors
AU1463499A (en) 1997-11-21 1999-06-15 Merck & Co., Inc. Substituted pyrrole derivatives as cell adhesion inhibitors
EP1034164B1 (de) 1997-11-24 2004-05-19 Merck & Co., Inc. Beta-alanin-derivate als zell-adhäsions-inhibitoren
JP2001524481A (ja) 1997-11-26 2001-12-04 デュポン ファーマシューティカルズ カンパニー αＶβ３アンタゴニストとしての１，３，４−チアジアゾール類および１，３，４−オキサジアゾール類
JP2002508323A (ja) 1997-12-17 2002-03-19 メルク エンド カムパニー インコーポレーテッド インテグリン受容体拮抗薬
IL136495A0 (en) 1997-12-17 2001-06-14 Merck & Co Inc Integrin receptor antagonists
JP3589633B2 (ja) 1997-12-17 2004-11-17 メルク エンド カムパニー インコーポレーテッド インテグリン受容体拮抗薬
EP0933367A1 (de) 1997-12-19 1999-08-04 Hoechst Marion Roussel Deutschland GmbH Acylguanidin Derivate als Inhibitoren von Knochenaufsauge und als Vitronectin Rezeptor Antagonisten
US6197794B1 (en) 1998-01-08 2001-03-06 Celltech Therapeutics Limited Phenylalanine derivatives
MY153569A (en) 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
US6329372B1 (en) 1998-01-27 2001-12-11 Celltech Therapeutics Limited Phenylalanine derivatives
WO1999043642A1 (en) 1998-02-26 1999-09-02 Celltech Therapeutics Limited Phenylalanine derivatives as inhibitors of alpha4 integrins
ZA994406B (en) 1998-03-04 2000-02-11 Searle & Co Meta-azacyclic amino benzoic acid and derivatives thereof.
US6521626B1 (en) 1998-03-24 2003-02-18 Celltech R&D Limited Thiocarboxamide derivatives
JP2002511462A (ja) 1998-04-10 2002-04-16 ジー・ディー・サール・アンド・カンパニー ビトロネクチンアンタゴニストとしてのヘテロ環式グリシルβ−アラニン誘導体
WO1999052879A1 (en) 1998-04-14 1999-10-21 American Home Products Corporation Acylresorcinol derivatives as selective vitronectin receptor inhibitors
IL138972A0 (en) 1998-04-16 2001-11-25 Texas Biotechnology Corp N,n-disubstituted amides that inhibit the binding of integrins to their receptors
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
GB9811159D0 (en) 1998-05-22 1998-07-22 Celltech Therapeutics Ltd Chemical compounds
AU8059598A (en) 1998-06-11 1999-12-30 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
TW591026B (en) 1998-06-23 2004-06-11 Upjohn Co Inhibitors of alpha4beta1 mediated cell adhesion
EP1091952B1 (de) 1998-06-29 2003-10-29 Biochem Pharma Inc Zur behandlung von krebs nützliche thiophen- und furan-2,5-dicarboxamide
JP2002519377A (ja) 1998-07-06 2002-07-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 血管形成阻害剤
WO2000006169A1 (en) 1998-07-29 2000-02-10 Merck & Co., Inc. Integrin receptor antagonists
US6458814B1 (en) 1998-08-07 2002-10-01 Smithkline Beecham Corporation Vitronectin receptor antagonists
US6630488B1 (en) 1998-09-21 2003-10-07 Biochem Pharma, Inc. Quinolizinones as integrin inhibitors
GB9821061D0 (en) * 1998-09-28 1998-11-18 Celltech Therapeutics Ltd Chemical compounds
FI982268A7 (fi) 1998-10-20 2000-04-21 Jarkko Rautio Ei-steroidaalisten anti-inflammatoristen karboksyylihappojen uudet prodrugit, niiden valmistus ja käyttö
AU6483699A (en) 1998-11-19 2000-06-13 Timebe, Ltd. Method and system for conducting commerce over a computer network
GB9826174D0 (en) 1998-11-30 1999-01-20 Celltech Therapeutics Ltd Chemical compounds
AU2357600A (en) 1998-12-14 2000-07-03 American Home Products Corporation 3,4-diamino-3-cyclobutene-1,2-dione derivatives which inhibit leukocyte adhesionmediated by vla-4
US6518283B1 (en) 1999-05-28 2003-02-11 Celltech R&D Limited Squaric acid derivatives
GB0021898D0 (en) * 2000-09-06 2000-10-25 Celltech Chiroscience Ltd Chemical compounds

Also Published As

Publication number Publication date
DE60130910T2 (de) 2008-07-10
US6780874B2 (en) 2004-08-24
DE60130910D1 (de) 2007-11-22
EP1332132A2 (de) 2003-08-06
AU2001248553A1 (en) 2001-10-30
US20030229116A1 (en) 2003-12-11
WO2001079173A2 (en) 2001-10-25
ES2295150T3 (es) 2008-04-16
EP1332132B1 (de) 2007-10-10
JP2003531141A (ja) 2003-10-21
US20020037909A1 (en) 2002-03-28
WO2001079173A3 (en) 2003-05-15
US6610700B2 (en) 2003-08-26

Similar Documents

Publication Publication Date Title
ATE375330T1 (de) Enamin-derivate als zell-adhäsionsmoleküle
ATE273273T1 (de) Phenylalaninderivate als inhibitoren von alpha4 integrinen
HUP0100348A2 (hu) Hattagú, egy vagy két nitrogénatomot tartalmazó kondenzál biciklusok, eljárás előállításukra, alkalmazásuk, a vegyületeket tartalmazó gyógyszerkészítmények, valamint intermedierek
BG106003A (en) New n-cyanomethylamides and compositions as protease inhibitors
IL146309A0 (en) Indole-type derivatives as inhibitors of p38 kinase
MXPA06013534A (es) Compuesto de cinamida.
YU69902A (sh) Novi derivati piperazina
WO2004035577A3 (en) Pre-organized tricyclic integrase inhibitor compounds
HUP0401729A2 (hu) IV típusú foszfodiészteráz inhibitor hatású alkin-aril-naftiridin-4(1H)-on-származékok és ezeket tartalmazó gyógyszerkészítmények
HUP9901590A2 (hu) Szubsztituált aza- és diaza-cikloheptán- és -ciklooktán-származékok, alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények
DE69709493D1 (de) Substituierte Indazolderivate
AU2382201A (en) Squaric acid derivatives as integrin antagonists
ATE250034T1 (de) Pyridylverbindungen und diese enthaltende pharmazeutische zubereitungen
AU8670791A (en) Thienoimidazole derivatives, their production and use
MXPA02012910A (es) Amidas de acidobifenilcarboxilico, su preparacion y su uso como medicinas.
ZA200705889B (en) New 3-phenylpropionic acid derivatives and their use as PPAR-GAMMA receptor ligands
CA2262997A1 (en) Pharmaceutical products for curing and preventing illnesses connected with the malfunction of vascular endothelial cells
YU49902A (sh) Supstituisani derivati piperazina kao mtp inhibitori
NO941273L (no) Ny anvendelse av substituert kinolinkarboksamid
ATE518858T1 (de) Pyrroloä3,2-cüpyridinderivate und herstellungsverfahren dafür
ZA200704584B (en) New 3-Phenylpropionic acid derivatives for the treatment of diabetes
DE69907683D1 (de) Zimtsäure-derivate als zelladhäsions-moleküle
BR9907911A (pt) Derivado de ácido carboxìlico, uso do mesmo, combinação, e, preparação de droga para administração oral, parenteral e intra-parenteral
PL363100A1 (en) Hiv inhibiting n-aminoimidazole derivatives
UA81626C2 (ru) 2,6-замещенные пиридин-3-карбонильные производные и промежуточные соединения

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties