DE69907683D1 - Zimtsäure-derivate als zelladhäsions-moleküle - Google Patents

Zimtsäure-derivate als zelladhäsions-moleküle

Info

Publication number
DE69907683D1
DE69907683D1 DE69907683T DE69907683T DE69907683D1 DE 69907683 D1 DE69907683 D1 DE 69907683D1 DE 69907683 T DE69907683 T DE 69907683T DE 69907683 T DE69907683 T DE 69907683T DE 69907683 D1 DE69907683 D1 DE 69907683D1
Authority
DE
Germany
Prior art keywords
moles
acid derivatives
cell adhesion
cinnamic acid
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69907683T
Other languages
English (en)
Other versions
DE69907683T2 (de
Inventor
Graham John Warrellow
John Clifford Head
John Robert Porter
Sarah Catherine Archibald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Celltech Ltd
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Publication of DE69907683D1 publication Critical patent/DE69907683D1/de
Application granted granted Critical
Publication of DE69907683T2 publication Critical patent/DE69907683T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • C07D213/82Amides; Imides in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE69907683T 1998-07-03 1999-07-02 Zimtsäure-derivate als zelladhäsions-moleküle Expired - Fee Related DE69907683T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9814414.0A GB9814414D0 (en) 1998-07-03 1998-07-03 Chemical compounds
GB9814414 1998-07-03
PCT/GB1999/002130 WO2000001690A1 (en) 1998-07-03 1999-07-02 Cinnamic acid derivatives as cell adhesion molecules

Publications (2)

Publication Number Publication Date
DE69907683D1 true DE69907683D1 (de) 2003-06-12
DE69907683T2 DE69907683T2 (de) 2004-03-11

Family

ID=10834875

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69907683T Expired - Fee Related DE69907683T2 (de) 1998-07-03 1999-07-02 Zimtsäure-derivate als zelladhäsions-moleküle

Country Status (9)

Country Link
US (1) US6465471B1 (de)
EP (1) EP1095036B1 (de)
JP (1) JP2002519420A (de)
AT (1) ATE239721T1 (de)
AU (1) AU4634999A (de)
DE (1) DE69907683T2 (de)
ES (1) ES2198138T3 (de)
GB (1) GB9814414D0 (de)
WO (1) WO2000001690A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6424722B1 (en) * 1997-01-13 2002-07-23 Micro Ear Technology, Inc. Portable system for programming hearing aids
KR20020067050A (ko) 1999-12-28 2002-08-21 화이자 프로덕츠 인코포레이티드 염증성, 자기면역 및 호흡기 질환의 치료에 유용한브이엘에이-4 의존성 세포 결합의 비펩티드계 억제제
US6960597B2 (en) 2000-06-30 2005-11-01 Orth-Mcneil Pharmaceutical, Inc. Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
EP1301488A1 (de) 2000-07-07 2003-04-16 Celltech R&D Limited Bicyclische heteroaromatische ring enthaltende quadratsäure-derivate als integrin-antagonisten
WO2014191726A1 (en) 2013-05-28 2014-12-04 Astrazeneca Ab Chemical compounds

Family Cites Families (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1437781A (en) 1972-04-04 1976-06-03 Beecham Group Ltd Pyridine derivatives having hypoglycaemic activity
JPS609718B2 (ja) 1977-08-25 1985-03-12 塩野義製薬株式会社 チアジアゾリルチオセフアロスポリン類縁抗生物質
JPS5683483A (en) 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
JPS5690045A (en) 1979-12-25 1981-07-21 Tokuyama Soda Co Ltd Alpha*alpha**di substituted amino phenylenediacetic acid
JPS56139455A (en) 1980-04-02 1981-10-30 Santen Pharmaceut Co Ltd Sulfur-containing acylaminoacid
JPS5780370A (en) * 1980-11-05 1982-05-19 Kowa Co Alpha-methylcinnamic acid derivative, its preparation and antilipemic agent containing the same
US4470973A (en) 1982-07-19 1984-09-11 E. R. Squibb & Sons, Inc. Substituted peptide compounds
FR2540871B1 (fr) 1983-02-16 1986-01-10 Lipha Amino-2 phenyl-5 benzodiazepines-1,3; procede de preparation et medicaments les contenant
GB8332704D0 (en) 1983-12-07 1984-01-11 Pfizer Ltd Growth promotants for animals
IT1176983B (it) 1984-10-16 1987-08-26 Zambon Spa Dipeptidi ad attivita' farmacologica
CN1030415A (zh) 1987-02-20 1989-01-18 山之内制药株式会社 饱和的杂环碳酰胺衍生物和它的制备方法
JPH0784424B2 (ja) 1987-04-15 1995-09-13 味の素株式会社 チロシン誘導体及びその用途
US5510346A (en) 1987-12-07 1996-04-23 Hoechst Marion Roussel, Inc. 4-heteroaryl-1,3-benzodiazepines and 2-substituted-gamma-(heteroaryl)benzeneethanamines
IT1223565B (it) 1987-12-21 1990-09-19 Zambon Spa Derivati dell'acido tiazolidin 4 carbossilico ad attivita' farmaceutica
US5256812A (en) 1989-01-31 1993-10-26 Hoffmann-La Roche Inc. Carboxamides and sulfonamides
US5164372A (en) 1989-04-28 1992-11-17 Fujisawa Pharmaceutical Company, Ltd. Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
JPH07121917B2 (ja) 1989-07-31 1995-12-25 四国化成工業株式会社 4(5)―チオカルバモイル―イミダゾール化合物及びその合成方法
DE4037003A1 (de) * 1990-05-30 1991-12-05 Bayer Ag Substituierte azine
IT1244548B (it) 1991-02-06 1994-07-15 Poli Ind Chimica Spa Derivati della 5-oxo-l-prolina e loro applicazioni farmaceutiche
PT100631B (pt) 1991-06-28 1999-06-30 Smithkline Beecham Corp Antagonistas biciclicos de fibrinogenio, seu uso e composicoes farmaceuticas que os contem
US5296486A (en) 1991-09-24 1994-03-22 Boehringer Ingelheim Pharmaceuticals, Inc. Leukotriene biosynthesis inhibitors
US5250679A (en) 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
AU3141693A (en) 1991-11-22 1993-06-15 Friedman, Mark M. Non-peptidic surrogates of the arg-gly-asp sequence and pharmaceutical compositions comprising them
US5227490A (en) 1992-02-21 1993-07-13 Merck & Co., Inc. Fibrinogen receptor antagonists
AU686115B2 (en) 1992-11-02 1998-02-05 Fujisawa Pharmaceutical Co., Ltd. Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation
FR2700167B1 (fr) 1993-01-07 1995-02-03 Rhone Poulenc Rorer Sa Dérivés de pyrrolidine et thiazolidine, leur préparation et les médicaments les contenant.
FR2700168B1 (fr) 1993-01-07 1995-02-03 Rhone Poulenc Rorer Sa Dérivés de thiazolidine, leur préparation et les médicaments les contenant.
GB9311661D0 (en) 1993-06-05 1993-07-21 Smithkline Beecham Plc Novel compounds
AU678503B2 (en) 1993-09-24 1997-05-29 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds and their use as squalene synthetase inhibitors
WO1995013811A1 (de) 1993-11-17 1995-05-26 Byk Nederland Bv Verwendung substituierter thiazolidinderivate zur behandlung von erhöhtem augeninnendruck
WO1995015973A1 (en) 1993-12-06 1995-06-15 Cytel Corporation Cs-1 peptidomimetics, compositions and methods of using the same
JP2973271B2 (ja) 1994-01-18 1999-11-08 参天製薬株式会社 エンドペプチダーゼ24.15阻害剤
AU694495B2 (en) * 1994-03-28 1998-07-23 Ciba-Geigy Japan Limited Antagonists of endothelin receptors
FR2721608B1 (fr) 1994-06-22 1996-07-19 Rhone Poulenc Rorer Sa Dérivés de thiazolidine, leur préparation et les médicaments les contenant.
DE69530392D1 (de) 1994-07-11 2003-05-22 Athena Neurosciences Inc Inhibitoren der leukozytenadhäsion
ES2123889T3 (es) 1994-11-02 1999-01-16 Merck Patent Gmbh Antagonistas de receptores de adhesion.
TW403748B (en) 1994-11-02 2000-09-01 Takeda Chemical Industries Ltd An oxazolidinedione derivative, its production and a pharmaceutical composition for lowering blood sugar and lipid in blood comprising the same
US6306840B1 (en) 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
WO1996026190A1 (en) 1995-02-22 1996-08-29 Smithkline Beecham Corporation Integrin receptor antagonists
US5977075A (en) * 1995-04-21 1999-11-02 Novartis Ag N-aroylamino acid amides as endothelin inhibitors
US6248713B1 (en) 1995-07-11 2001-06-19 Biogen, Inc. Cell adhesion inhibitors
ATE203234T1 (de) 1995-08-30 2001-08-15 Searle & Co Meta-guanidine, harnstoff, thioharnstoff oder azacyklische aminobenzoesäure-derivate als integrin antagonisten
US5714488A (en) 1995-10-03 1998-02-03 Abbott Laboratories Bis-heteroarylylmethoxyphenyl ketone derivatives as inhibitors of leukotriene biosynthesis
CA2240439A1 (en) 1995-12-22 1997-07-03 The Dupont Merck Pharmaceutical Company Novel integrin receptor antagonists
CN1209063A (zh) 1995-12-29 1999-02-24 史密丝克莱恩比彻姆公司 玻连蛋白受体拮抗剂
GB9604242D0 (en) 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
PT889876E (pt) 1996-03-29 2001-11-30 Searle & Co Derivados de fenilenossulfonamidas meta-substituidas
JP2000506538A (ja) 1996-03-29 2000-05-30 ジー.ディー.サール アンド カンパニー メタ―置換フェニレン誘導体
JP2000515493A (ja) 1996-03-29 2000-11-21 ジー.ディー.サール アンド カンパニー パラ―置換フェニレン誘導体
DE69705300T2 (de) 1996-03-29 2002-05-02 G.D. Searle & Co., Chicago Cyclopropylalkansäurederivate
DE19620041A1 (de) 1996-05-17 1998-01-29 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
JP3418624B2 (ja) 1996-06-10 2003-06-23 メルク エンド カンパニー インコーポレーテッド サイトカイン阻害活性を有する置換イミダゾール類
DE19654483A1 (de) 1996-06-28 1998-01-02 Merck Patent Gmbh Phenylalanin-Derivate
CA2259224A1 (en) 1996-06-28 1998-01-08 Merck Patent Gesellschaft Mit Beschraenkter Haftung Phenylalamine derivatives as integrin inhibitors
EP0917462B1 (de) 1996-07-25 2006-09-13 Biogen Idec MA Inc. Zelladhäsionsinhibitoren
EP0946165B1 (de) 1996-10-30 2003-04-09 Merck & Co., Inc. Integrin antagonist
DE19647380A1 (de) 1996-11-15 1998-05-20 Hoechst Ag 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
DE19647381A1 (de) 1996-11-15 1998-05-20 Hoechst Ag Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
DE69720062D1 (de) 1996-12-09 2003-04-24 Lilly Co Eli Integrin antagonisten
CA2277273C (en) 1997-01-17 2008-03-25 Merck & Co., Inc. Integrin antagonists
US6034136A (en) 1997-03-20 2000-03-07 Novartis Ag Certain cyclic thio substituted acylaminoacid amide derivatives
JP2002512625A (ja) 1997-05-29 2002-04-23 メルク エンド カンパニー インコーポレーテッド 細胞接着阻害薬としての複素環アミド化合物
WO1998053817A1 (en) 1997-05-29 1998-12-03 Merck & Co., Inc. Biarylalkanoic acids as cell adhesion inhibitors
CA2291708A1 (en) 1997-05-29 1998-12-03 Merck & Co., Inc. Sulfonamides as cell adhesion inhibitors
JP2002501518A (ja) 1997-05-30 2002-01-15 セルテック セラピューティックス リミテッド 抗炎症性チロシン誘導体
ES2206953T3 (es) 1997-06-23 2004-05-16 Tanabe Seiyaku Co., Ltd. Inhibidores de la adherencia celular mediada por alfa 4-beta 1.
EP0994895A1 (de) 1997-07-31 2000-04-26 Elan Pharmaceuticals, Inc. Dipeptide, die die vla-4 vermittelte adhäsion von leukozyten inhibieren
PL338413A1 (en) 1997-07-31 2000-11-06 Elan Pharm Inc Compound of 4-amino phenylalanine type inhibiting adhesion of leucocytes through the meditation of vla-4
CN1265670A (zh) 1997-07-31 2000-09-06 伊兰药品公司 抑制vla-4介导的白细胞粘附的二肽和相关的化合物
CN1133648C (zh) 1997-07-31 2004-01-07 伊兰药品公司 抑制vla-4介导的白细胞粘附的取代的苯丙氨酸型化合物
CN1265669A (zh) 1997-07-31 2000-09-06 伊兰药品公司 抑制由vla-4介导的白细胞粘着的化合物
WO1999006436A1 (en) 1997-07-31 1999-02-11 Elan Pharmaceuticals, Inc. Benzyl compounds which inhibit leukocyte adhesion mediated by vla-4
CN1265672A (zh) 1997-07-31 2000-09-06 伊兰药品公司 能抑制由vla-4介导的白细胞粘连的磺酰化二肽化合物
AR016133A1 (es) 1997-07-31 2001-06-20 Wyeth Corp Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria
NZ502813A (en) 1997-08-22 2002-10-25 F N-aroylphenylalanine derivatives as inhibitors of the interaction between a4 containing integrins and VCAM-1
CA2300121A1 (en) 1997-08-22 1999-03-04 F. Hoffmann-La Roche Ag N-alkanoylphenylalanine derivatives
AU1361499A (en) 1997-10-21 1999-05-10 Merck & Co., Inc. Azapeptide acids as cell adhesion inhibitors
AU1463499A (en) 1997-11-21 1999-06-15 Merck & Co., Inc. Substituted pyrrole derivatives as cell adhesion inhibitors
DE69824037T2 (de) 1997-11-24 2005-06-02 Merck & Co., Inc. Beta-alanin-derivate als zell-adhäsions-inhibitoren
IL136267A0 (en) 1997-11-26 2001-05-20 Du Pont Pharm Co 1,3,4-THIADIZOLES AND 1,3,4-OXADIAZOLES AS αVβ3 ANTAGONISTS
IL136495A0 (en) 1997-12-17 2001-06-14 Merck & Co Inc Integrin receptor antagonists
ATE298338T1 (de) 1997-12-17 2005-07-15 Merck & Co Inc Integrin-rezeptor-antagonisten
EP1047425A4 (de) 1997-12-17 2009-04-22 Merck & Co Inc Integrinrezeptor antagonisten
EP0933367A1 (de) 1997-12-19 1999-08-04 Hoechst Marion Roussel Deutschland GmbH Acylguanidin Derivate als Inhibitoren von Knochenaufsauge und als Vitronectin Rezeptor Antagonisten
US6197794B1 (en) 1998-01-08 2001-03-06 Celltech Therapeutics Limited Phenylalanine derivatives
MY153569A (en) 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
US6329372B1 (en) 1998-01-27 2001-12-11 Celltech Therapeutics Limited Phenylalanine derivatives
US6555562B1 (en) 1998-02-26 2003-04-29 Celltech R&D Limited Phenylalanine derivatives
ZA994406B (en) 1998-03-04 2000-02-11 Searle & Co Meta-azacyclic amino benzoic acid and derivatives thereof.
US6521626B1 (en) 1998-03-24 2003-02-18 Celltech R&D Limited Thiocarboxamide derivatives
CZ20003672A3 (cs) 1998-04-10 2001-08-15 G. D. Searle & Co. Heterocyklické glycyl-beta-alaninové deriváty jako agonisté vitronektinu
AU3561099A (en) 1998-04-14 1999-11-01 American Home Products Corporation Acylresorcinol derivatives as selective vitronectin receptor inhibitors
AU3563799A (en) 1998-04-16 1999-11-01 Texas Biotechnology Corporation Compounds that inhibit the binding of integrins to their receptors
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
GB9811159D0 (en) 1998-05-22 1998-07-22 Celltech Therapeutics Ltd Chemical compounds
AU8059598A (en) 1998-06-11 1999-12-30 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
TW591026B (en) 1998-06-23 2004-06-11 Upjohn Co Inhibitors of alpha4beta1 mediated cell adhesion
ATE253061T1 (de) 1998-06-29 2003-11-15 Iaf Biochem Int Zur behandlung von krebs nützliche thiophen- und furan-2,5-dicarboxamide
AU4862599A (en) 1998-07-06 2000-01-24 Merck Patent Gmbh Angiogenesis inhibitors

Also Published As

Publication number Publication date
AU4634999A (en) 2000-01-24
GB9814414D0 (en) 1998-09-02
US6465471B1 (en) 2002-10-15
EP1095036B1 (de) 2003-05-07
JP2002519420A (ja) 2002-07-02
ES2198138T3 (es) 2004-01-16
DE69907683T2 (de) 2004-03-11
WO2000001690A1 (en) 2000-01-13
EP1095036A1 (de) 2001-05-02
ATE239721T1 (de) 2003-05-15

Similar Documents

Publication Publication Date Title
ATE273273T1 (de) Phenylalaninderivate als inhibitoren von alpha4 integrinen
ATE281451T1 (de) Imidazolderivate und deren verwendung als raf kinase inhibitoren
SE9801526D0 (sv) New compounds
MY121294A (en) Novel hexanoic acid derivatives.
MX9702658A (es) Derivados novedosos de acido carboxilico, su preparacion y uso.
DK0623607T3 (da) Benzofuranyl- og -thiophenyl-alkancarboxylsyrederivater
NO178189C (no) Tetrazolmellomprodukter
ATE263157T1 (de) Nematizide trifluorbutene
TR199700844T1 (xx) Pirazolil-Benzoil T�revleri.
DE69710319D1 (de) Para-substituierte phenylpropansäure derivate als integrin-antagonisten
SE9704404D0 (sv) New compounds
ATE275559T1 (de) Aromatische amin-derivate verwendbar als pharmazeutische mittel
LV12047A (lv) Kondenseti pirimidina atvasinajumi un to lietosana par angiotenzina II antagonistiem
DE60027435D1 (de) Substituierte 2-arylbenzazole und ihre verwendung als antitumorale mittel
TR199802060T2 (xx) Aminoisokinolinler ve aminopiridin t�revlerinin iltihap �nleyiciler olarak kullan�m�.
MY118822A (en) Compounds for inhibition of gastric acid secretion
DE69021639D1 (de) Disäuren von Diarylstyrylchinolin.
DE69723863D1 (de) Chinoline und deren therapeutische verwendung
EA200200876A1 (ru) Алкилированные производные имидазопиридина
GB2387845B (en) Phenylalanine enamide derivatives
MY119012A (en) New compounds
ATE311389T1 (de) Wirkstoffvorläufer von imidazopyridin-derivaten
MY121387A (en) Imidazo[1,2-a]pyridine derivatives for the treatment of gastrointestinal diseases
NO984950L (no) Forbindelser med veksthormonfrigj°rende egenskaper
DE69907683D1 (de) Zimtsäure-derivate als zelladhäsions-moleküle

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee